EE200200148A - Kinasoliini derivaadid, nende valmistamise meetodning kasutamine - Google Patents
Kinasoliini derivaadid, nende valmistamise meetodning kasutamineInfo
- Publication number
- EE200200148A EE200200148A EEP200200148A EEP200200148A EE200200148A EE 200200148 A EE200200148 A EE 200200148A EE P200200148 A EEP200200148 A EE P200200148A EE P200200148 A EEP200200148 A EE P200200148A EE 200200148 A EE200200148 A EE 200200148A
- Authority
- EE
- Estonia
- Prior art keywords
- sup
- sub
- preparation
- methods
- quinazoline derivatives
- Prior art date
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108090000461 Aurora Kinase A Proteins 0.000 abstract 1
- 102100032311 Aurora kinase A Human genes 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catching Or Destruction (AREA)
- Ropes Or Cables (AREA)
- Earth Drilling (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9922173.1A GB9922173D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
| PCT/GB2000/003562 WO2001021595A1 (en) | 1999-09-21 | 2000-09-18 | Quinazoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200200148A true EE200200148A (et) | 2003-04-15 |
Family
ID=10861219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200200148A EE200200148A (et) | 1999-09-21 | 2000-09-18 | Kinasoliini derivaadid, nende valmistamise meetodning kasutamine |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7105669B1 (et) |
| EP (1) | EP1218357B1 (et) |
| JP (1) | JP2003509498A (et) |
| KR (1) | KR20020029136A (et) |
| CN (1) | CN1391560A (et) |
| AT (1) | ATE292628T1 (et) |
| AU (1) | AU7433000A (et) |
| BG (1) | BG106535A (et) |
| BR (1) | BR0014136A (et) |
| CA (1) | CA2384284A1 (et) |
| CZ (1) | CZ20021007A3 (et) |
| DE (1) | DE60019317T2 (et) |
| EE (1) | EE200200148A (et) |
| GB (1) | GB9922173D0 (et) |
| HK (1) | HK1046687A1 (et) |
| HU (1) | HUP0204226A3 (et) |
| IL (1) | IL148498A0 (et) |
| IS (1) | IS6309A (et) |
| NO (1) | NO20021395L (et) |
| PL (1) | PL354972A1 (et) |
| SK (1) | SK3842002A3 (et) |
| WO (1) | WO2001021595A1 (et) |
| ZA (1) | ZA200201831B (et) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| CA2419301C (en) | 2000-08-21 | 2009-12-08 | Astrazeneca Ab | Quinazoline derivatives |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| DE60144284D1 (de) | 2000-11-01 | 2011-05-05 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
| EP2258366B1 (en) * | 2001-06-22 | 2013-04-03 | Kirin Pharma Kabushiki Kaisha | Quinoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same |
| CN1627944A (zh) | 2002-01-17 | 2005-06-15 | 神经能质公司 | 取代的喹唑啉－4－基胺类似物作为辣椒辣素调节剂 |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| EP2280003B1 (en) | 2002-07-15 | 2014-04-02 | Symphony Evolution, Inc. | Process for preparing receptor-type kinase modulators |
| NZ544472A (en) | 2003-07-03 | 2009-04-30 | Myriad Genetics Inc | Compounds and therapeutical use thereof |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| US7329664B2 (en) | 2003-07-16 | 2008-02-12 | Neurogen Corporation | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues |
| GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| ES2305844T3 (es) | 2003-09-16 | 2008-11-01 | Astrazeneca Ab | Derivados de quinazolina como inhibidores de tirosina cinasa. |
| GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
| WO2005061519A1 (en) | 2003-12-19 | 2005-07-07 | Takeda San Diego, Inc. | Kinase inhibitors |
| WO2005072731A1 (en) * | 2004-01-29 | 2005-08-11 | X-Ceptor Therapeutics, Inc. | 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders |
| EP1778669A2 (en) | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase inhibitors |
| TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
| US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
| EP1802591B1 (en) | 2004-10-12 | 2012-01-11 | AstraZeneca AB | Quinazoline derivatives |
| ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| AU2006204724A1 (en) * | 2005-01-14 | 2006-07-20 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
| US7462639B2 (en) | 2005-04-14 | 2008-12-09 | Hoffmann-La Roche Inc. | Aminopyrazole derivatives |
| AU2006241825A1 (en) | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | Cyanopyridine derivative and use thereof as medicine |
| GB0510963D0 (en) * | 2005-05-28 | 2005-07-06 | Astrazeneca Ab | Chemical compounds |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US20090076075A1 (en) * | 2006-03-02 | 2009-03-19 | Frederic Henri Jung | Quinoline derivatives |
| UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
| AU2007249762A1 (en) * | 2006-05-15 | 2007-11-22 | Senex Biotechnology, Inc | Identification of CDKI pathway inhibitors |
| SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
| EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| EP2118075A1 (de) | 2007-02-06 | 2009-11-18 | Boehringer Ingelheim International GmbH | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| ES2385118T3 (es) * | 2008-01-17 | 2012-07-18 | Bayer Pharma Aktiengesellschaft | Derivados de quinazolina sustituida con sulfoximina como inmunomoduladores, su preparación y uso como medicamentos |
| CA2711582A1 (en) | 2008-02-07 | 2009-08-13 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles, formulations containing said compounds, use thereof and processes for the preparation thereof |
| EP2303276B1 (en) | 2008-05-13 | 2013-11-13 | AstraZeneca AB | Fumarate salt of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(n-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline |
| CA2733153C (en) | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
| CN105777654B (zh) * | 2016-03-28 | 2018-03-27 | 贵州大学 | 一种含喹唑啉的阿魏酸酯类衍生物、其制备方法和用途 |
| JP2021515767A (ja) | 2018-03-07 | 2021-06-24 | バイエル・アクチエンゲゼルシヤフト | Ｅｒｋ５阻害剤の同定及び使用 |
| US20240246940A1 (en) * | 2021-04-22 | 2024-07-25 | Voronoi Inc. | Heteroaryl derivative compound and use thereof |
| CN119504613B (zh) * | 2024-09-29 | 2026-02-27 | 江苏海洋大学 | 含喹唑啉单元的香豆素衍生物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9707453A (es) * | 1995-03-30 | 1997-12-31 | Pfizer | Derivados de quinazolina. |
| GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| AU2003247141A1 (en) * | 2002-08-01 | 2004-02-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases |
-
1999
- 1999-09-21 GB GBGB9922173.1A patent/GB9922173D0/en not_active Ceased
-
2000
- 2000-09-18 CZ CZ20021007A patent/CZ20021007A3/cs unknown
- 2000-09-18 EE EEP200200148A patent/EE200200148A/et unknown
- 2000-09-18 SK SK384-2002A patent/SK3842002A3/sk unknown
- 2000-09-18 PL PL00354972A patent/PL354972A1/xx not_active Application Discontinuation
- 2000-09-18 HK HK02108373.8A patent/HK1046687A1/zh unknown
- 2000-09-18 HU HU0204226A patent/HUP0204226A3/hu unknown
- 2000-09-18 AT AT00962682T patent/ATE292628T1/de not_active IP Right Cessation
- 2000-09-18 IL IL14849800A patent/IL148498A0/xx unknown
- 2000-09-18 CN CN00816000A patent/CN1391560A/zh active Pending
- 2000-09-18 AU AU74330/00A patent/AU7433000A/en not_active Abandoned
- 2000-09-18 KR KR1020027003679A patent/KR20020029136A/ko not_active Withdrawn
- 2000-09-18 CA CA002384284A patent/CA2384284A1/en not_active Abandoned
- 2000-09-18 EP EP00962682A patent/EP1218357B1/en not_active Expired - Lifetime
- 2000-09-18 WO PCT/GB2000/003562 patent/WO2001021595A1/en not_active Ceased
- 2000-09-18 JP JP2001524974A patent/JP2003509498A/ja active Pending
- 2000-09-18 DE DE60019317T patent/DE60019317T2/de not_active Expired - Fee Related
- 2000-09-18 US US10/088,852 patent/US7105669B1/en not_active Expired - Fee Related
- 2000-09-18 BR BR0014136-4A patent/BR0014136A/pt not_active IP Right Cessation
-
2002
- 2002-03-05 ZA ZA200201831A patent/ZA200201831B/xx unknown
- 2002-03-19 IS IS6309A patent/IS6309A/is unknown
- 2002-03-20 NO NO20021395A patent/NO20021395L/no unknown
- 2002-03-20 BG BG106535A patent/BG106535A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL354972A1 (en) | 2004-03-22 |
| EP1218357B1 (en) | 2005-04-06 |
| CA2384284A1 (en) | 2001-03-29 |
| ATE292628T1 (de) | 2005-04-15 |
| BG106535A (bg) | 2002-12-29 |
| BR0014136A (pt) | 2002-05-21 |
| NO20021395D0 (no) | 2002-03-20 |
| HUP0204226A2 (en) | 2003-05-28 |
| NO20021395L (no) | 2002-05-15 |
| IL148498A0 (en) | 2002-09-12 |
| CN1391560A (zh) | 2003-01-15 |
| ZA200201831B (en) | 2003-08-27 |
| HUP0204226A3 (en) | 2003-07-28 |
| US7105669B1 (en) | 2006-09-12 |
| AU7433000A (en) | 2001-04-24 |
| KR20020029136A (ko) | 2002-04-17 |
| IS6309A (is) | 2002-03-19 |
| JP2003509498A (ja) | 2003-03-11 |
| EP1218357A1 (en) | 2002-07-03 |
| WO2001021595A1 (en) | 2001-03-29 |
| DE60019317D1 (de) | 2005-05-12 |
| SK3842002A3 (en) | 2002-10-08 |
| GB9922173D0 (en) | 1999-11-17 |
| CZ20021007A3 (cs) | 2002-06-12 |
| DE60019317T2 (de) | 2006-03-09 |
| HK1046687A1 (zh) | 2003-01-24 |
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