EE9700090A - Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm - Google Patents

Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm

Info

Publication number: EE9700090A
Authority: EE; Estonia
Prior art keywords: interleukin; antagonist; receptor antagonist; new; intracellular isoform
Prior art date: 1994-10-13

Application number

EE9700090A

Other languages

English (en)

Other versions

EE03697B1 (et

Inventor

Colotta Francesco

Muzio Marta

Alberto Mantovani

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-13

Filing date

1995-10-12

Publication date

1997-10-15

1995-10-12 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

1997-10-15 Publication of EE9700090A publication Critical patent/EE9700090A/et

2002-04-15 Publication of EE03697B1 publication Critical patent/EE03697B1/et

Links

239000003407 interleukin 1 receptor blocking agent Substances 0.000 title abstract 2
101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 title 1
229940119178 Interleukin 1 receptor antagonist Drugs 0.000 title 1
102000051628 Interleukin-1 receptor antagonist Human genes 0.000 title 1
102000001708 Protein Isoforms Human genes 0.000 title 1
108010029485 Protein Isoforms Proteins 0.000 title 1
230000003834 intracellular effect Effects 0.000 title 1
239000005557 antagonist Substances 0.000 abstract 3
102000000589 Interleukin-1 Human genes 0.000 abstract 2
108010002352 Interleukin-1 Proteins 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
229940124084 Interleukin 1 antagonist Drugs 0.000 abstract 1
102000003777 Interleukin-1 beta Human genes 0.000 abstract 1
108090000193 Interleukin-1 beta Proteins 0.000 abstract 1
102000004125 Interleukin-1alpha Human genes 0.000 abstract 1
108010082786 Interleukin-1alpha Proteins 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
108020004511 Recombinant DNA Proteins 0.000 abstract 1
230000018276 interleukin-1 production Effects 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
General Engineering & Computer Science (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Rheumatology (AREA)
Microbiology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physics & Mathematics (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)

EE9700090A 1994-10-13 1995-10-12 Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm EE03697B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI942097A IT1270662B (it)	1994-10-13	1994-10-13	Antagonista della interleuchina-1
PCT/EP1995/004023 WO1996012022A1 (en)	1994-10-13	1995-10-12	Intracellular isoform of the interleukin-1 receptor antagonist

Publications (2)

Publication Number	Publication Date
EE9700090A true EE9700090A (et)	1997-10-15
EE03697B1 EE03697B1 (et)	2002-04-15

Family

ID=11369705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700090A EE03697B1 (et)	1994-10-13	1995-10-12	Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm

Country Status (18)

Country	Link
US (1)	US5739282A (et)
EP (1)	EP0786002B1 (et)
JP (1)	JPH10509306A (et)
KR (1)	KR100237936B1 (et)
CN (2)	CN1224707C (et)
AT (1)	ATE303439T1 (et)
BR (1)	BR9509317A (et)
CA (1)	CA2202470C (et)
DE (1)	DE69534419T2 (et)
EE (1)	EE03697B1 (et)
ES (1)	ES2243942T3 (et)
IT (1)	IT1270662B (et)
MX (1)	MX9702616A (et)
NO (1)	NO320494B1 (et)
PT (1)	PT786002E (et)
RU (1)	RU2193064C2 (et)
UA (1)	UA65522C2 (et)
WO (1)	WO1996012022A1 (et)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5075222A (en) *	1988-05-27	1991-12-24	Synergen, Inc.	Interleukin-1 inhibitors
US5872095A (en) *	1990-05-01	1999-02-16	Chiron Corporation	IL-1 receptor antagonists medicaments
EA001866B1 (ru) *	1996-10-31	2001-10-22	Апплайд Резеч Системз Арс Холдинг Н.В.	ПЕПТИД, СПОСОБНЫЙ СВЯЗЫВАТЬСЯ С ИНТЕРЛЕЙКИН-1-beta-КОНВЕРТИРУЮЩИМ ФЕРМЕНТОМ (ICE), И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ЕГО ОСНОВЕ
CA2273852C (en) *	1996-12-06	2009-09-29	Amgen Inc.	Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
US6294170B1 (en)	1997-08-08	2001-09-25	Amgen Inc.	Composition and method for treating inflammatory diseases
IL126562A0 (en) *	1998-10-14	1999-08-17	Interpharm Lab Ltd	Expression and secretion of icil-1 receptor antagonist type ii
US20020077276A1 (en) *	1999-04-27	2002-06-20	Fredeking Terry M.	Compositions and methods for treating hemorrhagic virus infections and other disorders
US7166712B2 (en) *	2000-07-12	2007-01-23	Philadelphia, Health And Education Corporation	Mammalian MDM2 binding proteins and uses thereof
JP4943161B2 (ja) *	2003-12-23	2012-05-30	ジェネンテック，インコーポレイテッド	新規抗ｉｌ１３モノクローナル抗体での癌の処置
ES2706848T3 (es)	2004-07-06	2019-04-01	Zymogenetics Inc	Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso
RU2326947C2 (ru) *	2004-11-23	2008-06-20	Общество с ограниченной ответственностью "ЦИТОКИН"	Способ получения рекомбинантного антагониста рецептора интерлейкина-1 человека "арил"
CN101374864A (zh) *	2006-01-31	2009-02-25	诺瓦提斯公司	用于靶向癌症的il-17拮抗性抗体
EP2217258B1 (en)	2007-11-14	2014-03-26	General Regeneratives Limited	Use of interleukin-1 receptor antagonist as a myeloprotective agent
CN101690801B (zh)	2009-10-26	2012-08-01	上海交通大学	白细胞介素-1受体拮抗剂的用途及其药物组合物
WO2012122985A1 (en)	2011-03-14	2012-09-20	University Of Copenhagen	Antagonists of the interleukin- 1 receptor
DK2859015T3 (en)	2012-06-08	2018-06-18	Alkermes Inc	LIGANDS MODIFIED BY CIRCULAR MODIFICATION AS AGONISTS AND ANTAGONISTS
WO2015191783A2 (en)	2014-06-10	2015-12-17	Abbvie Inc.	Biomarkers for inflammatory disease and methods of using same
EA202191354A1 (ru) *	2018-11-15	2021-08-11	Янссен Байотек, Инк.	Способы и композиции для прогнозирования ответа на терапию воспалительного заболевания кишечника

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0148009B1 (ko) *	1988-05-27	1998-08-01	그래고리 비. 아보트	인터루킨-1 억제제
HUT64582A (en) *	1989-11-29	1994-01-28	Synergen Inc	Method for producing recombinant human interleukin-1 inhibitor
AU649245B2 (en) *	1990-04-02	1994-05-19	Amgen, Inc.	Methods for treating interleukin-1 mediated diseases
AU7683391A (en) *	1990-04-27	1991-11-27	Upjohn Company, The	Modified interleukin-1 inhibitors
EP0534978B1 (en) *	1990-05-01	1999-03-24	Chiron Corporation	Interleukin-1 antagonist and uses thereof

1994
- 1994-10-13 IT ITMI942097A patent/IT1270662B/it active IP Right Grant
1995
- 1995-06-07 US US08/476,860 patent/US5739282A/en not_active Expired - Fee Related
- 1995-10-12 ES ES95936482T patent/ES2243942T3/es not_active Expired - Lifetime
- 1995-10-12 CN CNB951956647A patent/CN1224707C/zh not_active Expired - Fee Related
- 1995-10-12 BR BR9509317A patent/BR9509317A/pt not_active Application Discontinuation
- 1995-10-12 EP EP95936482A patent/EP0786002B1/en not_active Expired - Lifetime
- 1995-10-12 JP JP8512932A patent/JPH10509306A/ja active Pending
- 1995-10-12 WO PCT/EP1995/004023 patent/WO1996012022A1/en not_active Ceased
- 1995-10-12 DE DE69534419T patent/DE69534419T2/de not_active Expired - Fee Related
- 1995-10-12 RU RU97107461/13A patent/RU2193064C2/ru not_active IP Right Cessation
- 1995-10-12 EE EE9700090A patent/EE03697B1/et not_active IP Right Cessation
- 1995-10-12 CN CNB200510053993XA patent/CN100363053C/zh not_active Expired - Fee Related
- 1995-10-12 CA CA002202470A patent/CA2202470C/en not_active Expired - Fee Related
- 1995-10-12 PT PT95936482T patent/PT786002E/pt unknown
- 1995-10-12 AT AT95936482T patent/ATE303439T1/de not_active IP Right Cessation
- 1995-10-12 MX MX9702616A patent/MX9702616A/es not_active IP Right Cessation
- 1995-10-12 KR KR1019970701931A patent/KR100237936B1/ko not_active Expired - Fee Related
- 1995-12-10 UA UA97052129A patent/UA65522C2/uk unknown
1997
- 1997-04-09 NO NO19971624A patent/NO320494B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR970706391A (ko)	1997-11-03
NO971624D0 (no)	1997-04-09
CN1224707C (zh)	2005-10-26
HK1002659A1 (en)	1998-09-11
CA2202470C (en)	2008-09-16
CN1161058A (zh)	1997-10-01
US5739282A (en)	1998-04-14
AU3841795A (en)	1996-05-06
KR100237936B1 (ko)	2000-01-15
UA65522C2 (en)	2004-04-15
NO320494B1 (no)	2005-12-12
DE69534419T2 (de)	2006-06-14
IT1270662B (it)	1997-05-07
ES2243942T3 (es)	2005-12-01
EP0786002B1 (en)	2005-08-31
ATE303439T1 (de)	2005-09-15
AU701471B2 (en)	1999-01-28
JPH10509306A (ja)	1998-09-14
CA2202470A1 (en)	1996-04-25
RU2193064C2 (ru)	2002-11-20
MX9702616A (es)	1998-04-30
ITMI942097A1 (it)	1996-04-13
PT786002E (pt)	2005-11-30
WO1996012022A1 (en)	1996-04-25
NO971624L (no)	1997-05-30
ITMI942097A0 (it)	1994-10-13
CN1679919A (zh)	2005-10-12
BR9509317A (pt)	1997-10-14
CN100363053C (zh)	2008-01-23
HK1081124A1 (zh)	2006-05-12
EE03697B1 (et)	2002-04-15
DE69534419D1 (de)	2005-10-06
EP0786002A1 (en)	1997-07-30

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-10-15	GB1A	Change in the ownership or in the address of the owner
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2010-06-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20091012

Publication	Publication Date	Title
EE03697B1 (et)	2002-04-15	Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm
HUP9702458A2 (hu)	1998-04-28	Humán interleukin-1-receptor járulékos fehérje
ATE262914T1 (de)	2004-04-15	Entzündungsproteine aus makrophagen mip-3, mip-4 und mip-1gamma
FI960727A0 (fi)	1996-02-16	Neurokiniiniantagonisteina käyttökelpoiset heterosyklit
DK0669979T3 (da)	2006-03-06	C-C CKR-1, kemokinreceptor
DE69839992D1 (de)	2008-10-23	Vorbeugende- oder Heilmittel zur Behandlung von Multipler Sklerose, mit antagonistischen anti-IL6-Rezeptor Antikörpern als Wirkstoff
NO900227L (no)	1990-07-18	Ekstruderbar elastisk gel for anvendelse som baerer for terapeutisk middel.
NO975716L (no)	1998-02-04	Imidazolforbindelser
TR199900318T2 (xx)	1999-05-21	IL-8 resept�r antagonistleri.
BR0113213A (pt)	2003-07-08	Método para diagnosticar uma doença auto-imune, anticorpo, composição de diagnóstico, e, uso do anticorpo
ATE245196T1 (de)	2003-08-15	Regulierung der fruchtbarkeit mit transformierendem wachstumfaktor beta
IT1090154B (it)	1985-06-18	Dispositivo vibratore per sedie poltrone letti e simili
TR200103448T2 (tr)	2002-06-21	IL-8 reseptör antagonistleri.
IT8820705A0 (it)	1988-05-24	Procedimento di calibrazione numerica di installazione di radiologia e installazione di calibrazione numerica per la messa in opera del procedimento.
ATE57526T1 (de)	1990-11-15	P-acylaminobenzamide.
IT1294932B1 (it)	1999-04-23	Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
IT8321118U1 (it)	1984-09-15	Struttura di dispositivo implantologico, particolarmente per protesi dentarie e simili.
IT8430790V0 (it)	1984-07-12	Dispositivo orientabile per i comandi di movimento delle poltrone particolarmente per dentisti.
IT8430791V0 (it)	1984-07-12	Dispositivo per la sincronizzazione dello schienale particolarmente per poltrone di dentisti.
KR970017323U (ko)	1997-05-23	에스, 알, 에스 자기 진단장치의 방전구조
KR900020697U (ko)	1990-12-13	초음파 가습기의 진동자용 고무링
IT8921151A0 (it)	1989-07-11	Dispositivo per la determinazione della regolazione di altezza ottimale dello schienale di una sedia per ufficio, in funzione della statura dell'utilizzatore.
IT8485525A0 (it)	1984-02-10	Sistema di fissaggio dell'imbottitura sui fianchi di una poltrona.
IT8920658A0 (it)	1989-05-26	Dispositivo per la determinazione della regolazione di altezza ottimale di una sedia per ufficio in funzione della statura dell'utilizzazione.
ITCT920022A0 (it)	1992-07-27	Test immunoenzimatico competitivo per il rilievo quantitativo del frammento secretorio presente nel siero, nella saliva, nell'urina, nelle lacrime, nel succo gastrico, nel secreto vaginale, nelle feci.