EE200000117A - Asendatud oksindooli derivaadid kui proteiini türosiini kinaasi ja proteiini seriini/treoniini kinaasi inhibiitorid - Google Patents

Asendatud oksindooli derivaadid kui proteiini türosiini kinaasi ja proteiini seriini/treoniini kinaasi inhibiitorid

Info

Publication number
EE200000117A
EE200000117A EEP200000117A EEP200000117A EE200000117A EE 200000117 A EE200000117 A EE 200000117A EE P200000117 A EEP200000117 A EE P200000117A EE P200000117 A EEP200000117 A EE P200000117A EE 200000117 A EE200000117 A EE 200000117A
Authority
EE
Estonia
Prior art keywords
protein
inhibitors
kinase
oxindole derivatives
tyrosine kinase
Prior art date
Application number
EEP200000117A
Other languages
English (en)
Estonian (et)
Inventor
Thomas Davis Stephen
Vernon Frye Stephen
Howard Dickerson Scott
Anthony Harris Philip
Robert Neil Hunter, Iii
Frederick Kuyper Lee
Elizabeth Lackey Karen
Joseph Luzzio Michael
Marvin Veal James
Herrick Walker Duncan
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of EE200000117A publication Critical patent/EE200000117A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200000117A 1997-09-05 1998-09-03 Asendatud oksindooli derivaadid kui proteiini türosiini kinaasi ja proteiini seriini/treoniini kinaasi inhibiitorid EE200000117A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9718913.8A GB9718913D0 (en) 1997-09-05 1997-09-05 Substituted oxindole derivatives
PCT/EP1998/005559 WO1999015500A1 (fr) 1997-09-05 1998-09-03 Derives substitues d'oxindole en tant qu'inhibiteurs de la tyrosine kinase et de la serine/threonine kinase

Publications (1)

Publication Number Publication Date
EE200000117A true EE200000117A (et) 2000-12-15

Family

ID=10818643

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000117A EE200000117A (et) 1997-09-05 1998-09-03 Asendatud oksindooli derivaadid kui proteiini türosiini kinaasi ja proteiini seriini/treoniini kinaasi inhibiitorid

Country Status (23)

Country Link
US (4) US6387919B1 (fr)
EP (1) EP1009738B1 (fr)
JP (1) JP2001517652A (fr)
KR (1) KR20010023695A (fr)
CN (1) CN1278794A (fr)
AR (1) AR015432A1 (fr)
AT (1) ATE267170T1 (fr)
AU (1) AU747506B2 (fr)
BR (1) BR9812048A (fr)
CA (1) CA2302572A1 (fr)
CO (1) CO4960633A1 (fr)
DE (1) DE69824014T2 (fr)
EE (1) EE200000117A (fr)
ES (1) ES2221211T3 (fr)
GB (1) GB9718913D0 (fr)
HU (1) HUP0004490A3 (fr)
MA (1) MA26542A1 (fr)
PE (1) PE107699A1 (fr)
PL (1) PL338991A1 (fr)
TR (1) TR200001174T2 (fr)
TW (1) TW520358B (fr)
WO (1) WO1999015500A1 (fr)
ZA (1) ZA988078B (fr)

Families Citing this family (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407132B1 (en) * 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
DE19816624A1 (de) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19824922A1 (de) * 1998-06-04 1999-12-09 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6319918B1 (en) 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
KR20010101266A (ko) 1998-12-17 2001-11-14 프리돌린 클라우스너, 롤란드 비. 보레르 Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌
ES2192878T3 (es) * 1998-12-17 2003-10-16 Hoffmann La Roche 4,5-azolo-oxindoles.
DE69906152T2 (de) 1998-12-17 2004-02-12 F. Hoffmann-La Roche Ag 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2
ES2301255T3 (es) * 1998-12-17 2008-06-16 F. Hoffmann-La Roche Ag 4,5-pirazinaxindoles como inhibidores de proteinoquinasas.
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
EP1147214B1 (fr) 1999-01-13 2011-01-05 The Research Foundation Of State University Of New York Nouveau procede d'identification d'inhibiteurs de proteines kinase
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
GB9904932D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
GB9904930D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Thiazoloindolinone compounds
US6492398B1 (en) * 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
GB9911053D0 (en) * 1999-05-12 1999-07-14 Pharmacia & Upjohn Spa 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
DE19924401A1 (de) * 1999-05-27 2000-11-30 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
WO2001016130A1 (fr) * 1999-08-27 2001-03-08 Boehringer Ingelheim Pharma Kg Indolinones substituees utilisees comme inhibiteurs de la tyrosine kinase
AU771460B2 (en) * 1999-09-24 2004-03-25 Smithkline Beecham Corporation Thrombopoietin mimetics
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
DE19949209A1 (de) * 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
YU54202A (sh) * 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
EP1207864A2 (fr) 2000-02-05 2002-05-29 Vertex Pharmaceuticals Incorporated Compositions utiles comme inhibiteurs de erk
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
BR0110302A (pt) 2000-04-18 2003-01-14 Agouron Pharma Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
US6534531B2 (en) * 2000-04-27 2003-03-18 Bristol-Myers Squibb Company Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy
WO2001082967A1 (fr) * 2000-04-28 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicinales destinees a supprimer la production de ?-amyloide
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
BR0113139A (pt) 2000-08-09 2003-06-24 Agouron Pharma Compostos, seus sais, formas multiméricas, pró-drogas ou metabólitos, composições farmacêuticas, método de tratamento de uma doença ou disfunção mediana através da inibição de cdk4 ou um complexo de cdk4/ciclina, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase e método de modulação ou inibição da atividade de um receptor de proteìna cinase
MXPA03001452A (es) 2000-08-18 2004-05-04 Agouron Pharma Hidroximino-fluorenos heterociclicos y su uso para la inhibicion de las proteinas cinasas.
ES2230337T3 (es) 2000-09-01 2005-05-01 Glaxo Group Limited Derivados de oxindol.
WO2002020513A1 (fr) * 2000-09-01 2002-03-14 Glaxo Group Limited Derives d'oxindole
US7071217B2 (en) 2000-09-01 2006-07-04 Smithkline Beecham Corporation Substituted oxindole derivatives as tyrosine kinase inhibitors
EP1201765A3 (fr) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Kinases cellulaires impliqués dans l'infection par cytomégalovirus et leur inhibition
DE10054019A1 (de) * 2000-11-01 2002-05-23 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6638965B2 (en) 2000-11-01 2003-10-28 Boehringer Ingelheim Pharma Kg Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
DE10117204A1 (de) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
SE0101230L (sv) * 2001-04-06 2002-10-07 Innoventus Project Ab Ny användning av en tyrosinkinasinhibitor
KR20040000507A (ko) * 2001-05-24 2004-01-03 야마노우치세이야쿠 가부시키가이샤 3-퀴놀린-2(1ｈ)-일리덴인돌린-2-온 유도체
WO2003003006A2 (fr) 2001-06-29 2003-01-09 Ab Science Nouveaux inhibiteurs selectifs puissants et non toxiques de c-kit
PT1401416E (pt) 2001-06-29 2007-02-28 Ab Science Utilização de inibidores de c-kit para tratar doenças inflamatórias intestinais (dii)
ATE330608T1 (de) 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
DE60225590T2 (de) * 2001-09-20 2008-09-25 Ab Science C-kithemmer zur behandlung von bakteriellen infektionen
EP1461032B1 (fr) * 2001-09-20 2008-07-16 AB Science Utilisation d'inhibiteurs de la c-kit pour stimuler la pousse des cheveux
WO2003027109A1 (fr) * 2001-09-27 2003-04-03 Allergan, Inc. 3-(heteroarylamino)methylene-1, 3-dihydro-2h-indol-2-ones, inhibiteurs de kinase
US20030225152A1 (en) * 2001-09-27 2003-12-04 Andrews Steven W. 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
WO2003033491A1 (fr) * 2001-10-16 2003-04-24 Nippon Kayaku Kabushiki Kaisha Composition medicinale de prevention ou de soulagement d'effets secondaires chez les patients souffrant de cancer et composition anticancereuse medicinale
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
JP4623962B2 (ja) * 2001-10-22 2011-02-02 ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
EP1464645A1 (fr) * 2001-12-18 2004-10-06 Kyowa Hakko Kogyo Co., Ltd. Derive d'indole
US7482366B2 (en) * 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
FR2836914B1 (fr) 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
EP1497420A4 (fr) * 2002-04-30 2005-04-27 Alcon Inc Agents regulant, inhibant ou modulant l'activite et/ou l'expression du facteur de croissance du tissu conjonctif (ctgf) utilises comme moyen unique pour reduire la pression intraoculaire et traiter les retinopathies glaucomateuses/neuropathies optiques
MY142390A (en) 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7514468B2 (en) 2002-07-23 2009-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US20040082615A1 (en) * 2002-08-07 2004-04-29 Michael Konkel 3-Imino-2-indolones for the treatement of depression and/or anxiety
WO2004014854A1 (fr) * 2002-08-07 2004-02-19 Synaptic Pharmaceutical Corporation 3-imino-2-indolones pour traiter la depression et/ou l'anxiete
GB0225873D0 (en) * 2002-11-06 2002-12-11 Cyclacel Ltd Combination
AU2003284572A1 (en) * 2002-11-22 2004-06-18 Yamanouchi Pharmaceutical Co., Ltd. 2-oxoindoline derivatives
WO2004057340A1 (fr) 2002-12-23 2004-07-08 Astex Technology Limited Synthese et criblage de ligands par cristallographie a diffraction de rayons x
ES2421139T3 (es) 2003-07-30 2013-08-29 Rigel Pharmaceuticals, Inc. Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
GB0328180D0 (en) * 2003-12-04 2004-01-07 Cyclacel Ltd Combination
DE102004012069A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue aryl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
WO2005118551A2 (fr) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Composes modulant l'activite de la thrombopoietine et methodes associees
DE602005024599D1 (de) * 2004-10-25 2010-12-16 Ligand Pharm Inc Verbindungen modulierende thrombopoietinaktivität und verfahren
GT200500321A (es) * 2004-11-09 2006-09-04 Compuestos y composiciones como inhibidores de proteina kinase.
BRPI0516915A (pt) 2004-12-01 2008-03-11 Devgen Nv derivados de tiazol substituìdos por 5-carboxamido que interagem com canais de ìons, particularmante com canais de ìons da famìlia kv
EP1969940A3 (fr) 2004-12-17 2008-12-10 Devgen NV Compositions nematicides
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2006101937A1 (fr) * 2005-03-18 2006-09-28 Janssen Pharmaceutica N.V. Acylhydrazones en tant que modulateurs de kinase
WO2006119660A1 (fr) * 2005-05-11 2006-11-16 Givaudan Sa Procede d'encapsulation
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
WO2006133426A2 (fr) 2005-06-08 2006-12-14 Rigel Pharmaceuticals, Inc. Compositions et procedes d'inhibition de la voie jak
CA2602389A1 (fr) 2005-07-13 2007-01-18 Allergan, Inc. Inhibiteurs de kinase
EP1902024B1 (fr) 2005-07-13 2013-04-17 Allergan, Inc. Inhibiteurs de kinases
US7749530B2 (en) 2005-07-13 2010-07-06 Allergan, Inc. Kinase inhibitors
GB0523041D0 (en) * 2005-11-11 2005-12-21 Cyclacel Ltd Combination
WO2007098507A2 (fr) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions et méthodes destinées à l'inhibition de la voie jak
US8987474B2 (en) * 2006-04-07 2015-03-24 University Of South Florida Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
US8217177B2 (en) * 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
US8036664B2 (en) * 2006-09-22 2011-10-11 Kineto Wireless, Inc. Method and apparatus for determining rove-out
WO2008045627A2 (fr) * 2006-10-06 2008-04-17 Irm Llc Inhibiteurs de la protéine kinase et procédés pour utiliser ceux-ci
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
HRP20110709T1 (hr) * 2007-02-13 2011-11-30 Ab Science Postupak sinteze spojeva 2-aminotioazola kao inhibitora kinaza
WO2008134124A1 (fr) * 2007-04-30 2008-11-06 The Uab Research Foundation Inhibiteurs de ul97 utilisés pour traiter des troubles prolifératifs
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
US7863315B2 (en) * 2008-01-15 2011-01-04 Shenzhen Chipscreen Biosciences, Ltd. 2-indolinone derivatives as selective histone deacetylase inhibitors
HRP20170317T1 (hr) 2008-02-15 2017-04-21 Rigel Pharmaceuticals, Inc. Spojevi pirimidin-2-amina i njihova uporaba kao inhibitora jak kinaza
WO2009111644A2 (fr) * 2008-03-05 2009-09-11 The Regents Of The University Of Michigan Compositions et procédés pour diagnostiquer et traiter le cancer du pancréas
US8063058B2 (en) 2008-04-16 2011-11-22 Portola Pharmaceuticals, Inc. Inhibitors of syk and JAK protein kinases
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
EP2116236A1 (fr) 2008-04-21 2009-11-11 Université de Mons-Hainaut Dérivés de bisbenzamidine pour une utilisation en tant qu'antioxydants
BRPI0910668A2 (pt) 2008-04-22 2019-09-24 Portola Pharmaceutiacals Inc inibidores de proteína quinases
WO2009135000A2 (fr) * 2008-04-30 2009-11-05 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibition de la protéine tyrosine phosphatase shp2/ptpn11 par nsc-117199 et analogues
WO2009139834A1 (fr) * 2008-05-13 2009-11-19 Poniard Pharmaceuticals, Inc. Composés bioactifs pour le traitement du cancer et des maladies neurodégénératives
PL2307002T3 (pl) * 2008-06-09 2013-05-31 Cyclacel Ltd Kombinacje sapacytabiny lub cndac z inhibitorami metylotransferazy dna, takimi jak decytabina i prokaina
WO2010039997A2 (fr) * 2008-10-01 2010-04-08 The University Of North Carolina At Chapel Hill Protection hématopoïétique contre les composés chimiothérapeutiques au moyen d'inhibiteurs sélectifs des kinases dépendant des cyclines 4/6
AU2009310352A1 (en) * 2008-10-01 2010-05-06 The University Of North Carolina At Chapel Hill Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors
WO2010121212A2 (fr) 2009-04-17 2010-10-21 H. Lee Moffit Cancer Center And Research Institute, Inc. Inhibiteurs d'échafaudage d'indoline shp-2 et procédé de traitement du cancer
EP3025724B1 (fr) 2009-05-13 2018-07-11 The University of North Carolina At Chapel Hill Inhibiteurs de kinases cycline-dépendantes et leurs procédés d'utilisation
EP2434894B1 (fr) 2009-05-29 2016-08-31 Novartis AG Procédés d'administration de composés agonistes de la thrombopoïétine
MX337849B (es) * 2009-07-28 2016-03-09 Rigel Pharmaceuticals Inc Composiciones y metodos para inhibicion de la via jak.
CN102639700A (zh) 2009-09-30 2012-08-15 哈佛大学校长及研究员协会 通过调节自噬增强基因产物调节自噬的方法
US8652534B2 (en) 2009-10-14 2014-02-18 Berry Pharmaceuticals, LLC Compositions and methods for treatment of mammalian skin
JP5759471B2 (ja) * 2009-10-29 2015-08-05 ヴェクチュラ リミテッド Ｊａｋ３キナーゼ阻害剤としての窒素含有ヘテロアリール誘導体
EP2533793B1 (fr) 2010-02-12 2015-12-09 Emory University GAL-4 pour le traitement des maladies infectieuses
NZ602191A (en) 2010-03-02 2014-07-25 Amakem Nv Heterocyclic amides as rock inhibitors
US9168247B2 (en) 2010-06-25 2015-10-27 Facultes Universitaires Notre Dame De La Paix Beta carboline derivatives useful in the treatment of proliferative disorders
US8785648B1 (en) 2010-08-10 2014-07-22 The Regents Of The University Of California PKC-epsilon inhibitors
CA2808655C (fr) 2010-08-18 2019-11-26 Emory University Composes et compositions pour ossification et procedes associes a ceux-ci
WO2012022780A1 (fr) 2010-08-19 2012-02-23 Université Libre de Bruxelles Dérivés d'acide 18β-glycyrrhétinique ayant une activité antitumorale
US8691830B2 (en) 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
KR102186969B1 (ko) 2010-10-25 2020-12-04 쥐원 쎄라퓨틱스, 인크. Cdk 억제제
WO2012058211A2 (fr) 2010-10-29 2012-05-03 Emory University Dérivés quinazoline, compositions et utilisations correspondantes
EP2975027A1 (fr) 2010-11-01 2016-01-20 Portola Pharmaceuticals, Inc. Nicotinamides comme modulateurs de la kinase jak
GB201019043D0 (en) 2010-11-10 2010-12-22 Protea Biopharma N V Use of 2',5'-oligoadenylate derivative compounds
WO2012068381A2 (fr) 2010-11-17 2012-05-24 The University Of North Carolina At Chapel Hill Protection des tissus rénaux contre l'ischémie par le biais de l'inhibition des kinases prolifératives cdk4 et cdk6
AU2011336397B2 (en) 2010-12-03 2016-12-15 Emory University Chemokine CXCR4 receptor modulators and uses related thereto
US8691777B2 (en) 2011-01-27 2014-04-08 Emory University Combination therapy
US9295754B2 (en) 2011-02-24 2016-03-29 Emory University Noggin inhibitory compositions for ossification and methods related thereto
US11179500B2 (en) 2011-02-24 2021-11-23 Emory University JAB1 inhibitory compositions for ossification and methods related thereto
US9365523B2 (en) 2011-03-31 2016-06-14 Emory University Imidazolyl amide compounds and uses related thereto
PL2696878T3 (pl) 2011-04-14 2020-01-31 Cyclacel Limited Schemat dawkowania dla sapacytabiny i decytabiny w kombinacji do leczenia ostrej białaczki szpikowej
WO2012145234A2 (fr) 2011-04-21 2012-10-26 Emory University Dérivés cyclopropylés et leurs procédés d'utilisation
GB201107223D0 (en) 2011-04-29 2011-06-15 Amakem Nv Novel rock inhibitors
US20140079632A1 (en) 2011-05-09 2014-03-20 Universiteit Antwerpen Activity-based probes for the urokinase plasminogen activator
GB201108225D0 (en) 2011-05-17 2011-06-29 Amakem Nv Novel KBC inhibitors
EP2721011B1 (fr) 2011-06-20 2017-09-06 Emory University Antagonistes du récepteur ep2 des prostaglandines, dérivés, compositions et utilisations associés
GB201113689D0 (en) 2011-08-09 2011-09-21 Amakem Nv Novel PDE4 inhibitors
WO2013028543A1 (fr) 2011-08-19 2013-02-28 Emory University Agoniste de bax, compositions et procédés associés
GB201114854D0 (en) 2011-08-29 2011-10-12 Amakem Nv Novel rock inhibitors
EP2751079A1 (fr) 2011-08-31 2014-07-09 Amakem NV Biphénylcarboxamides utilisés en tant qu'inhibiteurs de kinase rock
PT2760453T (pt) 2011-09-30 2016-08-02 Ipsen Pharma Sas Inibidores macrocíclicos da cinase lrrk2
MX347765B (es) 2011-09-30 2017-05-12 Oncodesign Sa Inhibidores macrociclicos de la quinasa flt3.
GB201119358D0 (en) 2011-11-10 2011-12-21 Lewi Paulus J Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
DE102011119127A1 (de) * 2011-11-22 2013-05-23 Merck Patent Gmbh 3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate
EP2782579B1 (fr) 2011-11-23 2019-01-02 Portola Pharmaceuticals, Inc. Inhibiteurs de de la pyrazine kinase
EP2810198B1 (fr) 2012-01-30 2023-07-12 Universiteit Gent Composés anti-invasifs
GB201204756D0 (en) 2012-03-19 2012-05-02 Lewi Paulus J Triazines with suitable spacers for treatment and/or prevention of HIV infections
EP3216792B1 (fr) 2012-03-29 2020-05-27 G1 Therapeutics, Inc. Inhibiteurs de lactam kinase
WO2013181135A1 (fr) 2012-05-31 2013-12-05 Emory University Dérivés de quinazoline, compositions et utilisations associées
CN104487429B (zh) 2012-07-27 2017-07-14 爱默蕾大学 杂环黄酮衍生物、组合物及与其相关的方法
WO2014058921A2 (fr) 2012-10-08 2014-04-17 Portola Pharmaceuticals, Inc. Inhibiteurs substitués de pyrimidinyl kinase
WO2014059034A2 (fr) 2012-10-09 2014-04-17 President And Fellows Of Harvard College Précurseurs et biosynthèse de nad pour le traitement et la prévention du cancer et de sa prolifération
EP3369730B1 (fr) 2012-11-05 2020-08-05 Emory University Dérivés de 7,8-dihydoxyflavone et de flavone 7,8-substitués, compositions et procédés associés
WO2014072419A1 (fr) 2012-11-08 2014-05-15 Universiteit Antwerpen Nouveaux composés anti-vih
HUE033962T2 (en) 2013-01-29 2018-01-29 Redx Pharma Plc Pyridine derivatives as soft rock (RHO kinase) inhibitors
CA2906262A1 (fr) 2013-03-15 2014-09-18 Oncodesign S.A. Inhibiteurs macrocycliques de la kinase inductible par un sel
JP6430483B2 (ja) 2013-03-15 2018-11-28 ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 化学療法の間の正常細胞の一時的な保護
CA2906157C (fr) 2013-03-15 2022-05-17 G1 Therapeutics, Inc. Agents antineoplasiques et antiproliferatifs hautement actifs
WO2014145205A2 (fr) 2013-03-15 2014-09-18 St. Jude Children's Research Hospital Procédés et compositions de modulateurs de la transcription de p27kip1
KR101548803B1 (ko) * 2013-09-09 2015-09-01 경북대학교병원 ３­（６­（４­（트리플루오로메톡시）페닐아미노）피리미딘­４­일）벤자미드 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물
TW201542581A (zh) 2013-09-11 2015-11-16 艾默理大學 核苷酸與核苷治療組成物及其相關用途
WO2015055796A1 (fr) 2013-10-16 2015-04-23 Université Libre de Bruxelles Formulations utiles dans le traitement de maladies prolifératives affectant le tractus respiratoire
CN103588758A (zh) * 2013-11-04 2014-02-19 南京大学 一类含1,4-苯并二噁烷骨架的硝基咪唑衍生物的合成、制备及其在抗癌药物中的应用
WO2015071295A1 (fr) 2013-11-12 2015-05-21 Vrije Universiteit Brussel Vecteur de transcription d'arn et ses utilisations
CN115504924A (zh) 2013-11-27 2022-12-23 雷德伍德生物科技股份有限公司 肼基-吡咯并化合物及用于生成缀合物的方法
KR101602203B1 (ko) * 2014-03-11 2016-03-11 경북대학교병원 N­（2­하이드록시에틸）­3­（6­（4­（트리플루오로메톡시）페닐아미노）피리미딘-4-일）벤자미드 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물
WO2015150472A2 (fr) 2014-04-01 2015-10-08 Université Libre de Bruxelles Nouvelles stratégies de traitement du mélanome
WO2015150337A1 (fr) 2014-04-01 2015-10-08 Amakem Nv Inhibiteurs de la lim kinase
WO2015161283A1 (fr) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Lactames tricycliques à utiliser dans des traitements de la prolifération de cellules anormales rb-positives, épargnant les cellules souches et les cellules progénitrices hématopoïétiques (hspc)
CN106458821B (zh) 2014-05-05 2019-12-31 爱默蕾大学 Bh4拮抗剂及其相关方法
WO2015175855A1 (fr) 2014-05-16 2015-11-19 Emory University Modulateurs des récepteurs ccr5 et cxcr4 de la chimiokine et et leurs utilisations
WO2016003450A1 (fr) 2014-07-01 2016-01-07 The Regents Of The University Of California Inhibiteurs de pkc-epsilon
WO2016005340A1 (fr) 2014-07-08 2016-01-14 Universiteit Gent Analogues du hamamélitanin et leurs utilisations
EP3191098A4 (fr) 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinaisons et régimes posologiques pour traiter des tumeurs rb-positives
WO2016040848A1 (fr) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Traitement de tumeurs rb-négatives en utilisant des inhibiteurs de la topoisomérase en association avec des inhibiteurs des kinases cycline-dépendantes 4/6
AU2015316799B2 (en) 2014-09-17 2019-07-11 Oncodesign Precision Medicine (OPM) Macrocyclic RIP2 kinase inhibitors
ES2717510T3 (es) 2014-09-17 2019-06-21 Oncodesign Sa Inhibidores macrocíclicos de cinasa LRRK2
WO2016083490A1 (fr) 2014-11-27 2016-06-02 Remynd Nv Composés pour le traitement de maladies associées à la substance amyloïde
WO2016099982A2 (fr) 2014-12-15 2016-06-23 Emory University Phosphoramidates pour le traitement du virus de l'hépatite b
WO2016106050A1 (fr) 2014-12-26 2016-06-30 Emory University N4-hydroxycytidine, ses dérivés et utilisations anti-virales
WO2016146651A1 (fr) 2015-03-16 2016-09-22 Oncodesign Sa Inhibiteurs macrocycliques de récepteur kinase de type activine
CA2984379C (fr) 2015-04-28 2024-06-11 Newsouth Innovations Pty Limited Ciblage de nad+ pour traiter la deficience cognitive, les neuropathies et l'inactivite induites par la chimiotherapie et la radiotherapie
EP3288384A4 (fr) 2015-05-01 2019-01-23 Georgia State University Research Foundation Dérivés benzhydrol pour la prise en charge d'états associés à des facteurs inductibles par l'hypoxie
EP3804706B1 (fr) 2015-05-29 2023-08-23 Emory University 2-amino-n'-benzylidène-acétohydrazides et dérivés pour la prise en charge de maladies médiées par la protéine cftr
CN108137595B (zh) * 2015-06-18 2021-04-20 听治疗有限责任公司 预防和治疗听力损失的方法和组合物
WO2017083306A1 (fr) 2015-11-09 2017-05-18 R.P. Scherer Technologies, Llc Conjugués anticorps anti-her22-maytansine et méthodes d'utilisation de ceux-ci
US10716869B2 (en) 2016-02-29 2020-07-21 Oncodesign Sa Radiolabeled macrocyclic EGFR inhibitor
WO2017157882A1 (fr) 2016-03-14 2017-09-21 Université Catholique de Louvain Inhibiteurs de la voie de biosynthèse de la sérine
WO2017161253A1 (fr) * 2016-03-18 2017-09-21 Tufts Medical Center Compositions et méthodes de traitement et de prévention de troubles métaboliques
JP7129703B2 (ja) 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
US11166967B2 (en) 2016-05-19 2021-11-09 Universiteit Antwerpen Bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of PAR-related diseases
BE1023757B1 (nl) 2016-06-30 2017-07-12 Yun NV Bewaring van micro-organismen
WO2018065387A1 (fr) 2016-10-04 2018-04-12 Universiteit Gent Nouveaux analogues du hamamélitannin et leurs utilisations
US20190256573A1 (en) 2016-10-14 2019-08-22 Emory University Nanoparticles Having Molecules That Bind or Block PD-L1 and Uses In Treating Cancer
EP3532289B1 (fr) 2016-10-26 2024-03-06 Emory University Complexes de polyoxométallate et leurs utilisations dans la prise en charge du cancer
WO2018096088A1 (fr) 2016-11-24 2018-05-31 Universiteit Antwerpen Benzotropolones halogénées en tant qu'inhibiteurs d'atg4b
CA3046927A1 (fr) 2016-12-13 2018-06-21 Emory University Polypeptides pour la prise en charge d'infections virales
JP7229162B2 (ja) 2017-01-06 2023-02-27 ジー１ セラピューティクス， インコーポレイテッド 癌の治療に対する併用療法
WO2018138358A1 (fr) 2017-01-30 2018-08-02 Université de Liège Inhibiteurs de perk et d'ire-1a contre des troubles neurodéveloppementaux
US11497744B2 (en) 2017-02-21 2022-11-15 Emory University Chemokine CXCR4 receptor modulators and uses related thereto
WO2018160967A1 (fr) * 2017-03-02 2018-09-07 Board Of Regents, The University Of Texas System Dérivés d'indolinone utilisés comme inhibiteurs de la kinase de type fermeture éclair à leucine embryonnaire maternelle
CN106977508A (zh) * 2017-05-05 2017-07-25 遵义医学院 具有靛红结构的吡唑衍生物用于防治肿瘤的药物及其制法
US12178805B2 (en) 2017-05-11 2024-12-31 Remynd N.V. Inhibitors of PDE6Delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders
PL3621963T3 (pl) 2017-05-11 2024-05-20 Remynd N.V. Związki do leczenia epilepsji, zaburzeń neurodegeneracyjnych i innych zaburzeń oun
US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
EP3645001B1 (fr) 2017-06-29 2024-07-03 G1 Therapeutics, Inc. Formes morphiques de git38 et leurs procédés de fabrication
RU2020116571A (ru) 2017-12-07 2021-11-22 Эмори Юниверсити N4-гидроксицитидин и производные и связанные с этим противовирусные применения
CA3135420A1 (fr) 2018-04-05 2019-10-10 Universiteit Hasselt Inhibiteurs selectifs de pde4d contre des maladies demyelinisantes
CA3104397C (fr) 2018-06-29 2023-08-01 Rejuvenate Biomed Association pharmaceutique destinee a etre utilisee dans des maladies liees a l'age et/ou degeneratives
ES2974972T3 (es) 2018-08-07 2024-07-02 Univ Emory Derivados heterocíclicos de flavona, composiciones y métodos relacionados con los mismos
KR102962306B1 (ko) 2018-08-24 2026-05-08 쥐원 쎄라퓨틱스, 인크. 1,4-디아자스피로[5.5]운데칸-3-온의 개선된 합성
CA3110661A1 (fr) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition de proteines kinases pour traiter la maladie de friedreich
US20230009626A1 (en) * 2018-10-05 2023-01-12 Ichnos Sciences S.A. Indolinone compounds for use as map4k1 inhibitors
WO2020191208A1 (fr) 2019-03-20 2020-09-24 Emory University Antagonistes du récepteur ep2 de la prostaglandine, dérivés, et utilisations associés
AU2020274407B2 (en) 2019-05-14 2023-09-28 Suzhou Four Health Pharmaceuticals Co., Ltd Quinazoline-2,4-dione derivatives as PARP inhibitors
WO2020242933A1 (fr) 2019-05-24 2020-12-03 Emory University Inhibiteurs d'asparagine endopeptidase (aep), compositions et utilisations associées
WO2021016254A1 (fr) * 2019-07-22 2021-01-28 Radius Pharmaceuticals, Inc. Composés modulant les récepteurs des oestrogènes
US12577242B2 (en) 2020-02-24 2026-03-17 Katholieke Universiteit Leuven Pyrrolopyridine and imidazopyridine antiviral compounds
GB202003240D0 (en) 2020-03-05 2020-04-22 Ecosynth Nv Antiviral treatment
US20230158178A1 (en) 2020-03-16 2023-05-25 Emory University Radionuclide Tracers of 1-Amino-3,4-Difluorocyclopentane-1-Carboxylic Acid, Derivatives, and Uses Thereof
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
WO2022020114A2 (fr) 2020-07-10 2022-01-27 Ting Therapeutics Llc Méthodes de prévention et de traitement de la perte d'audition
WO2022157381A1 (fr) 2021-01-25 2022-07-28 Universiteit Hasselt Phlorétine destinée à être utilisée dans le traitement de maladies neurodégénératives et démyélinisantes
US20240325363A1 (en) * 2021-03-12 2024-10-03 Oncocross Co.,Ltd. Composition for treatment of anticancer agent-resistant cancer
KR20240040768A (ko) 2021-07-26 2024-03-28 셀퀴티 인크. 암의 치료에 사용하기 위한 1-(4-｛[4-(디메틸아미노)피페리딘-1-일]카르보닐｝페닐)-3-[4-(4,6-디모르폴린-4-일-1,3,5-트리아진-2-일)페닐]우레아 (게다톨리십) 및 그의 조합물
AU2022318349B2 (en) 2021-07-30 2025-12-18 Confo Therapeutics N.V. Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders that are associated with at2r and/or at2r mediated signaling
EP4387629A1 (fr) 2021-08-18 2024-06-26 Katholieke Universiteit Leuven KU Leuven Research & Development Analogues de ribonucléoside 7-déazapurine 6-substitués et 6,7-disubstitués
US20250066365A1 (en) 2021-09-23 2025-02-27 Katholieke Universiteit Leuven Ribonucleoside Analogues Against -Sars-Cov-2
WO2023105283A1 (fr) 2021-12-08 2023-06-15 Fundacio Privada Institut De Recerca De La Sida - Caixa Inhibiteurs nucléosidiques de la transcriptase inverse destinés à être utilisés dans le traitement du syndrome de down et de la maladie d'alzheimer
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
WO2023111683A1 (fr) 2021-12-16 2023-06-22 Ascletis Bioscience Co., Ltd. Dérivés de n4-hydroxycytidine et leur utilisation comme agent antiviral
WO2023139402A1 (fr) 2022-01-18 2023-07-27 Ascletis Bioscience Co., Ltd. Inhibiteurs de cystéine protéases et leurs procédés d'utilisation
US11760722B2 (en) 2022-01-18 2023-09-19 Ascletis Bioscience Co., Ltd. Inhibitors of cysteine proteases and methods of use thereof
WO2023180567A1 (fr) 2022-03-24 2023-09-28 Fundacion Privada Institut De Recerca De La Sida-Caixa Cyclodextrines destinées à être utilisées dans une thérapie contre une infection à coronavirus
WO2023241799A1 (fr) 2022-06-15 2023-12-21 Université Libre de Bruxelles Flavanols destinés à être utilisés dans le traitement d'infections rétrovirales
US20240025885A1 (en) 2022-07-08 2024-01-25 Ascletis BioScience Co., Ltd Triazine derivatives and methods of use thereof
CN117700397A (zh) * 2022-11-02 2024-03-15 徐诺药业(南京)有限公司 2-氧代吲哚啉类衍生物及其制备方法和应用
CN115504968B (zh) 2022-11-21 2023-04-18 歌礼生物科技（杭州）有限公司 三嗪衍生物
WO2024193451A1 (fr) 2023-03-17 2024-09-26 Ascletis BioScience Co., Ltd Dérivés de triazine, leur procédé de fabrication et leur procédé d'utilisation
WO2025104221A1 (fr) 2023-11-15 2025-05-22 Université Libre de Bruxelles Utilisations d'inhibiteurs kappa du récepteur de la protéine tyrosine phosphatase
WO2025155711A1 (fr) * 2024-01-17 2025-07-24 The Board Of Trustees Of The Leland Stanford Junior University Inhibiteurs de lrrk2 et compositions et utilisations associées
WO2026013165A1 (fr) 2024-07-10 2026-01-15 Université Libre de Bruxelles Association d'un inhibiteur de ship2 et d'un inhibiteur de plk1 destinée à être utilisée dans le traitement du cancer
WO2026024674A1 (fr) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Méthodes de traitement de cancers associés à skp2
US20260053814A1 (en) 2024-08-21 2026-02-26 Celcuity Inc. Treatment regimens for gedatolisib in hormonally-driven disorders

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447940A1 (fr) 1979-02-05 1980-08-29 Ato Chimie Nouveaux (co)polycarbonates resistant au feu contenant des fonctions diesters ou hemiesters alcalins d'acides phosphoniques
US5089516A (en) 1987-03-11 1992-02-18 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha 1-phenyl-3,5-pyrazolidinedione hydroxystyrene compounds which have tyrosine kinase inhibiting activity
US5202341A (en) 1987-03-11 1993-04-13 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Hydroxystyrene compounds having tyrosine kinase inhibiting activity
DE3874257T2 (de) 1987-03-11 1993-02-11 Kanegafuchi Chemical Ind Hydroxystyren-derivate.
GB8816944D0 (en) * 1988-07-15 1988-08-17 Sobio Lab Compounds
WO1990009381A1 (fr) 1989-02-08 1990-08-23 Abbott Laboratories Utilisation de 4-hydroxythiazoles en tant qu'inhibiteurs de 5-lipoxygenase
WO1991009598A1 (fr) 1990-01-05 1991-07-11 Pfizer Inc. Derives de l'azaoxindole
GB9004483D0 (en) 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
US5164404A (en) 1991-03-15 1992-11-17 Neurosearch A/S Hydrazone derivatives and their use
JPH06507787A (ja) 1991-05-16 1994-09-08 コールド スプリング ハーバー ラボラトリー Ｄ−型サイクリン並びにそれに関連する使用方法
GB9115160D0 (en) 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
WO1993006123A1 (fr) 1991-09-20 1993-04-01 Fred Hutchinson Cancer Research Center Cycline e humaine
US5294538A (en) 1991-11-18 1994-03-15 Cold Spring Harbor Labs. Method of screening for antimitotic compounds using the CDC25 tyrosine phosphatase
US5441880A (en) 1991-11-18 1995-08-15 Cold Spring Harbor Laboratory Human cdc25 genes, encoded products and uses thereof
US5770423A (en) 1991-11-18 1998-06-23 Cold Spring Harbor Laboratory Nucleic acids encoding cdc25 A and cdc25 B proteins and method of making cdc25 A and cdc25 B proteins
WO1993024514A1 (fr) 1992-05-26 1993-12-09 Mitotix Cycline de type d et utilisations correspondantes
WO1994023029A1 (fr) 1993-03-31 1994-10-13 Monash University Sequence de nucleotides codant une proteine chromosomique, proteines chromosomiques associees et leurs utilisations
US5443962A (en) 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase
GB9313638D0 (en) 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9412719D0 (en) 1994-06-24 1994-08-17 Erba Carlo Spa Substituted azaindolylidene compounds and process for their preparation
US5496828A (en) * 1994-08-22 1996-03-05 Eli Lilly And Company Methods of inhibiting ulcerative mucositis
CA2235810C (fr) 1994-10-24 2010-02-09 Baylor College Of Medicine Inhibiteurs de synthese d'adn produits dans des cellules senescentes
GB9423997D0 (en) 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
GB9501567D0 (en) 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
ATE243034T1 (de) 1996-01-17 2003-07-15 Taiho Pharmaceutical Co Ltd Intimale verdickungsinhibitoren
US5672508A (en) 1996-01-23 1997-09-30 Mitotix, Inc. Inhibitors of cell-cycle progression, and uses related thereto
EP0788890A1 (fr) 1996-02-06 1997-08-13 Agfa-Gevaert N.V. Colorants et éléments donneur de colorant pour l'enregistrement par transfert thermique de colorant
HUP9902160A3 (en) 1996-03-29 2001-02-28 Pfizer Benzyl(idene)-lactam derivatives, their use as selective (ant)agonists of 5-ht1a-and/or 5-ht1d receptors, pharmaceutical compositions containing these compounds
EP0931152A2 (fr) 1996-08-21 1999-07-28 Sugen, Inc. Structures cristallines d'une proteine tyrosine kinase
EP0929520B1 (fr) 1996-08-23 2005-11-02 Sugen, Inc. Banques combinatoires d'indolinone, produits et procedes associes pour traiter des maladies
CA2289102A1 (fr) * 1997-05-07 1998-11-12 Sugen, Inc. Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6319918B1 (en) 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
GB9904932D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
GB9904930D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Thiazoloindolinone compounds
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6620818B1 (en) * 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy

Also Published As

Publication number Publication date
AU747506B2 (en) 2002-05-16
US6369086B1 (en) 2002-04-09
HUP0004490A2 (en) 2001-03-28
US20030004351A1 (en) 2003-01-02
US6541503B2 (en) 2003-04-01
WO1999015500A1 (fr) 1999-04-01
CO4960633A1 (es) 2000-09-25
EP1009738A1 (fr) 2000-06-21
MA26542A1 (fr) 2004-12-20
TW520358B (en) 2003-02-11
DE69824014D1 (en) 2004-06-24
BR9812048A (pt) 2000-09-26
US7105529B2 (en) 2006-09-12
PE107699A1 (es) 1999-11-24
TR200001174T2 (tr) 2000-08-21
PL338991A1 (en) 2000-12-04
US6387919B1 (en) 2002-05-14
ES2221211T3 (es) 2004-12-16
ZA988078B (en) 2000-03-22
DE69824014T2 (de) 2005-05-12
US20030069430A1 (en) 2003-04-10
GB9718913D0 (en) 1997-11-12
CN1278794A (zh) 2001-01-03
ATE267170T1 (de) 2004-06-15
AU9740798A (en) 1999-04-12
AR015432A1 (es) 2001-05-02
EP1009738B1 (fr) 2004-05-19
HUP0004490A3 (en) 2002-10-28
JP2001517652A (ja) 2001-10-09
KR20010023695A (ko) 2001-03-26
CA2302572A1 (fr) 1999-04-01

Similar Documents

Publication Publication Date Title
PL338991A1 (en) Substituted oxindole derivatives as inhibitors of thyrosine kinase protein and serine/threonine kinase protein
EE04616B1 (et) Bitsüklilised heteroaromaatsed ühendid kui valgu türosiini kinaasi inhibiitorid
FI950859A7 (fi) Arylideeni- ja heteroarylideeni-oksindolijohdannaiset tyrosiinikinaasi-inhibiittoreina
CY2014034I2 (el) Υποκατεστημενες 3-κυανοκινολινες ως αναστολεις κινασων πρωτεϊνης τυροσινης
EE9900527A (et) Substitueeritud pürasoolid kui p38 kinaasi inhibiitorid
DK1117659T3 (da) Substituerede 3-cyanoquinoliner som hæmmere af proteintyrosinkinaser
NO20000487D0 (no) Substituerte quinazolinderivater og anvendelse derav som tyrosin kinase inhibitorer
AU3505000A (en) 3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors
FI972492A7 (fi) Imidatsolijohdoksia proteiinikinaasien, erityisesti EGF-R-tyrosiinikin aasin, inhibiittoreina
NO20020467L (no) Purinderivatinhibitorer av tyrosinproteinkinase syk
EE200000289A (et) Asendatud 4-amino-tiasool-2-üüli ühendid kui tsükliinisõltuvusega kinaaside inhibiitorid
HUP0102101A3 (en) Protein tyrosine kinase inhibitor benzothiazole derivatives and pharmaceutical compositions containing them
DK0912559T3 (da) Kondenserede heterocykliske forbindelser som proteintyrosinkinaseinhibitorer
NO990124D0 (no) Bicykliske heteroaromatiske forbindelser som protein-tyrosin-kinase-inhibitorer
NO990123D0 (no) Bicykliske heteroaromatiske forbindelser som protein-tyrosin-kinase-inhibitorer
EE200000706A (et) Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid
EE200100717A (et) Indasooliühendid ja farmatseutilised kompositsioonid proteiini kinaaside inhibeerimiseks ja meetodid nende kasutamiseks
ATE430149T1 (de) Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
DE69711020D1 (de) Thiazole derivate als protein kinase c inhibitoren
ATE205836T1 (de) Bicyclische 4-aralkylaminopyrimidin-derivate als tyrosinkinase-inhibitoren
NO20010053D0 (no) Farnesyl proteintransferaseinhibitorer for behandling av artropatier
DK1171440T3 (da) Substituerede 3-cyano-[1,7]-, [1,5]- og [1,8]-naphthyridininhibitorer af tyrosinkinaser
FI955661L (fi) Substituoidut beta-aryyli- ja beta-heteroaryyli-alfa-syanoakryyliamidijohdannaiset tyrosiinikinaasi-inhibiittoreina
ATE209626T1 (de) Alkyloxyamin-substituierte fluorenonderivate und ihre verwendung als proteinkinase-c-inhibitoren
HK1025569A (en) Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors