EE03612B1 - Asendatud tetratsüklilised tetrahüdrofuraanderivaadid - Google Patents

Asendatud tetratsüklilised tetrahüdrofuraanderivaadid

Info

Publication number: EE03612B1
Authority: EE; Estonia
Prior art keywords: 6alkyl; pct; zero; independently; optionally substituted
Prior art date: 1996-04-12

Application number

EE9800326A

Other languages

English (en)

Other versions

EE9800326A (et

Inventor

Javier Fernndez-Gadea Francisco

Franz Meert Theo

Gil-Lopetegui Pilar

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-04-09

Publication date

2002-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8223868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03612(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-04-09 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1999-04-15 Publication of EE9800326A publication Critical patent/EE9800326A/et

2002-02-15 Publication of EE03612B1 publication Critical patent/EE03612B1/et

Links

WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title 1
-1 cyano, hydroxy Chemical group 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 2
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
125000004970 halomethyl group Chemical group 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000815 N-oxide group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
235000006408 oxalic acid Nutrition 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Immunology (AREA)
Addiction (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EE9800326A 1996-04-12 1997-04-09 Asendatud tetratsüklilised tetrahüdrofuraanderivaadid EE03612B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96200990		1996-04-12
PCT/EP1997/001829 WO1997038991A1 (en)	1996-04-12	1997-04-09	Substituted tetracyclic tetrahydrofuran derivatives

Publications (2)

Publication Number	Publication Date
EE9800326A EE9800326A (et)	1999-04-15
EE03612B1 true EE03612B1 (et)	2002-02-15

Family

ID=8223868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800326A EE03612B1 (et)	1996-04-12	1997-04-09	Asendatud tetratsüklilised tetrahüdrofuraanderivaadid

Country Status (29)

Country	Link
US (3)	US6057441A (et)
EP (1)	EP0892793B1 (et)
JP (1)	JP3199751B2 (et)
KR (1)	KR100389298B1 (et)
CN (1)	CN1116291C (et)
AT (1)	ATE236893T1 (et)
BG (1)	BG63083B1 (et)
BR (1)	BR9706639A (et)
CA (1)	CA2232141C (et)
CY (1)	CY2382B1 (et)
CZ (1)	CZ288865B6 (et)
DE (1)	DE69720709T2 (et)
DK (1)	DK0892793T3 (et)
EA (1)	EA001002B1 (et)
EE (1)	EE03612B1 (et)
ES (1)	ES2196328T3 (et)
HU (1)	HUP9901613A3 (et)
IL (1)	IL123655A (et)
MY (1)	MY119321A (et)
NO (1)	NO317156B1 (et)
NZ (1)	NZ329953A (et)
PL (1)	PL190960B1 (et)
PT (1)	PT892793E (et)
SI (1)	SI0892793T1 (et)
SK (1)	SK283400B6 (et)
TR (1)	TR199801164T2 (et)
TW (1)	TW504506B (et)
WO (1)	WO1997038991A1 (et)
ZA (1)	ZA973114B (et)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EE03612B1 (et) *	1996-04-12	2002-02-15	Janssen Pharmaceutica N.V.	Asendatud tetratsüklilised tetrahüdrofuraanderivaadid
UA52778C2 (uk) *	1997-10-10	2003-01-15	Янссен Фармацевтика Н.В.	Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
US20050148018A1 (en)	1999-10-07	2005-07-07	David Weiner	Methods of identifying inverse agonists of the serotonin 2A receptor
HRP20000310A2 (en) *	2000-05-17	2002-02-28	Pliva Farmaceutska Ind Dioniko	New dibenzoazulene compounds as tumor necrosis factor inhibitors
WO2002056873A2 (en) *	2000-12-22	2002-07-25	Bayer Pharmaceuticals Corporation	2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones as growth hormone secretagogues
UA79248C2 (en) *	2001-11-09	2007-06-11	Janssen Pharmaceutica Nv	Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
WO2003048146A1 (en) *	2001-12-07	2003-06-12	Janssen Pharmaceutica N.V.	PREPARATION OF TRANS-FUSED 3,3a,8,12b-TETRAHYDRO-2H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-b]FURAN DERIVATIVES
HUP0402325A2 (hu)	2001-12-07	2005-02-28	Janssen Pharmaceutica N.V.	Eljárás cisz-fuzionált 3,3a,8,12b-tetrahidro-2H-dibenzo [3,4:6,7] ciklohepta [1,2-b]furán-származékok előállítására
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030160A2 (en) *	2003-03-06	2005-04-30	Pliva-Istra�iva�ki institut d.o.o.	1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) *	2003-11-03	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) *	2003-11-21	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) *	2003-11-21	2005-08-31	Pliva D.D.	USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030957A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030958A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) *	2004-01-30	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
AR049512A1 (es) *	2004-06-14	2006-08-09	Janssen Pharmaceutica Nv	Derivados de tetrahidrofurano tetraciclicos. composiciones farmaceuticas
CN1972949A (zh)	2004-06-23	2007-05-30	詹森药业有限公司	新型的不饱和四环四氢呋喃衍生物
AU2011202995B2 (en) *	2004-12-07	2012-02-02	Janssen Pharmaceutica N.V.	Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
AU2005313325C1 (en) *	2004-12-07	2011-11-10	Janssen Pharmaceutica N.V.	Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
WO2006079637A1 (en)	2005-01-27	2006-08-03	Janssen Pharmaceutica N.V.	Heterocyclic tetracyclic tetrahydrofuran derivatives as 5ht2 inhibitors in the treatment of cns disorders
EP1885715A1 (en) *	2005-05-19	2008-02-13	Janssen Pharmaceutica N.V.	Selected tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain
WO2006125812A1 (en) *	2005-05-26	2006-11-30	Janssen Pharmaceutica N.V.	Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament
NZ564181A (en) *	2005-06-17	2010-02-26	Janssen Pharmaceutica Nv	Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7605526A (nl) *	1976-05-24	1977-11-28	Akzo Nv	Nieuwe tetracyclische derivaten.
DE2742794A1 (de) *	1976-11-15	1978-05-18	Dec Int	Vorrichtung zur befoerderung von gemahlenem kaese
EP0361791B1 (en) *	1988-09-26	1995-11-08	Smithkline Beecham Farmaceutici S.p.A.	Azacyclic derivatives useful as medicaments
MY110227A (en) *	1991-08-12	1998-03-31	Ciba Geigy Ag	1-acylpiperindine compounds.
FR2681320B1 (fr) *	1991-09-12	1994-01-14	Synthelabo	Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
FR2681325B1 (fr) *	1991-09-16	1993-12-17	Fabre Medicament Pierre	Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
DE69631058T2 (de) *	1995-09-15	2004-06-03	Neurosearch A/S	Piperindinverbindungen als calcium-kanal-blocker
EE03612B1 (et) *	1996-04-12	2002-02-15	Janssen Pharmaceutica N.V.	Asendatud tetratsüklilised tetrahüdrofuraanderivaadid

1997
- 1997-04-09 EE EE9800326A patent/EE03612B1/et not_active IP Right Cessation
- 1997-04-09 SK SK1418-98A patent/SK283400B6/sk unknown
- 1997-04-09 JP JP53673397A patent/JP3199751B2/ja not_active Expired - Fee Related
- 1997-04-09 DK DK97920662T patent/DK0892793T3/da active
- 1997-04-09 ES ES97920662T patent/ES2196328T3/es not_active Expired - Lifetime
- 1997-04-09 DE DE69720709T patent/DE69720709T2/de not_active Expired - Lifetime
- 1997-04-09 HU HU9901613A patent/HUP9901613A3/hu unknown
- 1997-04-09 AT AT97920662T patent/ATE236893T1/de active
- 1997-04-09 BR BR9706639A patent/BR9706639A/pt not_active IP Right Cessation
- 1997-04-09 CA CA002232141A patent/CA2232141C/en not_active Expired - Fee Related
- 1997-04-09 KR KR10-1998-0703536A patent/KR100389298B1/ko not_active Expired - Fee Related
- 1997-04-09 US US09/155,840 patent/US6057441A/en not_active Expired - Lifetime
- 1997-04-09 WO PCT/EP1997/001829 patent/WO1997038991A1/en not_active Ceased
- 1997-04-09 PT PT97920662T patent/PT892793E/pt unknown
- 1997-04-09 IL IL12365597A patent/IL123655A/xx not_active IP Right Cessation
- 1997-04-09 CZ CZ19983243A patent/CZ288865B6/cs not_active IP Right Cessation
- 1997-04-09 CN CN97191422A patent/CN1116291C/zh not_active Expired - Fee Related
- 1997-04-09 SI SI9730551T patent/SI0892793T1/xx unknown
- 1997-04-09 TR TR1998/01164T patent/TR199801164T2/xx unknown
- 1997-04-09 EA EA199800348A patent/EA001002B1/ru not_active IP Right Cessation
- 1997-04-09 EP EP97920662A patent/EP0892793B1/en not_active Expired - Lifetime
- 1997-04-09 PL PL328575A patent/PL190960B1/pl not_active IP Right Cessation
- 1997-04-09 NZ NZ329953A patent/NZ329953A/xx not_active IP Right Cessation
- 1997-04-10 TW TW086104563A patent/TW504506B/zh not_active IP Right Cessation
- 1997-04-11 MY MYPI97001598A patent/MY119321A/en unknown
- 1997-04-11 ZA ZA973114A patent/ZA973114B/xx unknown
1998
- 1998-03-11 NO NO19981076A patent/NO317156B1/no not_active IP Right Cessation
- 1998-10-07 BG BG102820A patent/BG63083B1/bg unknown
2000
- 2000-03-22 US US09/533,625 patent/US6194405B1/en not_active Expired - Lifetime
- 2000-12-21 US US09/745,517 patent/US6288058B1/en not_active Expired - Fee Related
2003
- 2003-11-04 CY CY0300077A patent/CY2382B1/xx unknown

Also Published As

Publication number	Publication date
BR9706639A (pt)	1999-01-12
MY119321A (en)	2005-05-31
ES2196328T3 (es)	2003-12-16
SI0892793T1 (en)	2003-10-31
IL123655A0 (en)	1998-10-30
DE69720709T2 (de)	2004-03-11
CA2232141A1 (en)	1997-10-23
CZ324398A3 (cs)	1999-01-13
KR100389298B1 (ko)	2003-10-30
KR19990067514A (ko)	1999-08-25
US6057441A (en)	2000-05-02
PL190960B1 (pl)	2006-02-28
US6194405B1 (en)	2001-02-27
CA2232141C (en)	2006-05-23
NO317156B1 (no)	2004-08-30
NZ329953A (en)	1999-06-29
ATE236893T1 (de)	2003-04-15
US6288058B1 (en)	2001-09-11
JP3199751B2 (ja)	2001-08-20
CY2382B1 (en)	2004-06-04
HUP9901613A2 (hu)	1999-09-28
CZ288865B6 (cs)	2001-09-12
BG63083B1 (bg)	2001-03-30
SK141898A3 (en)	1999-03-12
PT892793E (pt)	2003-08-29
DE69720709D1 (de)	2003-05-15
AU2695997A (en)	1997-11-07
IL123655A (en)	2001-03-19
TW504506B (en)	2002-10-01
EA199800348A1 (ru)	1998-10-29
EA001002B1 (ru)	2000-08-28
TR199801164T2 (xx)	1998-10-21
NO981076L (no)	1998-10-09
SK283400B6 (sk)	2003-07-01
HUP9901613A3 (en)	2001-08-28
HK1015771A1 (en)	1999-10-22
BG102820A (en)	1999-08-31
CN1205006A (zh)	1999-01-13
EP0892793A1 (en)	1999-01-27
ZA973114B (en)	1998-10-12
WO1997038991A1 (en)	1997-10-23
EP0892793B1 (en)	2003-04-09
AU712154B2 (en)	1999-10-28
DK0892793T3 (da)	2003-07-21
JP2000508327A (ja)	2000-07-04
EE9800326A (et)	1999-04-15
CN1116291C (zh)	2003-07-30
PL328575A1 (en)	1999-02-01
NO981076D0 (no)	1998-03-11

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-12-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20080409

Publication	Publication Date	Title
ATE236893T1 (de)	2003-04-15	Substituierte tetracyclische tetrahydrofuranderivate
UA74391C2 (uk)	2005-12-15	Арил- або гетероарилконденсовані імідазоли як антизапальні і анальгетичні агенти
CA2305612A1 (en)	1999-04-22	Halogen substituted tetracyclic tetrahydrofuran derivatives
TW333532B (en)	1998-06-11	Benzopyrans
NZ329954A (en)	1999-07-29	Isoxazolidine tetracyclic and tricyclic ring system derivatives and medicaments
PL319870A1 (en)	1997-09-01	Derivatives of tetracyclic substituted oxazepin and thiazepin exhibiting affinity in respect to 5-ht2 receptors
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SE9701396D0 (sv)	1997-04-15	Compounds
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