EE05329B1 - GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid - Google Patents

GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid

Info

Publication number: EE05329B1
Authority: EE; Estonia
Prior art keywords: glyt; intermediates; inhibitors; preparation; compositions containing
Prior art date: 2001-02-16

Application number

EEP200300394A

Other languages

English (en)

Inventor

Egle Ian

Delaney William

Wang Zhaoqing

Shumacher Richard

T. Hopper Allen

Tehim Ashok

Maddaford Shawn

Original Assignee

Allelix Neuroscience, Inc.

Nps Allelix Corp.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-16

Filing date

2002-02-15

Publication date

2010-08-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23026417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE05329(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-02-15 Application filed by Allelix Neuroscience, Inc., Nps Allelix Corp. filed Critical Allelix Neuroscience, Inc.

2003-12-15 Publication of EE200300394A publication Critical patent/EE200300394A/et

2010-08-16 Publication of EE05329B1 publication Critical patent/EE05329B1/et

Links

102100023145 Sodium- and chloride-dependent glycine transporter 1 Human genes 0.000 title 1
101710083171 Sodium- and chloride-dependent glycine transporter 1 Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Epoxy Compounds (AREA)

EEP200300394A 2001-02-16 2002-02-15 GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid EE05329B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26924101P	2001-02-16	2001-02-16
PCT/CA2002/000176 WO2002066456A2 (en)	2001-02-16	2002-02-15	Thiophene substituted amine derivatives as glyt-1 inhibitors

Publications (2)

Publication Number	Publication Date
EE200300394A EE200300394A (et)	2003-12-15
EE05329B1 true EE05329B1 (et)	2010-08-16

Family

ID=23026417

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300394A EE05329B1 (et)	2001-02-16	2002-02-15	GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid

Country Status (30)

Country	Link
US (1)	US6667336B2 (et)
EP (1)	EP1368336B9 (et)
JP (2)	JP2004523548A (et)
KR (1)	KR100900020B1 (et)
CN (1)	CN1219776C (et)
AT (1)	ATE327986T1 (et)
AU (1)	AU2002235682C1 (et)
BG (1)	BG108164A (et)
BR (1)	BR0207307A (et)
CA (1)	CA2438367A1 (et)
CY (1)	CY1105529T1 (et)
CZ (1)	CZ20032503A3 (et)
DE (1)	DE60211866T2 (et)
DK (1)	DK1368336T3 (et)
EA (1)	EA006636B1 (et)
EE (1)	EE05329B1 (et)
ES (1)	ES2266446T3 (et)
HR (1)	HRP20030696A2 (et)
HU (1)	HUP0303185A3 (et)
IL (1)	IL157194A (et)
MX (1)	MXPA03007309A (et)
NO (1)	NO329038B1 (et)
NZ (1)	NZ527695A (et)
PL (1)	PL365024A1 (et)
PT (1)	PT1368336E (et)
SI (1)	SI1368336T1 (et)
SK (1)	SK287304B6 (et)
UA (1)	UA75114C2 (et)
WO (1)	WO2002066456A2 (et)
ZA (1)	ZA200307201B (et)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6191165B1 (en) *	1996-05-31	2001-02-20	Allelix Neuroscience Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
WO2006066121A2 (en) *	2004-12-16	2006-06-22	Janssen Pharmaceutica N.V.	Combination of a glycine transporter (glyt1) inhibitor and an antipsychotic for the treatment of symptoms of schizophrenia as well as its preparation and use thereof
US20090253918A1 (en) *	2006-10-02	2009-10-08	Janssen Pharmaceuticals, N.V.	Novel intermediate for glyt1 inhibitor
WO2008065500A2 (en) *	2006-11-30	2008-06-05	Pfizer Products Inc.	Heteroaryl amides as type i glycine transport inhibitors
CN103374057B (zh) *	2012-04-16	2015-08-19	中国医药集团总公司四川抗菌素工业研究所	一种对甘氨酸转运子具有抑制活性的化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3010599A1 (de)	1979-03-22	1980-10-09	Continental Pharma	Derivate von glycinamid, deren herstellung und verwendung
BE885303A (fr)	1980-09-19	1981-03-19	Continental Pharma	Glycinamides
US4383999A (en)	1981-05-26	1983-05-17	Smithkline Beckman Corporation	Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
AU552050B2 (en)	1981-05-26	1986-05-22	Smithkline Beckman Corporation	N-substituted azeheterocyclic carboxylic acids and their esters
US4514414A (en)	1982-10-25	1985-04-30	Smithkline Beckman Corporation	N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da)	1985-06-26	1985-06-26	Novo Industri As	Aminosyrederivater
FI864246A7 (fi)	1985-11-08	1987-05-09	Warner Lambert Co	N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
US4772615A (en)	1985-11-08	1988-09-20	Warner-Lambert Company	Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
DK165692C (da)	1986-01-07	1993-11-08	Novo Nordisk As	Phenylbutenderivater, fremgangsmaade til fremstilling heraf, farmaceutisk praeparat indeholdende disse, samt anvendelse af disse til fremstilling af et medikament nyttigt til inhibering af gaba-optagelse i mennesker
JPH02129158A (ja)	1988-11-07	1990-05-17	Nippon Steel Corp	光学活性なグリシン誘導体及びその製造方法
IE913279A1 (en) *	1990-09-26	1992-04-08	Astra Ab	(2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
ES2036926B1 (es)	1991-08-08	1994-01-16	Uriach & Cia Sa J	"procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
PT871440E (pt)	1995-12-07	2006-07-31	Daniel C Javitt	Tratamento de sintomas negativos e cognitivos de esquizofrenia com antagonistas da captacao de glicina
AU730789B2 (en) *	1996-05-31	2001-03-15	Nps Pharmaceuticals, Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
US6191165B1 (en)	1996-05-31	2001-02-20	Allelix Neuroscience Inc.	Pharmaceutical for treatment of neurological and neuropsychiatric disorders
EP1184370B1 (en) *	1996-07-22	2005-09-14	Novo Nordisk A/S	Compounds with growth hormone releasing properties
CA2317604C (en) *	1998-01-09	2004-12-21	Pfizer Inc.	Matrix metalloprotease inhibitors
US6103743A (en) *	1999-08-06	2000-08-15	Allelix Neuroscience, Inc.	Unsaturated amino acid derivatives

2002
- 2002-02-15 US US10/077,579 patent/US6667336B2/en not_active Expired - Fee Related
- 2002-02-15 ES ES02702186T patent/ES2266446T3/es not_active Expired - Lifetime
- 2002-02-15 SI SI200230381T patent/SI1368336T1/sl unknown
- 2002-02-15 HU HU0303185A patent/HUP0303185A3/hu unknown
- 2002-02-15 SK SK1144-2003A patent/SK287304B6/sk not_active IP Right Cessation
- 2002-02-15 BR BR0207307-2A patent/BR0207307A/pt not_active IP Right Cessation
- 2002-02-15 DK DK02702186T patent/DK1368336T3/da active
- 2002-02-15 CN CNB028050819A patent/CN1219776C/zh not_active Expired - Fee Related
- 2002-02-15 PL PL02365024A patent/PL365024A1/xx unknown
- 2002-02-15 MX MXPA03007309A patent/MXPA03007309A/es active IP Right Grant
- 2002-02-15 EA EA200300900A patent/EA006636B1/ru not_active IP Right Cessation
- 2002-02-15 DE DE60211866T patent/DE60211866T2/de not_active Expired - Lifetime
- 2002-02-15 EE EEP200300394A patent/EE05329B1/et not_active IP Right Cessation
- 2002-02-15 AT AT02702186T patent/ATE327986T1/de not_active IP Right Cessation
- 2002-02-15 WO PCT/CA2002/000176 patent/WO2002066456A2/en not_active Ceased
- 2002-02-15 NZ NZ527695A patent/NZ527695A/en unknown
- 2002-02-15 KR KR1020037010609A patent/KR100900020B1/ko not_active Expired - Fee Related
- 2002-02-15 JP JP2002565971A patent/JP2004523548A/ja active Pending
- 2002-02-15 EP EP02702186A patent/EP1368336B9/en not_active Expired - Lifetime
- 2002-02-15 CA CA002438367A patent/CA2438367A1/en not_active Abandoned
- 2002-02-15 UA UA2003087630A patent/UA75114C2/uk unknown
- 2002-02-15 AU AU2002235682A patent/AU2002235682C1/en not_active Ceased
- 2002-02-15 PT PT02702186T patent/PT1368336E/pt unknown
- 2002-02-15 CZ CZ20032503A patent/CZ20032503A3/cs unknown
- 2002-02-15 HR HR20030696A patent/HRP20030696A2/xx not_active Application Discontinuation
2003
- 2003-07-31 IL IL157194A patent/IL157194A/en not_active IP Right Cessation
- 2003-08-15 NO NO20033634A patent/NO329038B1/no not_active IP Right Cessation
- 2003-09-09 BG BG108164A patent/BG108164A/xx unknown
- 2003-09-15 ZA ZA200307201A patent/ZA200307201B/en unknown
2006
- 2006-08-22 CY CY20061101160T patent/CY1105529T1/el unknown
2009
- 2009-11-09 JP JP2009255663A patent/JP2010059182A/ja active Pending

Also Published As

Publication number	Publication date
NO329038B1 (no)	2010-08-02
PL365024A1 (en)	2004-12-27
HK1061025A1 (en)	2004-09-03
HUP0303185A3 (en)	2008-12-29
BR0207307A (pt)	2004-08-17
EP1368336B1 (en)	2006-05-31
CN1219776C (zh)	2005-09-21
BG108164A (en)	2004-07-30
NO20033634L (no)	2003-10-08
EP1368336A2 (en)	2003-12-10
DE60211866T2 (de)	2007-06-14
MXPA03007309A (es)	2004-06-30
SI1368336T1 (sl)	2006-10-31
KR100900020B1 (ko)	2009-06-01
WO2002066456A3 (en)	2002-10-17
HRP20030696A2 (en)	2005-04-30
NZ527695A (en)	2005-05-27
CZ20032503A3 (cs)	2004-02-18
PT1368336E (pt)	2006-10-31
CY1105529T1 (el)	2010-07-28
ATE327986T1 (de)	2006-06-15
WO2002066456A2 (en)	2002-08-29
EA006636B1 (ru)	2006-02-24
EP1368336B9 (en)	2007-02-14
AU2002235682C1 (en)	2008-12-11
SK11442003A3 (sk)	2004-03-02
JP2004523548A (ja)	2004-08-05
EA200300900A1 (ru)	2004-02-26
UA75114C2 (en)	2006-03-15
CN1491221A (zh)	2004-04-21
SK287304B6 (sk)	2010-06-07
IL157194A (en)	2006-12-31
AU2002235682B2 (en)	2007-04-26
HUP0303185A2 (hu)	2003-12-29
KR20040028719A (ko)	2004-04-03
ES2266446T3 (es)	2007-03-01
ZA200307201B (en)	2004-07-28
US6667336B2 (en)	2003-12-23
DE60211866D1 (de)	2006-07-06
EE200300394A (et)	2003-12-15
CA2438367A1 (en)	2002-08-29
DK1368336T3 (da)	2006-10-02
US20030176489A1 (en)	2003-09-18
NO20033634D0 (no)	2003-08-15
JP2010059182A (ja)	2010-03-18

Legal Events

Date	Code	Title	Description
2008-10-15	GB1A	Change in the ownership or in the address of the owner
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-10-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20110215

Publication	Publication Date	Title
EA200500376A1 (ru)	2005-08-25	Триазольные производные в качестве ингибиторов трансформирующего фактора роста (tgf)
NO20051008L (no)	2005-06-07	Nye imidazolforbindelser som transformerende vekst faktor (TGF) inhibitorer
EA200300788A1 (ru)	2003-12-25	Производные замещенных алкиламинов и их применение
EA200300776A1 (ru)	2004-06-24	Производные фенэтаноламина для лечения респираторных заболеваний
IL127244A (en)	2005-11-20	Substituted amines, methods of their preparation and pharmaceutical compositions containing them
EA200500354A1 (ru)	2005-10-27	Новые оксазольные и тиазольные соединения в качестве ингибиторов трансформирующего фактора роста (тфр)
MY136430A (en)	2008-10-31	N-adamantylmethyl derivatives, pharmaceutical compositions containing them and processes for their preparation
EA200500377A1 (ru)	2005-08-25	Пиразольные производные как ингибиторы трансформирующего фактора роста (tgf)
SE9903544D0 (sv)	1999-10-01	Novel compounds
SE0302760D0 (sv)	2003-10-20	New compounds
CY1107747T1 (el)	2013-04-18	Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
MXPA04005886A (es)	2004-09-13	Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6.
SE0101932D0 (sv)	2001-05-31	Pharmaceutical combinations
DOP2002000390A (es)	2003-03-15	Sal citrato de 5,8 14-hiezatetraciclo [10.3.1.0 2,11. 0.4.9] hexadeca-2(11),3,5,8,9, pentaeno y composiciones farmaceuticas de las mismas
SE0101322D0 (sv)	2001-04-12	Novel compounds
MXPA04005809A (es)	2004-09-13	Inhibidores de proteinas quinasas.
ATE253359T1 (de)	2003-11-15	Antithrombotische mittel
ATE266029T1 (de)	2004-05-15	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
MXPA05010783A (es)	2005-12-12	Derivados antimicrobianos de [3.1.0] biciclohexilfenil-oxazolidinona y analogos.
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate
DK1368336T3 (da)	2006-10-02	Thiophensubstituerede aminderivater som GlyT-1-inhibitorer
SE0102058D0 (sv)	2001-06-08	New Salts II
HN2002000111A (es)	2002-07-08	Agentes antibacterianos
SE0100295D0 (sv)	2001-02-01	New compounds
PL374919A1 (en)	2005-11-14	Novel indoline compound and medicinal use thereof

EE05329B1 - GlyT-1 inhibiitorid, neid sisaldavad kompositsioonid, nende kasutamine ja nende valmistamise vahehendid - Google Patents