EE04496B1 - Tetrahüdro-gamma-karboliinid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad kompositsioonid - Google Patents

Tetrahüdro-gamma-karboliinid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad kompositsioonid

Info

Publication number: EE04496B1
Authority: EE; Estonia
Prior art keywords: optionally substituted; preparation; compositions containing; carbolines; medicaments
Prior art date: 1997-09-08

Application number

EEP200000059A

Other languages

English (en)

Estonian (et)

Inventor

Edmond Josephine Kennis Ludo

Carolus Mertens Josephus

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-08

Filing date

1998-09-01

Publication date

2005-06-15

1998-09-01 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2000-10-16 Publication of EE200000059A publication Critical patent/EE200000059A/xx

2005-06-15 Publication of EE04496B1 publication Critical patent/EE04496B1/xx

Links

239000003814 drug Substances 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
125000000815 N-oxide group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EEP200000059A 1997-09-08 1998-09-01 Tetrahüdro-gamma-karboliinid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad kompositsioonid EE04496B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97202761A EP0905136A1 (en)	1997-09-08	1997-09-08	Tetrahydro gamma-carbolines
PCT/EP1998/005710 WO1999012926A1 (en)	1997-09-08	1998-09-01	Tetrahydro gamma-carbolines

Publications (2)

Publication Number	Publication Date
EE200000059A EE200000059A (et)	2000-10-16
EE04496B1 true EE04496B1 (et)	2005-06-15

Family

ID=8228715

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000059A EE04496B1 (et)	1997-09-08	1998-09-01	Tetrahüdro-gamma-karboliinid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad kompositsioonid

Country Status (27)

Country	Link
US (2)	US6303614B1 (es)
EP (2)	EP0905136A1 (es)
JP (1)	JP2001515899A (es)
KR (1)	KR100603896B1 (es)
CN (1)	CN1110496C (es)
AT (1)	ATE243209T1 (es)
AU (1)	AU752410B2 (es)
BR (1)	BR9811769A (es)
CA (1)	CA2301807A1 (es)
CZ (1)	CZ297220B6 (es)
DE (1)	DE69815700T2 (es)
EE (1)	EE04496B1 (es)
ES (1)	ES2202902T3 (es)
HR (1)	HRP20000108A2 (es)
HU (1)	HUP0003577A3 (es)
ID (1)	ID23954A (es)
IL (1)	IL134894A (es)
MY (1)	MY129176A (es)
NO (1)	NO315236B1 (es)
NZ (1)	NZ503096A (es)
PL (1)	PL191863B1 (es)
RU (1)	RU2208614C2 (es)
SK (1)	SK285594B6 (es)
TR (1)	TR200000616T2 (es)
TW (1)	TW531539B (es)
WO (1)	WO1999012926A1 (es)
ZA (1)	ZA988161B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG146683A1 (en)	2003-09-17	2008-10-30	Janssen Pharmaceutica Nv	Fused heterocyclic compounds as serotonin receptor modulators
UA85563C2 (ru) *	2003-09-17	2009-02-10	Янссен Фармацевтика Н.В.	Конденсированные гетероциклические соединения
EP1944306A1 (en) *	2003-09-17	2008-07-16	Janssen Pharmaceutica, N.V.	Fused heterocyclic compounds as serotonin receptor modulators
JP4816453B2 (ja) *	2004-04-12	2011-11-16	大正製薬株式会社	環状アミン化合物
JP2008530229A (ja)	2005-02-17	2008-08-07	ワイス	シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
FR2885905A1 (fr) *	2005-05-23	2006-11-24	Trophos Sa	Nouveaux composes chimiques et leurs utilisations comme medicament
WO2007009485A1 (en) *	2005-07-22	2007-01-25	Pharma C S.A.	Substituted 8-phenoxy-y-carboline derivatives with 5ht1 activity
WO2007058580A1 (en) *	2005-11-15	2007-05-24	Astrazeneca Ab	Novel 2-aminopyrimidinone derivatives and their use
US20080083807A1 (en) *	2006-10-06	2008-04-10	Beardsley John W	Surgical instrument including a locking assembly
AU2008302751A1 (en) *	2007-09-20	2009-03-26	D2E, Llc	Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
EP2236511A4 (en)	2007-12-21	2011-04-13	Alla Chem Llc	LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF
RU2374245C1 (ru)	2008-08-22	2009-11-27	Андрей Александрович Иващенко	Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
CN105399674B (zh)	2015-12-31	2017-02-15	青岛清原化合物有限公司	吡唑类化合物或其盐、制备方法、除草剂组合物及用途
CN106631941B (zh) *	2016-12-30	2018-09-28	青岛瀚生生物科技股份有限公司	一种2-甲基-3氯苯基甲硫醚的制备方法
GB201704325D0 (en) *	2017-03-17	2017-05-03	Argonaut Therapeutics Ltd	Compounds
CN110698474B (zh) *	2019-11-14	2021-11-02	福州大学	一种α位取代四氢-γ-咔啉类化合物及其制备方法和应用
US20230339949A1 (en) *	2020-10-09	2023-10-26	Shujing Biopharma Co., Ltd	HETEROCYCLIC SUBSTITUTED FUSED y-CARBOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3410286C2 (de) *	1984-03-21	1986-01-23	Fresenius AG, 6380 Bad Homburg	Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4636563A (en) *	1985-09-16	1987-01-13	American Home Products Corporation	Antipsychotic γ-carbolines
US4672117A (en) *	1985-09-16	1987-06-09	American Home Products Corporation	Antipsychotic gamma-carbolines
US4798896A (en) *	1988-01-19	1989-01-17	American Home Products Corporation	Antipsychotic gamma-carboline N-oxides
RU2067980C1 (ru) *	1992-06-30	1996-10-20	Глэксо Груп Лимитед	Производные лактама и фармацевтическая композиция, являющаяся антагонистом 5-окситраптамина /5-нт/ на 5- нт3 -рецепторах или их физиологически приемлемые соли и соловаты
ES2204932T3 (es) *	1994-09-12	2004-05-01	Eli Lilly And Company Limited	Moduladores serotonergicos.

1997
- 1997-09-08 EP EP97202761A patent/EP0905136A1/en not_active Withdrawn
1998
- 1998-09-01 DE DE69815700T patent/DE69815700T2/de not_active Expired - Fee Related
- 1998-09-01 KR KR1020007000970A patent/KR100603896B1/ko not_active Expired - Fee Related
- 1998-09-01 NZ NZ503096A patent/NZ503096A/en unknown
- 1998-09-01 AT AT98951365T patent/ATE243209T1/de not_active IP Right Cessation
- 1998-09-01 IL IL13489498A patent/IL134894A/xx not_active IP Right Cessation
- 1998-09-01 PL PL339143A patent/PL191863B1/pl not_active IP Right Cessation
- 1998-09-01 BR BR9811769-6A patent/BR9811769A/pt not_active Application Discontinuation
- 1998-09-01 HR HR20000108A patent/HRP20000108A2/xx not_active Application Discontinuation
- 1998-09-01 TR TR2000/00616T patent/TR200000616T2/xx unknown
- 1998-09-01 EE EEP200000059A patent/EE04496B1/xx not_active IP Right Cessation
- 1998-09-01 US US09/508,240 patent/US6303614B1/en not_active Expired - Fee Related
- 1998-09-01 CA CA002301807A patent/CA2301807A1/en not_active Abandoned
- 1998-09-01 SK SK299-2000A patent/SK285594B6/sk unknown
- 1998-09-01 EP EP98951365A patent/EP1015451B1/en not_active Expired - Lifetime
- 1998-09-01 ES ES98951365T patent/ES2202902T3/es not_active Expired - Lifetime
- 1998-09-01 CZ CZ20000726A patent/CZ297220B6/cs not_active IP Right Cessation
- 1998-09-01 WO PCT/EP1998/005710 patent/WO1999012926A1/en not_active Ceased
- 1998-09-01 JP JP2000510733A patent/JP2001515899A/ja not_active Withdrawn
- 1998-09-01 ID IDW20000432A patent/ID23954A/id unknown
- 1998-09-01 RU RU2000109310/04A patent/RU2208614C2/ru not_active IP Right Cessation
- 1998-09-01 CN CN98808818A patent/CN1110496C/zh not_active Expired - Fee Related
- 1998-09-01 AU AU97421/98A patent/AU752410B2/en not_active Ceased
- 1998-09-02 TW TW087114508A patent/TW531539B/zh not_active IP Right Cessation
- 1998-09-07 ZA ZA9808161A patent/ZA988161B/xx unknown
- 1998-09-07 MY MYPI98004080A patent/MY129176A/en unknown
- 1998-09-08 HU HU0003577A patent/HUP0003577A3/hu unknown
2000
- 2000-02-14 NO NO20000737A patent/NO315236B1/no unknown
2001
- 2001-08-15 US US09/930,005 patent/US6506768B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU752410B2 (en)	2002-09-19
DE69815700D1 (en)	2003-07-24
PL191863B1 (pl)	2006-07-31
PL339143A1 (en)	2000-12-04
TW531539B (en)	2003-05-11
RU2208614C2 (ru)	2003-07-20
CZ2000726A3 (cs)	2000-07-12
KR100603896B1 (ko)	2006-07-25
IL134894A (en)	2005-03-20
CA2301807A1 (en)	1999-03-18
CN1269800A (zh)	2000-10-11
EP0905136A1 (en)	1999-03-31
ES2202902T3 (es)	2004-04-01
NO20000737D0 (no)	2000-02-14
SK2992000A3 (en)	2001-03-12
DE69815700T2 (de)	2004-04-29
NO20000737L (no)	2000-05-08
CN1110496C (zh)	2003-06-04
JP2001515899A (ja)	2001-09-25
AU9742198A (en)	1999-03-29
TR200000616T2 (tr)	2000-07-21
WO1999012926A1 (en)	1999-03-18
US20020103209A1 (en)	2002-08-01
CZ297220B6 (cs)	2006-10-11
ID23954A (id)	2000-06-08
EP1015451A1 (en)	2000-07-05
SK285594B6 (sk)	2007-04-05
BR9811769A (pt)	2000-08-29
US6506768B2 (en)	2003-01-14
ZA988161B (en)	2000-03-22
HRP20000108A2 (en)	2000-12-31
HK1029107A1 (en)	2001-03-23
KR20010022391A (ko)	2001-03-15
US6303614B1 (en)	2001-10-16
NO315236B1 (no)	2003-08-04
EE200000059A (et)	2000-10-16
ATE243209T1 (de)	2003-07-15
HUP0003577A3 (en)	2003-05-28
NZ503096A (en)	2001-11-30
MY129176A (en)	2007-03-30
HUP0003577A2 (hu)	2001-09-28
EP1015451B1 (en)	2003-06-18
IL134894A0 (en)	2001-05-20

Legal Events

Date	Code	Title	Description
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-06-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20070901

Publication	Publication Date	Title
ID23954A (id)	2000-06-08	Tetrahidrogama-karbolin
MXPA03011244A (es)	2004-02-27	Nuevos derivados de indol con afinidad por el receptor 5-ht6.
DE3762618D1 (de)	1990-06-13	Amidderivate.
ATE104971T1 (de)	1994-05-15	2-aminopyrimidinon-derivate.
DK1029853T3 (da)	2004-05-24	Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler
EP0430201A3 (en)	1992-01-02	Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
EP0604354A3 (en)	1995-02-08	Antidepressant and anti-Parkinson's disease compounds.
IL86725A (en)	1993-01-14	1-alkyl-n-cycloalkyl- 6-methyl-ergoline-8'- carboxamides, their preparation and pharmaceutical compositions containing them
NO910904D0 (no)	1991-03-07	Fremgangsmaate for fremstilling av en substituert aminforbindelse.
ATE234086T1 (de)	2003-03-15	Creatine derivate für asthma
ATE169015T1 (de)	1998-08-15	Aminobenzoesäure derivate
DE69001004D1 (de)	1993-04-08	Zusammensetzung gegen leberkrankheiten.
IL99434A0 (en)	1992-08-18	3-(1h-indazol-3-yl)-4-pyridinamines,a process and intermediates for their preparation and pharmaceutical compositions containing them
BG105521A (en)	2001-12-29	Benzisoxazoles and phenons as alpha2-antagonists
DE68923231D1 (de)	1995-08-03	Antihypertensive 3-Piperidinylindazol-Derivate.
ES2141134T3 (es)	2000-03-16	Derivados de carbamoil pirrolidona para el tratamiento de la depresion y de los trastornos cerebrovasculares.
DE3783821D1 (de)	1993-03-11	Tetracyclische indolderivate.