ECSP982753A - THROMBIN RECEPTOR ANTAGONISTS - Google Patents
THROMBIN RECEPTOR ANTAGONISTSInfo
- Publication number
- ECSP982753A ECSP982753A ECSP982753A ECSP982753A EC SP982753 A ECSP982753 A EC SP982753A EC SP982753 A ECSP982753 A EC SP982753A EC SP982753 A ECSP982753 A EC SP982753A
- Authority
- EC
- Ecuador
- Prior art keywords
- dotted line
- line represents
- single bond
- absent
- double dotted
- Prior art date
Links
- 239000003856 thrombin receptor antagonist Substances 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000010235 heart cancer Diseases 0.000 abstract 1
- 208000024348 heart neoplasm Diseases 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen triciclicos heterociclicos-sustituidos de la fórmula (gráfico), o una sal farmacéuticamente aceptable de los mismos, en donde: la línea punteada doble representa un enlace simple opcional; la línea punteada doble representa un enlace simple opcional n es 0-2; Q es cicloalquilo opcionalmente sustituido, heterocicloalquilo, arilo o heteroarilo; Het es un grupo heteroaromático mono, bi o tricíclico opcionalmente sustituido; B es -(CH2)n3-, en donde n3 es 0-5, -CH2 -O-, -CH2S-, -CH2-, -NR6-, C(O)NR6-, NR6C(O)-, (gráfico), alquenilo opcionalmente sustituido o alquinilo opcionalmente sustituido; X es -O- o NR6- cuando la línea punteada doble representa un enlace simple, o X es -OH o -NHR20 cuando el enlace está ausente. Y es =O, -S, (H,H) (H,OH) o (H, alcoxi C1-C6) cuando la línea punteada doble representa un enlace simple, o cuando el enlace está ausente, Y es =O, (H,H) (H,OH), (H,SH) o (H, alcoxi C1-C6)R15 está ausente cuando la linea punteada doble representa un enlace simple y es H, -NR18-19, o -OR17 cuando el enlace está ausente; o y es y (gráfico), R15 es H o alquilo C1-C6 asi como también composiciones farmacéuticas que los contienen, y un método para el tratamiento de enfermedades asociadas con trombosis, aterosclerosis, restenosis, hipertensión, angina de pecho, arritmia, insuficiencia cardiaca, y cáncer administrando dichos compuestos.Heterocyclic-substituted tricyclics of the formula (graph), or a pharmaceutically acceptable salt thereof, are described wherein: the double dotted line represents an optional single bond; the double dotted line represents an optional single bond n is 0-2; Q is optionally substituted cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Het is an optionally substituted mono, bi or tricyclic heteroaromatic group; B is - (CH2) n3-, where n3 is 0-5, -CH2 -O-, -CH2S-, -CH2-, -NR6-, C (O) NR6-, NR6C (O) -, (graph ), optionally substituted alkenyl or optionally substituted alkynyl; X is -O- or NR6- when the double dotted line represents a single bond, or X is -OH or -NHR20 when the bond is absent. Y is = O, -S, (H, H) (H, OH) or (H, C1-C6 alkoxy) when the double dotted line represents a single bond, or when the bond is absent, Y is = O, ( H, H) (H, OH), (H, SH) or (H, C1-C6 alkoxy) R15 is absent when the double dotted line represents a single bond and is H, -NR18-19, or -OR17 when the link is absent; oy is y (graph), R15 is H or C1-C6 alkyl as well as pharmaceutical compositions containing them, and a method for the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina, arrhythmia, heart failure , and cancer administering said compounds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982753 ECSP982753A (en) | 1998-11-24 | 1998-11-24 | THROMBIN RECEPTOR ANTAGONISTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982753 ECSP982753A (en) | 1998-11-24 | 1998-11-24 | THROMBIN RECEPTOR ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982753A true ECSP982753A (en) | 1999-04-16 |
Family
ID=42043672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982753 ECSP982753A (en) | 1998-11-24 | 1998-11-24 | THROMBIN RECEPTOR ANTAGONISTS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982753A (en) |
-
1998
- 1998-11-24 EC ECSP982753 patent/ECSP982753A/en unknown
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