EE03772B1 - Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine - Google Patents

Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine

Info

Publication number: EE03772B1
Authority: EE; Estonia
Prior art keywords: alkyl; hydrogen; amino; alkoxy; phenyl
Prior art date: 1994-09-14

Application number

EE9700051A

Other languages

English (en)

Other versions

EE9700051A (et

Inventor

Moldt Peter

W�tjen Frank

Original Assignee

Neurosearch A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-14

Filing date

1995-09-12

Publication date

2002-06-17

1995-09-12 Application filed by Neurosearch A/S filed Critical Neurosearch A/S

1997-08-15 Publication of EE9700051A publication Critical patent/EE9700051A/et

2002-06-17 Publication of EE03772B1 publication Critical patent/EE03772B1/et

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
-1 hydroxy, amino Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EE9700051A 1994-09-14 1995-09-12 Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine EE03772B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK105494		1994-09-14
PCT/EP1995/003594 WO1996008495A1 (en)	1994-09-14	1995-09-12	Fused indole and quinoxaline derivatives, their preparation and use

Publications (2)

Publication Number	Publication Date
EE9700051A EE9700051A (et)	1997-08-15
EE03772B1 true EE03772B1 (et)	2002-06-17

Family

ID=8100467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700051A EE03772B1 (et)	1994-09-14	1995-09-12	Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine

Country Status (12)

Country	Link
US (1)	US5801174A (et)
EP (1)	EP0781285B1 (et)
JP (1)	JP3164372B2 (et)
AT (1)	ATE188701T1 (et)
AU (1)	AU686888B2 (et)
CA (1)	CA2199614C (et)
DE (1)	DE69514533T2 (et)
EE (1)	EE03772B1 (et)
FI (1)	FI112486B (et)
NO (1)	NO308851B1 (et)
NZ (1)	NZ293266A (et)
WO (1)	WO1996008495A1 (et)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk)	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2781482B1 (fr) *	1998-07-27	2001-08-31	Adir	Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK1183025T3 (da)	1999-05-19	2009-05-04	Painceptor Pharma Corp	Hæmmere af proton-styrede kationskanaler og deres anvendelse til behandling af iskæmiske lidelser
EP1255734B1 (en) *	2000-01-24	2006-06-21	NeuroSearch A/S	Isatine derivatives with neurotrophic activity
WO2007059608A1 (en)	2005-11-23	2007-05-31	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US7825122B2 (en)	2005-12-14	2010-11-02	Amgen Inc.	Diaza heterocyclic sulfonamide derivatives and their uses
CA2652307A1 (en) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US20090246134A1 (en) *	2007-05-30	2009-10-01	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
CA2868238A1 (en)	2012-04-18	2013-10-24	Ramot At Tel Aviv University Ltd.	Lipidated glycosaminoglycan particles for the delivery of nucleic acids
WO2016114655A1 (en) *	2015-01-12	2016-07-21	Ry Pharma B.V.	Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation
WO2017065602A1 (en) *	2015-10-13	2017-04-20	Ry Pharma B.V.	Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9204914A (es) *	1991-08-28	1993-07-01	Frank Watjen	Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
ATE157977T1 (de) *	1992-10-13	1997-09-15	Warner Lambert Co	Chinoxalinderivate als eaa antagonisten

1995
- 1995-09-12 EE EE9700051A patent/EE03772B1/et not_active IP Right Cessation
- 1995-09-12 AT AT95932730T patent/ATE188701T1/de not_active IP Right Cessation
- 1995-09-12 AU AU35665/95A patent/AU686888B2/en not_active Ceased
- 1995-09-12 JP JP50990896A patent/JP3164372B2/ja not_active Expired - Fee Related
- 1995-09-12 DE DE69514533T patent/DE69514533T2/de not_active Expired - Lifetime
- 1995-09-12 NZ NZ293266A patent/NZ293266A/en unknown
- 1995-09-12 US US08/809,086 patent/US5801174A/en not_active Expired - Lifetime
- 1995-09-12 CA CA002199614A patent/CA2199614C/en not_active Expired - Fee Related
- 1995-09-12 WO PCT/EP1995/003594 patent/WO1996008495A1/en not_active Ceased
- 1995-09-12 EP EP95932730A patent/EP0781285B1/en not_active Expired - Lifetime
1997
- 1997-02-25 FI FI970785A patent/FI112486B/fi active
- 1997-02-27 NO NO970903A patent/NO308851B1/no unknown

Also Published As

Publication number	Publication date
FI112486B (fi)	2003-12-15
NZ293266A (en)	1998-01-26
ATE188701T1 (de)	2000-01-15
EP0781285A1 (en)	1997-07-02
NO970903D0 (no)	1997-02-27
US5801174A (en)	1998-09-01
EE9700051A (et)	1997-08-15
DE69514533T2 (de)	2000-07-06
NO970903L (no)	1997-05-07
CA2199614A1 (en)	1996-03-21
JPH09511525A (ja)	1997-11-18
AU3566595A (en)	1996-03-29
FI970785A7 (fi)	1997-03-13
DE69514533D1 (de)	2000-02-17
JP3164372B2 (ja)	2001-05-08
FI970785A0 (fi)	1997-02-25
EP0781285B1 (en)	2000-01-12
CA2199614C (en)	2000-02-22
AU686888B2 (en)	1998-02-12
NO308851B1 (no)	2000-11-06
WO1996008495A1 (en)	1996-03-21

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-06-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20070912

Publication	Publication Date	Title
UA50767C2 (uk)	2002-11-15	Похідні індолу, що використовуються як антагоністи рецептора ендотеліну, спосіб їх одержання, фармацевтична композиція та спосіб лікування
EE03772B1 (et)	2002-06-17	Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine
SG128491A1 (en)	2007-01-30	Heterocyclic sulfonamide inhibitors of beta amyloid production
NO981609D0 (no)	1998-04-07	Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak
CA2404464A1 (en)	2001-11-01	Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders
PE20011212A1 (es)	2001-11-21	Compuestos para el tratamiento de la fibromialgia y el sindrome de fatiga cronica
NZ528997A (en)	2004-12-24	Sulfonamides
NO305287B1 (no)	1999-05-03	AMPA antagonister
HUP9700595A1 (hu)	2000-08-28	Fluor-alkil- és fluor-alkoxicsoporttal helyettesített heterociklikus bradikinin-antagonisták, eljárás ezek előállítására, valamint ezek alkalmazása
PT902684E (pt)	2003-08-29	Derivados hexa-hidro-pirido(4,3-b)indolo utilizados como farmacos antipsicoticos
ATE188700T1 (de)	2000-01-15	Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung
MXPA04005077A (es)	2004-08-19	Derivados de benzotiazol.
ES2182509T3 (es)	2003-03-01	Derivados de n-ariloxietilamina para el tratamiento de la depresion.
DE69526452D1 (de)	2002-05-23	Indolditerpen alkaloide
DE69510510D1 (de)	1999-08-05	N-benzoylmethylsubstituierte paroxetinderivate
DK0699197T3 (da)	2000-08-07	4-p-flourbenzoyl-1-piperidinyl-propoxy-chromen-4-on-derivater, deres fremstilling og deres anvendelse i behandlingen af psy
PT1082116E (pt)	2003-08-29	Utilizacao de derivados de 4-piperidinometanol no tratamento de desordens do neurodesenvolvimento
ES2161892T3 (es)	2001-12-16	Derivados de indol como profarmacos de agonistas de los receptores afines a 5-ht1.
ES8101045A1 (es)	1980-12-01	Procedimiento para la preparacion de derivados de acidos pi-rrolidinilsulfamoilbenzoicos sustituidos
ES8606355A1 (es)	1986-04-16	Un procedimiento para la preparacion de derivados de imida- zodiacepina