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Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
La presente invención se refiere a un compuesto de la fórmula I (grágico), en donde R es adamantilo sustituido; y n es de 0 a 3; en forma libre o en forma de sal de adición de ácido. Los compuestos de la fórmula I inhiben la actividad de DPP-IV(peptidiasa de dipeptidilo-IV). Por consiguiente, se indican para utilizarse como productos farmacéuticos en la inhibición de DPP-IV, y en el tratamiento de condiciones mediadas por DPP-IV, tales como diabetes mellitus no dependientes de insulina, artritis, obesidad, osteoporosis, y otras condiciones de tolerancia deteriorada a la glucosa.The present invention relates to a compound of formula I (magical), wherein R is substituted adamantyl; and n is 0 to 3; in free form or in the form of an acid addition salt. The compounds of formula I inhibit the activity of DPP-IV (dipeptidyl-IV peptidiase). Accordingly, they are indicated for use as pharmaceuticals in the inhibition of DPP-IV, and in the treatment of conditions mediated by DPP-IV, such as non-insulin dependent diabetes mellitus, arthritis, obesity, osteoporosis, and other conditions of tolerance. impaired glucose.
COMPOUNDS DERIVED FROM DIHYDROFENANTRIDIN-SULFONAMIDS REPLACED, ITS SALTS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; INTERMEDIARY COMPOUNDS; AND ITS USE IN THE TREATMENT OF TYPE II DIABETES, ALZHEIMER, SENILE DEMENTIA, ASTHMA, COL
process for the synthesis of (1s) -4,5-dimethoxy-1- (methylaminomethyl) benzocyclobutane and its addition salts, and application to the synthesis of ivabradine and its addition salts with a pharmaceutically acceptable acid
Compound, process to produce the same, pharmaceutical composition, use of the compound, processes to inhibit the production of nitric oxide and / or cytokine in mammals, and to prevent or treat heart disease, autoimmune disease or septic shock in mammals, and, for medications
PEPTIDES THAT INCLUDE AN ACID REGION, A LIPOFILICA OR AROMATICA AND A BASIC, WHICH PARTICIPATE IN INVERSE TRANSPORTATION OF COLESTEROL, PHARMACEUTICAL COMPOSITION CONTAINING THEM, USEFUL FOR THE TREATMENT OR PREVENTION OF HYPERCHOLESTEROLEMIA AND / OR ATEROSC
4-position fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnosis agent, as well as medicament containing them.
C-glycoside derivatives having fused phenyl ring or pharmaceutically acceptable salts thereof, method for preparing the same and pharmaceutical composition comprising the same