EE03568B1 - Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine - Google Patents

Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine

Info

Publication number
EE03568B1
EE03568B1 EE9700013A EE9700013A EE03568B1 EE 03568 B1 EE03568 B1 EE 03568B1 EE 9700013 A EE9700013 A EE 9700013A EE 9700013 A EE9700013 A EE 9700013A EE 03568 B1 EE03568 B1 EE 03568B1
Authority
EE
Estonia
Prior art keywords
preparation
benzimidazole derivatives
benzimidazole
derivatives
Prior art date
Application number
EE9700013A
Other languages
English (en)
Estonian (et)
Other versions
EE9700013A (et
Inventor
Dawes Chamberlain Stanley
Walter Koszalka George
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of EE9700013A publication Critical patent/EE9700013A/xx
Publication of EE03568B1 publication Critical patent/EE03568B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EE9700013A 1994-07-07 1995-07-06 Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine EE03568B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides
PCT/GB1995/001597 WO1996001833A1 (en) 1994-07-07 1995-07-06 Therapeutic compounds

Publications (2)

Publication Number Publication Date
EE9700013A EE9700013A (et) 1997-06-16
EE03568B1 true EE03568B1 (et) 2001-12-17

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700013A EE03568B1 (et) 1994-07-07 1995-07-06 Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine

Country Status (43)

Country Link
US (4) US6077832A (es)
EP (1) EP0769017B1 (es)
JP (1) JP3225045B2 (es)
KR (1) KR100376075B1 (es)
CN (2) CN1052010C (es)
AP (1) AP736A (es)
AT (1) ATE193298T1 (es)
AU (1) AU702248B2 (es)
BG (1) BG63435B1 (es)
BR (1) BR9508237A (es)
CY (1) CY2249B1 (es)
CZ (1) CZ290800B6 (es)
DE (1) DE69517172T2 (es)
DK (1) DK0769017T3 (es)
EE (1) EE03568B1 (es)
ES (1) ES2147294T3 (es)
FI (1) FI117629B (es)
GB (1) GB9413724D0 (es)
GE (1) GEP20002298B (es)
GR (1) GR3033744T3 (es)
HR (1) HRP950382B1 (es)
HU (1) HU227679B1 (es)
IL (1) IL114492A (es)
IS (1) IS1812B (es)
MD (1) MD1838G2 (es)
MX (1) MX9606732A (es)
MY (1) MY117892A (es)
NO (1) NO308854B1 (es)
NZ (1) NZ288722A (es)
OA (1) OA10339A (es)
PL (1) PL181136B1 (es)
PT (1) PT769017E (es)
RO (1) RO117699B1 (es)
RU (1) RU2145963C1 (es)
SA (1) SA95160202B1 (es)
SK (1) SK282046B6 (es)
TJ (1) TJ270B (es)
TR (1) TR199500832A2 (es)
TW (1) TW418196B (es)
UA (1) UA66744C2 (es)
WO (1) WO1996001833A1 (es)
YU (1) YU49443B (es)
ZA (1) ZA955644B (es)

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GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
WO1997007125A1 (en) * 1995-08-18 1997-02-27 The Regents Of The University Of Michigan 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
GB9518465D0 (en) * 1995-09-09 1995-11-08 Smithkline Beecham Seiyaku Kk Pharmaceuticals
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
US5840743A (en) * 1996-01-23 1998-11-24 The Regents Of The University Of Michigan Modified benzimidazole nucleosides as antiviral agents
US6475388B1 (en) 1996-11-13 2002-11-05 Transgenomic, Inc. Method and system for RNA analysis by matched ion polynucleotide chromatography
US6576133B2 (en) 1996-11-13 2003-06-10 Transgenomic, Inc Method and system for RNA analysis by matched ion polynucleotide chromatography
GB2319961A (en) * 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
US6413938B1 (en) 1997-02-13 2002-07-02 The Regents Of The University Of Michigan Benzimidazole derivatives for the treatment of viral infections
ID24054A (id) * 1997-06-10 2000-07-06 Glaxo Group Ltd Glaxo Turunan turunan benzimidazol
AU744176B2 (en) 1997-07-30 2002-02-14 Glaxo Group Limited Lyxofuranosyl benzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807355D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
GB0008939D0 (en) * 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
RU2262344C2 (ru) * 2001-07-25 2005-10-20 Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. Фармацевтическая композиция для лечения кожных инфекций и способ ее получения
RU2366661C2 (ru) * 2002-06-28 2009-09-10 Айденикс (Кайман) Лимитед Пролекарства модифицированных 2'- и 3'-нуклеозидов для лечения инфекций flaviviridae
CA2530490A1 (en) 2003-06-25 2005-01-13 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
WO2005063788A1 (ja) * 2003-12-26 2005-07-14 Kissei Pharmaceutical Co., Ltd. ベンズイミダゾール誘導体及びその医薬用途
RU2268741C1 (ru) * 2004-08-04 2006-01-27 Государственное образовательное учреждение высшего профессионального образования "Южно-Уральский государственный университет" Способ лечения герпетического поражения вестибулярного, спирального, тригеминального и коленчатого ганглиев
JPWO2006115137A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 ２−アミノベンズイミダゾール誘導体及びその医薬用途
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US9447050B2 (en) 2011-04-05 2016-09-20 The Translational Genomics Research Institute Solid forms of curcumin
US20140004307A1 (en) 2012-06-29 2014-01-02 The Procter & Gamble Company Textured Fibrous Webs, Apparatus And Methods For Forming Textured Fibrous Webs
WO2014145852A2 (en) 2013-03-15 2014-09-18 Knopp Biosciences Llc Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
ES2749103T3 (es) 2014-09-12 2020-03-19 Knopp Biosciences Llc Benzoimidazol-1,2-ilamidas como activadores del canal Kv7
EP3223816B1 (en) * 2014-11-26 2020-04-22 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
CN119118926A (zh) 2018-03-19 2024-12-13 诺普生物科学有限责任公司 Kv7通道激活剂组合物和使用方法
KR102449266B1 (ko) * 2020-06-23 2022-09-30 (주)바이오메트릭스 테크놀로지 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법
IL319923A (en) 2022-10-12 2025-05-01 Takeda Pharmaceuticals Co Maribavir preparation method
WO2024103979A1 (zh) * 2022-11-17 2024-05-23 北京凯因科技股份有限公司 一种抑制疱疹病毒的化合物

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CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
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JP6217655B2 (ja) * 2015-01-15 2017-10-25 トヨタ自動車株式会社 電力変換装置

Also Published As

Publication number Publication date
HRP950382B1 (en) 2000-12-31
EP0769017A1 (en) 1997-04-23
JPH10502356A (ja) 1998-03-03
RO117699B1 (ro) 2002-06-28
YU45095A (sh) 1999-03-04
CZ4097A3 (en) 1997-08-13
HK1003711A1 (en) 1998-11-06
FI117629B (fi) 2006-12-29
MX9606732A (es) 1997-04-30
HUT77285A (hu) 1998-03-30
CN1052010C (zh) 2000-05-03
OA10339A (en) 1997-10-07
DE69517172D1 (de) 2000-06-29
US20010003744A1 (en) 2001-06-14
AP9600895A0 (en) 1997-01-31
CZ290800B6 (cs) 2002-10-16
BG63435B1 (bg) 2002-01-31
EE9700013A (et) 1997-06-16
IS1812B (is) 2002-05-15
ATE193298T1 (de) 2000-06-15
MD1838G2 (ro) 2002-08-31
PT769017E (pt) 2000-09-29
AP736A (en) 1999-03-09
WO1996001833A1 (en) 1996-01-25
US5998605A (en) 1999-12-07
HRP950382A2 (en) 1997-08-31
MD1838F2 (en) 2002-01-31
KR100376075B1 (ko) 2004-02-18
TR199500832A2 (tr) 1996-06-21
AU702248B2 (en) 1999-02-18
CN1236616A (zh) 1999-12-01
SA95160202B1 (ar) 2005-04-16
GEP20002298B (en) 2000-11-25
TJ270B (en) 2000-08-07
PL181136B1 (pl) 2001-06-29
SK168896A3 (en) 1997-09-10
GR3033744T3 (en) 2000-10-31
FI970032A0 (fi) 1997-01-03
IL114492A (en) 2002-05-23
DK0769017T3 (da) 2000-09-11
UA66744C2 (en) 2004-06-15
CN1159194A (zh) 1997-09-10
ZA955644B (en) 1997-01-06
TW418196B (en) 2001-01-11
DE69517172T2 (de) 2000-10-19
YU49443B (sh) 2006-03-03
JP3225045B2 (ja) 2001-11-05
NO970040L (no) 1997-01-29
CY2249B1 (en) 2003-07-04
PL318062A1 (en) 1997-05-12
NO970040D0 (no) 1997-01-06
MY117892A (en) 2004-08-30
HU227679B1 (en) 2011-11-28
NO308854B1 (no) 2000-11-06
FI970032L (fi) 1997-01-03
ES2147294T3 (es) 2000-09-01
HU9700034D0 (en) 1997-02-28
BG101118A (en) 1998-04-30
NZ288722A (en) 1998-07-28
EP0769017B1 (en) 2000-05-24
SK282046B6 (sk) 2001-10-08
GB9413724D0 (en) 1994-08-24
IL114492A0 (en) 1995-11-27
US6077832A (en) 2000-06-20
RU2145963C1 (ru) 2000-02-27
IS4394A (is) 1996-12-09
BR9508237A (pt) 1999-06-01
AU2805195A (en) 1996-02-09
US6307043B1 (en) 2001-10-23

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