EE03904B1 - Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid - Google Patents

Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid

Info

Publication number
EE03904B1
EE03904B1 EEP199900453A EEP9900453A EE03904B1 EE 03904 B1 EE03904 B1 EE 03904B1 EE P199900453 A EEP199900453 A EE P199900453A EE P9900453 A EEP9900453 A EE P9900453A EE 03904 B1 EE03904 B1 EE 03904B1
Authority
EE
Estonia
Prior art keywords
granules
granule
drug
preparation
dosage form
Prior art date
Application number
EEP199900453A
Other languages
English (en)
Estonian (et)
Inventor
Florent Victor De Cond Valentin
Petrus Gerebern Vandecruys Roger
Marie Victor Gilis Paul
Peeters Jozef
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE9900453A publication Critical patent/EE9900453A/xx
Publication of EE03904B1 publication Critical patent/EE03904B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EEP199900453A 1997-03-26 1998-03-18 Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid EE03904B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en) 1997-03-26 1998-03-18 Pellets having a core coated with an antifungal and a polymer

Publications (2)

Publication Number Publication Date
EE9900453A EE9900453A (et) 2000-04-17
EE03904B1 true EE03904B1 (et) 2002-12-16

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900453A EE03904B1 (et) 1997-03-26 1998-03-18 Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid

Country Status (30)

Country Link
EP (1) EP0969821B1 (de)
JP (1) JP3608800B2 (de)
KR (1) KR100520936B1 (de)
CN (1) CN1206984C (de)
AP (1) AP1227A (de)
AT (1) ATE241969T1 (de)
AU (1) AU734248B2 (de)
BG (1) BG64434B1 (de)
BR (1) BR9806174A (de)
CA (1) CA2269501C (de)
CY (1) CY2384B1 (de)
CZ (1) CZ295502B6 (de)
DE (1) DE69815316T2 (de)
DK (1) DK0969821T3 (de)
EE (1) EE03904B1 (de)
ES (1) ES2201485T3 (de)
HU (1) HU224217B1 (de)
ID (1) ID21477A (de)
IL (1) IL129575A (de)
NO (1) NO325102B1 (de)
NZ (1) NZ335364A (de)
OA (1) OA11162A (de)
PL (1) PL190566B1 (de)
PT (1) PT969821E (de)
RU (1) RU2218153C2 (de)
SI (1) SI0969821T1 (de)
SK (1) SK284813B6 (de)
TR (1) TR199900990T2 (de)
UA (1) UA60318C2 (de)
WO (1) WO1998042318A1 (de)

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BR9906712A (pt) * 1998-07-17 2000-10-10 Janssen Pharmaceutica Nv Péletes que apresentam um núcleo revestido com um antifúngico e um polìmero
ES2157731B1 (es) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
ES2251985T3 (es) 1999-03-24 2006-05-16 R.P. Scherer Technologies, Inc. Particula granulada para mejorar la solubilidad acuosa de farmacos, y su procedimiento de preparacion.
KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
ES2275866T3 (es) 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.
AR035819A1 (es) 2001-04-09 2004-07-14 Tibotec Pharm Ltd 2-(amino sustituido)-benzoxazol sulfonamidas, inhibidoras de la proteasa del hiv, composiciones farmaceuticas que comprenden dichos compuestos, metodo in vitro para inhibir la replicacion retroviral y uso de dichos compuestos en la fabricacion de medicamentos
EA009590B1 (ru) 2001-05-11 2008-02-28 Тиботек Фармасьютикалз Лтд. 2-аминобензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра
WO2002100407A1 (en) * 2001-06-12 2002-12-19 Smartrix Technologies Inc. Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
JP4578101B2 (ja) 2001-12-21 2010-11-10 テイボテク・フアーマシユーチカルズ・リミテツド 幅広いスペクトルのｈｉｖプロテアーゼ阻害剤である複素環置換フェニル含有スルホンアミド
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
KR101019648B1 (ko) 2002-05-17 2011-03-07 티보텍 파마슈티컬즈 광범위 스펙트럼의 치환된 벤즈이속사졸 설폰아미드ｈｉｖ 프로테아제 저해제
JP4681296B2 (ja) 2002-08-14 2011-05-11 テイボテク・フアーマシユーチカルズ・リミテツド スペクトルの広い置換オキシインドールスルホンアミドｈｉｖプロテアーゼ阻害剤
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
DK1438961T4 (da) * 2003-01-14 2014-11-17 Acino Pharma Ag Bioækvivalent sammensætning af itraconazol dispergeret i en hydrofil polymer
EP1438960B2 (de) * 2003-01-14 2012-12-19 Acino Pharma AG Zusammensetzung in Form eines festen Dispersion enthaltend Itraconazol und ein hydrophilisches Polymer mit einer verbesserten Bioverfügbarkeit
WO2005013939A1 (en) 2003-08-06 2005-02-17 Nirmal Mulye Pharmaceutical composition containing water soluble drug
UA84020C2 (ru) 2003-09-11 2008-09-10 Тиботек Фармасьютикелз Лтд. Ингибитор проникновения вируса вил
EP1568369A1 (de) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
EP2422781A1 (de) 2004-05-07 2012-02-29 Sequoia Pharmaceuticals, Inc. Resistenzabweisende retrovirale Proteaseinhibitoren
CN1953982B (zh) 2004-05-17 2011-07-06 泰博特克药品有限公司 4-取代-1,5-二氢-吡啶并[3,2-b]吲哚-2-酮
TW200607503A (en) 2004-05-17 2006-03-01 Tibotec Pharm Ltd 1-heterocyclyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones
ES2351702T3 (es) 2004-05-17 2011-02-09 Tibotec Pharmaceuticals 1-fenil-1,5-dihidro-pirido[3,2-b]indol-2-onas 6,7,8,9-sustituidas útiles como agentes farmacéuticos antiinfecciosos.
US7994187B2 (en) 2006-04-03 2011-08-09 Tibotec Pharmaceuticals Ltd. HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones
CA2661172A1 (en) * 2006-09-04 2008-05-29 Panacea Biotec Limited Programmable buoyant delivery technology
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
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US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
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US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
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Also Published As

Publication number Publication date
TR199900990T2 (xx) 1999-10-21
HU224217B1 (hu) 2005-06-28
EE9900453A (et) 2000-04-17
IL129575A (en) 2004-06-20
EP0969821B1 (de) 2003-06-04
EP0969821A1 (de) 2000-01-12
JP2001520663A (ja) 2001-10-30
CZ139899A3 (cs) 1999-10-13
KR100520936B1 (ko) 2005-10-17
ATE241969T1 (de) 2003-06-15
SI0969821T1 (en) 2003-10-31
BG64434B1 (en) 2005-02-28
CN1244796A (zh) 2000-02-16
NZ335364A (en) 2000-08-25
ID21477A (id) 1999-06-17
NO992114D0 (no) 1999-04-30
SK54499A3 (en) 2000-01-18
CA2269501C (en) 2005-11-08
RU2218153C2 (ru) 2003-12-10
IL129575A0 (en) 2000-02-29
PL335542A1 (en) 2000-04-25
AP9901516A0 (en) 1999-06-30
PT969821E (pt) 2003-10-31
BR9806174A (pt) 1999-10-19
CA2269501A1 (en) 1998-10-01
KR20000052971A (ko) 2000-08-25
CN1206984C (zh) 2005-06-22
BG103356A (en) 2000-03-31
JP3608800B2 (ja) 2005-01-12
NO992114L (no) 1999-08-26
OA11162A (en) 2003-04-16
HUP0002056A2 (hu) 2000-12-28
CY2384B1 (en) 2004-06-04
DE69815316T2 (de) 2004-04-29
DE69815316D1 (de) 2003-07-10
AP1227A (en) 2003-11-24
NO325102B1 (no) 2008-02-04
PL190566B1 (pl) 2005-12-30
CZ295502B6 (cs) 2005-08-17
HUP0002056A3 (en) 2001-01-29
UA60318C2 (uk) 2003-10-15
SK284813B6 (sk) 2005-12-01
WO1998042318A1 (en) 1998-10-01
DK0969821T3 (da) 2003-09-15
AU7210798A (en) 1998-10-20
HK1022840A1 (en) 2000-08-25
AU734248B2 (en) 2001-06-07
ES2201485T3 (es) 2004-03-16

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