EE04836B1 - N-piperidino-5-(4-klorofenüül)-1-(2,4-diklorofenüül)-4-metüülpürasool-3-karboksamii di kasutamine ravimtoodete valmistamiseks, aitamaks loobuda tubakatarbimisest - Google Patents

N-piperidino-5-(4-klorofenüül)-1-(2,4-diklorofenüül)-4-metüülpürasool-3-karboksamii di kasutamine ravimtoodete valmistamiseks, aitamaks loobuda tubakatarbimisest

Info

Publication number
EE04836B1
EE04836B1 EEP200200439A EEP200200439A EE04836B1 EE 04836 B1 EE04836 B1 EE 04836B1 EE P200200439 A EEP200200439 A EE P200200439A EE P200200439 A EEP200200439 A EE P200200439A EE 04836 B1 EE04836 B1 EE 04836B1
Authority
EE
Estonia
Prior art keywords
methylpyrazole
piperidino
dichlorophenyl
carboxamide
chlorophenyl
Prior art date
Application number
EEP200200439A
Other languages
English (en)
Estonian (et)
Inventor
Charles Blanchard Jean
Menard Fran�ois
Original Assignee
Sanofi-Synthlabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthlabo filed Critical Sanofi-Synthlabo
Publication of EE200200439A publication Critical patent/EE200200439A/xx
Publication of EE04836B1 publication Critical patent/EE04836B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EEP200200439A 2000-02-09 2001-02-07 N-piperidino-5-(4-klorofenüül)-1-(2,4-diklorofenüül)-4-metüülpürasool-3-karboksamii di kasutamine ravimtoodete valmistamiseks, aitamaks loobuda tubakatarbimisest EE04836B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0001682A FR2804604B1 (fr) 2000-02-09 2000-02-09 Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac
PCT/FR2001/000356 WO2001058450A2 (fr) 2000-02-09 2001-02-07 Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac

Publications (2)

Publication Number Publication Date
EE200200439A EE200200439A (et) 2003-12-15
EE04836B1 true EE04836B1 (et) 2007-06-15

Family

ID=8846875

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200439A EE04836B1 (et) 2000-02-09 2001-02-07 N-piperidino-5-(4-klorofenüül)-1-(2,4-diklorofenüül)-4-metüülpürasool-3-karboksamii di kasutamine ravimtoodete valmistamiseks, aitamaks loobuda tubakatarbimisest

Country Status (32)

Country Link
US (2) US6930122B2 (is)
EP (1) EP1257275B1 (is)
JP (2) JP2003522145A (is)
CN (1) CN1250220C (is)
AR (1) AR028505A1 (is)
AT (1) ATE292467T1 (is)
AU (1) AU781827B2 (is)
BG (2) BG110386A (is)
BR (1) BR0108126A (is)
CA (1) CA2397262C (is)
CZ (1) CZ296685B6 (is)
DE (1) DE60109903T2 (is)
DK (1) DK1257275T3 (is)
EE (1) EE04836B1 (is)
ES (1) ES2240416T3 (is)
FR (1) FR2804604B1 (is)
HU (1) HU225328B1 (is)
IL (1) IL150710A0 (is)
IS (1) IS6450A (is)
MX (1) MXPA02007766A (is)
NO (1) NO324521B1 (is)
NZ (1) NZ519924A (is)
PL (1) PL201685B1 (is)
PT (1) PT1257275E (is)
RS (1) RS50404B (is)
RU (1) RU2257207C2 (is)
SI (1) SI1257275T1 (is)
SK (1) SK284952B6 (is)
TW (1) TWI243677B (is)
UA (1) UA72783C2 (is)
WO (1) WO2001058450A2 (is)
ZA (1) ZA200205317B (is)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804604B1 (fr) * 2000-02-09 2005-05-27 Sanofi Synthelabo Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac
US6462237B1 (en) * 2001-06-14 2002-10-08 Usv Limited Cyclodextrin stabilized pharmaceutical compositions of bupropion hydrochloride
CA2457675A1 (en) 2001-08-13 2003-02-27 Honeywell International Inc. Providing current control over wafer borne semiconductor devices using trenches
AU2003217961B2 (en) 2002-03-08 2008-02-28 Signal Pharmaceuticals, Llc Combination therapy for treating, preventing or managing proliferative disorders and cancers
JP3813152B2 (ja) 2002-03-12 2006-08-23 メルク エンド カムパニー インコーポレーテッド 置換アミド類
US7423067B2 (en) 2002-03-26 2008-09-09 Merck & Co., Inc. Diphenyl cyclopentyl amides as cannabinoid-1 receptor inverse agonists
AU2003225964B2 (en) 2002-03-28 2008-11-20 Merck Sharp & Dohme Corp. Substituted 2,3-diphenyl pyridines
WO2003086288A2 (en) 2002-04-12 2003-10-23 Merck & Co., Inc. Bicyclic amides
US6825209B2 (en) 2002-04-15 2004-11-30 Research Triangle Institute Compounds having unique CB1 receptor binding selectivity and methods for their production and use
AU2003257145B2 (en) 2002-08-02 2008-11-13 Merck Sharp & Dohme Corp. Substituted furo (2,3-b) pyridine derivatives
WO2004029204A2 (en) 2002-09-27 2004-04-08 Merck & Co., Inc. Substituted pyrimidines
US7129239B2 (en) 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
US7247628B2 (en) 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
KR20050088194A (ko) 2002-12-19 2005-09-02 머크 앤드 캄파니 인코포레이티드 치환된 아미드
US7329658B2 (en) 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7268133B2 (en) 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
US20040224963A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal
US20040224962A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US7169942B2 (en) * 2003-05-20 2007-01-30 University Of Tennessee Research Foundation Cannabinoid derivatives, methods of making, and use thereof
US7232823B2 (en) 2003-06-09 2007-06-19 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
AU2004287849A1 (en) * 2003-10-30 2005-05-19 Merck Sharp & Dohme Corp. Aralkyl amines as cannabinoid receptor modulators
CA2586011C (en) 2004-07-12 2011-07-19 Cadila Healthcare Limited Tricyclic pyrazole derivatives as cannabinoid receptor modulators
US20060025448A1 (en) 2004-07-22 2006-02-02 Cadila Healthcare Limited Hair growth stimulators
MX2007006695A (es) 2004-12-03 2007-08-14 Schering Corp Piperazinas sustituidas como antagonistas de cb1.
BRPI0706623A2 (pt) * 2006-01-18 2011-04-12 Schering Corp moduladores de receptor canabinóide
WO2007121687A1 (en) * 2006-04-26 2007-11-01 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China 4-methyl-1h-diaryl pyrazole derivatives and their uses as medicament
CN101062919B (zh) * 2006-04-26 2012-08-15 中国人民解放军军事医学科学院毒物药物研究所 4-甲基-1h-二芳基吡唑衍生物及其作为药物的用途
US20070287734A1 (en) * 2006-06-09 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted pyrazole compounds with cannabinoid receptor activity
RU2455981C2 (ru) * 2006-06-16 2012-07-20 Теракос, Инк. Лечение ожирения антагонистами мускаринового рецептора м1
WO2008046905A1 (en) * 2006-10-20 2008-04-24 Solvay Pharmaceuticals B.V. Micellar nanoparticles of chemical substances
US20100197564A1 (en) * 2007-04-19 2010-08-05 Schering Corporation Diaryl morpholines as cb1 modulators
CA2692268A1 (en) * 2007-06-28 2009-01-08 Intervet International B.V. Substituted piperazines as cb1 antagonists
CN101790521A (zh) * 2007-06-28 2010-07-28 英特维特国际股份有限公司 作为cb1拮抗剂的取代哌嗪
EP2095814A1 (de) * 2008-02-26 2009-09-02 Wolfgang J. Kox Medikamentengestützter Nikotinentzug
WO2010018856A1 (ja) * 2008-08-13 2010-02-18 持田製薬株式会社 カンナビノイド受容体関連疾患の予防／改善または治療剤
RU2533224C2 (ru) * 2010-07-21 2014-11-20 Мапикс Эс.Эй.Ар.Эл. Способ лечения зависимости от психоактивных веществ, алкоголизма и табакокурения и лекарственное средство для лечения зависимости от психоактивных веществ, алкоголизма и табакокурения
WO2013068371A1 (en) 2011-11-08 2013-05-16 Intervet International B.V. Soft chewable dosage form compositions of cannabinoid receptor type 1 (cb-1) antagonists
WO2014181357A1 (en) * 2013-05-09 2014-11-13 Council Of Scientific & Industrial Research Novel pyrazole derivatives with silicon incorporation
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780051A (en) * 1992-04-02 1998-07-14 Dynagen, Inc. Methods and articles of manufacture for nicotine cessation and monitoring nicotine use
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr) * 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
US5596106A (en) * 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
FR2758723B1 (fr) * 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
FR2765107B1 (fr) * 1997-06-26 2000-03-24 Sanofi Sa Utilisation d'un antagoniste specifique des recepteurs 5ht2 pour la preparation de medicaments utiles dans le traitement du syndrome d'apnee du sommeil
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
FR2804604B1 (fr) * 2000-02-09 2005-05-27 Sanofi Synthelabo Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac

Also Published As

Publication number Publication date
UA72783C2 (en) 2005-04-15
FR2804604B1 (fr) 2005-05-27
HUP0300237A3 (en) 2003-09-29
TWI243677B (en) 2005-11-21
HU225328B1 (en) 2006-09-28
US20050187253A1 (en) 2005-08-25
RS50404B (sr) 2009-12-31
EP1257275B1 (fr) 2005-04-06
EP1257275A2 (fr) 2002-11-20
ZA200205317B (en) 2003-09-04
PL201685B1 (pl) 2009-04-30
RU2257207C2 (ru) 2005-07-27
RU2002118309A (ru) 2004-02-20
CN1250220C (zh) 2006-04-12
BR0108126A (pt) 2003-01-28
AU3562001A (en) 2001-08-20
PL358221A1 (en) 2004-08-09
JP2010018622A (ja) 2010-01-28
NO20023765D0 (no) 2002-08-08
IL150710A0 (en) 2003-02-12
WO2001058450A3 (fr) 2002-04-25
JP2003522145A (ja) 2003-07-22
BG65856B1 (bg) 2010-03-31
NO324521B1 (no) 2007-11-12
WO2001058450A2 (fr) 2001-08-16
IS6450A (is) 2002-06-28
EE200200439A (et) 2003-12-15
AR028505A1 (es) 2003-05-14
HUP0300237A2 (hu) 2003-07-28
BG106946A (bg) 2003-05-30
HK1051140A1 (en) 2003-07-25
NZ519924A (en) 2005-01-28
FR2804604A1 (fr) 2001-08-10
ES2240416T3 (es) 2005-10-16
DE60109903D1 (de) 2005-05-12
AU781827B2 (en) 2005-06-16
MXPA02007766A (es) 2002-10-11
ATE292467T1 (de) 2005-04-15
CA2397262C (en) 2007-09-11
US20030087933A1 (en) 2003-05-08
CZ296685B6 (cs) 2006-05-17
DK1257275T3 (da) 2005-08-08
US6930122B2 (en) 2005-08-16
CA2397262A1 (en) 2001-08-16
BG110386A (en) 2009-09-30
YU59002A (sh) 2005-07-19
SI1257275T1 (en) 2005-10-31
NO20023765L (no) 2002-10-09
CZ20022698A3 (cs) 2002-11-13
PT1257275E (pt) 2005-07-29
SK284952B6 (sk) 2006-03-02
CN1406128A (zh) 2003-03-26
SK11292002A3 (sk) 2003-02-04
DE60109903T2 (de) 2006-02-09

Similar Documents

Publication Publication Date Title
EE04836B1 (et) N-piperidino-5-(4-klorofenüül)-1-(2,4-diklorofenüül)-4-metüülpürasool-3-karboksamii di kasutamine ravimtoodete valmistamiseks, aitamaks loobuda tubakatarbimisest
ATE352552T1 (de) Substituierte pyrazole
UA49056C2 (uk) Фармацевтична композиція для перорального застосування аміду n-піперидин-5-(4-хлорфеніл)-1-(2,4-дихлорфеніл)-4-метилпіразол-3-карбонової кислоти, його солей і сольватів та спосіб її отримання
PL375551A1 (en) Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
IL151418A0 (en) Aryl substituted pyrazole, triazole, and tetrazole derivatives and pharmaceutical compositions containing the same
ATE333445T1 (de) Pyrazolderivate
HUP0402489A3 (en) 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine
IL156389A0 (en) Pyrazole derivatives and pharmaceutical compositions containing the same
IL154817A0 (en) Pyrazole derivatives and pharmaceutical compositions containing the same
IL145757A0 (en) Pyrazole derivatives and pharmaceutical compositions containing the same
IL145756A0 (en) Pyrazole derivatives and pharmaceutical compositions containing the same
IS5736A (is) Pýrasólínafleiður, framleiðsla þeirra og notkun sem lyfja
DE50102752D1 (de) Fungizide wirkstoffkombinationen
ATE260260T1 (de) Parasitizide pyrazole
AU2003272903A1 (en) Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
NO20064603L (no) Anvendelse av antagonister av CBI-reseptoren av preparat anvendelig for behandling av leversykdommer.
ITMI20000374A0 (it) Procedimento per la produzione di manufatti tubolari in particolare claze chiusi in corrispondenza di un'estremita' assiale con macchine cir
NO20044049L (no) Fremstilling av N1-(2`-pyridyl)-1,2-propandiaminsulfaminsyre og den anvendelse ved syntese av biologisk aktive piperaziner
AR028254A1 (es) Accesorio dosificador y de devolucion de producto al recipiente
ITPC990011V0 (it) Stampo per la produzione di pasta ripiena in particolare per ravioli.
ATE412001T1 (de) Zwischenprodukte bei der cephalosoprinherstellung
HUP0402238A3 (en) Insecticidal and acaricidal 3-substituted pyrazoles
NO20052197D0 (no) Fremgangsmate for fremstilling av pyrazol
AU7865000A (en) Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides
EP1384767A4 (en) LAMINATE

Legal Events

Date Code Title Description
HC1A Change of owner name
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20100207