EE200300041A - N- [5 - [[[5-alkyl-2-oxazolyl] methyl] thio] -2-thiazolyl] carboxamide inhibitors of cyclin-dependent kinases - Google Patents

N- [5 - [[[5-alkyl-2-oxazolyl] methyl] thio] -2-thiazolyl] carboxamide inhibitors of cyclin-dependent kinases

Info

Publication number: EE200300041A
Authority: EE; Estonia
Prior art keywords: cyclin; oxazolyl; thiazolyl; thio; alkyl
Prior art date: 2000-07-26

Application number

EEP200300041A

Other languages

Estonian (et)

Inventor

N. Misra Raj

Xiao Hai-Yun

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-26

Filing date

2001-05-09

Publication date

2005-04-15

2000-12-01 Priority claimed from US09/727,957 external-priority patent/US6515004B1/en

2000-12-22 Priority claimed from US09/746,060 external-priority patent/US6414156B2/en

2001-05-09 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

2005-04-15 Publication of EE200300041A publication Critical patent/EE200300041A/en

Links

108091007914 CDKs Proteins 0.000 title 1
102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
125000000446 sulfanediyl group Chemical group *S* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EEP200300041A 2000-07-26 2001-05-09 N- [5 - [[[5-alkyl-2-oxazolyl] methyl] thio] -2-thiazolyl] carboxamide inhibitors of cyclin-dependent kinases EE200300041A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US61662700A	2000-07-26	2000-07-26
US09/727,957 US6515004B1 (en)	1999-12-15	2000-12-01	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US09/746,060 US6414156B2 (en)	1998-10-21	2000-12-22	Process for preparing azacycloalkanoylaminothiazoles
PCT/US2001/015081 WO2002010162A1 (en)	2000-07-26	2001-05-09	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases

Publications (1)

Publication Number	Publication Date
EE200300041A true EE200300041A (en)	2005-04-15

Family

ID=27417184

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300041A EE200300041A (en)	2000-07-26	2001-05-09	N- [5 - [[[5-alkyl-2-oxazolyl] methyl] thio] -2-thiazolyl] carboxamide inhibitors of cyclin-dependent kinases

Country Status (26)

Country	Link
EP (1)	EP1303513A1 (en)
JP (1)	JP2004509857A (en)
KR (1)	KR20030016429A (en)
CN (1)	CN100457753C (en)
AR (1)	AR030563A1 (en)
AU (1)	AU2001259704A1 (en)
BG (1)	BG65132B1 (en)
BR (1)	BR0112674A (en)
CA (1)	CA2417254A1 (en)
CZ (1)	CZ2003237A3 (en)
EE (1)	EE200300041A (en)
EG (1)	EG24409A (en)
GE (1)	GEP20043367B (en)
HR (1)	HRP20030116A2 (en)
HU (1)	HUP0303698A2 (en)
IL (2)	IL153591A0 (en)
LV (1)	LV13037B (en)
MX (1)	MXPA03000774A (en)
MY (1)	MY129635A (en)
NO (1)	NO20030394L (en)
PL (1)	PL365170A1 (en)
SI (1)	SI21099A (en)
SK (1)	SK18392002A3 (en)
TW (1)	TWI302533B (en)
WO (1)	WO2002010162A1 (en)
YU (1)	YU4903A (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6414156B2 (en)	1998-10-21	2002-07-02	Bristol-Myers Squibb Company	Process for preparing azacycloalkanoylaminothiazoles
EP2311818B1 (en) *	2002-02-28	2013-01-16	Novartis AG	Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug
TWI314928B (en)	2002-02-28	2009-09-21	Novartis A	5-phenylthiazole derivatives and use as pi3 kinase inhibitors
NZ539163A (en)	2002-09-04	2007-03-30	Schering Corp	Pyrazolo[1,5-a]pyrimidine compounds useful as cyclin dependent kinase (CDK) inhibitors
PT1537116E (en)	2002-09-04	2010-09-03	Schering Corp	Pyrazolopyrimidines suitable for the treatment of cancer diseases
US8580782B2 (en)	2002-09-04	2013-11-12	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en)	2002-09-04	2014-03-18	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7186740B2 (en)	2002-09-23	2007-03-06	Schering Corporation	Imidazopyrazines as cyclin dependent kinase inhibitors
TW200413378A (en)	2002-09-23	2004-08-01	Schering Corp	Novel imidazopyrazines as cyclin dependent kinase inhibitors
GB0320197D0 (en) *	2003-08-28	2003-10-01	Novartis Ag	Organic compounds
EP1555264A1 (en) *	2004-01-15	2005-07-20	Sireen AG	Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
DE102005008310A1 (en) *	2005-02-17	2006-08-24	Schering Ag	Use of CDKII inhibitors for fertility control
CN101287728A (en) *	2005-08-17	2008-10-15	先灵公司	Novel high-affinity thienyl and furyl kinase ligands
CA2621983A1 (en)	2005-09-09	2007-03-22	Schering Corporation	Azafused cyclin dependent kinase inhibitors
CN101321760A (en)	2005-10-06	2008-12-10	先灵公司	Pyrazolopyrimidines as protein kinase inhibitors
US20090175852A1 (en)	2006-06-06	2009-07-09	Schering Corporation	Imidazopyrazines as protein kinase inhibitors
WO2007146039A2 (en) *	2006-06-06	2007-12-21	Bristol-Myers Squibb Company	Crystalline forms of n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl] thio]-2-thiazolyl]-4-piperidinecarboxamide
AR063531A1 (en)	2006-10-31	2009-01-28	Schering Corp	DERIVATIVES OF ANILINOPIPERAZINE AND PHARMACEUTICAL COMPOSITION
CA2668210C (en)	2006-10-31	2013-03-12	Schering Corporation	Anilinopiperazine derivatives and methods of use thereof
EP2409700A1 (en)	2007-05-08	2012-01-25	Schering Corporation	Methods of treatment using intravenous formulations comprising temozolomide
TW200922564A (en)	2007-09-10	2009-06-01	Curis Inc	CDK inhibitors containing a zinc binding moiety
WO2010075542A1 (en)	2008-12-23	2010-07-01	Curis, Inc.	Cdk inhibitors
WO2011025706A2 (en)	2009-08-26	2011-03-03	Schering Corporation	Heterocyclic amide compounds as protein kinase inhibitors
WO2013148775A1 (en)	2012-03-30	2013-10-03	Merck Sharp & Dohme Corp.	Predictive biomarker useful for cancer therapy mediated by a cdk inhibitor
JP6212831B2 (en) *	2013-12-04	2017-10-18	杭州源昶医薬科技有限公司	Gemcitabine derivative, composition containing the derivative and pharmaceutical use of the derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6262096B1 (en) *	1997-11-12	2001-07-17	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
US6040321A (en) *	1997-11-12	2000-03-21	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
CA2332325A1 (en) *	1998-06-18	1999-12-23	Bristol-Myers Squibb Company	Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) *	1998-10-21	2002-07-02	Bristol-Myers Squibb Company	Process for preparing azacycloalkanoylaminothiazoles
MY125768A (en) *	1999-12-15	2006-08-30	Bristol Myers Squibb Co	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

2001
- 2001-05-09 PL PL01365170A patent/PL365170A1/en not_active Application Discontinuation
- 2001-05-09 YU YU4903A patent/YU4903A/en unknown
- 2001-05-09 SK SK1839-2002A patent/SK18392002A3/en unknown
- 2001-05-09 CA CA002417254A patent/CA2417254A1/en not_active Abandoned
- 2001-05-09 GE GE5063A patent/GEP20043367B/en unknown
- 2001-05-09 CN CNB018133673A patent/CN100457753C/en not_active Expired - Fee Related
- 2001-05-09 SI SI200120051A patent/SI21099A/en not_active IP Right Cessation
- 2001-05-09 BR BR0112674-1A patent/BR0112674A/en not_active Application Discontinuation
- 2001-05-09 WO PCT/US2001/015081 patent/WO2002010162A1/en not_active Ceased
- 2001-05-09 IL IL15359101A patent/IL153591A0/en unknown
- 2001-05-09 MX MXPA03000774A patent/MXPA03000774A/en unknown
- 2001-05-09 EP EP01933266A patent/EP1303513A1/en not_active Withdrawn
- 2001-05-09 HR HR20030116A patent/HRP20030116A2/en not_active Application Discontinuation
- 2001-05-09 JP JP2002515891A patent/JP2004509857A/en not_active Withdrawn
- 2001-05-09 HU HU0303698A patent/HUP0303698A2/en unknown
- 2001-05-09 CZ CZ2003237A patent/CZ2003237A3/en unknown
- 2001-05-09 KR KR10-2003-7001141A patent/KR20030016429A/en not_active Ceased
- 2001-05-09 EE EEP200300041A patent/EE200300041A/en unknown
- 2001-05-09 AU AU2001259704A patent/AU2001259704A1/en not_active Abandoned
- 2001-05-16 TW TW090111741A patent/TWI302533B/en not_active IP Right Cessation
- 2001-05-22 MY MYPI20012414A patent/MY129635A/en unknown
- 2001-05-23 EG EG20010550A patent/EG24409A/en active
- 2001-05-24 AR ARP010102516A patent/AR030563A1/en unknown
2002
- 2002-12-23 IL IL153591A patent/IL153591A/en not_active IP Right Cessation
2003
- 2003-01-16 BG BG107468A patent/BG65132B1/en unknown
- 2003-01-24 NO NO20030394A patent/NO20030394L/en not_active Application Discontinuation
- 2003-02-26 LV LVP-03-24A patent/LV13037B/en unknown

Also Published As

Publication number	Publication date
PL365170A1 (en)	2004-12-27
WO2002010162A1 (en)	2002-02-07
TWI302533B (en)	2008-11-01
SK18392002A3 (en)	2003-09-11
YU4903A (en)	2006-03-03
HUP0303698A2 (en)	2004-04-28
IL153591A0 (en)	2003-07-06
CN100457753C (en)	2009-02-04
EG24409A (en)	2009-05-20
EP1303513A1 (en)	2003-04-23
GEP20043367B (en)	2004-06-10
NO20030394D0 (en)	2003-01-24
NO20030394L (en)	2003-03-03
IL153591A (en)	2009-07-20
MY129635A (en)	2007-04-30
AR030563A1 (en)	2003-08-27
BR0112674A (en)	2003-12-30
LV13037B (en)	2003-11-20
KR20030016429A (en)	2003-02-26
HRP20030116A2 (en)	2005-02-28
BG65132B1 (en)	2007-03-30
SI21099A (en)	2003-06-30
CA2417254A1 (en)	2002-02-07
MXPA03000774A (en)	2003-09-10
CN1444584A (en)	2003-09-24
CZ2003237A3 (en)	2003-06-18
BG107468A (en)	2004-01-30
AU2001259704A1 (en)	2002-02-13
JP2004509857A (en)	2004-04-02

Publication	Publication Date	Title
EE200300041A (en)	2005-04-15	N- [5 - [[[5-alkyl-2-oxazolyl] methyl] thio] -2-thiazolyl] carboxamide inhibitors of cyclin-dependent kinases
DK1240166T3 (en)	2005-06-20	N- [5 - [[[5-alkyl-2-oxazolyl] methyl] thio] -2-thiazolyl] carboxamides as inhibitors of cyclin-dependent kinases
NO20032645D0 (en)	2003-06-11	Heterocyclic sulfonamide inhibitors of <beta> - amyloid production
EE200300015A (en)	2004-10-15	Colchinol derivatives as inhibitors of angiogenesis
NO20024627L (en)	2002-11-22	Inhibition of cyclooxygenase-2 activity
AR028281A1 (en)	2003-04-30	DERIVATIVES OF 2- (ARILALQUILAMINO) PIRIMIDONA AND DERIVATIVES OF 2- (HETEROAROARILALQUILAMINO) PIRIMIDONA
AU2001249670A1 (en)	2001-10-15	Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1
CY2008008I1 (en)	2009-11-04	N-Substituted Hydroxypyrimidinone Carboxamide Inhibitors of HIV Integration
NO20025978L (en)	2002-12-12	Benzothiazole derivatives
ZA200606082B (en)	2008-10-29	Antibody inhibitors of GDF-8 and BMP-11 and uses thereof
DE60115885D1 (en)	2006-01-19	REDUCTION OF SURFACE VOLTAGE
EE200200701A (en)	2004-08-16	Highly concentrated stable solutions of meloxicam
DK1326853T3 (en)	2005-12-12	Novel thiadiazoles and oxadiazoles and their use as inhibitors of phosphodiesterase 7
PT1432685E (en)	2005-07-29	CRYSTALLINE HYDRATES OF NICOTHINIC ACID AND BENZOYLENYLIDAN ANILIDA DERIVATIVES
PT1322592E (en)	2004-12-31	SUBSTITUTED DERIVATIVES OF 1-AMINOBUTAN-3-OL
IS6696A (en)	2003-01-23	N- [5 - [[[5-alkyl-2-oxazolyl] methyl] thio] -2-thiazolyl] carboxamide inhibits cyclin-dependent kinases
PT1392670E (en)	2005-10-31	SUBSTITUTED DERIVATIVES OF C-FURAN-2-IL-METHYLAMINE AND C-THIOFEN-2-IL-METHYLAMINE
NO20030507L (en)	2003-03-26	Tartrate salts of thiazolidinedione derivatives
FI963882L (en)	1996-09-27	Benzothiazole derivatives as inhibitors of 5-lipoxygenase biosynthesis
FI20020292A0 (en)	2002-02-13	Method for Reducing Temperature Dependence of Capacitive Sensor and Capacitive Sensor Design
DK1556378T3 (en)	2008-03-17	Acyl derivatives of 5- (2- (4- (1,2-benzisothiazol-3-yl) -1-piperazinyl) ethyl) -6-chloro-1,3-dihydro-2H-indo-2-one with neuroleptic activity
HK1052930A (en)	2003-10-03	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases
PL360544A1 (en)	2004-09-06	Thiazole derivatives of 2-methoxyimino-2-(pyridinyloxymethyl)-phenyl-acetamides useful as fungicides
NO20030508L (en)	2003-03-20	Tartrate salts of thiazolidinedione derivatives
NO20030530L (en)	2003-02-03	Tartrate salts of thiazolidinedione derivatives