EE200100044A - Heterotsüklilised ühendid kui rotamaasensüümide inhibiitorid - Google Patents

Heterotsüklilised ühendid kui rotamaasensüümide inhibiitorid

Info

Publication number
EE200100044A
EE200100044A EEP200100044A EEP200100044A EE200100044A EE 200100044 A EE200100044 A EE 200100044A EE P200100044 A EEP200100044 A EE P200100044A EE P200100044 A EEP200100044 A EE P200100044A EE 200100044 A EE200100044 A EE 200100044A
Authority
EE
Estonia
Prior art keywords
inhibitors
heterocyclic compounds
rotamase enzymes
rotamase
enzymes
Prior art date
Application number
EEP200100044A
Other languages
English (en)
Estonian (et)
Inventor
Ian Kemp Mark
James Wythes Martin
John Palmer Michael
Allen Sanner Mark
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of EE200100044A publication Critical patent/EE200100044A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
EEP200100044A 1998-07-21 1999-06-28 Heterotsüklilised ühendid kui rotamaasensüümide inhibiitorid EE200100044A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9815880.1A GB9815880D0 (en) 1998-07-21 1998-07-21 Heterocycles
PCT/IB1999/001211 WO2000005232A1 (fr) 1998-07-21 1999-06-28 Composes heterocycliques inhibiteurs d'enzymes rotamase

Publications (1)

Publication Number Publication Date
EE200100044A true EE200100044A (et) 2002-06-17

Family

ID=10835920

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100044A EE200100044A (et) 1998-07-21 1999-06-28 Heterotsüklilised ühendid kui rotamaasensüümide inhibiitorid

Country Status (45)

Country Link
US (2) US6372736B1 (fr)
EP (1) EP1100797B1 (fr)
JP (2) JP3795329B2 (fr)
KR (2) KR100468185B1 (fr)
CN (3) CN1511837A (fr)
AP (1) AP2001002046A0 (fr)
AR (1) AR019427A1 (fr)
AT (1) ATE233261T1 (fr)
AU (1) AU765925B2 (fr)
BG (1) BG105254A (fr)
BR (1) BR9912330A (fr)
CA (1) CA2338214C (fr)
CO (1) CO5080782A1 (fr)
CR (1) CR6073A (fr)
DE (1) DE69905582T2 (fr)
DK (1) DK1100797T3 (fr)
DZ (1) DZ2851A1 (fr)
EA (1) EA003513B1 (fr)
EE (1) EE200100044A (fr)
ES (1) ES2191484T3 (fr)
GB (1) GB9815880D0 (fr)
GE (1) GEP20033028B (fr)
GT (1) GT199900115A (fr)
HK (1) HK1039779A1 (fr)
HN (1) HN1999000106A (fr)
HR (1) HRP20010052A2 (fr)
HU (1) HUP0103413A3 (fr)
ID (1) ID26991A (fr)
IL (1) IL140244A0 (fr)
IS (1) IS5790A (fr)
MA (1) MA24936A1 (fr)
MY (1) MY118222A (fr)
NO (1) NO20010322L (fr)
NZ (2) NZ522270A (fr)
OA (1) OA11585A (fr)
PA (1) PA8478501A1 (fr)
PE (1) PE20001037A1 (fr)
PL (1) PL345734A1 (fr)
SI (1) SI1100797T1 (fr)
SK (1) SK772001A3 (fr)
SV (1) SV1999000102A (fr)
TN (1) TNSN99147A1 (fr)
TR (1) TR200100135T2 (fr)
TW (1) TWI229672B (fr)
WO (1) WO2000005232A1 (fr)

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GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics
GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
ES2234318T3 (es) 1998-11-03 2005-06-16 ABBOTT GMBH & CO. KG 2-fenil-benzimidazoles sustituidos, su preparacion y uso.
DOP2000000107A (es) 1999-12-01 2002-09-16 Agouron Pharmaceutical Inc Compuestos, composiciones y metodos para estimular el crecimiento y alongamiento de las neuronas
FR2805818B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
DE10124953A1 (de) * 2001-05-21 2002-12-12 Marlies Knipper Substanz für die therapeutische Behandlung von Tinnitus
EP1778637B1 (fr) * 2004-06-29 2012-02-22 Aventis Pharmaceuticals Inc. Composition de liaison aux protéines FKBP et utilisation pharmaceutique associée
US7728026B2 (en) * 2005-04-11 2010-06-01 Abbott Laboratories, Inc. 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
WO2007041357A1 (fr) * 2005-09-29 2007-04-12 Abbott Laboratories 1h-benzimidazole-4-carboxamides a substitution phenyle en position 2, utilises comme inhibiteurs de la parp
ATE461923T1 (de) * 2005-11-15 2010-04-15 Abbott Lab Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren
PL1976828T3 (pl) 2005-12-29 2017-07-31 Celtaxsys, Inc. Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4
RU2462458C2 (ru) * 2006-02-10 2012-09-27 Байомарин Ига Лимитед Лечение миодистрофии дюшена
GB0602768D0 (en) * 2006-02-10 2006-03-22 Vastox Plc Treatment of muscular dystrophy
KR101472248B1 (ko) 2006-02-10 2014-12-16 서미트 코포레이션 피엘씨 뒤시엔느 근이영양증의 치료
ES2385849T3 (es) * 2006-05-02 2012-08-01 Abbott Laboratories Las 1H-bencimidazol-4-carboxamidas substituidas son potentes inhibidores de la PARP
US8338455B2 (en) 2006-12-20 2012-12-25 Amgen Inc. Compounds and methods of use
CL2008000666A1 (es) * 2007-03-07 2008-06-13 Xenon Pharmaceuticals Inc Compuestos derivados de triciclos sustituidos, inhibidores del transportador de metales divalentes-1; y uso para tratar una enfermedad asociada con un trastorno del hierro.
US8067613B2 (en) * 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
PE20090510A1 (es) * 2007-08-03 2009-05-22 Summit Corp Plc Combinaciones de drogas para el tratamiento de la distrofia muscular de duchenne
GB0715937D0 (en) * 2007-08-15 2007-09-26 Vastox Plc Method of treatment og duchenne muscular dystrophy
GB0715939D0 (en) * 2007-08-15 2007-09-26 Vastox Plc Method of treatment of duchenne muscular dystrophy
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
WO2010083199A1 (fr) * 2009-01-19 2010-07-22 Abbott Laboratories Inhibiteurs benzthiazole de la poly(adp-ribose)polymérase
GB0905664D0 (en) * 2009-04-02 2009-05-13 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
JP6527851B2 (ja) 2013-03-12 2019-06-05 セルタクシス,インコーポレイテッド ロイコトリエンa4加水分解酵素を阻害する方法
EP2968264A4 (fr) 2013-03-14 2016-11-02 Celtaxsys Inc Inhibiteurs de la leucotriène a4 hydrolase
AU2014239585B2 (en) 2013-03-14 2019-04-04 Celtaxsys, Inc. Inhibitors of leukotriene A4 hydrolase
AU2014239567B2 (en) 2013-03-14 2017-12-14 Celtaxsys, Inc. Inhibitors of leukotriene A4 hydrolase
US10045979B2 (en) * 2014-05-19 2018-08-14 Merial Inc. Anthelmintic compounds
CA3102077A1 (fr) 2018-05-31 2019-12-05 Sanjeev AHUJA Procede de reduction d'exacerbations pulmonaires chez des patients atteints d'une maladie respiratoire
CN109111376B (zh) * 2018-09-18 2021-09-14 四川医立特生物医药有限公司 一种2,5-双脱氧链霉胺衍生物及其应用

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JPS6428245A (en) 1987-07-22 1989-01-30 Sumitomo Electric Industries Production of fluoride glass
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US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
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US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5811434A (en) 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
US5780484A (en) 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
US5840736A (en) 1996-11-13 1998-11-24 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5721256A (en) 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics
GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles

Also Published As

Publication number Publication date
HN1999000106A (es) 1999-11-11
EA003513B1 (ru) 2003-06-26
TNSN99147A1 (fr) 2005-11-10
TR200100135T2 (tr) 2001-06-21
PA8478501A1 (es) 2000-05-24
DK1100797T3 (da) 2003-04-22
HUP0103413A3 (en) 2002-10-28
JP3795329B2 (ja) 2006-07-12
EA200100052A1 (ru) 2001-06-25
BG105254A (en) 2001-10-31
IS5790A (is) 2000-12-22
CN1611499A (zh) 2005-05-04
SK772001A3 (en) 2001-12-03
NO20010322L (no) 2001-03-15
GEP20033028B (en) 2003-07-25
NO20010322D0 (no) 2001-01-19
NZ508838A (en) 2002-12-20
KR100468185B1 (ko) 2005-01-26
KR20010071013A (ko) 2001-07-28
AR019427A1 (es) 2002-02-20
KR20040062640A (ko) 2004-07-07
HK1039779A1 (zh) 2002-05-10
PL345734A1 (en) 2002-01-02
CA2338214C (fr) 2006-08-01
SI1100797T1 (en) 2003-06-30
DE69905582T2 (de) 2003-09-04
DZ2851A1 (fr) 2004-02-04
GT199900115A (es) 2001-01-10
GB9815880D0 (en) 1998-09-16
CO5080782A1 (es) 2001-09-25
CR6073A (es) 2004-04-29
US6372736B1 (en) 2002-04-16
KR100450008B1 (ko) 2004-09-24
US6562964B1 (en) 2003-05-13
CN1310718A (zh) 2001-08-29
HUP0103413A2 (hu) 2002-05-29
AU4285899A (en) 2000-02-14
HRP20010052A2 (en) 2001-12-31
BR9912330A (pt) 2001-04-17
ATE233261T1 (de) 2003-03-15
CN1174978C (zh) 2004-11-10
IL140244A0 (en) 2002-02-10
ID26991A (id) 2001-02-22
JP2002521382A (ja) 2002-07-16
CN1511837A (zh) 2004-07-14
AU765925B2 (en) 2003-10-02
MA24936A1 (fr) 2000-04-01
SV1999000102A (es) 2000-07-06
CA2338214A1 (fr) 2000-02-03
AP2001002046A0 (en) 2001-03-31
OA11585A (en) 2004-07-26
EP1100797B1 (fr) 2003-02-26
DE69905582D1 (de) 2003-04-03
EP1100797A1 (fr) 2001-05-23
JP2004002374A (ja) 2004-01-08
NZ522270A (en) 2004-03-26
WO2000005232A1 (fr) 2000-02-03
PE20001037A1 (es) 2000-10-11
ES2191484T3 (es) 2003-09-01
TWI229672B (en) 2005-03-21
MY118222A (en) 2004-09-30

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