ECSP993290A - OXIMES AND HYDRAZONES SUBSTITUTED AS NEUROQUININE ANTAGONISTS - Google Patents
OXIMES AND HYDRAZONES SUBSTITUTED AS NEUROQUININE ANTAGONISTSInfo
- Publication number
- ECSP993290A ECSP993290A ECSP993290A ECSP993290A EC SP993290 A ECSP993290 A EC SP993290A EC SP993290 A ECSP993290 A EC SP993290A EC SP993290 A ECSP993290 A EC SP993290A
- Authority
- EC
- Ecuador
- Prior art keywords
- heteroaryl
- phenyl
- alkyl
- substituted
- heterocycloalkyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuesto representado por la fórmula estructural (gráfico), o una sal farmacéuticamente aceptable del mismo, donde: a es O3; b,d y e son idependientemente 0-2; R es H alquilo F o OR6; A es una oxima o hidrazon opcionalmente sustituida; d no es O, X es una ligadura, -C(O)-, -O-, -NR9-, S(O)e- -N(R6)C(O)-, -C(O)N(R6)-, OC(O)NR6-, -OC(=S)NR6, -N(R6)C(=S)O-, S(O)2N(R6)-, N(R6)S(O)2, -N(R6)C(O)O-, OC(O)- o -N(R6)C(O)NR7-; o d es O y X es una ligadura o -NR6-, T es H, arilo, heterocicloalquilo o heteroarilo; Q es fenilo, naftilo o heteroarilo; R6 es H, alquilo, hidroxialquilo, alcoxialquilo, fenilo y bencilo R9 es R6 u -OR6 R6a, R7n, R8a y R9a son H o alquilo; Z es un grupo heterociclo que contiene nitrógeno, por ejemplo, piperidinilo, sustituido por un grupo heterociclo o heterocicloalquilo, donde los grupos fenilo, bencilo, arilo, heterocicloalquilo, heteroarilo y cicloalquilo son opcionalmente sustituidos; se revelan métodos de tratamiento de enfermedades, tales como asma, tos, broncoespasmo, depresión, émesis, enfermedades inflamatorias y trastornos gastrointestinales con dichos compuestos y composiciones farmacéuticas que comprenden dichos compuestos.Compound represented by the structural formula (graph), or a pharmaceutically acceptable salt thereof, where: a is O3; b, d and e are independently 0-2; R is H alkyl F or OR6; A is an optionally substituted oxime or hydrazon; d is not O, X is a ligation, -C (O) -, -O-, -NR9-, S (O) e- -N (R6) C (O) -, -C (O) N (R6 ) -, OC (O) NR6-, -OC (= S) NR6, -N (R6) C (= S) O-, S (O) 2N (R6) -, N (R6) S (O) 2 , -N (R6) C (O) O-, OC (O) - or -N (R6) C (O) NR7-; or d is O and X is a ligation or -NR6-, T is H, aryl, heterocycloalkyl or heteroaryl; Q is phenyl, naphthyl, or heteroaryl; R6 is H, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl and benzyl. R9 is R6 or -OR6 R6a, R7n, R8a and R9a are H or alkyl; Z is a nitrogen-containing heterocycle group, eg, piperidinyl, substituted by a heterocycle or heterocycloalkyl group, where phenyl, benzyl, aryl, heterocycloalkyl, heteroaryl and cycloalkyl groups are optionally substituted; Methods of treating diseases, such as asthma, cough, bronchospasm, depression, emesis, inflammatory diseases and gastrointestinal disorders, are disclosed with said compounds and pharmaceutical compositions comprising said compounds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993290 ECSP993290A (en) | 1999-12-21 | 1999-12-21 | OXIMES AND HYDRAZONES SUBSTITUTED AS NEUROQUININE ANTAGONISTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993290 ECSP993290A (en) | 1999-12-21 | 1999-12-21 | OXIMES AND HYDRAZONES SUBSTITUTED AS NEUROQUININE ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993290A true ECSP993290A (en) | 2000-08-18 |
Family
ID=42044281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993290 ECSP993290A (en) | 1999-12-21 | 1999-12-21 | OXIMES AND HYDRAZONES SUBSTITUTED AS NEUROQUININE ANTAGONISTS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993290A (en) |
-
1999
- 1999-12-21 EC ECSP993290 patent/ECSP993290A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL129376A0 (en) | Substituted oxime derivatives useful as neurokinin antagonists | |
| MX9708415A (en) | Substituted oximes, hydrazones and olefins as neurokinin antagonists. | |
| WO2001044200A3 (en) | Selective neurokinin antagonists | |
| SE0104332D0 (en) | Therapeutic agents | |
| NZ332308A (en) | 2-piperidylamino-4-amino pyrimidine derivates as dopamine d4 receptor antagonists | |
| EA200300391A1 (en) | IMIDAZOLIC COMPOUNDS, ARYL OR HETEROARYL CONDENSED AS ANTI-INFLAMMATORY AND ANALGETIC MEANS | |
| NZ307505A (en) | Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds | |
| FI940229A0 (en) | Tricyclic fused heterocyclic compounds, their preparation and use | |
| CO5160341A1 (en) | OXYMES AND HYDRAZONS REPLACED AS NEUROQUININE ANTAGONISTS | |
| IS6459A (en) | Aryl fused azapolycyclic compounds | |
| CO5190663A1 (en) | POLIFORMS OF A CRYSTALLINE DICLORHYDRATE OF AZOBICICLO [2.2.2] OCT-3 ILAMINE AND ITS PHARMACEUTICAL COMPOSITIONS | |
| DK0556813T3 (en) | Amphoteric tricyclic compounds such as antihistamine and antiallergic agents | |
| CA2268866A1 (en) | Substituted arylalkylamines as neurokinin antagonists | |
| NO20060444L (en) | N- {4'-substituted piperazine-1-sulfonylmethylalkyl} -N-hydroxyformamide compounds as metal proteinase inhibitors | |
| DE69714758D1 (en) | SUBSTITUTED OXIME, HYDRAZONE AND OLEFINE AS NEUROKININ ANTAGONISTS | |
| NO20065057L (en) | benzoxazocines and their therapeutic use as monoamine reuptake inhibitors | |
| ATE395325T1 (en) | NEW CRYSTALLINE STILBEN DERIVATIVE AND METHOD FOR THE PRODUCTION THEREOF | |
| MY114455A (en) | Substituted oximes, hydrazones and olefins as neurokinin antagonists | |
| NO20022891L (en) | New Cyclic <alfa> -amino- <gamma> -hydroxyamide Compounds, Methods of their Preparation and Pharmaceutical Compositions Containing Them | |
| AR006262A1 (en) | OXIMES, HYDRAZONES AND SUBSTITUTED OLEFINS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF MEDICINES USEFUL AS ANTAGONISTS OF NEUROKININ | |
| AU645685B2 (en) | New 1-amidooctahydropyrido(2,1-c)(1,4)oxazine compounds, processes for preparing these and pharmaceutical compositions containing them | |
| CO4650032A1 (en) | HYXRAZONE OXIMAS AND SUBSTITUTED OLEFINS THAT ARE USEFUL AS AN ANTAGONISTS OF TACHYKININE RECEPTORS | |
| AR042379A1 (en) | NEW CYCLLOBUTAINDOL CARBOXAMIDE COMPOUNDS, PROCEDURE FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| RU94000717A (en) | TRICYCLIC CONDENSED HETEROCYCLIC COMPOUNDS, METHOD OF THEIR PREPARATION, APPLICATION OF COMPOSITION FORMS, METHOD OF TREATMENT |