EE03783B1 - A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule - Google Patents

A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule

Info

Publication number: EE03783B1
Authority: EE; Estonia
Prior art keywords: antibody; epitheliomas; treatment; pharmaceutical composition; antibody molecule
Prior art date: 1995-12-06

Application number

EE9800164A

Other languages

Estonian (et)

Other versions

EE9800164A (en

Inventor

Heider Karl-Heinz

Adolf G�nther

Ostermann Elinborg

Patzelt Erik

Sproll Marlies

Original Assignee

Boehringer Ingelheim International Gmbh

Forschungszentrum Karlsruhe Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-06

Filing date

1996-12-05

Publication date

2002-06-17

1995-12-06 Priority claimed from DE19545472A external-priority patent/DE19545472A1/en

1996-12-05 Application filed by Boehringer Ingelheim International Gmbh, Forschungszentrum Karlsruhe Gmbh filed Critical Boehringer Ingelheim International Gmbh

1998-12-15 Publication of EE9800164A publication Critical patent/EE9800164A/en

2002-06-17 Publication of EE03783B1 publication Critical patent/EE03783B1/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70585—CD44
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Biochemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Optics & Photonics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Cell Biology (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EE9800164A 1995-12-06 1996-12-05 A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule EE03783B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19545472A DE19545472A1 (en)	1995-12-06	1995-12-06	Diagnosis of squamous epithelial cell carcinoma
DE19615074		1996-04-17
PCT/EP1996/005448 WO1997021104A1 (en)	1995-12-06	1996-12-05	Method of diagnosing and treating epithelioma

Publications (2)

Publication Number	Publication Date
EE9800164A EE9800164A (en)	1998-12-15
EE03783B1 true EE03783B1 (en)	2002-06-17

Family

ID=26020988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800164A EE03783B1 (en)	1995-12-06	1996-12-05	A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule

Country Status (25)

Country	Link
EP (1)	EP0865609B1 (en)
JP (1)	JP2000502067A (en)
KR (1)	KR100473824B1 (en)
CN (1)	CN1151377C (en)
AR (1)	AR004360A1 (en)
AT (1)	ATE235056T1 (en)
AU (1)	AU726704B2 (en)
BG (1)	BG62985B1 (en)
BR (1)	BR9611901A (en)
CA (1)	CA2239709A1 (en)
CO (1)	CO4520233A1 (en)
CZ (1)	CZ174198A3 (en)
DE (1)	DE59610248D1 (en)
DK (1)	DK0865609T3 (en)
EE (1)	EE03783B1 (en)
ES (1)	ES2190484T3 (en)
MX (1)	MX9804459A (en)
NO (1)	NO319903B1 (en)
NZ (1)	NZ324314A (en)
PL (1)	PL184521B1 (en)
PT (1)	PT865609E (en)
SK (1)	SK284378B6 (en)
TR (1)	TR199801027T2 (en)
UY (1)	UY24389A1 (en)
WO (1)	WO1997021104A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050100542A1 (en) *	1999-10-08	2005-05-12	Young David S.	Cytotoxicity mediation of cells evidencing surface expression of CD44
US7947496B2 (en) *	1999-10-08	2011-05-24	Hoffmann-La Roche Inc.	Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) *	1999-10-08	2007-03-13	Arius Research Inc.	Cytotoxicity mediation of cells evidencing surface expression of CD44
EP1258255A1 (en) *	2001-05-18	2002-11-20	Boehringer Ingelheim International GmbH	Conjugates of an antibody to CD44 and a maytansinoid
AR036154A1 (en) *	2001-05-18	2004-08-18	Boehringer Ingelheim Pharma	SPECIFIC ANTIBODIES OF CD44V6.
US20030103985A1 (en)	2001-05-18	2003-06-05	Boehringer Ingelheim International Gmbh	Cytotoxic CD44 antibody immunoconjugates
US6972324B2 (en)	2001-05-18	2005-12-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Antibodies specific for CD44v6
EP1391213A1 (en) *	2002-08-21	2004-02-25	Boehringer Ingelheim International GmbH	Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) *	2002-11-08	2004-05-12	Boehringer Ingelheim International GmbH	Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
MA34010B1 (en) *	2010-02-04	2013-02-01	Hoffmann La Roche	Monoclonal anti-cd44 antibiotics for use to treat squamous cell carcinoma of the head and neck
US9218450B2 (en) *	2012-11-29	2015-12-22	Roche Molecular Systems, Inc.	Accurate and fast mapping of reads to genome
EP3755717A4 (en) *	2018-02-22	2022-01-26	Multitude Inc.	THERAPEUTIC ANTIBODIES AND ASSOCIATED USES
CN119451984A (en)	2022-05-25	2025-02-14	阿基拉姆治疗有限公司	Anti-CD44V6 antibodies and their use in treating CD44V6 overexpressing cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE159953T1 (en) *	1993-06-18	1997-11-15	Biotie Therapies Oy	COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODIES AGAINST CD44V6
EP0767379A1 (en) *	1993-06-22	1997-04-09	BOEHRINGER INGELHEIM INTERNATIONAL GmbH	Method for the diagnosis and analysis of colon carcinoma
DE4326573A1 (en) *	1993-08-07	1995-02-23	Boehringer Ingelheim Int	Polypeptides encoded by exon v5 of the CD44 gene as targets for immunotherapy and immunoscintigraphy of tumors
UA58482C2 (en) *	1994-06-08	2003-08-15	Бьорінгер Інгельхайм Інтернаціональ Гмбх	MONOCLONAL ANTIBODY VFF-18 AGAINST CD44V6 AND ITS FRAGMENTS

1996
- 1996-12-03 UY UY24389A patent/UY24389A1/en not_active IP Right Cessation
- 1996-12-04 AR ARP960105480A patent/AR004360A1/en unknown
- 1996-12-05 DK DK96942362T patent/DK0865609T3/en active
- 1996-12-05 TR TR1998/01027T patent/TR199801027T2/en unknown
- 1996-12-05 CN CNB961992484A patent/CN1151377C/en not_active Expired - Fee Related
- 1996-12-05 CA CA002239709A patent/CA2239709A1/en not_active Abandoned
- 1996-12-05 ES ES96942362T patent/ES2190484T3/en not_active Expired - Lifetime
- 1996-12-05 PT PT96942362T patent/PT865609E/en unknown
- 1996-12-05 CO CO96063967A patent/CO4520233A1/en unknown
- 1996-12-05 KR KR10-1998-0704242A patent/KR100473824B1/en not_active Expired - Fee Related
- 1996-12-05 SK SK736-98A patent/SK284378B6/en unknown
- 1996-12-05 EE EE9800164A patent/EE03783B1/en not_active IP Right Cessation
- 1996-12-05 CZ CZ981741A patent/CZ174198A3/en unknown
- 1996-12-05 BR BR9611901A patent/BR9611901A/en not_active Application Discontinuation
- 1996-12-05 AT AT96942362T patent/ATE235056T1/en not_active IP Right Cessation
- 1996-12-05 WO PCT/EP1996/005448 patent/WO1997021104A1/en not_active Ceased
- 1996-12-05 DE DE59610248T patent/DE59610248D1/en not_active Expired - Fee Related
- 1996-12-05 NZ NZ324314A patent/NZ324314A/en unknown
- 1996-12-05 EP EP96942362A patent/EP0865609B1/en not_active Expired - Lifetime
- 1996-12-05 PL PL96327066A patent/PL184521B1/en not_active IP Right Cessation
- 1996-12-05 JP JP9520993A patent/JP2000502067A/en not_active Ceased
- 1996-12-05 AU AU11773/97A patent/AU726704B2/en not_active Ceased
1998
- 1998-06-04 MX MX9804459A patent/MX9804459A/en not_active IP Right Cessation
- 1998-06-05 NO NO19982588A patent/NO319903B1/en unknown
- 1998-06-05 BG BG102513A patent/BG62985B1/en unknown

Also Published As

Publication number	Publication date
BR9611901A (en)	1999-03-02
NO319903B1 (en)	2005-09-26
CN1151377C (en)	2004-05-26
CN1207811A (en)	1999-02-10
WO1997021104A1 (en)	1997-06-12
PL327066A1 (en)	1998-11-23
NO982588D0 (en)	1998-06-05
PL184521B1 (en)	2002-11-29
TR199801027T2 (en)	1998-10-21
PT865609E (en)	2003-08-29
BG102513A (en)	1999-02-26
BG62985B1 (en)	2000-12-29
EP0865609A1 (en)	1998-09-23
ATE235056T1 (en)	2003-04-15
CO4520233A1 (en)	1997-10-15
DE59610248D1 (en)	2003-04-24
ES2190484T3 (en)	2003-08-01
NO982588L (en)	1998-08-05
CZ174198A3 (en)	1999-02-17
MX9804459A (en)	1998-09-30
DK0865609T3 (en)	2003-06-23
KR19990071952A (en)	1999-09-27
EP0865609B1 (en)	2003-03-19
HK1011560A1 (en)	1999-07-16
UY24389A1 (en)	2001-10-25
KR100473824B1 (en)	2005-09-30
AR004360A1 (en)	1998-11-04
AU726704B2 (en)	2000-11-16
CA2239709A1 (en)	1997-06-12
SK73698A3 (en)	1999-01-11
AU1177397A (en)	1997-06-27
JP2000502067A (en)	2000-02-22
SK284378B6 (en)	2005-02-04
NZ324314A (en)	2000-02-28
EE9800164A (en)	1998-12-15

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2006-08-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20051205

Publication	Publication Date	Title
BR9611986A (en)	1999-02-17	Process compounds for the preparation of the same pharmaceutical composition and use of the compounds
NO20004345D0 (en)	2000-09-01	Pharmaceutical composition
FI973048L (en)	1997-09-16	Methods and compositions for lipidizing hydrophilic molecules
BR1100824A (en)	1999-08-31	Pharmaceutical composition and composition
FI964028L (en)	1996-10-08	New pharmaceutical formulation and method
NO954146D0 (en)	1995-10-18	Coated pharmaceutical preparations
FI944832A0 (en)	1994-10-14	Pharmaceutical composition
BR9602705A (en)	1998-09-08	Compound pharmaceutical composition process for the preparation of a compound and use
EE03783B1 (en)	2002-06-17	A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule
EE04681B1 (en)	2006-08-15	3,6-Half-Ketals of the 9a-Azalides, Method of Preparation and Pharmaceutical Composition
BR9509688A (en)	1997-09-30	Pharmaceutical composition and composition
BR9507768A (en)	1997-09-02	Pharmaceutical composition
LV11727A (en)	1997-04-20	Pharmaceutical composition
FI973229L (en)	1997-08-05	New pharmaceutical composition
FI971427A7 (en)	1997-05-26	Peptides and pharmaceutical compositions containing them
FI973280A0 (en)	1997-08-08	Pharmaceutical composition
FI964113A7 (en)	1996-10-14	Pharmaceutical composition for treating tardive dyskinesia and its use
BR9610851A (en)	1999-07-13	Compound compound preparation process medicine pharmaceutical composition and use of the compound
LV10579A (en)	1995-04-20	Pharmaceutical composition
BR9605777A (en)	1998-08-25	Pharmaceutical composition
NO964309D0 (en)	1996-10-10	Pharmaceutical composition
BR9505130A (en)	1997-09-09	Pharmaceutical composition and composition
IT1272935B (en)	1997-07-01	PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CISTEIN
BR1100838A (en)	1999-08-31	Pharmaceutical composition and composition
FI955181A7 (en)	1995-10-30	Pharmaceutical compositions containing trimoctonan and ATZ