ATE303439T1 - Intrazelluläre isoform von interleukin-1 rezeptor antagonist - Google Patents

Intrazelluläre isoform von interleukin-1 rezeptor antagonist

Info

Publication number: ATE303439T1
Authority: AT; Austria
Prior art keywords: interleukin; antagonist; receptor antagonist; new; intracellular isoform
Prior art date: 1994-10-13

Application number

AT95936482T

Other languages

English (en)

Inventor

Francesco Colotta

Marta Muzio

Alberto Mantovani

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-13

Filing date

1995-10-12

Publication date

2005-09-15

1995-10-12 Application filed by Applied Research Systems filed Critical Applied Research Systems

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE303439T1 publication Critical patent/ATE303439T1/de

Links

239000003407 interleukin 1 receptor blocking agent Substances 0.000 title abstract 2
101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 title 1
229940119178 Interleukin 1 receptor antagonist Drugs 0.000 title 1
102000051628 Interleukin-1 receptor antagonist Human genes 0.000 title 1
102000001708 Protein Isoforms Human genes 0.000 title 1
108010029485 Protein Isoforms Proteins 0.000 title 1
230000003834 intracellular effect Effects 0.000 title 1
239000005557 antagonist Substances 0.000 abstract 3
102000000589 Interleukin-1 Human genes 0.000 abstract 2
108010002352 Interleukin-1 Proteins 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
229940124084 Interleukin 1 antagonist Drugs 0.000 abstract 1
102000003777 Interleukin-1 beta Human genes 0.000 abstract 1
108090000193 Interleukin-1 beta Proteins 0.000 abstract 1
102000004125 Interleukin-1alpha Human genes 0.000 abstract 1
108010082786 Interleukin-1alpha Proteins 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
108020004511 Recombinant DNA Proteins 0.000 abstract 1
230000018276 interleukin-1 production Effects 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Oncology (AREA)
Hematology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Diabetes (AREA)
AIDS & HIV (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physics & Mathematics (AREA)
Pain & Pain Management (AREA)

AT95936482T 1994-10-13 1995-10-12 Intrazelluläre isoform von interleukin-1 rezeptor antagonist ATE303439T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI942097A IT1270662B (it)	1994-10-13	1994-10-13	Antagonista della interleuchina-1
PCT/EP1995/004023 WO1996012022A1 (en)	1994-10-13	1995-10-12	Intracellular isoform of the interleukin-1 receptor antagonist

Publications (1)

Publication Number	Publication Date
ATE303439T1 true ATE303439T1 (de)	2005-09-15

Family

ID=11369705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95936482T ATE303439T1 (de)	1994-10-13	1995-10-12	Intrazelluläre isoform von interleukin-1 rezeptor antagonist

Country Status (18)

Country	Link
US (1)	US5739282A (de)
EP (1)	EP0786002B1 (de)
JP (1)	JPH10509306A (de)
KR (1)	KR100237936B1 (de)
CN (2)	CN100363053C (de)
AT (1)	ATE303439T1 (de)
BR (1)	BR9509317A (de)
CA (1)	CA2202470C (de)
DE (1)	DE69534419T2 (de)
EE (1)	EE03697B1 (de)
ES (1)	ES2243942T3 (de)
IT (1)	IT1270662B (de)
MX (1)	MX9702616A (de)
NO (1)	NO320494B1 (de)
PT (1)	PT786002E (de)
RU (1)	RU2193064C2 (de)
UA (1)	UA65522C2 (de)
WO (1)	WO1996012022A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5075222A (en) *	1988-05-27	1991-12-24	Synergen, Inc.	Interleukin-1 inhibitors
US5872095A (en) *	1990-05-01	1999-02-16	Chiron Corporation	IL-1 receptor antagonists medicaments
US6380162B1 (en) *	1996-10-31	2002-04-30	Applied Research Systems Ars Holding N.V.	Ice inhibiting peptides
ES2312179T3 (es) *	1996-12-06	2009-02-16	Amgen Inc.	Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1.
US6294170B1 (en)	1997-08-08	2001-09-25	Amgen Inc.	Composition and method for treating inflammatory diseases
IL126562A0 (en) *	1998-10-14	1999-08-17	Interpharm Lab Ltd	Expression and secretion of icil-1 receptor antagonist type ii
US20020077276A1 (en) *	1999-04-27	2002-06-20	Fredeking Terry M.	Compositions and methods for treating hemorrhagic virus infections and other disorders
US7166712B2 (en) *	2000-07-12	2007-01-23	Philadelphia, Health And Education Corporation	Mammalian MDM2 binding proteins and uses thereof
PL3718564T3 (pl) *	2003-12-23	2024-03-18	Genentech, Inc.	Nowe przeciwciała anty-IL 13 i ich zastosowania
ES2706848T3 (es)	2004-07-06	2019-04-01	Zymogenetics Inc	Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso
RU2326947C2 (ru) *	2004-11-23	2008-06-20	Общество с ограниченной ответственностью "ЦИТОКИН"	Способ получения рекомбинантного антагониста рецептора интерлейкина-1 человека "арил"
BRPI0706788A2 (pt) *	2006-01-31	2011-04-05	Novartis Ag	anticorpos antagonistas il-17
CN101918018B (zh)	2007-11-14	2012-12-05	再生医药有限公司	使用白介素-1受体拮抗剂作为骨髓保护剂的方法
CN101690801B (zh)	2009-10-26	2012-08-01	上海交通大学	白细胞介素-1受体拮抗剂的用途及其药物组合物
ES2600616T3 (es)	2011-03-14	2017-02-10	Phlogo Aps	Antagonistas del receptor de la interleucina-1
US9156897B2 (en)	2012-06-08	2015-10-13	Alkermes, Inc.	Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide
WO2015191783A2 (en)	2014-06-10	2015-12-17	Abbvie Inc.	Biomarkers for inflammatory disease and methods of using same
EA202191354A1 (ru) *	2018-11-15	2021-08-11	Янссен Байотек, Инк.	Способы и композиции для прогнозирования ответа на терапию воспалительного заболевания кишечника

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0148009B1 (ko) *	1988-05-27	1998-08-01	그래고리 비. 아보트	인터루킨-1 억제제
EP0502956B1 (de) *	1989-11-29	1997-04-23	Amgen Boulder Inc.	Herstellung eines rekombinanten menschlichen interleukin-1-hemmers
AU649245B2 (en) *	1990-04-02	1994-05-19	Amgen, Inc.	Methods for treating interleukin-1 mediated diseases
WO1991017184A1 (en) *	1990-04-27	1991-11-14	The Upjohn Company	Modified interleukin-1 inhibitors
AU655766B2 (en) *	1990-05-01	1995-01-12	Chiron Corporation	Interleukin-1 antagonist and uses thereof

1994
- 1994-10-13 IT ITMI942097A patent/IT1270662B/it active IP Right Grant
1995
- 1995-06-07 US US08/476,860 patent/US5739282A/en not_active Expired - Fee Related
- 1995-10-12 MX MX9702616A patent/MX9702616A/es not_active IP Right Cessation
- 1995-10-12 AT AT95936482T patent/ATE303439T1/de not_active IP Right Cessation
- 1995-10-12 CA CA002202470A patent/CA2202470C/en not_active Expired - Fee Related
- 1995-10-12 EP EP95936482A patent/EP0786002B1/de not_active Expired - Lifetime
- 1995-10-12 RU RU97107461/13A patent/RU2193064C2/ru not_active IP Right Cessation
- 1995-10-12 JP JP8512932A patent/JPH10509306A/ja active Pending
- 1995-10-12 ES ES95936482T patent/ES2243942T3/es not_active Expired - Lifetime
- 1995-10-12 CN CNB200510053993XA patent/CN100363053C/zh not_active Expired - Fee Related
- 1995-10-12 EE EE9700090A patent/EE03697B1/xx not_active IP Right Cessation
- 1995-10-12 BR BR9509317A patent/BR9509317A/pt not_active Application Discontinuation
- 1995-10-12 PT PT95936482T patent/PT786002E/pt unknown
- 1995-10-12 WO PCT/EP1995/004023 patent/WO1996012022A1/en not_active Ceased
- 1995-10-12 KR KR1019970701931A patent/KR100237936B1/ko not_active Expired - Fee Related
- 1995-10-12 CN CNB951956647A patent/CN1224707C/zh not_active Expired - Fee Related
- 1995-10-12 DE DE69534419T patent/DE69534419T2/de not_active Expired - Fee Related
- 1995-12-10 UA UA97052129A patent/UA65522C2/uk unknown
1997
- 1997-04-09 NO NO19971624A patent/NO320494B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69534419D1 (de)	2005-10-06
CA2202470C (en)	2008-09-16
DE69534419T2 (de)	2006-06-14
EP0786002B1 (de)	2005-08-31
IT1270662B (it)	1997-05-07
NO320494B1 (no)	2005-12-12
CA2202470A1 (en)	1996-04-25
NO971624L (no)	1997-05-30
BR9509317A (pt)	1997-10-14
CN100363053C (zh)	2008-01-23
WO1996012022A1 (en)	1996-04-25
KR970706391A (ko)	1997-11-03
NO971624D0 (no)	1997-04-09
RU2193064C2 (ru)	2002-11-20
EP0786002A1 (de)	1997-07-30
CN1679919A (zh)	2005-10-12
ES2243942T3 (es)	2005-12-01
KR100237936B1 (ko)	2000-01-15
JPH10509306A (ja)	1998-09-14
AU701471B2 (en)	1999-01-28
CN1224707C (zh)	2005-10-26
EE9700090A (et)	1997-10-15
MX9702616A (es)	1998-04-30
EE03697B1 (et)	2002-04-15
ITMI942097A0 (it)	1994-10-13
AU3841795A (en)	1996-05-06
ITMI942097A1 (it)	1996-04-13
CN1161058A (zh)	1997-10-01
UA65522C2 (en)	2004-04-15
US5739282A (en)	1998-04-14
HK1002659A1 (en)	1998-09-11
PT786002E (pt)	2005-11-30
HK1081124A1 (zh)	2006-05-12

Legal Events

Date

Code

Title

Description

2006-10-15

UEP

Publication of translation of european patent specification

Ref document number: 0786002

Country of ref document: EP

2010-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE303439T1 (de)	2005-09-15	Intrazelluläre isoform von interleukin-1 rezeptor antagonist
FI960727A0 (fi)	1996-02-16	Neurokiniiniantagonisteina käyttökelpoiset heterosyklit
DK0669979T3 (da)	2006-03-06	C-C CKR-1, kemokinreceptor
PT735818E (pt)	2004-07-30	Proteinas inflamatorias de macrofagos pim-3 pim-4 e pim-1y
DK0751992T3 (da)	2006-03-06	Karendotelvækstfaktor 2
NO900227L (no)	1990-07-18	Ekstruderbar elastisk gel for anvendelse som baerer for terapeutisk middel.
NO975716L (no)	1998-02-04	Imidazolforbindelser
NO963280L (no)	1996-10-04	Anvendelse av anti-TNF antistoffer som legemidler i behandling av sykdommer som involverer forhöyede interleukin-6 serumnivåer
NO306678B1 (no)	1999-12-06	Pyrrolopyrimidiner som CRF-antagonister og farmasöytisk preparat
DK165185D0 (da)	1985-04-12	Hudplejemiddel, specielt til anvendelse i forbindelse med barbering
TR199900318T2 (xx)	1999-05-21	IL-8 resept�r antagonistleri.
TR199700956T1 (xx)	1998-02-21	Indazolkarboksamidler.
TR200103448T2 (tr)	2002-06-21	IL-8 reseptör antagonistleri.
IT1090154B (it)	1985-06-18	Dispositivo vibratore per sedie poltrone letti e simili
ATE28188T1 (de)	1987-07-15	Antikonvulsive mittel.
DK412286A (da)	1987-03-01	4-acylaminobenzamid-derivater, fremgangsmaade til fremstilling heraf samt mellemprodukter til brug ved fremgangsmaaden
IT1294932B1 (it)	1999-04-23	Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
IT8321118U1 (it)	1984-09-15	Struttura di dispositivo implantologico, particolarmente per protesi dentarie e simili.
IT8430790V0 (it)	1984-07-12	Dispositivo orientabile per i comandi di movimento delle poltrone particolarmente per dentisti.
IT8723123A0 (it)	1987-12-21	Metodo per la protezione superficiale di frese diamantate per uso odontoiatrico, e attrezzatura per la sua applicazione.
KR900020697U (ko)	1990-12-13	초음파 가습기의 진동자용 고무링
NO880522D0 (no)	1988-02-05	Brille for toalettsete.