EE04156B1 - Sulfoonamiidid endoteliini vahendatud haiguste ravimiseks - Google Patents

Sulfoonamiidid endoteliini vahendatud haiguste ravimiseks

Info

Publication number: EE04156B1
Authority: EE; Estonia
Prior art keywords: endothelin; sulfonamides; treatment; mediated diseases; mediated
Prior art date: 1997-04-28

Application number

EEP199900469A

Other languages

English (en)

Inventor

Wu Chengde

Blok Natalie

Kogan Timothy

Keller Karin

Woodard Patricia

Original Assignee

Texas Biotechnology Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-28

Filing date

1998-04-02

Publication date

2003-10-15

1997-04-28 Priority claimed from US08/847,797 external-priority patent/US5783705A/en

1998-04-02 Application filed by Texas Biotechnology Corporation filed Critical Texas Biotechnology Corporation

1998-04-02 Priority to EEP200300214A priority Critical patent/EE200300214A/et

2000-06-15 Publication of EE9900469A publication Critical patent/EE9900469A/et

2003-10-15 Publication of EE04156B1 publication Critical patent/EE04156B1/et

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
230000001404 mediated effect Effects 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

EEP199900469A 1997-04-28 1998-04-02 Sulfoonamiidid endoteliini vahendatud haiguste ravimiseks EE04156B1 (et)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EEP200300214A EE200300214A (et)	1997-04-28	1998-04-02	Sulfoonamiidid endoteliini vahendatud haiguste ravimiseks

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/847,797 US5783705A (en)	1997-04-28	1997-04-28	Process of preparing alkali metal salys of hydrophobic sulfonamides
US08/938,444 US6248767B1 (en)	1997-04-28	1997-09-26	Formulation of sulfonamides for treatment of endothelin-mediated disorders
PCT/US1998/006680 WO1998049162A1 (en)	1997-04-28	1998-04-02	Sulfonamides for treatment of endothelin-mediated disorders

Publications (2)

Publication Number	Publication Date
EE9900469A EE9900469A (et)	2000-06-15
EE04156B1 true EE04156B1 (et)	2003-10-15

Family

ID=27126732

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900469A EE04156B1 (et)	1997-04-28	1998-04-02	Sulfoonamiidid endoteliini vahendatud haiguste ravimiseks

Country Status (25)

Country	Link
US (3)	US6432994B1 (et)
EP (1)	EP0980369B1 (et)
JP (3)	JP3455233B2 (et)
CN (2)	CN1179961C (et)
AP (1)	AP9901643A0 (et)
AT (1)	ATE292129T1 (et)
AU (1)	AU749167B2 (et)
BR (1)	BR9812258A (et)
CA (2)	CA2496680A1 (et)
CZ (1)	CZ301452B6 (et)
DE (2)	DE69829558T2 (et)
EA (1)	EA003993B1 (et)
EE (1)	EE04156B1 (et)
ES (1)	ES2241133T3 (et)
HU (1)	HU227183B1 (et)
ID (1)	ID25921A (et)
IL (2)	IL156977A (et)
NO (1)	NO995221L (et)
NZ (1)	NZ336898A (et)
OA (1)	OA11167A (et)
PL (1)	PL197843B1 (et)
SG (2)	SG100767A1 (et)
SK (1)	SK143399A3 (et)
TR (3)	TR199902401T2 (et)
WO (1)	WO1998049162A1 (et)

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CN1253560A (zh)	2000-05-17
AU6950498A (en)	1998-11-24
JP2001520643A (ja)	2001-10-30
CZ301452B6 (cs)	2010-03-10
CN1636994B (zh)	2010-05-12
SG100767A1 (en)	2003-12-26
TR199902401T2 (xx)	2000-08-21
ATE292129T1 (de)	2005-04-15
OA11167A (en)	2003-04-29
EP0980369A1 (en)	2000-02-23
US20020091270A1 (en)	2002-07-11
BR9812258A (pt)	2000-07-25
US6432994B1 (en)	2002-08-13
TR200101905T2 (tr)	2002-06-21
SG100766A1 (en)	2003-12-26
EE9900469A (et)	2000-06-15
ES2241133T3 (es)	2005-10-16
CA2496680A1 (en)	1998-11-05
PL336290A1 (en)	2000-06-19
HU227183B1 (en)	2010-09-28
HUP0001442A2 (hu)	2001-11-28
HK1028033A1 (en)	2001-03-02
JP2008074875A (ja)	2008-04-03
TR200202738T2 (tr)	2003-03-21
IL131318A0 (en)	2001-01-28
EA199900966A1 (ru)	2000-08-28
US20010039289A1 (en)	2001-11-08
US6683103B2 (en)	2004-01-27
HUP0001442A3 (en)	2001-12-28
EA003993B1 (ru)	2003-12-25
JP3455233B2 (ja)	2003-10-14
CZ367599A3 (cs)	2000-02-16
NO995221L (no)	1999-12-28
AU749167B2 (en)	2002-06-20
PL197843B1 (pl)	2008-05-30
US6458805B2 (en)	2002-10-01
AP9901643A0 (en)	1999-10-02
ID25921A (id)	2000-11-09
DE69839534D1 (de)	2008-07-03
CA2281090C (en)	2005-06-07
JP2003176288A (ja)	2003-06-24
IL131318A (en)	2004-08-31
CA2281090A1 (en)	1998-11-05
SK143399A3 (en)	2000-05-16
CN1636994A (zh)	2005-07-13
IL156977A (en)	2005-03-20
JP4256150B2 (ja)	2009-04-22
WO1998049162A1 (en)	1998-11-05
IL156977A0 (en)	2004-02-08
NZ336898A (en)	2001-10-26
NO995221D0 (no)	1999-10-26
DE69829558T2 (de)	2006-02-16
DE69829558D1 (de)	2005-05-04
CN1179961C (zh)	2004-12-15
EP0980369B1 (en)	2005-03-30

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