EE9900081A - Protsess kontrastainete valmistamiseks - Google Patents

Protsess kontrastainete valmistamiseks

Info

Publication number: EE9900081A
Authority: EE; Estonia
Prior art keywords: carboxylic acid; contrast media; alkylation; phenyl; making contrast
Prior art date: 1996-08-29

Application number

EEP199900081A

Other languages

English (en)

Inventor

Einar Ingvoldstad Odd

Terje Holmaas Lars

Gulbrandsen Trygve

Original Assignee

Nycomed Imaging As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-29

Filing date

1997-08-29

Publication date

1999-10-15

1997-08-29 Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As

1999-10-15 Publication of EE9900081A publication Critical patent/EE9900081A/et

Links

238000000034 method Methods 0.000 title abstract 2
229940039231 contrast media Drugs 0.000 title 1
239000002872 contrast media Substances 0.000 title 1
238000007126 N-alkylation reaction Methods 0.000 abstract 2
230000010933 acylation Effects 0.000 abstract 2
238000005917 acylation reaction Methods 0.000 abstract 2
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
RWZYAGGXGHYGMB-UHFFFAOYSA-N o-aminobenzenecarboxylic acid Natural products NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 2
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000007791 liquid phase Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Glass Compositions (AREA)
Steroid Compounds (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Exposure Of Semiconductors, Excluding Electron Or Ion Beam Exposure (AREA)
Hydrogenated Pyridines (AREA)

EEP199900081A 1996-08-29 1997-08-29 Protsess kontrastainete valmistamiseks EE9900081A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9618055.9A GB9618055D0 (en)	1996-08-29	1996-08-29	Process
PCT/GB1997/002335 WO1998008805A1 (en)	1996-08-29	1997-08-29	Process for the preparation of contrast agents

Publications (1)

Publication Number	Publication Date
EE9900081A true EE9900081A (et)	1999-10-15

Family

ID=10799119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900081A EE9900081A (et)	1996-08-29	1997-08-29	Protsess kontrastainete valmistamiseks

Country Status (21)

Country	Link
EP (1)	EP0923537B1 (et)
JP (1)	JP4113587B2 (et)
KR (1)	KR100539647B1 (et)
CN (1)	CN1092182C (et)
AT (1)	ATE207880T1 (et)
AU (1)	AU717842B2 (et)
BG (1)	BG103288A (et)
BR (1)	BR9711358A (et)
CA (1)	CA2263426A1 (et)
CZ (1)	CZ296230B6 (et)
DE (1)	DE69707901T2 (et)
EE (1)	EE9900081A (et)
ES (1)	ES2167014T3 (et)
GB (1)	GB9618055D0 (et)
HU (1)	HUP9903852A3 (et)
IL (1)	IL128685A0 (et)
NO (1)	NO322141B1 (et)
NZ (1)	NZ334818A (et)
PL (1)	PL193698B1 (et)
SK (1)	SK26399A3 (et)
WO (1)	WO1998008805A1 (et)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9618056D0 (en) *	1996-08-29	1996-10-09	Nycomed Imaging As	Process
GB9903109D0 (en)	1999-02-11	1999-04-07	Nycomed Imaging As	Process
ITMI20010773A1 (it) *	2001-04-11	2002-10-11	Chemi Spa	Processo per la produzione di ioexolo ad elevata purezza
CN100344606C (zh) *	2005-12-28	2007-10-24	江苏省原子医学研究所	一种碘昔兰的制备方法
US20110021822A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
CN103058880B (zh) *	2011-10-21	2015-08-05	连云港润众制药有限公司	碘克沙醇及其合成中间体的制备方法
EP3077368B1 (en) *	2013-12-06	2018-07-11	GE Healthcare AS	Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
ES2683712T3 (es) *	2013-12-06	2018-09-27	Ge Healthcare As	Proceso alternativo para la purificación de un intermedio en la síntesis de agentes de contraste de rayos X no iónicos
CN104356023B (zh) *	2014-10-29	2016-04-13	武汉工程大学	一种碘曲仑的制备方法
CN118993930A (zh) *	2024-10-24	2024-11-22	南昌大学	一种碘佛醇水解物连续流合成工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2132530B1 (et) *	1971-04-07	1974-08-02	Guerbet Lab Andre
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
DK162045C (da) *	1982-10-01	1992-02-10	Nyegaard & Co As	Trijodbenzenderivater, fremgangsmaade til fremstilling deraf og radiologiske praeparater indeholdende saadanne forbindelser
US4584401A (en) *	1983-10-20	1986-04-22	Biophysica Foundation	Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
JPH0813794B2 (ja) *	1985-08-09	1996-02-14	クツクイマジング，インコ−ポレイテイド	イオン性コントラスト媒体からの非イオン性ポリオ−ルコントラスト媒体

1996
- 1996-08-29 GB GBGB9618055.9A patent/GB9618055D0/en active Pending
1997
- 1997-08-29 ES ES97937743T patent/ES2167014T3/es not_active Expired - Lifetime
- 1997-08-29 IL IL12868597A patent/IL128685A0/xx unknown
- 1997-08-29 AT AT97937743T patent/ATE207880T1/de not_active IP Right Cessation
- 1997-08-29 EP EP97937743A patent/EP0923537B1/en not_active Expired - Lifetime
- 1997-08-29 KR KR10-1999-7001685A patent/KR100539647B1/ko not_active Expired - Lifetime
- 1997-08-29 BR BR9711358A patent/BR9711358A/pt not_active Application Discontinuation
- 1997-08-29 HU HU9903852A patent/HUP9903852A3/hu unknown
- 1997-08-29 CN CN97197523A patent/CN1092182C/zh not_active Expired - Lifetime
- 1997-08-29 JP JP51140198A patent/JP4113587B2/ja not_active Expired - Lifetime
- 1997-08-29 CA CA002263426A patent/CA2263426A1/en not_active Abandoned
- 1997-08-29 PL PL97331821A patent/PL193698B1/pl unknown
- 1997-08-29 SK SK263-99A patent/SK26399A3/sk unknown
- 1997-08-29 CZ CZ0067099A patent/CZ296230B6/cs not_active IP Right Cessation
- 1997-08-29 EE EEP199900081A patent/EE9900081A/et unknown
- 1997-08-29 NZ NZ334818A patent/NZ334818A/xx unknown
- 1997-08-29 AU AU40267/97A patent/AU717842B2/en not_active Ceased
- 1997-08-29 DE DE69707901T patent/DE69707901T2/de not_active Expired - Lifetime
- 1997-08-29 WO PCT/GB1997/002335 patent/WO1998008805A1/en not_active Ceased
1999
- 1999-02-25 NO NO19990890A patent/NO322141B1/no not_active IP Right Cessation
- 1999-03-26 BG BG103288A patent/BG103288A/xx unknown

Also Published As

Publication number	Publication date
SK26399A3 (en)	2000-03-13
CZ67099A3 (cs)	1999-08-11
CZ296230B6 (cs)	2006-02-15
EP0923537B1 (en)	2001-10-31
AU4026797A (en)	1998-03-19
KR20000035944A (ko)	2000-06-26
PL331821A1 (en)	1999-08-02
CN1092182C (zh)	2002-10-09
KR100539647B1 (ko)	2005-12-29
DE69707901D1 (de)	2001-12-06
NO322141B1 (no)	2006-08-21
PL193698B1 (pl)	2007-03-30
HUP9903852A3 (en)	2001-08-28
JP2000517313A (ja)	2000-12-26
CA2263426A1 (en)	1998-03-05
JP4113587B2 (ja)	2008-07-09
NO990890D0 (no)	1999-02-25
GB9618055D0 (en)	1996-10-09
NO990890L (no)	1999-02-25
CN1228762A (zh)	1999-09-15
BR9711358A (pt)	1999-08-17
AU717842B2 (en)	2000-04-06
BG103288A (en)	2000-01-31
IL128685A0 (en)	2000-01-31
EP0923537A1 (en)	1999-06-23
DE69707901T2 (de)	2002-07-18
HUP9903852A2 (hu)	2000-03-28
ES2167014T3 (es)	2002-05-01
NZ334818A (en)	2000-08-25
WO1998008805A1 (en)	1998-03-05
ATE207880T1 (de)	2001-11-15

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