EE03976B1 - Erütromütsiinid ja nende valmistamise meetod - Google Patents

Erütromütsiinid ja nende valmistamise meetod

Info

Publication number: EE03976B1
Authority: EE; Estonia
Prior art keywords: erythromycins; preparation
Prior art date: 1996-07-05

Application number

EEP199900014A

Other languages

English (en)

Other versions

EE9900014A (et

Inventor

Francis Leadlay Peter

Stephen Pacey Michael

Staunton James

Cortes Jesus

Original Assignee

Biotica Technology Limited

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-05

Filing date

1997-07-04

Publication date

2003-02-17

1996-07-05 Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en

1997-05-28 Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en

1997-07-04 Application filed by Biotica Technology Limited, Pfizer Inc. filed Critical Biotica Technology Limited

1999-08-16 Publication of EE9900014A publication Critical patent/EE9900014A/et

2003-02-17 Publication of EE03976B1 publication Critical patent/EE03976B1/et

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Tropical Medicine & Parasitology (AREA)
Physics & Mathematics (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EEP199900014A 1996-07-05 1997-07-04 Erütromütsiinid ja nende valmistamise meetod EE03976B1 (et)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9614189.0A GB9614189D0 (en)	1996-07-05	1996-07-05	Polyketides and their synthesis
US2418896P	1996-08-19	1996-08-19
GBGB9710962.3A GB9710962D0 (en)	1997-05-28	1997-05-28	Polyketides and their synthesis
PCT/GB1997/001810 WO1998001571A2 (en)	1996-07-05	1997-07-04	Erythromycins and process for their preparation

Publications (2)

Publication Number	Publication Date
EE9900014A EE9900014A (et)	1999-08-16
EE03976B1 true EE03976B1 (et)	2003-02-17

Family

ID=27268361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900014A EE03976B1 (et)	1996-07-05	1997-07-04	Erütromütsiinid ja nende valmistamise meetod

Country Status (28)

Country	Link
EP (3)	EP0910633B1 (et)
JP (2)	JP2000511063A (et)
KR (1)	KR20000023579A (et)
CN (1)	CN1179046C (et)
AP (1)	AP1029A (et)
AT (2)	ATE296893T1 (et)
AU (2)	AU731301B2 (et)
BG (1)	BG103133A (et)
BR (1)	BR9710209A (et)
CA (2)	CA2259463A1 (et)
DE (2)	DE69733416T2 (et)
DK (2)	DK0910633T3 (et)
EA (1)	EA001744B1 (et)
EE (1)	EE03976B1 (et)
ES (2)	ES2337424T3 (et)
GB (1)	GB2331518B (et)
GE (1)	GEP20012348B (et)
IL (1)	IL127916A0 (et)
IS (1)	IS4940A (et)
NO (1)	NO990012L (et)
NZ (1)	NZ333861A (et)
OA (1)	OA10952A (et)
PL (1)	PL331285A1 (et)
PT (1)	PT909327E (et)
SI (1)	SI0910633T1 (et)
SK (1)	SK182498A3 (et)
TR (1)	TR199900006T2 (et)
WO (2)	WO1998001571A2 (et)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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US6063561A (en) *	1991-01-17	2000-05-16	Abbott Laboratories	Polyketide derivatives and recombinant methods for making same
US6060234A (en) *	1991-01-17	2000-05-09	Abbott Laboratories	Polyketide derivatives and recombinant methods for making same
US6558942B1 (en)	1994-05-06	2003-05-06	The Leland Stanford Junior University	Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6500960B1 (en)	1995-07-06	2002-12-31	Stanford University (Board Of Trustees Of The Leland Stanford Junior University)	Method to produce novel polyketides
US20030170725A1 (en)	1993-09-20	2003-09-11	Chaitan Khosla	Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6927057B2 (en)	1993-09-20	2005-08-09	Kosan Biosciences	Macrolide analogs
US5712146A (en)	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides
US6495348B1 (en)	1993-10-07	2002-12-17	Regents Of The University Of Minnesota	Mitomycin biosynthetic gene cluster
JP3633629B2 (ja)	1995-07-06	2005-03-30	ザレランドスタンフォードジュニアユニバーシティ	ポリケチドの無細胞合成
WO1997022711A1 (en)	1995-12-19	1997-06-26	Regents Of The University Of Minnesota	Metabolic engineering of polyhydroxyalkanoate monomer synthases
US6271255B1 (en)	1996-07-05	2001-08-07	Biotica Technology Limited	Erythromycins and process for their preparation
US6399789B1 (en)	1996-12-18	2002-06-04	Kosan Biosciences, Inc.	Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6902913B2 (en)	1997-04-30	2005-06-07	Kosan Biosciences, Inc.	Recombinant narbonolide polyketide synthase
IL132590A0 (en)	1997-04-30	2001-03-19	Kosan Biosciences Inc	Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold
US6503741B1 (en)	1998-05-28	2003-01-07	Kosan Biosciences, Inc.	Polyketide synthase genes from Streptomyces venezuelae
JP2008169226A (ja) *	1997-04-30	2008-07-24	Kosan Biosciences Inc	足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
US6117659A (en)	1997-04-30	2000-09-12	Kosan Biosciences, Inc.	Recombinant narbonolide polyketide synthase
NZ501998A (en)	1997-07-10	2001-04-27	Kosan Biosciences Inc	Production of polyketides in plants
AP1060A (en)	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
JP2002508968A (ja) *	1998-01-14	2002-03-26	グラクソグループリミテッド	ポリケチドおよびその合成
EP1082439A2 (en) *	1998-05-28	2001-03-14	Kosan Biosciences, Inc.	Recombinant narbonolide polyketide synthase
US6265202B1 (en)	1998-06-26	2001-07-24	Regents Of The University Of Minnesota	DNA encoding methymycin and pikromycin
GB9814006D0 (en) *	1998-06-29	1998-08-26	Biotica Tech Ltd	Polyketides and their synthesis
US6221641B1 (en)	1998-07-02	2001-04-24	Leland Stanford Junior University	Method for making polyketides
GB9814622D0 (en) *	1998-07-06	1998-09-02	Biotica Tech Ltd	Polyketides,their preparation,and materials for use therein
CA2347128A1 (en)	1998-10-28	2000-05-04	Kosan Biosciences, Inc.	Library of novel "unnatural" natural products
TR200200436T2 (tr)	1998-11-03	2002-06-21	Pfizer Inc.	Yeni makrolit antibiyotikler
US6358712B1 (en)	1999-01-05	2002-03-19	Trustee Of Boston University	Ordered gene assembly
JP2002537762A (ja)	1999-01-05	2002-11-12	トラスティーズオブボストンユニバーシティ	改良型核酸クローニング
AP2001002222A0 (en)	1999-01-27	2001-09-30	Pfizer Prod Inc	Ketolide antibiotics.
EP1153124A2 (en) *	1999-02-09	2001-11-14	The Board Of Trustees Of The Leland Stanford Junior University	Methods to mediate polyketide synthase module effectiveness
US7001748B2 (en)	1999-02-09	2006-02-21	The Board Of Trustees Of The Leland Stanford Junior University	Methods of making polyketides using hybrid polyketide synthases
US6395710B1 (en)	1999-04-16	2002-05-28	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6451768B1 (en)	1999-04-16	2002-09-17	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6939861B2 (en)	1999-04-16	2005-09-06	Kosan Biosciences, Inc.	Amido macrolides
US6590083B1 (en)	1999-04-16	2003-07-08	Ortho-Mcneil Pharmaceutical, Inc.	Ketolide antibacterials
IL145976A0 (en)	1999-04-16	2002-07-25	Ortho Mcneil Pharm Inc	Ketolide antibacterials
US6514944B2 (en)	1999-04-16	2003-02-04	Kosan Biosciences, Inc.	Macrolide antiinfective agents
IL145739A0 (en)	1999-05-24	2002-07-25	Pfizer Prod Inc	13-methyl-erythromycin derivatives
GB9912563D0 (en) *	1999-05-28	1999-07-28	Biotica Tech Ltd	Polyketides and their synthesis
ATE356880T1 (de) *	1999-10-29	2007-04-15	Kosan Biosciences Inc	Rapamycin analoge
EP1101769A3 (en)	1999-11-18	2001-10-24	Pfizer Products Inc.	Nitrogen containing erythromycin derivatives
US6562795B2 (en)	2000-02-18	2003-05-13	Kosan Biosciences, Inc.	Motilide compounds
EP1146051A3 (en) *	2000-04-10	2001-10-31	Pfizer Products Inc.	Erythromycin A derivatives
CA2405958C (en)	2000-04-13	2011-08-09	Biotica Technology Limited	Hybrid glycosylated products and their production and use
JP4765032B2 (ja) *	2002-02-19	2011-09-07	ダウ・アグロサイエンス・エル・エル・シー	新規スピノシンを産生するポリケチド合成酵素
ES2296063T3 (es)	2002-07-16	2008-04-16	Biotica Technology Limited	Produccion de poliquetidos y otros productos naturales.
DK200201957A (da) *	2002-12-20	2003-01-20	Alpharma Aps	10-substituted erythromycin ketolides and methods of making
GB0230217D0 (en) *	2002-12-27	2003-02-05	Biotica Tech Ltd	Borrelidin-producing polyketide synthase and its uses
CA2673334C (en)	2003-06-16	2013-11-12	Andrx Pharmaceuticals, Llc	Oral extended-release composition
GB0327720D0 (en)	2003-11-28	2003-12-31	Biotica Tech Ltd	Erythromycins and process for their preparation
GB0417852D0 (en)	2004-08-11	2004-09-15	Biotica Tech Ltd	Production of polyketides and other natural products
US7582611B2 (en) *	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
US8962329B2 (en)	2008-09-24	2015-02-24	Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences	Gene cluster
GB0904540D0 (en)	2009-03-17	2009-04-29	Biotica Tech Ltd	Novel compounds and methods for their production
GB0914589D0 (en)	2009-08-20	2009-09-30	Biotica Tech Ltd	Novel compounds and methods for their production
WO2011098808A1 (en)	2010-02-09	2011-08-18	Biotica Technology Limited	Sanglifehrin based compounds
WO2011098805A1 (en)	2010-02-09	2011-08-18	Biotica Technology Limited	Sanglifehrin based compounds
AU2011214135B2 (en)	2010-02-09	2014-07-31	Neurovive Pharmaceutical Ab	Sanglifehrin based compounds
GB201118334D0 (en)	2011-10-24	2011-12-07	Biotica Tech Ltd	Novel dosage form
WO2013172782A1 (en) *	2012-05-16	2013-11-21	Nanyang Technological University	A polyketide synthase construct and its use in the preparation of polyketides
EP4289950A3 (en)	2015-01-09	2024-01-24	Revolution Medicines, Inc.	Macrocyclic compounds that participate in cooperative binding and medical uses thereof
KR102359972B1 (ko)	2016-04-12	2022-02-10	징코 바이오웍스, 인크.	화합물의 제조를 위한 조성물 및 방법
EP3960857A1 (en)	2016-07-29	2022-03-02	Isomerase Therapeutics Limited	Novel methods
AU2017350898A1 (en) *	2016-10-28	2019-06-13	Ginkgo Bioworks, Inc.	Compositions and methods for the production of compounds
WO2018081592A2 (en)	2016-10-28	2018-05-03	Warp Drive Bio, Inc.	Compositions and methods for the production of compounds
WO2018153960A1 (en)	2017-02-22	2018-08-30	Immune System Regulation Holding Ab	Novel immune stimulating macrolides
CA3054023A1 (en)	2017-02-22	2018-08-30	Immune System Regulation Holding Ab	Novel immune stimulating macrolides
EP3768277A1 (en)	2018-03-23	2021-01-27	Isr Immune System Regulation Holding Ab (Publ)	Combinations of macrolide compounds and immune checkpoint inhibitors
EP4272825A3 (en)	2019-01-22	2023-12-06	Aeovian Pharmaceuticals, Inc.	Mtorc modulators and uses thereof
PE20221277A1 (es)	2019-11-04	2022-09-05	Revolution Medicines Inc	Inhibidores de ras
CN114786777A (zh)	2019-11-04	2022-07-22	锐新医药公司	Ras抑制剂
CN114867735A (zh)	2019-11-04	2022-08-05	锐新医药公司	Ras抑制剂
AU2021345111B2 (en)	2020-09-15	2025-11-27	Revolution Medicines, Inc.	Indole derivatives as Ras inhibitors in the treatment of cancer
CR20230558A (es)	2021-05-05	2024-01-24	Revolution Medicines Inc	Inhibidores de ras para el tratamiento del cáncer
AR127308A1 (es)	2021-10-08	2024-01-10	Revolution Medicines Inc	Inhibidores ras
KR102775118B1 (ko)	2022-07-26	2025-02-27	강원대학교산학협력단	에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법
CN117288869B (zh) *	2023-11-24	2024-02-09	中国医学科学院医药生物技术研究所	一种原料药中对甲苯磺酸酯类杂质的检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993013663A1 (en) *	1992-01-17	1993-07-22	Abbott Laboratories	Method of directing biosynthesis of specific polyketides
US6060234A (en) *	1991-01-17	2000-05-09	Abbott Laboratories	Polyketide derivatives and recombinant methods for making same
US5712146A (en) *	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides
ES2164713T3 (es) *	1993-09-20	2002-03-01	Univ Leland Stanford Junior	Produccion recombinante de nuevos poliquetidos.

1997
- 1997-07-04 DK DK97930631.3T patent/DK0910633T3/da active
- 1997-07-04 PT PT97930626T patent/PT909327E/pt unknown
- 1997-07-04 AU AU34509/97A patent/AU731301B2/en not_active Ceased
- 1997-07-04 WO PCT/GB1997/001810 patent/WO1998001571A2/en not_active Ceased
- 1997-07-04 DE DE69733416T patent/DE69733416T2/de not_active Expired - Lifetime
- 1997-07-04 DK DK97930626T patent/DK0909327T3/da active
- 1997-07-04 CN CNB97197649XA patent/CN1179046C/zh not_active Expired - Fee Related
- 1997-07-04 CA CA002259463A patent/CA2259463A1/en not_active Abandoned
- 1997-07-04 DE DE69739688T patent/DE69739688D1/de not_active Expired - Lifetime
- 1997-07-04 AT AT97930626T patent/ATE296893T1/de active
- 1997-07-04 AP APAP/P/1999/001444A patent/AP1029A/en active
- 1997-07-04 EP EP97930631A patent/EP0910633B1/en not_active Expired - Lifetime
- 1997-07-04 GB GB9900156A patent/GB2331518B/en not_active Expired - Fee Related
- 1997-07-04 AU AU34514/97A patent/AU731654B2/en not_active Ceased
- 1997-07-04 EP EP97930626A patent/EP0909327B1/en not_active Expired - Lifetime
- 1997-07-04 IL IL12791697A patent/IL127916A0/xx unknown
- 1997-07-04 EE EEP199900014A patent/EE03976B1/et not_active IP Right Cessation
- 1997-07-04 EP EP09178121A patent/EP2182067A3/en not_active Withdrawn
- 1997-07-04 ES ES97930631T patent/ES2337424T3/es not_active Expired - Lifetime
- 1997-07-04 SK SK1824-98A patent/SK182498A3/sk unknown
- 1997-07-04 JP JP10504933A patent/JP2000511063A/ja not_active Withdrawn
- 1997-07-04 TR TR1999/00006T patent/TR199900006T2/xx unknown
- 1997-07-04 CA CA002259420A patent/CA2259420C/en not_active Expired - Fee Related
- 1997-07-04 AT AT97930631T patent/ATE451455T1/de not_active IP Right Cessation
- 1997-07-04 WO PCT/GB1997/001819 patent/WO1998001546A2/en not_active Ceased
- 1997-07-04 BR BR9710209-1A patent/BR9710209A/pt not_active Application Discontinuation
- 1997-07-04 EA EA199900087A patent/EA001744B1/ru not_active IP Right Cessation
- 1997-07-04 PL PL97331285A patent/PL331285A1/xx unknown
- 1997-07-04 GE GEAP19974661A patent/GEP20012348B/en unknown
- 1997-07-04 ES ES97930626T patent/ES2244001T3/es not_active Expired - Lifetime
- 1997-07-04 JP JP50492598A patent/JP4173551B2/ja not_active Expired - Fee Related
- 1997-07-04 SI SI9730793T patent/SI0910633T1/sl unknown
- 1997-07-04 NZ NZ333861A patent/NZ333861A/xx unknown
1999
- 1999-01-04 OA OA9900002A patent/OA10952A/en unknown
- 1999-01-04 IS IS4940A patent/IS4940A/is unknown
- 1999-01-04 NO NO990012A patent/NO990012L/no not_active Application Discontinuation
- 1999-01-05 KR KR1019997000024A patent/KR20000023579A/ko not_active Ceased
- 1999-01-29 BG BG103133A patent/BG103133A/xx unknown

Also Published As

Publication number	Publication date
KR20000023579A (ko)	2000-04-25
GB9900156D0 (en)	1999-02-24
DE69739688D1 (de)	2010-01-21
DK0909327T3 (da)	2005-09-26
OA10952A (en)	2002-02-25
JP2000516450A (ja)	2000-12-12
SK182498A3 (en)	2000-05-16
GEP20012348B (en)	2001-01-25
CN1229438A (zh)	1999-09-22
AP9901444A0 (en)	1999-03-31
TR199900006T2 (xx)	1999-04-21
CA2259463A1 (en)	1998-01-15
IL127916A0 (en)	1999-11-30
SI0910633T1 (sl)	2010-04-30
GB2331518B (en)	2001-03-14
WO1998001571A2 (en)	1998-01-15
JP2000511063A (ja)	2000-08-29
AU731654B2 (en)	2001-04-05
CA2259420A1 (en)	1998-01-15
AU3451497A (en)	1998-02-02
CN1179046C (zh)	2004-12-08
CA2259420C (en)	2007-09-18
BG103133A (en)	2000-04-28
EA199900087A1 (ru)	1999-08-26
EP2182067A3 (en)	2010-07-14
BR9710209A (pt)	2000-01-11
EP0909327B1 (en)	2005-06-01
EE9900014A (et)	1999-08-16
PT909327E (pt)	2005-10-31
ES2337424T3 (es)	2010-04-23
AU731301B2 (en)	2001-03-29
DE69733416D1 (de)	2005-07-07
WO1998001571A3 (en)	1998-02-19
NO990012D0 (no)	1999-01-04
ES2244001T3 (es)	2005-12-01
PL331285A1 (en)	1999-07-05
AU3450997A (en)	1998-02-02
EA001744B1 (ru)	2001-08-27
EP0910633B1 (en)	2009-12-09
WO1998001546A3 (en)	1998-04-09
NO990012L (no)	1999-02-23
IS4940A (is)	1999-01-04
WO1998001546A2 (en)	1998-01-15
EP2182067A2 (en)	2010-05-05
EP0909327A2 (en)	1999-04-21
ATE451455T1 (de)	2009-12-15
EP0910633A2 (en)	1999-04-28
GB2331518A (en)	1999-05-26
DK0910633T3 (da)	2010-03-29
DE69733416T2 (de)	2006-04-27
NZ333861A (en)	2000-08-25
AP1029A (en)	2001-12-11
JP4173551B2 (ja)	2008-10-29
ATE296893T1 (de)	2005-06-15

Legal Events

Date	Code	Title	Description
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2005-04-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20040704

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EE9900014A (et)	1999-08-16	Erütromütsiinid ja nende valmistamise protsess
FI973750L (fi)	1997-09-22	2-metyylitienobentsodiatsepiinin valmistus ja kiteiset muodot
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EE04540B1 (et)	2005-10-17	Meetod bioloogiliselt sobivate biodegradeeruvate mikroosakeste valmistamiseks ja mikroosakeste kasutamine
FI973074A7 (fi)	1998-01-23	Leivontamenetelmä ja siihen liittyvä laite
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EE9800161A (et)	1998-12-15	Vähivaktsiin ja selle valmistamismeetod
FR2744442B1 (fr)	1998-02-27	Preparation du 1,1,1,3,3-pentachlorobutane et du 1,1,1,3,3,-pentafluorobutane
EE9800234A (et)	1998-12-15	Ravimeetod ja farmatseutiline kompositsioon
FI980246A0 (fi)	1998-02-04	Menetelmä keittimen käyttämiseksi ja keitin
KR960007649A (ko)	1996-03-22	공중합 폴리아미드 및 그의 제조방법
EE9900141A (et)	1999-12-15	Keerdotstega suletav pakend ja meetod pakendamiseks
FI963172A7 (fi)	1998-02-14	Kytkentämenetelmä ja laite
FI951060A7 (fi)	1995-09-09	Formulaatioita ja hoitomenetelmiä
FI964869L (fi)	1997-10-05	Paikannusmenetelmä ja järjestelmä
FI963325L (fi)	1996-10-21	Inhibiinikoostumukset ja menetelmät niiden käyttämiseksi
FI973434L (fi)	1997-08-21	Aminotetralonijohdannaisia ja menetelmä niiden valmistamiseksi
DE69524527D1 (de)	2002-01-24	AIDS-hemmende Arzneizubereitung und Verfahren
FI972464L (fi)	1997-08-21	Diaminoeetterin diklavulanaattisuola ja menetelmä sen valmistamiseksi
DE19749117B4 (de)	2005-10-20	Pleuelstange und Herstellungsverfahren dafür