ECSP982717A - Derivados de d-prolina - Google Patents
Derivados de d-prolinaInfo
- Publication number
- ECSP982717A ECSP982717A ECSP982717A ECSP982717A EC SP982717 A ECSP982717 A EC SP982717A EC SP982717 A ECSP982717 A EC SP982717A EC SP982717 A ECSP982717 A EC SP982717A
- Authority
- EC
- Ecuador
- Prior art keywords
- naphthyl
- benzyl
- phenylene
- ch2c6h5
- oxadiazolyl
- Prior art date
Links
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical class OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 title 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- -1 thiazol-2,5-diyl Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 3
- 150000008567 D-prolines Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
- YMRIDJQAEZFTSC-UHFFFAOYSA-N 2,3-dihydro-1h-tetrazole Chemical compound N1NC=NN1 YMRIDJQAEZFTSC-UHFFFAOYSA-N 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000004939 6-pyridyl group Chemical group N1=CC=CC=C1* 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 206010002022 amyloidosis Diseases 0.000 abstract 1
- 125000002529 biphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C12)* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000004316 oxathiadiazolyl group Chemical group O1SNN=C1* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000009897 systematic effect Effects 0.000 abstract 1
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L presente inevnción se refiere a D-prolinas de fórmula (gráfico), en donde R es SH, bencilo o fenilo, opcionalmente sustituido con hidroxilo o alcoxilo inferior o el grupo (gráfico), R1 es hidrógeno o halógeno; X es -(CH2)n-; -CH(R2)(CH2)n; -CH2O(CH2)n; -CH2NH-; bencilo, -C(R2)=CH-; -CH2CH(OH)-; ó tiazol-2,5-diilo; Y es -S-S-; -(CH2)n; -O-; -NH-; -CH=CH-; -NHC(O) NH-; -N(R2)C(O) N(R2)-; -N(CH2C6H3(OCH3)2)-; -N(CH2C6H5)-; -N(CH2C6H5)C (O)N(CH2C6H5)-; -N(alcoxialquil)-; N (cicloalquil-metil)-; 2,6-piridilo; 2,5-furanilo; 2,5-tienilo; 1,2-ciclohexilo; 1,3-ciclohexilo; 1,4-ciclohexilo; 1,2-naftilo; 1,4-naftilo; 1,5-naftilo; 1,6-naftilo; bifenileno; ó 1,2-fenileno, 1,3-fenileno y 1,4-fenileno, en donde los grupos fenileno están opcionalmente sustituidos con 1-4 sustituyentes seleccionados entre halógeno, alquilo inferior, alcoxilo inferior, hidroxilo, carboxilo, -COO-alquilo inferior, nitrilo, 5-tetrazol, (2-ácido carboxiclico-pirrolidin-1-ilo)-2-oxo-etoxilo, N-hidroxicarbamimidoilo,5-oxo-[1,2,4]oxadiazolilo, 2-oxo-[1,2,3,5] oxatiadiazolilo, 5-tioxo-[1,2,4] oxadiazolilo y 5-terc-butilsulfanil-[1,2,4]oxadiazolilo; X¿es -(CH2)n-; -(CH2)nCH(R2)-; -(CH2)nOCH2-; -NHCH2-; bencilo, -CH=C(R2)-; -CH(OH)CH2; ó tiazol -2,5-diilo; R2 es alquilo inferior, alcoxilo inferior o bencilo, y n es 0-3, y a las sales farmacéuticamente aceptables y a los mono y diésteres de los mismos. Las D-prolinas de fórmula I-A y I-B pueden emplearse en el tratamiento o prevención de todas las formas de amiloidosis central y sistemática.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982717 ECSP982717A (es) | 1998-10-30 | 1998-10-30 | Derivados de d-prolina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982717 ECSP982717A (es) | 1998-10-30 | 1998-10-30 | Derivados de d-prolina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982717A true ECSP982717A (es) | 2000-05-08 |
Family
ID=42043635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982717 ECSP982717A (es) | 1998-10-30 | 1998-10-30 | Derivados de d-prolina |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982717A (es) |
-
1998
- 1998-10-30 EC ECSP982717 patent/ECSP982717A/es unknown
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