ECSP972301A - SUBSTITUTED TRICYCLES - Google Patents
SUBSTITUTED TRICYCLESInfo
- Publication number
- ECSP972301A ECSP972301A ECSP972301A ECSP972301A EC SP972301 A ECSP972301 A EC SP972301A EC SP972301 A ECSP972301 A EC SP972301A EC SP972301 A ECSP972301 A EC SP972301A
- Authority
- EC
- Ecuador
- Prior art keywords
- nitrogen
- group
- sulfur
- oxygen
- carbon
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 14
- 229910052757 nitrogen Inorganic materials 0.000 abstract 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- 239000001301 oxygen Substances 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 239000011593 sulfur Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 230000002452 interceptive effect Effects 0.000 abstract 3
- 125000005647 linker group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
El invento se refiere a un compuesto de la fórmula III (gráfico), donde: A es fenilo o piridil donde el nitrógeno está en la posición 5-,6-,7- o 8; uno de B o D es nitrógeno y el otro es carbono; Z es ciclohexenil, fenil, piridil, donde el nitrógeno está en la posición 1-,2- o 3 o un anillo heterocíclico de 6 miembros conteniendo un heterroátomo seleccionado de entre el grupo que consiste en azufre u oxígeno en la posición 1,2 o 3 y nitrógeno en la posición 1-,2-,3-, o 4; es un enlace doble o simple. R20 es seleccionado de entre los grupos (a)(b) y (c) donde ; (a) es -(C5-C20) alquilo, -(C5-C20) alquenil, -(C5-C20) alquini, radicales carbocíclicas o radicales heterocíclicas o (b) es un miembro de (a) sustituído con uno o más sustituyentes que no interfieren independientemente seleccionado; o (c) es el grupo -(L)- R80; donde -(L)- es un grupo de unión divalente de 1 a 12 átomos seleccionados de entre carbono, hidrógeno, oxígeno, nitrógeno y azufre; donde la combinación de átomos en-(L) son seleccionados del grupo que consiste de (i) carbono e hidrógeno solamente, (ii) solamente un azufre, (iii) solamente un oxígeno, (iv) solamente uno o dos nitrógeno e hidrógenos (v) carbono, hidrógeno y azufre solamente y (vi) y cabono, hidrógeno y solamente oxígeno; y donde R80 es un grupo seleccionado de entre (a) o (b); R21 es un sustituyente de no interferencia R1 es -NHNH2 o -NH2; R2 es seleccionada del grupo -OH, -08CH2) tR5 donde R5 es CN o fenil, o (La) - (grupo ácidico), donde -(La)- es un enlasador que tiene un enlasador ácido de longitud de 1 a 7 y t es 1-5; R3 es seleccionado a partir de un sustituyente de no interferencia, radicales carbocíclicos, radicales carbocíclicos sustituidos con sustituyente que no interfieran, radicales heterocíclicos y radicales heterocíclicos sustituídos con sustituyentes que no interfieran; o una sal farmacéuticamente aceptable, racemato, solvato, tautómero somer óptico o derivados prodrogas de esto; provisto de que cuando R3 es H, R20 es bencilo y m es 1 o 2; R2 no puede ser -O(CH2)mH; y cuando D es nitrógeno, el heterroátomo de Z es seleccionado de entre el grupo que consiste de azufre u oxígeno en la posición 1-,2- o 3 y nitrógeno en la posición 1-, 2-, 3 o 4.The invention relates to a compound of formula III (graph), where: A is phenyl or pyridyl where the nitrogen is in the 5-, 6-, 7- or 8-position; one of B or D is nitrogen and the other is carbon; Z is cyclohexenyl, phenyl, pyridyl, where the nitrogen is in the 1-, 2- or 3-position or a 6-membered heterocyclic ring containing a hetero atom selected from the group consisting of sulfur or oxygen in the 1,2-position or 3 and nitrogen at position 1-, 2-, 3-, or 4; it is a double or single bond. R20 is selected from groups (a) (b) and (c) where; (a) is - (C5-C20) alkyl, - (C5-C20) alkenyl, - (C5-C20) alkylin, carbocyclic radicals or heterocyclic radicals or (b) is a member of (a) substituted with one or more substituents they do not interfere independently selected; or (c) is the group - (L) -R80; where - (L) - is a divalent linking group of 1 to 12 atoms selected from carbon, hydrogen, oxygen, nitrogen and sulfur; where the combination of en- (L) atoms are selected from the group consisting of (i) carbon and hydrogen only, (ii) only one sulfur, (iii) only one oxygen, (iv) only one or two nitrogen and hydrogens ( v) carbon, hydrogen and sulfur only and (vi) and carbon, hydrogen and only oxygen; and where R80 is a group selected from (a) or (b); R21 is a non-interference substituent; R1 is -NHNH2 or -NH2; R2 is selected from the group -OH, -08CH2) tR5 where R5 is CN or phenyl, or (La) - (acidic group), where - (La) - is a linker having an acid linker of length 1 to 7 and t is 1-5; R3 is selected from a non-interfering substituent, carbocyclic radicals, non-interfering substituent substituted carbocyclic radicals, heterocyclic radicals, and heterocyclic radicals substituted with non-interfering substituents; or a pharmaceutically acceptable salt, racemate, solvate, someroptic tautomer or prodrug derivatives thereof; provided that when R3 is H, R20 is benzyl and m is 1 or 2; R2 cannot be -O (CH2) mH; and when D is nitrogen, the hetero atom of Z is selected from the group consisting of sulfur or oxygen in position 1-, 2- or 3 and nitrogen in position 1-, 2-, 3 or 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972301 ECSP972301A (en) | 1997-10-30 | 1997-10-30 | SUBSTITUTED TRICYCLES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972301 ECSP972301A (en) | 1997-10-30 | 1997-10-30 | SUBSTITUTED TRICYCLES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972301A true ECSP972301A (en) | 1998-12-14 |
Family
ID=42043130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972301 ECSP972301A (en) | 1997-10-30 | 1997-10-30 | SUBSTITUTED TRICYCLES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972301A (en) |
-
1997
- 1997-10-30 EC ECSP972301 patent/ECSP972301A/en unknown
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