ECSP972346A - VINYL CEPHALOSPORINS - PYRROLIDINONES WITH BASIC SUBSTITUTES - Google Patents
VINYL CEPHALOSPORINS - PYRROLIDINONES WITH BASIC SUBSTITUTESInfo
- Publication number
- ECSP972346A ECSP972346A ECSP972346A ECSP972346A EC SP972346 A ECSP972346 A EC SP972346A EC SP972346 A ECSP972346 A EC SP972346A EC SP972346 A ECSP972346 A EC SP972346A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydrogen
- formula
- hydroxy
- compounds
- carbamimidoyl
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 1
- 229920002554 vinyl polymer Polymers 0.000 title 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical class C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 title 1
- -1 pyrrolidin-2-ylmethyl Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 229910001413 alkali metal ion Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000006242 amine protecting group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
El presente invento se refiere a derivados de cefalosporina de la fórmula general (gráfico), en donde X es CH o N; R1 es hidrógeno o ciclopentilo; R2 es un grupo de la fórmula (gráfico), R3 es hidrógeno, un ión de metal alcalino o un grupo de amonto terciario; R4 es hidrógeno, un grupo protector amínico, pirrolidin-2-ilmetilo, azetidin -3-ilmetilo, iminometilo, 1-carbamimidoilo; R5 es hidrógeno, dialquilcarbamoilo, ew-hidroxialquilo, w-aminoalquilo, piridino-1-metilo, 1-hidroxi-3- aminometil-propilo o (hidroxi)-(pirrolidin-2-il)-metilo; R6 es hidrógeno, trifluorometilo o hidroxilo; y R7 es alquilo, w-hidroxi-alquilo, cicloalquilo, 3-pirrolidinilo, 3-azetidinilo, iminometilo o 1 -carbamimidoilo; así como sus ésteres fácilmente hidrolizable, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de fórmula I y de sus ésteres y sales; el invento se refiere también a la preparación de compuestos de fórmula I; a su empleo como sustancias y farmacéuticamente activas, particularmente para el tratamiento y profilaxis de enfermedades infecciosas.The present invention relates to cephalosporin derivatives of the general formula (graph), wherein X is CH or N; R1 is hydrogen or cyclopentyl; R2 is a group of the formula (graph), R3 is hydrogen, an alkali metal ion or a tertiary ammonium group; R4 is hydrogen, an amine protecting group, pyrrolidin-2-ylmethyl, azetidin -3-ylmethyl, iminomethyl, 1-carbamimidoyl; R5 is hydrogen, dialkylcarbamoyl, ew-hydroxyalkyl, w-aminoalkyl, pyridine-1-methyl, 1-hydroxy-3-aminomethyl-propyl or (hydroxy) - (pyrrolidin-2-yl) -methyl; R6 is hydrogen, trifluoromethyl or hydroxyl; and R7 is alkyl, w-hydroxy-alkyl, cycloalkyl, 3-pyrrolidinyl, 3-azetidinyl, iminomethyl or 1-carbamimidoyl; as well as its easily hydrolyzable esters, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and their esters and salts; the invention also relates to the preparation of compounds of formula I; to their use as substances and pharmaceutically active, particularly for the treatment and prophylaxis of infectious diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972346 ECSP972346A (en) | 1997-12-19 | 1997-12-19 | VINYL CEPHALOSPORINS - PYRROLIDINONES WITH BASIC SUBSTITUTES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972346 ECSP972346A (en) | 1997-12-19 | 1997-12-19 | VINYL CEPHALOSPORINS - PYRROLIDINONES WITH BASIC SUBSTITUTES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972346A true ECSP972346A (en) | 1998-12-22 |
Family
ID=42043175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972346 ECSP972346A (en) | 1997-12-19 | 1997-12-19 | VINYL CEPHALOSPORINS - PYRROLIDINONES WITH BASIC SUBSTITUTES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972346A (en) |
-
1997
- 1997-12-19 EC ECSP972346 patent/ECSP972346A/en unknown
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