EE200300041A - Tsükliin-sõltuvate kinaaside N-[5-[[[5-alküül-2-oksasolüül]metüül]tio]-2-tiasolüül]karboksamiidinhibiitorid - Google Patents

Tsükliin-sõltuvate kinaaside N-[5-[[[5-alküül-2-oksasolüül]metüül]tio]-2-tiasolüül]karboksamiidinhibiitorid

Info

Publication number: EE200300041A
Authority: EE; Estonia
Prior art keywords: cyclin; oxazolyl; thiazolyl; thio; alkyl
Prior art date: 2000-07-26

Application number

EEP200300041A

Other languages

English (en)

Inventor

N. Misra Raj

Xiao Hai-Yun

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-26

Filing date

2001-05-09

Publication date

2005-04-15

2000-12-01 Priority claimed from US09/727,957 external-priority patent/US6515004B1/en

2000-12-22 Priority claimed from US09/746,060 external-priority patent/US6414156B2/en

2001-05-09 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

2005-04-15 Publication of EE200300041A publication Critical patent/EE200300041A/et

Links

108091007914 CDKs Proteins 0.000 title 1
102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
125000000446 sulfanediyl group Chemical group *S* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Diabetes (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EEP200300041A 2000-07-26 2001-05-09 Tsükliin-sõltuvate kinaaside N-[5-[[[5-alküül-2-oksasolüül]metüül]tio]-2-tiasolüül]karboksamiidinhibiitorid EE200300041A (et)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US61662700A	2000-07-26	2000-07-26
US09/727,957 US6515004B1 (en)	1999-12-15	2000-12-01	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US09/746,060 US6414156B2 (en)	1998-10-21	2000-12-22	Process for preparing azacycloalkanoylaminothiazoles
PCT/US2001/015081 WO2002010162A1 (en)	2000-07-26	2001-05-09	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases

Publications (1)

Publication Number	Publication Date
EE200300041A true EE200300041A (et)	2005-04-15

Family

ID=27417184

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300041A EE200300041A (et)	2000-07-26	2001-05-09	Tsükliin-sõltuvate kinaaside N-[5-[[[5-alküül-2-oksasolüül]metüül]tio]-2-tiasolüül]karboksamiidinhibiitorid

Country Status (26)

Country	Link
EP (1)	EP1303513A1 (et)
JP (1)	JP2004509857A (et)
KR (1)	KR20030016429A (et)
CN (1)	CN100457753C (et)
AR (1)	AR030563A1 (et)
AU (1)	AU2001259704A1 (et)
BG (1)	BG65132B1 (et)
BR (1)	BR0112674A (et)
CA (1)	CA2417254A1 (et)
CZ (1)	CZ2003237A3 (et)
EE (1)	EE200300041A (et)
EG (1)	EG24409A (et)
GE (1)	GEP20043367B (et)
HR (1)	HRP20030116A2 (et)
HU (1)	HUP0303698A2 (et)
IL (2)	IL153591A0 (et)
LV (1)	LV13037B (et)
MX (1)	MXPA03000774A (et)
MY (1)	MY129635A (et)
NO (1)	NO20030394L (et)
PL (1)	PL365170A1 (et)
SI (1)	SI21099A (et)
SK (1)	SK18392002A3 (et)
TW (1)	TWI302533B (et)
WO (1)	WO2002010162A1 (et)
YU (1)	YU4903A (et)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6414156B2 (en)	1998-10-21	2002-07-02	Bristol-Myers Squibb Company	Process for preparing azacycloalkanoylaminothiazoles
EP2311818B1 (en) *	2002-02-28	2013-01-16	Novartis AG	Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug
AR038703A1 (es)	2002-02-28	2005-01-26	Novartis Ag	Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3
EP1545533A1 (en)	2002-09-04	2005-06-29	Schering Corporation	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en)	2002-09-04	2013-11-12	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en)	2002-09-04	2014-03-18	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
RU2380369C9 (ru)	2002-09-04	2011-07-10	Шеринг Корпорейшн	Новые пиразолопиримидины как ингибиторы циклин-зависимой киназы
JP4799864B2 (ja)	2002-09-23	2011-10-26	シェーリングコーポレイション	サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン
KR20060010709A (ko)	2002-09-23	2006-02-02	쉐링 코포레이션	사이클린 의존성 키나제 억제제로서의 신규한 이미다조피라진
GB0320197D0 (en) *	2003-08-28	2003-10-01	Novartis Ag	Organic compounds
EP1555264A1 (en) *	2004-01-15	2005-07-20	Sireen AG	Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
DE102005008310A1 (de) *	2005-02-17	2006-08-24	Schering Ag	Verwendung von CDKII Inhibitoren zur Fertilitätskontrolle
EP1928865A1 (en) *	2005-08-17	2008-06-11	Schering Corporation	Novel high affinity thiophene-based and furan-based kinase ligands
CA2621983A1 (en)	2005-09-09	2007-03-22	Schering Corporation	Azafused cyclin dependent kinase inhibitors
PE20070543A1 (es)	2005-10-06	2007-06-14	Schering Corp	Pirazolopirimidinas como inhibidores de protein quinasas
JP2009539846A (ja) *	2006-06-06	2009-11-19	ブリストル−ミエルススクイッブカンパニー	Ｎ−［５−［［［５−（１，１−ジメチルエチル）−２−オキサゾリル］メチル］チオ］−２−チアゾリル］−４−ピペリジンカルボキサミドの結晶形
US20090175852A1 (en)	2006-06-06	2009-07-09	Schering Corporation	Imidazopyrazines as protein kinase inhibitors
EP2078003B1 (en)	2006-10-31	2017-03-08	Merck Sharp & Dohme Corp.	Anilinopiperazine derivatives and methods of use thereof
KR20090082440A (ko)	2006-10-31	2009-07-30	쉐링 코포레이션	단백질 키나제 억제제로서의 2-아미노티아졸-4-카복실산 아미드
CA2686848A1 (en)	2007-05-08	2008-11-20	Schering Corporation	Methods of treatment using intravenous formulations comprising temozolomide
TW200922564A (en)	2007-09-10	2009-06-01	Curis Inc	CDK inhibitors containing a zinc binding moiety
WO2010075542A1 (en)	2008-12-23	2010-07-01	Curis, Inc.	Cdk inhibitors
EP2470183B1 (en)	2009-08-26	2015-09-16	Merck Sharp & Dohme Corp.	Heterocyclic amide compounds as protein kinase inhibitors
ES2685709T3 (es)	2012-03-30	2018-10-10	Merck Sharp & Dohme Corp.	Biomarcador predictivo mediado por un inhibidor de CDK útil para la terapia contra el cáncer
EP3078671A4 (en) *	2013-12-04	2017-05-31	Hangzhou Minsheng Institutes for Pharma Research Co., Ltd.	Gemcitabine derivative, composition containing the derivative and pharmaceutical use of the derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6262096B1 (en) *	1997-11-12	2001-07-17	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
US6040321A (en) *	1997-11-12	2000-03-21	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
AU768751B2 (en) *	1998-06-18	2004-01-08	Bristol-Myers Squibb Company	Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) *	1998-10-21	2002-07-02	Bristol-Myers Squibb Company	Process for preparing azacycloalkanoylaminothiazoles
MY125768A (en) *	1999-12-15	2006-08-30	Bristol Myers Squibb Co	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

2001
- 2001-05-09 WO PCT/US2001/015081 patent/WO2002010162A1/en not_active Ceased
- 2001-05-09 SK SK1839-2002A patent/SK18392002A3/sk unknown
- 2001-05-09 HR HR20030116A patent/HRP20030116A2/hr not_active Application Discontinuation
- 2001-05-09 IL IL15359101A patent/IL153591A0/xx unknown
- 2001-05-09 GE GE5063A patent/GEP20043367B/en unknown
- 2001-05-09 CZ CZ2003237A patent/CZ2003237A3/cs unknown
- 2001-05-09 EE EEP200300041A patent/EE200300041A/et unknown
- 2001-05-09 BR BR0112674-1A patent/BR0112674A/pt not_active Application Discontinuation
- 2001-05-09 KR KR10-2003-7001141A patent/KR20030016429A/ko not_active Ceased
- 2001-05-09 AU AU2001259704A patent/AU2001259704A1/en not_active Abandoned
- 2001-05-09 HU HU0303698A patent/HUP0303698A2/hu unknown
- 2001-05-09 CN CNB018133673A patent/CN100457753C/zh not_active Expired - Fee Related
- 2001-05-09 MX MXPA03000774A patent/MXPA03000774A/es unknown
- 2001-05-09 PL PL01365170A patent/PL365170A1/xx not_active Application Discontinuation
- 2001-05-09 JP JP2002515891A patent/JP2004509857A/ja not_active Withdrawn
- 2001-05-09 SI SI200120051A patent/SI21099A/sl not_active IP Right Cessation
- 2001-05-09 YU YU4903A patent/YU4903A/sh unknown
- 2001-05-09 CA CA002417254A patent/CA2417254A1/en not_active Abandoned
- 2001-05-09 EP EP01933266A patent/EP1303513A1/en not_active Withdrawn
- 2001-05-16 TW TW090111741A patent/TWI302533B/zh not_active IP Right Cessation
- 2001-05-22 MY MYPI20012414A patent/MY129635A/en unknown
- 2001-05-23 EG EG20010550A patent/EG24409A/xx active
- 2001-05-24 AR ARP010102516A patent/AR030563A1/es unknown
2002
- 2002-12-23 IL IL153591A patent/IL153591A/en not_active IP Right Cessation
2003
- 2003-01-16 BG BG107468A patent/BG65132B1/bg unknown
- 2003-01-24 NO NO20030394A patent/NO20030394L/no not_active Application Discontinuation
- 2003-02-26 LV LVP-03-24A patent/LV13037B/en unknown

Also Published As

Publication number	Publication date
SI21099A (sl)	2003-06-30
LV13037B (en)	2003-11-20
BG107468A (en)	2004-01-30
TWI302533B (en)	2008-11-01
JP2004509857A (ja)	2004-04-02
BG65132B1 (bg)	2007-03-30
CN1444584A (zh)	2003-09-24
HRP20030116A2 (en)	2005-02-28
SK18392002A3 (sk)	2003-09-11
KR20030016429A (ko)	2003-02-26
GEP20043367B (en)	2004-06-10
IL153591A0 (en)	2003-07-06
YU4903A (sh)	2006-03-03
CA2417254A1 (en)	2002-02-07
AU2001259704A1 (en)	2002-02-13
IL153591A (en)	2009-07-20
NO20030394D0 (no)	2003-01-24
NO20030394L (no)	2003-03-03
EG24409A (en)	2009-05-20
MXPA03000774A (es)	2003-09-10
CN100457753C (zh)	2009-02-04
CZ2003237A3 (cs)	2003-06-18
PL365170A1 (en)	2004-12-27
MY129635A (en)	2007-04-30
HUP0303698A2 (hu)	2004-04-28
EP1303513A1 (en)	2003-04-23
BR0112674A (pt)	2003-12-30
WO2002010162A1 (en)	2002-02-07
AR030563A1 (es)	2003-08-27

Publication	Publication Date	Title
NO20030394L (no)	2003-03-03	N-[5-[[[5-alkyl-2-oksazolyl]metyl]tio]-2-tiazolyl]karboksamid-inhibitorer for cyklin-avhengige kinaser
DK1240166T3 (da)	2005-06-20	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamider som inhibitorer for cyclin-afhængige kinaser
NO20032645L (no)	2003-08-05	Heterocykliske sulfonamidinhibitorer av <beta>- amyloidproduksjonen
EP1496894A4 (en)	2007-06-06	ANGIOGENESIS INHIBITORS
FR20C1039I2 (fr)	2021-08-13	Derives de l'uk-2a
EE200300015A (et)	2004-10-15	Kolhinooli derivaadid kui angiogeneesi inhibiitorid
NO20045220L (no)	2005-01-19	Heterocykliske inhibitorer for kinaser
AR028567A1 (es)	2003-05-14	Nuevos derivados de fenil-propargileter
NO20024627L (no)	2002-11-22	Inhibering av cyklooksygenase-2 aktivitet
AU2001249670A1 (en)	2001-10-15	Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1
CY2008008I1 (el)	2009-11-04	Ν-υποκατεστημενοι υδροξυπυριμιδινονο-καρβοξαμιδικοι ανσατολεις της ιντεγρασης hiv
PT1432685E (pt)	2005-07-29	Hidratos cristalinos de derivados de anilida do acido nicotinico e de benzoilanilida
EP1556089A4 (en)	2008-01-09	INHIBITION OF GENE EXPRESSION WITH MITRNA INFLUENCING AGENTS
NO20023956L (no)	2002-10-07	Priperidin- og piperazinsubstituerte N-hydroksyformamider som inhibitorer av metalloproteinaser
PT1322592E (pt)	2004-12-31	Derivados substituidos de 1-aminobutan-3-ol
NO20041938L (no)	2004-05-11	Anvendelse av fosfodiesterase IV-inhibitorer
IS6696A (is)	2003-01-23	N-[5-[[[5-alkýl-2-oxazólýl]metýl]þíó]-2-þíazólýl]karboxamíð tálmar sýklínháðra kínasa
NO20030507L (no)	2003-03-26	Tartratsalter av tiazolidindionderivater
EP1450810A4 (en)	2005-11-30	XANTHINE INHIBITION
DE60310733D1 (de)	2007-02-08	Prodrug eines beta-lactamase-inhibitors
FI963882L (fi)	1996-09-27	Bentsotiatsolijohdannaiset 5-lipoksigenaasibiosynteesin estoaineina
EP1222308A4 (en)	2005-02-16	INHIBITORS OF HISTONE ACETYL ANTIPROTOZOA TRANSFERASE
FI20020292A0 (fi)	2002-02-13	Menetelmä kapasitiivisen anturin lämpötilariippuvuuden pienentämiseksi sekä kapasitiivinen anturirakenne
HK1052930A (en)	2003-10-03	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases
PL360544A1 (en)	2004-09-06	Thiazole derivatives of 2-methoxyimino-2-(pyridinyloxymethyl)-phenyl-acetamides useful as fungicides