EE03783B1 - Farmatseutiline kompositsioon epitelioomide raviks ja antikeha või antikeha molekuli kasutamine - Google Patents

Farmatseutiline kompositsioon epitelioomide raviks ja antikeha või antikeha molekuli kasutamine

Info

Publication number
EE03783B1
EE03783B1 EE9800164A EE9800164A EE03783B1 EE 03783 B1 EE03783 B1 EE 03783B1 EE 9800164 A EE9800164 A EE 9800164A EE 9800164 A EE9800164 A EE 9800164A EE 03783 B1 EE03783 B1 EE 03783B1
Authority
EE
Estonia
Prior art keywords
antibody
epitheliomas
treatment
pharmaceutical composition
antibody molecule
Prior art date
Application number
EE9800164A
Other languages
English (en)
Other versions
EE9800164A (et
Inventor
Heider Karl-Heinz
Adolf G�nther
Ostermann Elinborg
Patzelt Erik
Sproll Marlies
Original Assignee
Boehringer Ingelheim International Gmbh
Forschungszentrum Karlsruhe Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19545472A external-priority patent/DE19545472A1/de
Application filed by Boehringer Ingelheim International Gmbh, Forschungszentrum Karlsruhe Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of EE9800164A publication Critical patent/EE9800164A/et
Publication of EE03783B1 publication Critical patent/EE03783B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EE9800164A 1995-12-06 1996-12-05 Farmatseutiline kompositsioon epitelioomide raviks ja antikeha või antikeha molekuli kasutamine EE03783B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19545472A DE19545472A1 (de) 1995-12-06 1995-12-06 Verfahren zur Diagnose und Therapie von Plattenepithelkarzinomen
DE19615074 1996-04-17
PCT/EP1996/005448 WO1997021104A1 (de) 1995-12-06 1996-12-05 Verfahren zur diagnose und therapie von plattenepithelkarzinomen

Publications (2)

Publication Number Publication Date
EE9800164A EE9800164A (et) 1998-12-15
EE03783B1 true EE03783B1 (et) 2002-06-17

Family

ID=26020988

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800164A EE03783B1 (et) 1995-12-06 1996-12-05 Farmatseutiline kompositsioon epitelioomide raviks ja antikeha või antikeha molekuli kasutamine

Country Status (25)

Country Link
EP (1) EP0865609B1 (et)
JP (1) JP2000502067A (et)
KR (1) KR100473824B1 (et)
CN (1) CN1151377C (et)
AR (1) AR004360A1 (et)
AT (1) ATE235056T1 (et)
AU (1) AU726704B2 (et)
BG (1) BG62985B1 (et)
BR (1) BR9611901A (et)
CA (1) CA2239709A1 (et)
CO (1) CO4520233A1 (et)
CZ (1) CZ174198A3 (et)
DE (1) DE59610248D1 (et)
DK (1) DK0865609T3 (et)
EE (1) EE03783B1 (et)
ES (1) ES2190484T3 (et)
MX (1) MX9804459A (et)
NO (1) NO319903B1 (et)
NZ (1) NZ324314A (et)
PL (1) PL184521B1 (et)
PT (1) PT865609E (et)
SK (1) SK284378B6 (et)
TR (1) TR199801027T2 (et)
UY (1) UY24389A1 (et)
WO (1) WO1997021104A1 (et)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7947496B2 (en) * 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
EA200301169A1 (ru) * 2001-05-18 2004-06-24 Бёрингер Ингельхайм Интернациональ Гмбх АНТИТЕЛА, СПЕЦИФИЧЕСКИЕ В ОТНОШЕНИИ CD44v6
US20030103985A1 (en) 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
US6972324B2 (en) 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
EP1258255A1 (en) * 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Conjugates of an antibody to CD44 and a maytansinoid
EP1391213A1 (en) * 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) * 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
SI2531527T1 (sl) * 2010-02-04 2014-07-31 F. Hoffmann-La Roche Ag Monoklonsko protitelo proti CD44 za uporabo pri zdravljenju skvamoznoceličnega karcinoma glave in vratu
US9218450B2 (en) * 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
KR20210004961A (ko) * 2018-02-22 2021-01-13 아브마트 상하이 컴퍼니, 엘티디. 치료 항체 및 그의 용도
EP4532019A2 (en) 2022-05-25 2025-04-09 Akiram Therapeutics AB Anti-cd44v6 antibodies and their use to treat cd44v6 overexpressing cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2165461A1 (en) * 1993-06-18 1995-01-05 Sirpa Jalkanen Compositions and diagnostic methods using monoclonal antibodies against cd44v6
CA2164728A1 (en) * 1993-06-22 1995-01-05 Helmut Ponta Processes for diagnosing and analysing tumours
DE4326573A1 (de) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren
UA58482C2 (uk) * 1994-06-08 2003-08-15 Бьорінгер Інгельхайм Інтернаціональ Гмбх Моноклональне антитіло vff-18 проти сd44v6 і його фрагменти

Also Published As

Publication number Publication date
HK1011560A1 (en) 1999-07-16
BG102513A (en) 1999-02-26
KR100473824B1 (ko) 2005-09-30
EP0865609A1 (de) 1998-09-23
TR199801027T2 (xx) 1998-10-21
CZ174198A3 (cs) 1999-02-17
JP2000502067A (ja) 2000-02-22
EP0865609B1 (de) 2003-03-19
CA2239709A1 (en) 1997-06-12
SK73698A3 (en) 1999-01-11
SK284378B6 (sk) 2005-02-04
EE9800164A (et) 1998-12-15
CN1207811A (zh) 1999-02-10
AU1177397A (en) 1997-06-27
DK0865609T3 (da) 2003-06-23
NZ324314A (en) 2000-02-28
AU726704B2 (en) 2000-11-16
KR19990071952A (ko) 1999-09-27
AR004360A1 (es) 1998-11-04
CO4520233A1 (es) 1997-10-15
PL327066A1 (en) 1998-11-23
NO319903B1 (no) 2005-09-26
PL184521B1 (pl) 2002-11-29
BG62985B1 (bg) 2000-12-29
UY24389A1 (es) 2001-10-25
ATE235056T1 (de) 2003-04-15
NO982588L (no) 1998-08-05
DE59610248D1 (de) 2003-04-24
MX9804459A (es) 1998-09-30
NO982588D0 (no) 1998-06-05
CN1151377C (zh) 2004-05-26
WO1997021104A1 (de) 1997-06-12
ES2190484T3 (es) 2003-08-01
BR9611901A (pt) 1999-03-02
PT865609E (pt) 2003-08-29

Similar Documents

Publication Publication Date Title
BR9611986A (pt) Compostos processo para a preparação dos mesmos composição farmcéutica e utilização dos compostos
FI953479A7 (fi) 1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö
NO20021172L (no) Farmasöytisk sammensetning
FI973048L (fi) Menetelmät ja koostumukset hydrofiilisten molekyylien lipidisoimiseksi
BR9500784A (pt) Composto e formulação farmacêutica
BR9504060A (pt) Composto e formulação farmacêutica
FI964028L (fi) Uusi farmaseuttinen formulaatio ja menetelmä
FI955144L (fi) Päällystetyt farmaseuttiset koostumukset
FI972366A7 (fi) Lipopolyamiinit transfektoivina aineina ja niiden farmaseuttinen käytt ö
BR9607317A (pt) Peptídios e composição farmacêutica
BR9607318A (pt) Peptidos e composição farmacêutica
FI944832A7 (fi) Farmaseuttinen koostumus
BR9602705A (pt) Composto composição farmacéutica processo para a preparação de um composto e uso
DE69618587D1 (de) Chinazoline und pharmazeutische zusammensetzungen
FI955685L (fi) Uusia tiatsolidiinidioneja ja näitä sisältäviä lääkkeitä
FI971750A0 (fi) Koostumuksia multippeliskleroosia varten ja sen hoito
EE04681B1 (et) 3,6-poolketaalid 9a-asaliidide klassist, nende valmistamismeetod ja farmatseutiline kompositsioon
BR9610733A (pt) Composto processos para a preparação do mesmo e para o tratamento de um mamífero composição farmacêutica e utilização de um composto
BR9507768A (pt) Composição farmacêutica
FI972988A0 (fi) Menetelmiä ja farmaseuttisia koostumuksia, joissa käytetään desmetyyliselegiliiniä
FI972757L (fi) Runsaasti hydroksiproliinia sisältävät proteiinit ja niitä sisältävät farmaseuttiset ja kosmeettiset koostumukset
FI973229L (fi) Uusi farmaseuttinen koostumus
FI971427L (fi) Peptidit ja niitä sisältävät farmaseuttiset koostumukset
BR9612206A (pt) Composto uso do composto composição farmacêutica processo para preparação do composto e para o tratamento da dor
FI964113A7 (fi) Lääkekoostumus hoitamaan tardiivia dyskinesiaa ja sen käyttö

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

MM4A Lapsed by not paying the annual fees

Effective date: 20051205