ATE188700T1 - Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung - Google Patents
Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendungInfo
- Publication number
- ATE188700T1 ATE188700T1 AT95932729T AT95932729T ATE188700T1 AT E188700 T1 ATE188700 T1 AT E188700T1 AT 95932729 T AT95932729 T AT 95932729T AT 95932729 T AT95932729 T AT 95932729T AT E188700 T1 ATE188700 T1 AT E188700T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- date
- dione
- indole
- preparation
- Prior art date
Links
- LNMAXZZQNSPQSR-UHFFFAOYSA-N 3-(hydroxyamino)indol-2-one Chemical class C1=CC=CC2=NC(=O)C(NO)=C21 LNMAXZZQNSPQSR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK105394 | 1994-09-14 | ||
| PCT/EP1995/003593 WO1996008494A1 (en) | 1994-09-14 | 1995-09-12 | Indole-2,3-dione-3-oxime derivatives, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE188700T1 true ATE188700T1 (de) | 2000-01-15 |
Family
ID=8100455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95932729T ATE188700T1 (de) | 1994-09-14 | 1995-09-12 | Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5917053A (de) |
| EP (1) | EP0781284B1 (de) |
| JP (1) | JP3164371B2 (de) |
| AT (1) | ATE188700T1 (de) |
| AU (1) | AU687255B2 (de) |
| CA (1) | CA2199613C (de) |
| DE (1) | DE69514532T2 (de) |
| EE (1) | EE03355B1 (de) |
| FI (1) | FI112482B (de) |
| NO (1) | NO308852B1 (de) |
| NZ (1) | NZ293265A (de) |
| WO (1) | WO1996008494A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
| WO1999049864A1 (en) * | 1998-03-31 | 1999-10-07 | Neurosearch A/S | Indole-2,3-dione-3-oxime derivatives for therapeutic use |
| WO2000071102A2 (en) | 1999-05-19 | 2000-11-30 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
| EP1736468A3 (de) * | 2000-01-24 | 2007-01-03 | NeuroSearch A/S | Isatinderivate mit neurotropischer Aktivität geeignet zur Behandlung von NGF-bedingten Krankheiten |
| JP2004523543A (ja) * | 2001-02-15 | 2004-08-05 | ニューロサーチ、アクティーゼルスカブ | 神経栄養活性を有する化合物とドパミン活性を増加させる化合物の組み合わせ作用によるパーキンソン病の治療法 |
| MXPA04000358A (es) | 2001-07-13 | 2004-05-04 | Pharmacia & Up John Company | Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht. |
| KR20080070749A (ko) | 2005-11-23 | 2008-07-30 | 페인셉터 파마 코포레이션 | 개폐 이온 통로를 조절하기 위한 조성물 및 방법 |
| EP2066323A2 (de) * | 2006-09-12 | 2009-06-10 | NeuroSearch AS | Pharmazeutische zusammensetzungen mit kombinationen aus einer antagonistischen ampa-/kainat-verbindung und einem hemmer eines multdrug-resistenzproteins |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE69677B1 (en) * | 1989-12-11 | 1996-10-02 | Neurosearch As | Isatine derivatives their preparation and use |
| MX9204914A (es) * | 1991-08-28 | 1993-07-01 | Frank Watjen | Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende. |
| ATE157977T1 (de) * | 1992-10-13 | 1997-09-15 | Warner Lambert Co | Chinoxalinderivate als eaa antagonisten |
-
1995
- 1995-09-12 NZ NZ293265A patent/NZ293265A/en unknown
- 1995-09-12 AT AT95932729T patent/ATE188700T1/de not_active IP Right Cessation
- 1995-09-12 DE DE69514532T patent/DE69514532T2/de not_active Expired - Lifetime
- 1995-09-12 US US08/809,082 patent/US5917053A/en not_active Expired - Lifetime
- 1995-09-12 EP EP95932729A patent/EP0781284B1/de not_active Expired - Lifetime
- 1995-09-12 EE EE9700052A patent/EE03355B1/xx not_active IP Right Cessation
- 1995-09-12 WO PCT/EP1995/003593 patent/WO1996008494A1/en not_active Ceased
- 1995-09-12 JP JP50990796A patent/JP3164371B2/ja not_active Expired - Fee Related
- 1995-09-12 CA CA002199613A patent/CA2199613C/en not_active Expired - Fee Related
- 1995-09-12 AU AU35664/95A patent/AU687255B2/en not_active Ceased
-
1997
- 1997-02-21 FI FI970750A patent/FI112482B/fi active
- 1997-02-27 NO NO970904A patent/NO308852B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI112482B (fi) | 2003-12-15 |
| NO970904L (no) | 1997-04-24 |
| AU687255B2 (en) | 1998-02-19 |
| FI970750L (fi) | 1997-03-13 |
| EP0781284B1 (de) | 2000-01-12 |
| CA2199613C (en) | 2000-02-29 |
| US5917053A (en) | 1999-06-29 |
| CA2199613A1 (en) | 1996-03-21 |
| JP3164371B2 (ja) | 2001-05-08 |
| DE69514532T2 (de) | 2000-07-06 |
| DE69514532D1 (de) | 2000-02-17 |
| NO970904D0 (no) | 1997-02-27 |
| NZ293265A (en) | 1998-01-26 |
| JPH09511524A (ja) | 1997-11-18 |
| WO1996008494A1 (en) | 1996-03-21 |
| NO308852B1 (no) | 2000-11-06 |
| AU3566495A (en) | 1996-03-29 |
| FI970750A0 (fi) | 1997-02-21 |
| EP0781284A1 (de) | 1997-07-02 |
| EE03355B1 (et) | 2001-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |