EE200000072A - Insuliini C-peptiidi rekombinantne ekspressioon - Google Patents

Insuliini C-peptiidi rekombinantne ekspressioon

Info

Publication number: EE200000072A
Authority: EE; Estonia
Prior art keywords: insulin; peptide; recombinant expression; recombinant; expression
Prior art date: 1997-08-07

Application number

EEP200000072A

Other languages

English (en)

Inventor

St�hl Stefan

Uhl�n Mathias

Nygren Per-Ke

Jonasson Per

Original Assignee

Creative Peptides Sweden Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-07

Filing date

1998-08-07

Publication date

2000-10-16

1998-08-07 Application filed by Creative Peptides Sweden Ab filed Critical Creative Peptides Sweden Ab

2000-10-16 Publication of EE200000072A publication Critical patent/EE200000072A/et

Links

VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 title 1
238000003259 recombinant expression Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Diabetes (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EEP200000072A 1997-08-07 1998-08-07 Insuliini C-peptiidi rekombinantne ekspressioon EE200000072A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9716790.2A GB9716790D0 (en)	1997-08-07	1997-08-07	Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof
PCT/GB1998/002382 WO1999007735A2 (en)	1997-08-07	1998-08-07	Recombinant expression of insulin c-peptide

Publications (1)

Publication Number	Publication Date
EE200000072A true EE200000072A (et)	2000-10-16

Family

ID=10817184

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000072A EE200000072A (et)	1997-08-07	1998-08-07	Insuliini C-peptiidi rekombinantne ekspressioon

Country Status (21)

Country	Link
US (1)	US6558924B1 (et)
EP (1)	EP1001980A1 (et)
JP (1)	JP2001512745A (et)
KR (1)	KR20010022590A (et)
CN (1)	CN1268141A (et)
AU (1)	AU750685B2 (et)
BG (1)	BG104161A (et)
BR (1)	BR9811850A (et)
CA (1)	CA2297382A1 (et)
EA (1)	EA200000202A1 (et)
EE (1)	EE200000072A (et)
GB (1)	GB9716790D0 (et)
HU (1)	HUP0004626A1 (et)
IL (1)	IL134372A0 (et)
IS (1)	IS5368A (et)
NO (1)	NO20000575L (et)
NZ (1)	NZ502450A (et)
PL (1)	PL339085A1 (et)
SK (1)	SK1532000A3 (et)
TR (1)	TR200000288T2 (et)
WO (1)	WO1999007735A2 (et)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040005669A1 (en) *	1997-08-07	2004-01-08	Stefan Stahl	Recombinant expression of insulin C-peptide
FR2810675B1 (fr) *	2000-06-22	2002-09-27	Pf Medicament	Construction modifiee en aval du codon d'initiation pour la surexpression de proteines recombinantes
FR2810674A1 (fr) *	2000-06-22	2001-12-28	Pf Medicament	Construction modifiee en amont du codon d'initiation pour la surexpression de proteines recombinantes
AU2002233230B2 (en) *	2000-12-20	2007-02-01	F. Hoffmann-La Roche Ag	Erythropoietin conjugates
CN101044154A (zh) *	2002-02-14	2007-09-26	威廉·J·鲁特	治疗宿主中切割的嵌合分子
WO2004047871A2 (en)	2002-11-26	2004-06-10	Nobex Corporation	Modified naturetic compounds, conjugates, and uses thereof
US20050026826A1 (en) *	2003-01-17	2005-02-03	Margarethe Hoenig	Feline proinsulin, insulin and constituent peptides
CN1298742C (zh) *	2003-06-03	2007-02-07	上海新药研究开发中心	一种适合于高效表达的融合蛋白及其生产方法
WO2005087811A2 (en) *	2004-03-10	2005-09-22	Creighton University	Estrogen receptors and methods of use
KR20130115086A (ko)	2010-05-17	2013-10-21	세빅스 인코포레이티드	페길화된 c-펩티드
US8962553B2 (en)	2011-11-17	2015-02-24	Cebix Ab	Method of treating a diabetic subject having a microvascular impairment disorder by a pegylated C-peptide
SG11201405721VA (en) *	2012-03-19	2014-10-30	Madeleine Pharmaceuticals Ρτy Ltd	Method of producing a recombinant peptide
WO2016145389A1 (en)	2015-03-12	2016-09-15	Board Of Trustees Of Michigan State University	Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases
CN109705221B (zh) *	2018-12-27	2021-03-09	美康生物科技股份有限公司	C肽免疫原及其单克隆抗体对及该抗体对在c肽磁微粒化学发光免疫试剂中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5210872B2 (et)	1973-07-14	1977-03-26
GB2068971B (en)	1980-01-30	1983-06-08	Searle & Co	Recombinant dna techniques
CA1213537A (en)	1984-05-01	1986-11-04	Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee	Polypeptide expression method
US5013653A (en)	1987-03-20	1991-05-07	Creative Biomolecules, Inc.	Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
EP0305500B1 (en)	1987-03-20	1994-11-09	Creative Biomolecules, Inc.	Process for the purification of recombinant polypeptides
SE501169C2 (sv)	1988-02-05	1994-11-28	Aake Nygren	Framställning av serumalbuminbindande fusionsproteiner vilka innehåller protein G-domäner
US5130236A (en)	1989-12-07	1992-07-14	Eli Lilly And Company	Process for producing des(64,65)-proinsulin
US5595887A (en)	1990-07-16	1997-01-21	Bionebraska, Inc.	Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
GB9015825D0 (en)	1990-07-18	1990-09-05	Ciba Geigy Ag	In vitro processing of fusion proteins
JPH07108232B2 (ja)	1990-10-09	1995-11-22	エム・ディ・リサーチ株式会社	ペプチド又は蛋白質の製造方法
US5953418A (en)	1995-06-14	1999-09-14	David Hall	Providing selective data broadcast receiver addressability
WO1997023639A1 (en)	1995-12-22	1997-07-03	Toray Industries, Inc.	Process for producing biologically active fused proteins

1997
- 1997-08-07 GB GBGB9716790.2A patent/GB9716790D0/en active Pending
1998
- 1998-08-07 SK SK153-2000A patent/SK1532000A3/sk unknown
- 1998-08-07 HU HU0004626A patent/HUP0004626A1/hu unknown
- 1998-08-07 EP EP98937689A patent/EP1001980A1/en not_active Withdrawn
- 1998-08-07 AU AU86407/98A patent/AU750685B2/en not_active Ceased
- 1998-08-07 US US09/485,286 patent/US6558924B1/en not_active Expired - Fee Related
- 1998-08-07 BR BR9811850-1A patent/BR9811850A/pt not_active Application Discontinuation
- 1998-08-07 PL PL98339085A patent/PL339085A1/xx not_active Application Discontinuation
- 1998-08-07 TR TR2000/00288T patent/TR200000288T2/xx unknown
- 1998-08-07 IL IL13437298A patent/IL134372A0/xx unknown
- 1998-08-07 WO PCT/GB1998/002382 patent/WO1999007735A2/en not_active Ceased
- 1998-08-07 CN CN98808075A patent/CN1268141A/zh active Pending
- 1998-08-07 KR KR1020007001182A patent/KR20010022590A/ko not_active Withdrawn
- 1998-08-07 NZ NZ502450A patent/NZ502450A/xx unknown
- 1998-08-07 JP JP2000506237A patent/JP2001512745A/ja active Pending
- 1998-08-07 EA EA200000202A patent/EA200000202A1/ru unknown
- 1998-08-07 EE EEP200000072A patent/EE200000072A/et unknown
- 1998-08-07 CA CA002297382A patent/CA2297382A1/en not_active Abandoned
2000
- 2000-02-01 IS IS5368A patent/IS5368A/is unknown
- 2000-02-04 NO NO20000575A patent/NO20000575L/no not_active Application Discontinuation
- 2000-02-17 BG BG104161A patent/BG104161A/xx unknown

Also Published As

Publication number	Publication date
SK1532000A3 (en)	2000-09-12
WO1999007735A3 (en)	1999-04-29
CA2297382A1 (en)	1999-02-18
NO20000575D0 (no)	2000-02-04
IS5368A (is)	2000-02-01
US6558924B1 (en)	2003-05-06
KR20010022590A (ko)	2001-03-26
HUP0004626A1 (hu)	2001-04-28
WO1999007735A2 (en)	1999-02-18
GB9716790D0 (en)	1997-10-15
EP1001980A1 (en)	2000-05-24
TR200000288T2 (tr)	2000-06-21
AU8640798A (en)	1999-03-01
JP2001512745A (ja)	2001-08-28
PL339085A1 (en)	2000-12-04
IL134372A0 (en)	2001-04-30
NO20000575L (no)	2000-04-04
BR9811850A (pt)	2000-08-08
NZ502450A (en)	2002-10-25
CN1268141A (zh)	2000-09-27
AU750685B2 (en)	2002-07-25
BG104161A (en)	2000-12-29
EA200000202A1 (ru)	2001-04-23

Publication	Publication Date	Title
NO2006014I1 (no)	2006-11-13	Insulin glulisin
NO2010013I2 (no)	2015-05-18	Rekombinant FSH-CTP
BR9510090A (pt)	1998-07-14	Utilização de um adenovírus recombinante
DK0884053T3 (da)	2002-11-04	Stabile insulinpræparater
DE69825982D1 (de)	2004-10-07	Spritze
DE69822160D1 (de)	2004-04-08	Verbesserte injektionsspritze
FI972292A0 (fi)	1997-05-30	Administrering av diabetes
ATA101795A (de)	2001-06-15	Insulinanalogon-protamin-komplex
DK0963211T3 (da)	2005-05-30	Hypodermisk injektionssystem
NO952357D0 (no)	1995-06-14	Formulering av insulinanaloger
ID27741A (id)	2001-04-26	Larutan teriparatide yang distabilkan
DE69822495D1 (de)	2004-04-22	Nadellose injektionsstelle
FI970132A7 (fi)	1997-02-11	Injektioruisku
DE69816443D1 (de)	2003-08-21	Sicherheitsspritze
DE69810382D1 (de)	2003-02-06	Spritzennadel
DE69812588D1 (de)	2003-04-30	Medizinischer injektor
IS5368A (is)	2000-02-01	Tjáning raðbrigða C-peptíðs insúlíns
NO952336D0 (no)	1995-06-13	Insulin analoger
ATE283706T1 (de)	2004-12-15	ßGEGEN RACEMISIERUNG STABILISIERTE PHARMAZEUTISCHE ZUBEREITUNGEN VON CILANSETRONß
DE69824327D1 (de)	2004-07-15	Inhalationsgerät
NO974924D0 (no)	1997-10-24	Modifiserte polypeptider med öket immunogenisitet
NO970576D0 (no)	1997-02-07	Selvdestruerende injeksjonsspröyte
DE69522857D1 (de)	2001-10-31	Insulinstandardlösung
FR2749172B1 (fr)	1998-11-06	Seringue hypodermique
HK1028050A (en)	2001-02-02	Recombinant expression of insulin c-peptide