ECSP993006A - Derivados de di-o triaza- espiro [4,5] decano - Google Patents
Derivados de di-o triaza- espiro [4,5] decanoInfo
- Publication number
- ECSP993006A ECSP993006A ECSP993006A ECSP993006A EC SP993006 A ECSP993006 A EC SP993006A EC SP993006 A ECSP993006 A EC SP993006A EC SP993006 A ECSP993006 A EC SP993006A
- Authority
- EC
- Ecuador
- Prior art keywords
- lower alkyl
- coor4
- decahydro
- alkoxy
- optionally substituted
- Prior art date
Links
- -1 DI-O Chemical class 0.000 title abstract 4
- NRUQNUIWEUZVLI-UHFFFAOYSA-O diethanolammonium nitrate Chemical compound [O-][N+]([O-])=O.OCC[NH2+]CCO NRUQNUIWEUZVLI-UHFFFAOYSA-O 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 102000016978 Orphan receptors Human genes 0.000 abstract 1
- 108070000031 Orphan receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004129 indan-1-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])* 0.000 abstract 1
- 125000004130 indan-2-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])(*)C2([H])[H] 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula general (gráfico), en donde R1 es cicloalquilo de 6 a 10 átomos de carbono, substituidos opcionalmente con alquilo inferior o -C(O)O-alquilo inferior; decahidro-naftalen-1-ilo; decahidro-naftalen-2-ilo; indan-1-ilo ó indan-2-ilo, opcionalmente substituido con alquilo inferior; decahidro-azulen-2-ilo; biciclo[6.2.0] dec-9-ilo; acenaften-1-ilo; 2,3 -dihidro-1H-fenalen-1-ilo; 2,3,3a,4,5,6-hexahidro-1H-fenalen-1-ilo o octahidro-inden-2-ilo; R2 es hidrógeno; alquilo inferior, halógeno o alcoxilo; A es ciclohexilo o fenilo, opcionalmente substituido con alquilo inferior, halógeno o alcoxilo; X es -CH(OH)-; -C(O)-; -CHR3-; -CR3=; -O-; -S-; -CH(COOR4)- ó -C(COOR4)=; Y es -CH2-; -CH=; -CH(COOR4)-, -C(COOR4)=; ó -C(CN)-; R3 es hidrógeno o alcoxilo inferior; R4 es alquilo inferior, cicloalquilo, fenilo o bencilo; o bien a o b son opcionalmente un enlace adicional, y a sus sales de adición ácida farmacéuticamente aceptables de los mismos. Los compuestos son agonistas y/o antagonistas del receptor de la orfanina FQ (QFQ), y por lo tanto de utilidad en el tratamiento de enfermedades en relación con este receptor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993006 ECSP993006A (es) | 1999-06-11 | 1999-06-11 | Derivados de di-o triaza- espiro [4,5] decano |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993006 ECSP993006A (es) | 1999-06-11 | 1999-06-11 | Derivados de di-o triaza- espiro [4,5] decano |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993006A true ECSP993006A (es) | 2000-01-27 |
Family
ID=42043995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993006 ECSP993006A (es) | 1999-06-11 | 1999-06-11 | Derivados de di-o triaza- espiro [4,5] decano |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993006A (es) |
-
1999
- 1999-06-11 EC ECSP993006 patent/ECSP993006A/es unknown
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