ECSP993255A - ORGANIC COMPOUNDS - Google Patents
ORGANIC COMPOUNDSInfo
- Publication number
- ECSP993255A ECSP993255A ECSP993255A ECSP993255A EC SP993255 A ECSP993255 A EC SP993255A EC SP993255 A ECSP993255 A EC SP993255A EC SP993255 A ECSP993255 A EC SP993255A
- Authority
- EC
- Ecuador
- Prior art keywords
- dpp
- formula
- organic compounds
- conditions
- compounds
- Prior art date
Links
- 150000002894 organic compounds Chemical class 0.000 title 1
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 abstract 3
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a un compuesto de la fórmula I (grágico), en donde R es adamantilo sustituido; y n es de 0 a 3; en forma libre o en forma de sal de adición de ácido. Los compuestos de la fórmula I inhiben la actividad de DPP-IV(peptidiasa de dipeptidilo-IV). Por consiguiente, se indican para utilizarse como productos farmacéuticos en la inhibición de DPP-IV, y en el tratamiento de condiciones mediadas por DPP-IV, tales como diabetes mellitus no dependientes de insulina, artritis, obesidad, osteoporosis, y otras condiciones de tolerancia deteriorada a la glucosa.The present invention relates to a compound of formula I (magical), wherein R is substituted adamantyl; and n is 0 to 3; in free form or in the form of an acid addition salt. The compounds of formula I inhibit the activity of DPP-IV (dipeptidyl-IV peptidiase). Accordingly, they are indicated for use as pharmaceuticals in the inhibition of DPP-IV, and in the treatment of conditions mediated by DPP-IV, such as non-insulin dependent diabetes mellitus, arthritis, obesity, osteoporosis, and other conditions of tolerance. impaired glucose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993255 ECSP993255A (en) | 1999-12-09 | 1999-12-09 | ORGANIC COMPOUNDS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993255 ECSP993255A (en) | 1999-12-09 | 1999-12-09 | ORGANIC COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993255A true ECSP993255A (en) | 2000-03-22 |
Family
ID=42044244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993255 ECSP993255A (en) | 1999-12-09 | 1999-12-09 | ORGANIC COMPOUNDS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993255A (en) |
-
1999
- 1999-12-09 EC ECSP993255 patent/ECSP993255A/en unknown
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