EE200000161A - Halogeenasendatud tetratsüklilise tetrahüdrofuraani derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon - Google Patents

Halogeenasendatud tetratsüklilise tetrahüdrofuraani derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon

Info

Publication number
EE200000161A
EE200000161A EEP200000161A EEP200000161A EE200000161A EE 200000161 A EE200000161 A EE 200000161A EE P200000161 A EEP200000161 A EE P200000161A EE P200000161 A EEP200000161 A EE P200000161A EE 200000161 A EE200000161 A EE 200000161A
Authority
EE
Estonia
Prior art keywords
halogen
pharmaceutical composition
tetrahydrofuran derivatives
substituted tetracyclic
tetracyclic tetrahydrofuran
Prior art date
Application number
EEP200000161A
Other languages
English (en)
Inventor
Javier Fernndez-Gadea Francisco
Ignacio Andr�s-Gil Jos�
Gil-Lopetegui Pilar
D�az-Mart�nez Adolfo
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200000161A publication Critical patent/EE200000161A/et
Publication of EE04526B1 publication Critical patent/EE04526B1/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200000161A 1997-10-10 1998-10-06 Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon EE04526B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203154 1997-10-10
PCT/EP1998/006352 WO1999019317A1 (en) 1997-10-10 1998-10-06 Halogen substituted tetracyclic tetrahydrofuran derivatives

Publications (2)

Publication Number Publication Date
EE200000161A true EE200000161A (et) 2001-04-16
EE04526B1 EE04526B1 (et) 2005-08-15

Family

ID=8228817

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000161A EE04526B1 (et) 1997-10-10 1998-10-06 Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon

Country Status (35)

Country Link
US (2) US6511976B1 (et)
EP (1) EP1021432B1 (et)
JP (1) JP3248902B2 (et)
KR (1) KR100366014B1 (et)
CN (1) CN100340554C (et)
AP (1) AP1239A (et)
AR (1) AR017325A1 (et)
AT (1) ATE235479T1 (et)
AU (1) AU737334B2 (et)
BG (1) BG64387B1 (et)
BR (1) BR9812871A (et)
CA (1) CA2305612C (et)
CZ (1) CZ296928B6 (et)
DE (1) DE69812668T2 (et)
DK (1) DK1021432T3 (et)
EA (1) EA003698B1 (et)
EE (1) EE04526B1 (et)
ES (1) ES2195403T3 (et)
HR (1) HRP20000189A2 (et)
HU (1) HU225161B1 (et)
ID (1) ID23903A (et)
IL (1) IL135538A (et)
MY (1) MY117783A (et)
NO (1) NO317159B1 (et)
NZ (1) NZ503294A (et)
OA (1) OA11898A (et)
PL (1) PL339833A1 (et)
PT (1) PT1021432E (et)
SI (1) SI1021432T1 (et)
SK (1) SK284028B6 (et)
TR (1) TR200000918T2 (et)
TW (1) TW567186B (et)
UA (1) UA52778C2 (et)
WO (1) WO1999019317A1 (et)
ZA (1) ZA989204B (et)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
ATE294168T1 (de) * 2001-12-07 2005-05-15 Janssen Pharmaceutica Nv Herstellung von trans-kondensierte 3,3a,8,12b- tetrahydro-2h-dibenzo(3,4:6,7)cyclohepta(1,2- b)furan derivaten
HUP0402325A2 (hu) * 2001-12-07 2005-02-28 Janssen Pharmaceutica N.V. Eljárás cisz-fuzionált 3,3a,8,12b-tetrahidro-2H-dibenzo [3,4:6,7] ciklohepta [1,2-b]furán-származékok előállítására
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030959A2 (et) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
WO2005121113A1 (en) * 2004-06-14 2005-12-22 Janssen Pharmaceutica N.V. Novel tetracyclic tetrahydrofuran derivatives
US8022102B2 (en) * 2004-06-23 2011-09-20 Janssen Pharmaceutica, Nv Unsaturated tetracyclic tetrahydrofuran derivatives
RU2401257C2 (ru) * 2004-12-07 2010-10-10 Янссен Фармацевтика Н.В. Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена
AU2011202995B2 (en) * 2004-12-07 2012-02-02 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
MX2007009092A (es) * 2005-01-27 2007-09-12 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetraciclicos heterociclicos como inhibidores de 5ht2 en el tratamiento de trastornos del sistema nervioso central.
CN101175749B (zh) * 2005-05-19 2011-05-18 詹森药业有限公司 选择的含环胺侧链的四环四氢呋喃衍生物
NZ562008A (en) * 2005-05-26 2010-03-26 Janssen Pharmaceutica Nv Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament
CN101228154B (zh) * 2005-06-17 2014-01-29 詹森药业有限公司 包含环状胺侧链的四环四氢呋喃衍生物
US9125866B1 (en) 2015-01-28 2015-09-08 King Saud University Antidepressant compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552399A (en) * 1994-11-02 1996-09-03 Janssen Pharmaceutica N.V. Substituted tetracyclic azepine derivatives
PT789702E (pt) 1994-11-02 2001-07-31 Janssen Pharmaceutica N V Jans Derivados de oxazepina e tiazepina tetraciclicos substituidos com afinidade para receptores 5-ht2
DE69720709T2 (de) 1996-04-12 2004-03-11 Janssen Pharmaceutica N.V. Substituierte tetracyclische tetrahydrofuranderivate
EP0929299B1 (en) 1996-08-28 2003-10-08 Eli Lilly And Company SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA(b)BENZOFURANS

Also Published As

Publication number Publication date
HK1029106A1 (en) 2001-03-23
BG64387B1 (bg) 2004-12-30
EP1021432A1 (en) 2000-07-26
ATE235479T1 (de) 2003-04-15
EP1021432B1 (en) 2003-03-26
OA11898A (en) 2006-04-10
HU225161B1 (en) 2006-07-28
US20030134852A1 (en) 2003-07-17
SK284028B6 (sk) 2004-08-03
ZA989204B (en) 2000-04-10
DK1021432T3 (da) 2003-07-14
US6511976B1 (en) 2003-01-28
WO1999019317A1 (en) 1999-04-22
CA2305612A1 (en) 1999-04-22
NO20001792D0 (no) 2000-04-06
KR100366014B1 (ko) 2002-12-26
NZ503294A (en) 2001-08-31
EE04526B1 (et) 2005-08-15
EA200000400A1 (ru) 2000-10-30
UA52778C2 (uk) 2003-01-15
AU9629698A (en) 1999-05-03
SI1021432T1 (en) 2003-08-31
CZ296928B6 (cs) 2006-07-12
NO317159B1 (no) 2004-08-30
ID23903A (id) 2000-05-25
TW567186B (en) 2003-12-21
CZ20001136A3 (cs) 2000-08-16
NO20001792L (no) 2000-04-06
KR20010023292A (ko) 2001-03-26
EA003698B1 (ru) 2003-08-28
IL135538A0 (en) 2001-05-20
AP2000001784A0 (en) 2000-06-30
DE69812668D1 (de) 2003-04-30
CN100340554C (zh) 2007-10-03
CN1274353A (zh) 2000-11-22
JP3248902B2 (ja) 2002-01-21
BR9812871A (pt) 2000-08-08
ES2195403T3 (es) 2003-12-01
IL135538A (en) 2005-07-25
AR017325A1 (es) 2001-09-05
PL339833A1 (en) 2001-01-02
JP2001519425A (ja) 2001-10-23
AU737334B2 (en) 2001-08-16
BG104287A (en) 2000-11-30
HUP0003748A2 (hu) 2002-01-28
US6699858B2 (en) 2004-03-02
SK4712000A3 (en) 2000-10-09
HUP0003748A3 (en) 2002-02-28
AP1239A (en) 2004-01-15
TR200000918T2 (tr) 2000-07-21
CA2305612C (en) 2007-07-31
MY117783A (en) 2004-08-30
HRP20000189A2 (en) 2001-02-28
DE69812668T2 (de) 2004-01-29
PT1021432E (pt) 2003-08-29

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