ECSP993006A - DERIVATIVES OF DI-O TRIAZA- ESPIRO [4,5] DEAN - Google Patents
DERIVATIVES OF DI-O TRIAZA- ESPIRO [4,5] DEANInfo
- Publication number
- ECSP993006A ECSP993006A ECSP993006A ECSP993006A EC SP993006 A ECSP993006 A EC SP993006A EC SP993006 A ECSP993006 A EC SP993006A EC SP993006 A ECSP993006 A EC SP993006A
- Authority
- EC
- Ecuador
- Prior art keywords
- lower alkyl
- coor4
- decahydro
- alkoxy
- optionally substituted
- Prior art date
Links
- -1 DI-O Chemical class 0.000 title abstract 4
- NRUQNUIWEUZVLI-UHFFFAOYSA-O diethanolammonium nitrate Chemical compound [O-][N+]([O-])=O.OCC[NH2+]CCO NRUQNUIWEUZVLI-UHFFFAOYSA-O 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 102000016978 Orphan receptors Human genes 0.000 abstract 1
- 108070000031 Orphan receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004129 indan-1-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])* 0.000 abstract 1
- 125000004130 indan-2-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])(*)C2([H])[H] 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula general (gráfico), en donde R1 es cicloalquilo de 6 a 10 átomos de carbono, substituidos opcionalmente con alquilo inferior o -C(O)O-alquilo inferior; decahidro-naftalen-1-ilo; decahidro-naftalen-2-ilo; indan-1-ilo ó indan-2-ilo, opcionalmente substituido con alquilo inferior; decahidro-azulen-2-ilo; biciclo[6.2.0] dec-9-ilo; acenaften-1-ilo; 2,3 -dihidro-1H-fenalen-1-ilo; 2,3,3a,4,5,6-hexahidro-1H-fenalen-1-ilo o octahidro-inden-2-ilo; R2 es hidrógeno; alquilo inferior, halógeno o alcoxilo; A es ciclohexilo o fenilo, opcionalmente substituido con alquilo inferior, halógeno o alcoxilo; X es -CH(OH)-; -C(O)-; -CHR3-; -CR3=; -O-; -S-; -CH(COOR4)- ó -C(COOR4)=; Y es -CH2-; -CH=; -CH(COOR4)-, -C(COOR4)=; ó -C(CN)-; R3 es hidrógeno o alcoxilo inferior; R4 es alquilo inferior, cicloalquilo, fenilo o bencilo; o bien a o b son opcionalmente un enlace adicional, y a sus sales de adición ácida farmacéuticamente aceptables de los mismos. Los compuestos son agonistas y/o antagonistas del receptor de la orfanina FQ (QFQ), y por lo tanto de utilidad en el tratamiento de enfermedades en relación con este receptor.The present invention relates to compounds of the general formula (graph), wherein R1 is cycloalkyl of 6 to 10 carbon atoms, optionally substituted with lower alkyl or -C (O) O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted with lower alkyl; decahydro-azulen-2-yl; bicycle [6.2.0] dec-9-yl; acenaphten-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a, 4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl; R2 is hydrogen; lower alkyl, halogen or alkoxy; A is cyclohexyl or phenyl, optionally substituted with lower alkyl, halogen, or alkoxy; X is -CH (OH) -; -CO)-; -CHR3-; -CR3 =; -OR-; -S-; -CH (COOR4) - or -C (COOR4) =; Y is -CH2-; -CH =; -CH (COOR4) -, -C (COOR4) =; or -C (CN) -; R3 is hydrogen or lower alkoxy; R4 is lower alkyl, cycloalkyl, phenyl, or benzyl; or a or b are optionally an additional bond, and to their pharmaceutically acceptable acid addition salts thereof. The compounds are agonists and / or antagonists of the CF orphan receptor (QFQ), and therefore useful in the treatment of diseases related to this receptor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993006 ECSP993006A (en) | 1999-06-11 | 1999-06-11 | DERIVATIVES OF DI-O TRIAZA- ESPIRO [4,5] DEAN |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993006 ECSP993006A (en) | 1999-06-11 | 1999-06-11 | DERIVATIVES OF DI-O TRIAZA- ESPIRO [4,5] DEAN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993006A true ECSP993006A (en) | 2000-01-27 |
Family
ID=42043995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993006 ECSP993006A (en) | 1999-06-11 | 1999-06-11 | DERIVATIVES OF DI-O TRIAZA- ESPIRO [4,5] DEAN |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993006A (en) |
-
1999
- 1999-06-11 EC ECSP993006 patent/ECSP993006A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL217446A0 (en) | Process for preparing benzazepine compounds or salts thereof | |
| GEP20074166B (en) | Acetyl 2-hydroxy-1,3 diaminoalkanes | |
| Qiao et al. | 5-Amidinobenzo [b] thiophenes as dual inhibitors of factors IXa and Xa | |
| AP2003002720A0 (en) | Carboxamide compounds and their use as antagonists of a human 11 CBY receptor. | |
| DE60329513D1 (en) | ANTAGONIST OF MELANINE CONCENTRATING HORMONE RECEPTOR, CONTAINING A BENZIMIDAZOLE DERIVATIVE AS AN ACTIVE SUBSTANCE | |
| PE20100093A1 (en) | ACETYLENE DERIVATIVES | |
| YU49700A (en) | 1,2,4,5-tetrahydro-benzo/d/azepines | |
| MXPA03011682A (en) | Substituted n-acyl aniline derivatives, production and use thereof as medicaments. | |
| ES2162503T3 (en) | DIAZA-ESPIRO DERIVATIVES (3,5) NONANS. | |
| CO5040061A1 (en) | DERIVATIVES OF DI-O TRIAZA-ESPIRO [4,5] DECANO | |
| WO2003028732A1 (en) | Receptor antagonist | |
| CO5160261A1 (en) | SUBSTITUTED BIFENYL DERIVATIVES THAT ARE NK-1 ANTAGONISTS, THEIR SYNTHESIS PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| NZ535170A (en) | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines | |
| EP2279741A3 (en) | Caprolactams and their use as anti-inflammatory agents | |
| ES2188260T3 (en) | 3-TETRAHYDROPIRIDIN-4-IL-INDOLES FOR THE TREATMENT OF PSYCHOTIC DISORDERS. | |
| SE0003186D0 (en) | New process | |
| AR026244A1 (en) | COMPOUNDS | |
| TNSN05067A1 (en) | Acetyl 2-hydroxy- 1,3 diaminoalkanes | |
| GB0428137D0 (en) | Novel herbicides | |
| ATE552003T1 (en) | QUINOXALINE DERIVATIVES | |
| DE60137451D1 (en) | N-substituted amides as NK1 receptor antagonists | |
| ECSP993008A (en) | DERIVATIVES OF DIAZA- ESPIRO [3,5] NONANO | |
| AR057748A1 (en) | DERIVATIVES OF 2,3 DIHYDROINDOL. PHARMACEUTICAL COMPOSITIONS | |
| PE20020842A1 (en) | ANTAGONISTS OF EXCITING AMINO ACID RECEPTORS | |
| EP0976735A4 (en) | Process for producing piperidinecarboxylic acid amides |