MY114455A - Substituted oximes, hydrazones and olefins as neurokinin antagonists - Google Patents
Substituted oximes, hydrazones and olefins as neurokinin antagonistsInfo
- Publication number
- MY114455A MY114455A MYPI97001119A MYPI19971119A MY114455A MY 114455 A MY114455 A MY 114455A MY PI97001119 A MYPI97001119 A MY PI97001119A MY PI19971119 A MYPI19971119 A MY PI19971119A MY 114455 A MY114455 A MY 114455A
- Authority
- MY
- Malaysia
- Prior art keywords
- formula
- heteroaryl
- alkyl
- substituted
- cycloalkyl
- Prior art date
Links
- 150000001336 alkenes Chemical class 0.000 title abstract 2
- 150000007857 hydrazones Chemical class 0.000 title abstract 2
- 150000002923 oximes Chemical class 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- -1 MORPHOLINYL Chemical class 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 208000009079 Bronchial Spasm Diseases 0.000 abstract 1
- 208000014181 Bronchial disease Diseases 0.000 abstract 1
- 206010006482 Bronchospasm Diseases 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 101001109689 Homo sapiens Nuclear receptor subfamily 4 group A member 3 Proteins 0.000 abstract 1
- 101000598778 Homo sapiens Protein OSCP1 Proteins 0.000 abstract 1
- 101001067395 Mus musculus Phospholipid scramblase 1 Proteins 0.000 abstract 1
- 102100022673 Nuclear receptor subfamily 4 group A member 3 Human genes 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Chemical class CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPOUND REPRESENTED BY THE STRUCTURAL FORMULA (FORMULA 1) OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, WHEREIN: A IS 0, 1, 2, OR 3; B, D AND E ARE INDEPENDENTLY 0, 1 OR 2; R IS H, C1-6 ALKYL, -OH OR C2-C6 HYDROXYALKYL;A IS AN OPTIONALLY SUBSTITUTED OXIME, HYDRAZONE OR OLEFIN; X IS A BOND, -C(O)-, -O-, -NR6, -S(O)E-, -N(R6)C(O)-, -C(O)N(R6)-, -OC(O)NR6-, -OC(=S)NR6-, -N(R6)C(=S)O-, -C(=NOR1)-, -S(O)2N(R6)-, -N(R6)S(O)2-, -N(R6)C(O)O-, OR -OC(O)-; T IS H, PHTHALIMIDYL, ARYL, HETEROCYCLOALKYL, HETEROARYL, CYCLOALKYL OR BRIDGED CYCLOALKYL; Q IS -SR6, -N(R6)(R7), -OR6, PHENYL, NAPHTHYLOR HETEROARYL; R6A, R7A, R8A, R9A, R6 AND R7 ARE H, C1-6 ALKYL, C2-C6 HYDROXYALKYL, C1-C6 ALKOXY-C1-C6 ALKYL, PHENYL OR BENZYL; OR R6 AND R7, TOGETHER WITH THE NITROGEN TO WHICH THEY ARE ATTACHED, FORM A RING; R9A IS R6 OR -OR6; Z IS MORPHOLINYL, OPTIONALLY N-SUBSTITUTED PIPERAZINYL, OPTIONALLYSUBSTITUTED, ( FORMULA ) OR SUBSTITUTED ( FORMULA ) G IS 0-3 AND H IS 1-4, PROVIDED THE SUM OF H AND G IS 1-7; WHEREIN ARYL, HETEROCYCLOALKYL, HETEROARYL, CYCLOALKYL AND BRIDGED CYCLOALKYL GROUPS ARE OPTIONALLY SUBSTITUTED; METHODS OF TREATING ASTHMA, COUGH, BRONCHOSPASM, IMFLAMMATORY DISEASES, AND GASTROINTESTINAL DISORDERS WITH SAID COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS ARE DISCLOSED.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI97001119A MY114455A (en) | 1997-03-17 | 1997-03-17 | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI97001119A MY114455A (en) | 1997-03-17 | 1997-03-17 | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY114455A true MY114455A (en) | 2002-10-31 |
Family
ID=79646308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI97001119A MY114455A (en) | 1997-03-17 | 1997-03-17 | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY114455A (en) |
-
1997
- 1997-03-17 MY MYPI97001119A patent/MY114455A/en unknown
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