EE04642B1 - (1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod - Google Patents

(1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod

Info

Publication number: EE04642B1
Authority: EE; Estonia
Prior art keywords: quinolizin; benzo; derivatives; synthesis; compounds
Prior art date: 1998-08-03

Application number

EEP200100060A

Other languages

English (en)

Estonian (et)

Inventor

Guarna Antonio

Serio Mario

Giovanni Occhiato Ernesto

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-03

Filing date

1999-07-23

Publication date

2006-06-15

1999-07-23 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

2002-06-17 Publication of EE200100060A publication Critical patent/EE200100060A/xx

2006-06-15 Publication of EE04642B1 publication Critical patent/EE04642B1/xx

Links

HHWOCYWGVOSDOP-UHFFFAOYSA-N 1,2-dihydrobenzo[f]quinolizin-3-one Chemical class C1=CC=C2N3CCC(=O)C=C3C=CC2=C1 HHWOCYWGVOSDOP-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Carbon And Carbon Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200100060A 1998-08-03 1999-07-23 (1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod EE04642B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98114524		1998-08-03
PCT/EP1999/005277 WO2000008019A1 (en)	1998-08-03	1999-07-23	Process for the synthesis of (1h)-benzo[c]quinolizin-3-ones derivatives

Publications (2)

Publication Number	Publication Date
EE200100060A EE200100060A (et)	2002-06-17
EE04642B1 true EE04642B1 (et)	2006-06-15

Family

ID=8232396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100060A EE04642B1 (et)	1998-08-03	1999-07-23	(1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod

Country Status (28)

Country	Link
US (1)	US6723850B1 (de)
EP (1)	EP1102765B1 (de)
JP (1)	JP2002522435A (de)
KR (1)	KR100624239B1 (de)
CN (1)	CN1128148C (de)
AT (1)	ATE250057T1 (de)
AU (1)	AU751873B2 (de)
BG (1)	BG65062B1 (de)
BR (1)	BR9912870A (de)
CA (1)	CA2338498C (de)
CZ (1)	CZ291648B6 (de)
DE (1)	DE69911430T2 (de)
DK (1)	DK1102765T3 (de)
EA (1)	EA003997B1 (de)
EE (1)	EE04642B1 (de)
ES (1)	ES2203169T3 (de)
HU (1)	HUP0103241A3 (de)
IL (2)	IL141212A0 (de)
NO (1)	NO20010559L (de)
NZ (1)	NZ509243A (de)
PL (1)	PL198963B1 (de)
PT (1)	PT1102765E (de)
SI (1)	SI1102765T1 (de)
SK (1)	SK285438B6 (de)
TR (1)	TR200100286T2 (de)
UA (1)	UA67787C2 (de)
WO (1)	WO2000008019A1 (de)
ZA (1)	ZA200100365B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2881078C (en)	2004-06-24	2018-10-02	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
US8354427B2 (en) *	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
WO2007075901A2 (en) *	2005-12-24	2007-07-05	Vertex Pharmaceuticals Incorporated	Quinolin- 4 - one derivatives as modulators of abc transporters
LT1993360T (lt)	2005-12-28	2017-06-12	Vertex Pharmaceuticals Incorporated	N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
SI3330255T1 (sl)	2009-03-20	2021-03-31	Vertex Pharmaceuticals Incorporated	Postopek izdelave regulatorja transmembranske prevodnosti pri cistični fibrozi
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
CA2820934C (en) *	2010-12-14	2019-04-09	Syngenta Participations Ag	Strigolactam derivatives and their use as plant growth regulators
EP2819670B1 (de)	2012-02-27	2026-05-20	Vertex Pharmaceuticals Incorporated	Pharmazeutische zubereitung und deren verabreichungen
CA2963945C (en)	2014-10-07	2023-01-10	Vertex Pharmaceuticals Incorporated	Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CN105001216B (zh) *	2015-07-08	2017-03-01	中国科学院兰州化学物理研究所	一种喹嗪酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5064961A (en) *	1989-12-18	1991-11-12	E. R. Squibb & Sons, Inc.	Process for preparing an optically active cyclobutane nucleoside
FR2696465B1 (fr) *	1992-10-02	1994-12-23	Adir	Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1286545B1 (it) *	1996-02-09	1998-07-15	Antonio Guarna	Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
JPH09316076A (ja) *	1996-05-24	1997-12-09	Nippon Paper Ind Co Ltd	９−置換プリン誘導体及びその抗ウイルス剤としての用途

1999
- 1999-07-23 US US09/743,373 patent/US6723850B1/en not_active Expired - Fee Related
- 1999-07-23 EE EEP200100060A patent/EE04642B1/xx not_active IP Right Cessation
- 1999-07-23 AT AT99941269T patent/ATE250057T1/de not_active IP Right Cessation
- 1999-07-23 DK DK99941269T patent/DK1102765T3/da active
- 1999-07-23 CA CA002338498A patent/CA2338498C/en not_active Expired - Fee Related
- 1999-07-23 EP EP99941269A patent/EP1102765B1/de not_active Expired - Lifetime
- 1999-07-23 BR BR9912870-5A patent/BR9912870A/pt not_active Application Discontinuation
- 1999-07-23 JP JP2000563652A patent/JP2002522435A/ja active Pending
- 1999-07-23 SI SI9930419T patent/SI1102765T1/xx unknown
- 1999-07-23 CN CN99809204A patent/CN1128148C/zh not_active Expired - Fee Related
- 1999-07-23 SK SK167-2001A patent/SK285438B6/sk not_active IP Right Cessation
- 1999-07-23 WO PCT/EP1999/005277 patent/WO2000008019A1/en not_active Ceased
- 1999-07-23 EA EA200100213A patent/EA003997B1/ru not_active IP Right Cessation
- 1999-07-23 IL IL14121299A patent/IL141212A0/xx active IP Right Grant
- 1999-07-23 DE DE69911430T patent/DE69911430T2/de not_active Expired - Fee Related
- 1999-07-23 AU AU63123/99A patent/AU751873B2/en not_active Ceased
- 1999-07-23 CZ CZ2001434A patent/CZ291648B6/cs not_active IP Right Cessation
- 1999-07-23 PL PL345802A patent/PL198963B1/pl not_active IP Right Cessation
- 1999-07-23 NZ NZ509243A patent/NZ509243A/xx not_active IP Right Cessation
- 1999-07-23 TR TR2001/00286T patent/TR200100286T2/xx unknown
- 1999-07-23 PT PT99941269T patent/PT1102765E/pt unknown
- 1999-07-23 UA UA2001020777A patent/UA67787C2/uk unknown
- 1999-07-23 ES ES99941269T patent/ES2203169T3/es not_active Expired - Lifetime
- 1999-07-23 KR KR1020017000325A patent/KR100624239B1/ko not_active Expired - Fee Related
- 1999-07-23 HU HU0103241A patent/HUP0103241A3/hu unknown
2001
- 2001-01-12 ZA ZA200100365A patent/ZA200100365B/en unknown
- 2001-01-30 BG BG105198A patent/BG65062B1/bg unknown
- 2001-02-01 NO NO20010559A patent/NO20010559L/no not_active Application Discontinuation
- 2001-02-01 IL IL141212A patent/IL141212A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA200100365B (en)	2001-07-26
CN1311788A (zh)	2001-09-05
PL345802A1 (en)	2002-01-02
CA2338498A1 (en)	2000-02-17
EP1102765B1 (de)	2003-09-17
CZ291648B6 (cs)	2003-04-16
IL141212A0 (en)	2002-03-10
EA003997B1 (ru)	2003-12-25
ATE250057T1 (de)	2003-10-15
HK1037368A1 (en)	2002-02-08
EA200100213A1 (ru)	2001-08-27
NO20010559D0 (no)	2001-02-01
IL141212A (en)	2006-12-31
DK1102765T3 (da)	2004-02-02
TR200100286T2 (tr)	2001-07-23
DE69911430D1 (de)	2003-10-23
EE200100060A (et)	2002-06-17
SI1102765T1 (en)	2003-12-31
WO2000008019A1 (en)	2000-02-17
KR100624239B1 (ko)	2006-09-13
NZ509243A (en)	2002-11-26
HUP0103241A2 (hu)	2002-01-28
CA2338498C (en)	2009-05-19
CN1128148C (zh)	2003-11-19
JP2002522435A (ja)	2002-07-23
AU6312399A (en)	2000-02-28
NO20010559L (no)	2001-02-01
KR20010074684A (ko)	2001-08-09
AU751873B2 (en)	2002-08-29
US6723850B1 (en)	2004-04-20
BR9912870A (pt)	2001-10-16
ES2203169T3 (es)	2004-04-01
PT1102765E (pt)	2003-12-31
CZ2001434A3 (cs)	2001-08-15
UA67787C2 (uk)	2004-07-15
SK285438B6 (sk)	2007-01-04
DE69911430T2 (de)	2004-07-22
EP1102765A1 (de)	2001-05-30
BG105198A (en)	2001-12-29
PL198963B1 (pl)	2008-08-29
BG65062B1 (bg)	2007-01-31
SK1672001A3 (en)	2001-08-06
HUP0103241A3 (en)	2002-10-28

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Legal Events

Date	Code	Title	Description
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-10-15	GB1A	Change in the ownership or in the address of the owner
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-04-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20100723