EE04283B1 - 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis - Google Patents

15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis

Info

Publication number: EE04283B1
Authority: EE; Estonia
Prior art keywords: ketoazalides; preparation; treatment; pharmaceutical composition; composition containing
Prior art date: 1998-04-06

Application number

EEP200000587A

Other languages

English (en)

Estonian (et)

Inventor

Lazarevski Gorjana

Kobrehel Gabrijela

Kelneric Zeljko

Original Assignee

PLIVA, farmaceutska industrija, dionicko dru�tvo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-06

Filing date

1999-04-02

Publication date

2004-04-15

1999-04-02 Application filed by PLIVA, farmaceutska industrija, dionicko dru�tvo filed Critical PLIVA, farmaceutska industrija, dionicko dru�tvo

2002-04-15 Publication of EE200000587A publication Critical patent/EE200000587A/xx

2004-04-15 Publication of EE04283B1 publication Critical patent/EE04283B1/xx

Links

208000035143 Bacterial infection Diseases 0.000 title 1
208000022362 bacterial infectious disease Diseases 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Hydrogenated Pyridines (AREA)

EEP200000587A 1998-04-06 1999-04-02 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis EE04283B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HR980189A HRP980189B1 (en)	1998-04-06	1998-04-06	Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en)	1998-04-06	1999-04-02	15-membered lactams ketolides with antibacterial activity

Publications (2)

Publication Number	Publication Date
EE200000587A EE200000587A (et)	2002-04-15
EE04283B1 true EE04283B1 (et)	2004-04-15

Family

ID=10946724

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000587A EE04283B1 (et)	1998-04-06	1999-04-02	15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis

Country Status (26)

Country	Link
US (1)	US6110965A (de)
EP (1)	EP1070077B1 (de)
JP (1)	JP2002510701A (de)
KR (1)	KR100600463B1 (de)
CN (1)	CN1141312C (de)
AR (1)	AR019261A1 (de)
AT (1)	ATE241638T1 (de)
AU (1)	AU3046499A (de)
BG (1)	BG64600B1 (de)
BR (1)	BR9910115A (de)
CA (1)	CA2327775C (de)
DE (1)	DE69908338T2 (de)
DK (1)	DK1070077T3 (de)
EE (1)	EE04283B1 (de)
ES (1)	ES2200512T3 (de)
HR (1)	HRP980189B1 (de)
HU (1)	HUP0101817A3 (de)
IL (2)	IL138837A0 (de)
NO (1)	NO317982B1 (de)
PL (1)	PL193742B1 (de)
PT (1)	PT1070077E (de)
RU (1)	RU2211222C2 (de)
SI (1)	SI1070077T1 (de)
SK (1)	SK284169B6 (de)
UA (1)	UA70941C2 (de)
WO (1)	WO1999051616A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP990116B1 (en) *	1999-04-20	2007-10-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
AU2001263812B2 (en) *	2000-03-28	2004-09-23	Sandoz Ag	Granulated particles with masked taste
GB0025688D0 (en) *	2000-10-19	2000-12-06	Glaxo Group Ltd	Macrolides
CA2458135A1 (en) *	2001-08-21	2003-03-06	Pfizer Products Inc.	Single dose azithromycin for treating respiratory infections
US7271154B2 (en)	2002-02-15	2007-09-18	Merckle Gmbh	Antibiotic conjugates
EP1483579A4 (de)	2002-02-15	2006-07-12	Merckle Gmbh	Konjugate biologisch aktiver verbindungen, verfahren zu ihrer herstellung und verwendung, formulierung und pharmazeutische anwendungen davon
AU2003219770B2 (en)	2002-02-15	2008-10-09	Merckle Gmbh	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003264917A1 (en)	2002-07-08	2004-01-23	Pliva - Istrazivacki Institut D.O.O.	Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
RS20050008A (sr)	2002-07-08	2007-06-04	Pliva-Istraživački Institut D.O.O.,	Nova jedinjenja,kompozicije i metode za lečenje inflamatornih oboljenja i stanja
HRP20020779A2 (en)	2002-09-27	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en)	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005030227A1 (en) *	2003-09-23	2005-04-07	Enanta Pharmaceuticals, Inc.	9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
PT1851236E (pt)	2005-01-13	2010-10-25	Glaxosmithkline Zagreb	Macrólidos com actividade anti-inflamatória
WO2006120541A1 (en)	2005-05-10	2006-11-16	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Ether linked macrolides useful for the treatment of microbial infections
RU2455308C2 (ru) *	2006-05-01	2012-07-10	Тайсо Фармасьютикал Ко., Лтд.	Макролидные производные
WO2009007988A1 (en) *	2007-07-11	2009-01-15	Alembic Limited	Process for the preparation of 6-o-methylerythromycin a 9-oxime
CN102378763A (zh)	2009-01-30	2012-03-14	葛兰素集团有限公司	消炎的大环内酯
WO2011131749A1 (en)	2010-04-23	2011-10-27	Glaxo Group Limited	New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
PT2673285T (pt) *	2010-12-09	2017-10-19	Wockhardt Ltd	Resumo
DK3883647T3 (da) *	2018-11-19	2026-03-23	Zikani Therapeutics Inc	C10-alkylensubstituerede 13-ledede makrolider og anvendelser deraf
CA3156529A1 (en) *	2019-10-29	2021-05-06	Sudhir Nambiar	Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU43116B (en) *	1979-04-02	1989-04-30	Pliva Pharm & Chem Works	Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
US4331803A (en) *	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) *	1989-10-07	1994-04-12	Taisho Pharmaceutical Co., Ltd.	6-O-methylerythromycin a oxime derivatives
US5166967A (en) *	1990-08-27	1992-11-24	Fabian Carl E	Markers for dental x-ray film and packets for simplified film mounting
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5202434A (en) *	1991-04-05	1993-04-13	Merck & Co., Inc.	8a-aza-8a-homoerythromycin lactams
CA2064985A1 (en) *	1991-04-05	1992-10-06	Robert R. Wilkening	8a-aza-8a-homoertyhromycin cyclic lactams
EP0549040A1 (de) *	1991-12-20	1993-06-30	Merck & Co. Inc.	Verfahren zur Herstellung von 4"-Derivaten von 9-Deoxo-8a-Aza-8a-Alkyl-8a-Homoerythromycin A
FR2697524B1 (fr) *	1992-11-05	1994-12-23	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
US5686587A (en) *	1993-05-19	1997-11-11	Pfizer Inc.	Intermediate for azithromycin
FR2718450B1 (fr) *	1994-04-08	1997-01-10	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
RU2144541C1 (ru) *	1995-12-08	2000-01-20	Руссель Юклаф	Производные эритромицина, способ их получения, промежуточный продукт, фармацевтическая композиция

1998
- 1998-04-06 HR HR980189A patent/HRP980189B1/xx not_active IP Right Cessation
- 1998-07-31 US US09/127,764 patent/US6110965A/en not_active Expired - Lifetime
1999
- 1999-02-04 UA UA2000106059A patent/UA70941C2/uk unknown
- 1999-04-02 RU RU2000128042/04A patent/RU2211222C2/ru not_active IP Right Cessation
- 1999-04-02 SK SK1502-2000A patent/SK284169B6/sk not_active IP Right Cessation
- 1999-04-02 PL PL99343441A patent/PL193742B1/pl unknown
- 1999-04-02 PT PT99911955T patent/PT1070077E/pt unknown
- 1999-04-02 WO PCT/HR1999/000004 patent/WO1999051616A1/en not_active Ceased
- 1999-04-02 CA CA002327775A patent/CA2327775C/en not_active Expired - Fee Related
- 1999-04-02 AT AT99911955T patent/ATE241638T1/de not_active IP Right Cessation
- 1999-04-02 DK DK99911955T patent/DK1070077T3/da active
- 1999-04-02 IL IL13883799A patent/IL138837A0/xx not_active IP Right Cessation
- 1999-04-02 EE EEP200000587A patent/EE04283B1/xx not_active IP Right Cessation
- 1999-04-02 KR KR1020007011140A patent/KR100600463B1/ko not_active Expired - Fee Related
- 1999-04-02 SI SI9930366T patent/SI1070077T1/xx unknown
- 1999-04-02 BR BR9910115-7A patent/BR9910115A/pt not_active Application Discontinuation
- 1999-04-02 DE DE69908338T patent/DE69908338T2/de not_active Expired - Lifetime
- 1999-04-02 AU AU30464/99A patent/AU3046499A/en not_active Abandoned
- 1999-04-02 JP JP2000542337A patent/JP2002510701A/ja active Pending
- 1999-04-02 CN CNB998063568A patent/CN1141312C/zh not_active Expired - Fee Related
- 1999-04-02 ES ES99911955T patent/ES2200512T3/es not_active Expired - Lifetime
- 1999-04-02 EP EP99911955A patent/EP1070077B1/de not_active Expired - Lifetime
- 1999-04-02 HU HU0101817A patent/HUP0101817A3/hu unknown
- 1999-04-05 AR ARP990101519A patent/AR019261A1/es active IP Right Grant
2000
- 2000-10-03 IL IL138837A patent/IL138837A/en unknown
- 2000-10-05 NO NO20005015A patent/NO317982B1/no unknown
- 2000-11-06 BG BG104913A patent/BG64600B1/bg unknown

Also Published As

Publication number	Publication date
PL193742B1 (pl)	2007-03-30
AR019261A1 (es)	2002-02-13
WO1999051616A1 (en)	1999-10-14
DE69908338T2 (de)	2004-04-08
NO20005015D0 (no)	2000-10-05
UA70941C2 (uk)	2004-11-15
BR9910115A (pt)	2000-12-26
JP2002510701A (ja)	2002-04-09
EP1070077A1 (de)	2001-01-24
CN1141312C (zh)	2004-03-10
DE69908338D1 (de)	2003-07-03
HRP980189A2 (en)	2000-12-31
IL138837A0 (en)	2001-10-31
US6110965A (en)	2000-08-29
SK284169B6 (sk)	2004-10-05
PT1070077E (pt)	2003-10-31
NO20005015L (no)	2000-12-04
KR20010034754A (ko)	2001-04-25
ATE241638T1 (de)	2003-06-15
BG64600B1 (bg)	2005-08-31
EP1070077B1 (de)	2003-05-28
SI1070077T1 (en)	2004-02-29
AU3046499A (en)	1999-10-25
CA2327775A1 (en)	1999-10-14
SK15022000A3 (sk)	2001-03-12
PL343441A1 (en)	2001-08-13
EE200000587A (et)	2002-04-15
HUP0101817A3 (en)	2003-07-28
CA2327775C (en)	2007-08-07
HK1036457A1 (en)	2002-01-04
KR100600463B1 (ko)	2006-07-13
BG104913A (en)	2001-08-31
ES2200512T3 (es)	2004-03-01
RU2211222C2 (ru)	2003-08-27
DK1070077T3 (da)	2003-09-22
HUP0101817A2 (hu)	2001-11-28
CN1301268A (zh)	2001-06-27
HRP980189B1 (en)	2004-04-30
IL138837A (en)	2006-10-05
NO317982B1 (no)	2005-01-17

Similar Documents

Publication	Publication Date	Title
EE04283B1 (et)	2004-04-15	15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis
EE05149B1 (et)	2009-04-15	Biarlkarboksamiidid, meetod nende valmistamiseks, neid sisaldav ravimkoostis ning nende kasutamine ravis
EE05001B1 (et)	2008-04-15	Heterotsüklilised ühendid, meetod nende valmistamiseks, neid sisaldav ravimkoostis ning nende kasutamine ravis
EE200100495A (et)	2002-12-16	Sahhariidijääkidega asendatud 1,4-bensotiasepiin-1,1-dioksiidi derivaadid, meetod nende valmistamiseks, ühendite kasutamine ning neid sisaldav ravim
EE200000707A (et)	2002-04-15	Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE200200202A (et)	2003-06-16	Uudsed tritsüklilised ühendid, nende saamine ja kasutamine ravimi valmistamiseks, mis on ette nähtud HIV-nakkuse raviks, ning neid sisaldav farmatseutiline kompositsioon
EE04175B1 (et)	2003-12-15	Meetod topiramaadi farmatseutilise kompositsioonivalmistamiseks, farmatseutiline kompositsioon ning topiramaadi kasutamine diabeedi raviks ette nähtud ravimi valmistamiseks
EE04273B1 (et)	2004-04-15	Bensotsüklohepteenid, nende valmistamise meetod, neid sisaldavad farmatseutilised preparaadid ja nende kasutamine ravimite valmistamiseks
EE05418B1 (et)	2011-06-15	Diarltskloalklderivaadid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim
EE200000791A (et)	2002-02-15	Uudsed atsüülpseudopeptiidid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
EE05183B1 (et)	2009-06-15	Asabitsklilised hendid, nende valmistamine ja kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
EE200200065A (et)	2003-04-15	3-aminopürasooli derivaadid, nende valmistamine ja kasutamine vähivastaste toimeainetena ning neid sisaldav farmatseutiline kompositsioon
EE04399B1 (et)	2004-12-15	Spiroasabitsüklilised heterotsüklilised ühendid, nende valmistamise protsess, neid sisaldavad ravimkoostised ja nende kasutamine ravis
EE05086B1 (et)	2008-10-15	Primidiini derivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod, kombinatsioon ning saadus
EE200300080A (et)	2005-02-15	Polüarüülkarboksamiidühendid, nende valmistamine ja kasutamine lipiiditaset alandavate toimeainetena ning neid sisaldav farmatseutiline kompositsioon
EE04498B1 (et)	2005-06-15	Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon
EE200100684A (et)	2003-04-15	Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE05109B1 (et)	2008-12-15	Sulfoonamiidi derivaadid, nende kasutamine meditsiinis ning meetod nende valmistamiseks
EE200000430A (et)	2001-12-17	Triasolopüridasiini derivaadid, nende valmistamismeetod, neid sisaldav kompositsioon ning kasutamine ängistus- ja krambivastaste ravimite valmistamiseks
EE04850B1 (et)	2007-06-15	Pürimidiini derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud HIV nakkuse raviks, ühend, seda sisaldav farmatseutiline kompositsioon, meetod ühendi ja kompositsiooni valmistamiseks ning kombineeritud preparaat kasutamiseks HIV nakku
HUP0303524A3 (en)	2008-03-28	Novel quinuclidine derivatives, process for their preparation and medicinal compositions containing the same and their use
NO20016198L (no)	2002-02-05	Orale farmasöytiske sammensetninger som inneholder taxaner og fremgangsmåter for anvendelse av samme i behandling
EE200000620A (et)	2002-04-15	3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon
EE200000596A (et)	2002-06-17	Tienüülasolüülalkoksüetaanamiinderivaadid, nende ja nende soolade valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja kasutamine ning vaheühend ja selle valmistamismeetod
PL344246A1 (en)	2001-10-22	Novel pharmaceutical composition for use in emergency treatment and preparation method thereof

Legal Events

Date	Code	Title	Description
2005-02-15	GB1A	Change in the ownership or in the address of the owner
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2009-12-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20090402