ECSP992851A - PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS - Google Patents
PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINSInfo
- Publication number
- ECSP992851A ECSP992851A ECSP992851A ECSP992851A EC SP992851 A ECSP992851 A EC SP992851A EC SP992851 A ECSP992851 A EC SP992851A EC SP992851 A ECSP992851 A EC SP992851A
- Authority
- EC
- Ecuador
- Prior art keywords
- hedgehog
- support
- proteins
- protein
- negatively charged
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000003693 Hedgehog Proteins Human genes 0.000 title 1
- 108090000031 Hedgehog Proteins Proteins 0.000 title 1
- 241000289669 Erinaceus europaeus Species 0.000 abstract 5
- 229920000936 Agarose Polymers 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una composición farmacéutica de una proteína "erizo" que se caracteriza porque la proteina "erizo" se une a un soporte hidrofilico que es biocompatible y biodegradable, en donde el soporte es un polímero, el cual: -se une a la proteína "erizo" como un soporte cargado negativamente a causa de interacciones iónicas, -no desnaturtaliza la proteína "erizo" cuando está se une al soporte, -contiene por lo menos de 0,1 a 2 radicales cargados negativamente por monómero en condiciones neutras, -contiene la carga en forma de grupos de caracter ácido, -tiene un peso molecular medio de por lo menos 50000Da, -y no contiene agarosa, reversible y activamente libera las proteínas "erizo" in vivo a partir de un soporte, en forma retardada.A pharmaceutical composition of a "hedgehog" protein characterized in that the "hedgehog" protein binds to a hydrophilic support that is biocompatible and biodegradable, where the support is a polymer, which: -binds to the "hedgehog" protein as a negatively charged support due to ionic interactions, -does not denaturize the "hedgehog" protein when bound to the support, -contains at least 0.1 to 2 negatively charged radicals per monomer under neutral conditions, -contains charge as acidic groups, -has an average molecular weight of at least 50,000Da, -and does not contain agarose, reversibly and actively releases "hedgehog" proteins in vivo from a support, in a delayed manner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP992851 ECSP992851A (en) | 1999-02-04 | 1999-02-04 | PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP992851 ECSP992851A (en) | 1999-02-04 | 1999-02-04 | PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP992851A true ECSP992851A (en) | 2000-09-22 |
Family
ID=42043840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP992851 ECSP992851A (en) | 1999-02-04 | 1999-02-04 | PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP992851A (en) |
-
1999
- 1999-02-04 EC ECSP992851 patent/ECSP992851A/en unknown
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