ECSP982717A - D-PROLINE DERIVATIVES - Google Patents
D-PROLINE DERIVATIVESInfo
- Publication number
- ECSP982717A ECSP982717A ECSP982717A ECSP982717A EC SP982717 A ECSP982717 A EC SP982717A EC SP982717 A ECSP982717 A EC SP982717A EC SP982717 A ECSP982717 A EC SP982717A
- Authority
- EC
- Ecuador
- Prior art keywords
- naphthyl
- benzyl
- phenylene
- ch2c6h5
- oxadiazolyl
- Prior art date
Links
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical class OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 title 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- -1 thiazol-2,5-diyl Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 3
- 150000008567 D-prolines Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
- YMRIDJQAEZFTSC-UHFFFAOYSA-N 2,3-dihydro-1h-tetrazole Chemical compound N1NC=NN1 YMRIDJQAEZFTSC-UHFFFAOYSA-N 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000004939 6-pyridyl group Chemical group N1=CC=CC=C1* 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 206010002022 amyloidosis Diseases 0.000 abstract 1
- 125000002529 biphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C12)* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000004316 oxathiadiazolyl group Chemical group O1SNN=C1* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000009897 systematic effect Effects 0.000 abstract 1
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L presente inevnción se refiere a D-prolinas de fórmula (gráfico), en donde R es SH, bencilo o fenilo, opcionalmente sustituido con hidroxilo o alcoxilo inferior o el grupo (gráfico), R1 es hidrógeno o halógeno; X es -(CH2)n-; -CH(R2)(CH2)n; -CH2O(CH2)n; -CH2NH-; bencilo, -C(R2)=CH-; -CH2CH(OH)-; ó tiazol-2,5-diilo; Y es -S-S-; -(CH2)n; -O-; -NH-; -CH=CH-; -NHC(O) NH-; -N(R2)C(O) N(R2)-; -N(CH2C6H3(OCH3)2)-; -N(CH2C6H5)-; -N(CH2C6H5)C (O)N(CH2C6H5)-; -N(alcoxialquil)-; N (cicloalquil-metil)-; 2,6-piridilo; 2,5-furanilo; 2,5-tienilo; 1,2-ciclohexilo; 1,3-ciclohexilo; 1,4-ciclohexilo; 1,2-naftilo; 1,4-naftilo; 1,5-naftilo; 1,6-naftilo; bifenileno; ó 1,2-fenileno, 1,3-fenileno y 1,4-fenileno, en donde los grupos fenileno están opcionalmente sustituidos con 1-4 sustituyentes seleccionados entre halógeno, alquilo inferior, alcoxilo inferior, hidroxilo, carboxilo, -COO-alquilo inferior, nitrilo, 5-tetrazol, (2-ácido carboxiclico-pirrolidin-1-ilo)-2-oxo-etoxilo, N-hidroxicarbamimidoilo,5-oxo-[1,2,4]oxadiazolilo, 2-oxo-[1,2,3,5] oxatiadiazolilo, 5-tioxo-[1,2,4] oxadiazolilo y 5-terc-butilsulfanil-[1,2,4]oxadiazolilo; X¿es -(CH2)n-; -(CH2)nCH(R2)-; -(CH2)nOCH2-; -NHCH2-; bencilo, -CH=C(R2)-; -CH(OH)CH2; ó tiazol -2,5-diilo; R2 es alquilo inferior, alcoxilo inferior o bencilo, y n es 0-3, y a las sales farmacéuticamente aceptables y a los mono y diésteres de los mismos. Las D-prolinas de fórmula I-A y I-B pueden emplearse en el tratamiento o prevención de todas las formas de amiloidosis central y sistemática.The present invention refers to D-prolines of the formula (graph), wherein R is SH, benzyl or phenyl, optionally substituted with hydroxyl or lower alkoxy or the group (graph), R1 is hydrogen or halogen; X is - (CH2) n-; -CH (R2) (CH2) n; -CH2O (CH2) n; -CH2NH-; benzyl, -C (R2) = CH-; -CH2CH (OH) -; or thiazol-2,5-diyl; Y is -S-S-; - (CH2) n; -OR-; -NH-; -CH = CH-; -NHC (O) NH-; -N (R2) C (O) N (R2) -; -N (CH2C6H3 (OCH3) 2) -; -N (CH2C6H5) -; -N (CH2C6H5) C (O) N (CH2C6H5) -; -N (alkoxyalkyl) -; N (cycloalkyl-methyl) -; 2,6-pyridyl; 2,5-furanyl; 2,5-thienyl; 1,2-cyclohexyl; 1,3-cyclohexyl; 1,4-cyclohexyl; 1,2-naphthyl; 1,4-naphthyl; 1,5-naphthyl; 1,6-naphthyl; biphenylene; or 1,2-phenylene, 1,3-phenylene and 1,4-phenylene, where the phenylene groups are optionally substituted with 1-4 substituents selected from halogen, lower alkyl, lower alkoxy, hydroxyl, carboxyl, -COO-alkyl lower, nitrile, 5-tetrazole, (2-carboxylic acid-pyrrolidin-1-yl) -2-oxo-ethoxy, N-hydroxycarbamimidoyl, 5-oxo- [1,2,4] oxadiazolyl, 2-oxo- [1 2,3,5] oxathiadiazolyl, 5-thioxo- [1,2,4] oxadiazolyl and 5-tert-butylsulfanyl- [1,2,4] oxadiazolyl; X¿es - (CH2) n-; - (CH2) nCH (R2) -; - (CH2) nOCH2-; -NHCH2-; benzyl, -CH = C (R2) -; -CH (OH) CH2; or thiazole -2,5-diyl; R2 is lower alkyl, lower alkoxy or benzyl, and n is 0-3, and to pharmaceutically acceptable salts and mono- and diesters thereof. The D-prolines of formula I-A and I-B can be used in the treatment or prevention of all forms of central and systematic amyloidosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982717 ECSP982717A (en) | 1998-10-30 | 1998-10-30 | D-PROLINE DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982717 ECSP982717A (en) | 1998-10-30 | 1998-10-30 | D-PROLINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982717A true ECSP982717A (en) | 2000-05-08 |
Family
ID=42043635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982717 ECSP982717A (en) | 1998-10-30 | 1998-10-30 | D-PROLINE DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982717A (en) |
-
1998
- 1998-10-30 EC ECSP982717 patent/ECSP982717A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2252163A1 (en) | D-proline derivatives | |
| IS6565A (en) | The tropane derivatives are useful in the treatment | |
| NO20015172L (en) | 1-methyl-erythromycin derivatives | |
| DE60027648D1 (en) | SULPHONAMIDE-CONTAINING INDOIND DERIVATIVES | |
| HU229605B1 (en) | Substituted 4-(phenyl-n-alkyl)-piperidine derivatives, their use as modulators of dopamine neurotransmission and pharmaceutical compositions containing them | |
| NZ514873A (en) | 4,5,6,7-tetrahydroindazole derivatives as antitumor agents | |
| MY137156A (en) | Dual nk1/nk3 derivatives | |
| EA200300071A1 (en) | THERAPEUTIC PREPARATION FOR THE TREATMENT OF FEAR NEUROSIS (ALARM) OR DEPRESSIONS AND DERIVATIVES OF PIPERAZINE | |
| PT992509E (en) | NEW MACROLIDED DERIVATIVES | |
| EE04564B1 (en) | Bifen lamidine derivatives, prodrug, blood coagulation inhibitor and prophylactic and therapeutic agent for thrombosis or embolism | |
| ECSP982717A (en) | D-PROLINE DERIVATIVES | |
| NZ533795A (en) | Carboxamidine derivatives and their use in the treatment of vascular diseases | |
| DE50013571D1 (en) | MEDICAMENT FOR THE TREATMENT OF NEUROPATHIES | |
| DE60220678D1 (en) | INHIBITORS OF THE AGGREGATION OF POLYQ | |
| IT1313583B1 (en) | 2-AMINOTETRALINIC DERIVATIVES FOR GLAUCOMA THERAPY. | |
| NZ332530A (en) | D-proline derivatives, a process of manufacture and their use as a medicament to treat amyloidosis | |
| DK0784973T3 (en) | Quinoxaline derivatives for the treatment of tinnitus | |
| PE20001073A1 (en) | AMINOALKYL-3,4-DIHYDROQUINOLEINE DERIVATIVES FROM FORMULA (I) | |
| EA200000922A1 (en) | AMINOANTRACYCLINON DERIVATIVES AND THEIR APPLICATION IN THE TREATMENT OF AMYLOIDOSIS | |
| WO2002007714A3 (en) | Use of anellated dihydropyridines for the preparation of pharmaceutical compositions for the treatment of chronic pain | |
| ATE243219T1 (en) | 9A, 11B-DEHYDRO DERIVATIVES OF 9-OXIME-3-KETO-6-0-METHYLERYTHROMYCIN | |
| AR011139A1 (en) | 4-AMINOALCOXI-1,3-DIHIDRO-BENZOIMIDAZOLE-2-TIONAS, ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM |