EE9900612A - Inimese papilloomiviiruse stabiliseeritud preparaadid - Google Patents

Inimese papilloomiviiruse stabiliseeritud preparaadid

Info

Publication number: EE9900612A
Authority: EE; Estonia
Prior art keywords: human papillomavirus; stabilized preparations; formulations; hpv; polysorbate
Prior art date: 1997-04-08

Application number

EEP199900612A

Other languages

English (en)

Estonian (et)

Inventor

Sanyal Gautum

B. Volkin David

Shi Li

Original Assignee

Merck & Co., Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-08

Filing date

1998-04-07

Publication date

2000-08-15

1997-05-07 Priority claimed from GBGB9709351.2A external-priority patent/GB9709351D0/en

1998-04-07 Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.

2000-08-15 Publication of EE9900612A publication Critical patent/EE9900612A/xx

Links

241000701806 Human papillomavirus Species 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
238000009472 formulation Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000000427 antigen Substances 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000002736 nonionic surfactant Substances 0.000 abstract 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
229920000136 polysorbate Polymers 0.000 abstract 1
229920000053 polysorbate 80 Polymers 0.000 abstract 1
229940068968 polysorbate 80 Drugs 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1
230000004845 protein aggregation Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Plant Substances (AREA)

EEP199900612A 1997-04-08 1998-04-07 Inimese papilloomiviiruse stabiliseeritud preparaadid EE9900612A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4280897P	1997-04-08	1997-04-08
GBGB9709351.2A GB9709351D0 (en)	1997-05-07	1997-05-07	Stabilized human papillomavirus formulations
PCT/US1998/006825 WO1998044944A2 (fr)	1997-04-08	1998-04-07	Formulations stabilisees du virus du papillome humain

Publications (1)

Publication Number	Publication Date
EE9900612A true EE9900612A (et)	2000-08-15

Family

ID=26311501

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900612A EE9900612A (et)	1997-04-08	1998-04-07	Inimese papilloomiviiruse stabiliseeritud preparaadid

Country Status (18)

Country	Link
EP (1)	EP0973546B1 (fr)
JP (1)	JP4598201B2 (fr)
KR (1)	KR20010006169A (fr)
CN (1)	CN1259051A (fr)
AT (1)	ATE261734T1 (fr)
AU (1)	AU739829B2 (fr)
CA (1)	CA2286294A1 (fr)
DE (1)	DE69822452T2 (fr)
DK (1)	DK0973546T3 (fr)
EE (1)	EE9900612A (fr)
ES (1)	ES2216280T3 (fr)
IL (1)	IL132201A0 (fr)
NO (1)	NO994879L (fr)
NZ (1)	NZ500028A (fr)
PL (1)	PL336715A1 (fr)
PT (1)	PT973546E (fr)
SK (1)	SK138199A3 (fr)
WO (1)	WO1998044944A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPP765398A0 (en) *	1998-12-11	1999-01-14	University Of Queensland, The	Treatment of papillomavirus infections
AU764138B2 (en)	1999-02-05	2003-08-14	Merck Sharp & Dohme Corp.	Human papilloma virus vaccine formulations
US6245568B1 (en) *	1999-03-26	2001-06-12	Merck & Co., Inc.	Human papilloma virus vaccine with disassembled and reassembled virus-like particles
DE10137102A1 (de)	2001-07-30	2003-02-27	Deutsches Krebsforsch	Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung
GB0206360D0 (en)	2002-03-18	2002-05-01	Glaxosmithkline Biolog Sa	Viral antigens
TW200806315A (en) *	2006-04-26	2008-02-01	Wyeth Corp	Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
EP2066354B1 (fr)	2006-09-29	2013-04-17	Ligocyte Pharmaceuticals, Inc.	Formulations de vaccin contre un norovirus
CN104740624B (zh)	2007-09-18	2018-04-24	武田疫苗股份有限公司	赋予针对诺如病毒的保护性免疫应答的疫苗
WO2009092113A2 (fr) *	2008-01-19	2009-07-23	Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methodes et compositions d'administration de vaccins dans un epithelium rompu
CN106822883A (zh) *	2010-12-14	2017-06-13	葛兰素史密丝克莱恩生物有限公司	分枝杆菌抗原组合物
CN102085354A (zh) *	2010-12-30	2011-06-08	重庆大学	一种治疗人乳头瘤病毒16型引发的肿瘤的多肽药物
EP4112074A1 (fr)	2011-07-11	2023-01-04	Takeda Vaccines, Inc.	Formulations de vaccin parentéral contre un norovirus
CN105177025B (zh) *	2013-12-03	2022-11-01	北京康乐卫士生物技术股份有限公司	18型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN107002085A (zh) *	2014-09-11	2017-08-01	卡迪拉保健有限公司	具有优异免疫学特性的优异的人乳头瘤病毒抗原和含有其的疫苗
CN106399329B (zh) *	2015-08-12	2021-06-11	北京康乐卫士生物技术股份有限公司	33型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN106701797B (zh) *	2015-08-12	2021-06-15	北京康乐卫士生物技术股份有限公司	31型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN108201623A (zh) *	2016-12-19	2018-06-26	无锡鑫连鑫生物医药科技有限公司	人乳头瘤病毒重组四价疫苗、其制备方法及其应用
JP7688576B6 (ja) *	2018-11-28	2025-07-04	ザジェネラルホスピタルコーポレイション	共生ウイルスに対するｔ細胞指向性抗がんワクチン

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2949031A1 (de) *	1978-12-15	1980-07-17	Sandoz Ag	Vakzine
US4606918A (en) *	1983-08-22	1986-08-19	Syntex (U.S.A.) Inc.	Polyoxypropylene-polyoxyethylene block polymer based adjuvants
JPS63239234A (ja) *	1988-01-14	1988-10-05	Green Cross Corp:The	ワクチン製剤
JPH085803B2 (ja) *	1988-11-10	1996-01-24	武田薬品工業株式会社	日本脳炎ワクチンの製造法
JP3814290B2 (ja) *	1993-12-09	2006-08-23	エスクナー，ハインリッヒ	抗原用のアジュバントおよびその製法ならびに用途
AUPM566794A0 (en) *	1994-05-17	1994-06-09	University Of Queensland, The	Process and product
AR004464A1 (es) *	1994-11-14	1998-12-16	Merck Sharp & Dohme	Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) *	1995-03-22	2005-11-20	Merck & Co Inc	Dna encoding human papillomavirus type 18
IL117591A0 (en) *	1995-03-30	1996-07-23	Merck & Co Inc	Synthetic DNA encoding human papillomavirus type 11 L1 protein
US5718904A (en) *	1995-06-02	1998-02-17	American Home Products Corporation	Adjuvants for viral vaccines

1998
- 1998-04-07 PT PT98915319T patent/PT973546E/pt unknown
- 1998-04-07 KR KR1019997009248A patent/KR20010006169A/ko not_active Withdrawn
- 1998-04-07 PL PL98336715A patent/PL336715A1/xx unknown
- 1998-04-07 WO PCT/US1998/006825 patent/WO1998044944A2/fr not_active Ceased
- 1998-04-07 SK SK1381-99A patent/SK138199A3/sk unknown
- 1998-04-07 EP EP98915319A patent/EP0973546B1/fr not_active Expired - Lifetime
- 1998-04-07 IL IL13220198A patent/IL132201A0/xx unknown
- 1998-04-07 ES ES98915319T patent/ES2216280T3/es not_active Expired - Lifetime
- 1998-04-07 EE EEP199900612A patent/EE9900612A/xx unknown
- 1998-04-07 CA CA002286294A patent/CA2286294A1/fr not_active Abandoned
- 1998-04-07 CN CN98805728A patent/CN1259051A/zh active Pending
- 1998-04-07 AU AU69533/98A patent/AU739829B2/en not_active Ceased
- 1998-04-07 NZ NZ500028A patent/NZ500028A/en unknown
- 1998-04-07 AT AT98915319T patent/ATE261734T1/de not_active IP Right Cessation
- 1998-04-07 DK DK98915319T patent/DK0973546T3/da active
- 1998-04-07 JP JP54301498A patent/JP4598201B2/ja not_active Expired - Fee Related
- 1998-04-07 DE DE69822452T patent/DE69822452T2/de not_active Expired - Lifetime
1999
- 1999-10-07 NO NO994879A patent/NO994879L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL132201A0 (en)	2001-03-19
DK0973546T3 (da)	2004-06-28
CN1259051A (zh)	2000-07-05
EP0973546A2 (fr)	2000-01-26
NO994879L (no)	1999-12-07
KR20010006169A (ko)	2001-01-26
DE69822452D1 (de)	2004-04-22
ES2216280T3 (es)	2004-10-16
PT973546E (pt)	2004-06-30
WO1998044944A3 (fr)	1998-12-30
JP4598201B2 (ja)	2010-12-15
PL336715A1 (en)	2000-07-03
SK138199A3 (en)	2000-06-12
AU739829B2 (en)	2001-10-18
EP0973546B1 (fr)	2004-03-17
DE69822452T2 (de)	2006-04-20
WO1998044944A2 (fr)	1998-10-15
ATE261734T1 (de)	2004-04-15
AU6953398A (en)	1998-10-30
NO994879D0 (no)	1999-10-07
NZ500028A (en)	2001-08-31
CA2286294A1 (fr)	1998-10-15
JP2001519814A (ja)	2001-10-23

Publication	Publication Date	Title
EE9900612A (et)	2000-08-15	Inimese papilloomiviiruse stabiliseeritud preparaadid
TR200302105T4 (tr)	2004-02-23	Siklosporin, hiyalüronik asit ve polisorbat içeren göz formülasyonları.
JO3404B1 (ar)	2019-10-20	تركيبة صيدلانية سائلة تحتوي على مشتقات اريثروبويتين
DE69531314D1 (de)	2003-08-21	Verwendung von metallionen chelatoren zur stabilisierung von interferon-enthaltenden pharmazeutischen zubereitungen
EP0731712A4 (fr)	2005-11-09	Compositions physiologiquement stables d'acide butyrique, de sels et de derives d'acide butyrique, utilisees comme agents antineoplasiques
NO20004721L (no)	2000-09-21	Bruseformuleringer
CY1113609T1 (el)	2015-08-05	ΔΙΑΛΥΤΟΤΗΤΑ ΙFΝ-ΒΗΤΑ-1b ΣΕ ΔΙΑΛΥΜΑΤΑ ΧΛΩΡΙΟΥΧΟΥ ΝΑΤΡΙΟΥ
IL117990A (en)	2001-01-28	Emulsion suitable for administering a poorly water-soluble photosensitizing compound and use thereof
GB2359747B (en)	2002-04-24	Anaesthetic formulations
DK1079803T3 (da)	2004-11-22	Proteinholdige præparater
CA2060560A1 (fr)	1992-08-04	Methode pour assurer un apport suffisant en glutathione intracellulaire dans les tissus
SE9402880D0 (sv)	1994-08-30	New peptide derivatives
DE69933875D1 (de)	2006-12-14	Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt.
EP1269978A3 (fr)	2003-05-07	Utilisation de dérivés de la bis-resorcinyl triazine dans des préparations cosmétiques ou dermatologiques
UY27373A1 (es)	2003-02-28	Formulaciones de interferón beta-humano
DE69736779D1 (de)	2006-11-16	Zusammensetzungen von rekombinanten papillomavirus vakzinen
ATE301453T1 (de)	2005-08-15	Injizierbare arzneiformulierungen von partricin derivaten
ATE263576T1 (de)	2004-04-15	Prostaglandine und benzylalcohol enthaltende lösung
SE8402199L (sv)	1984-10-23	Farmaceutiskt preparat innehallande co-dergocrin och en kalciumantagonist
EA199900915A1 (ru)	2000-06-26	Стабилизированные композиции вируса папилломы человека
NO911788D0 (no)	1991-05-07	Galeniske vandige preparater av erytropoietin.
SE9904132D0 (sv)	1999-11-16	Pharmaceutical composition for treatment of diarrhea
RU94032143A (ru)	1996-08-20	Композиция, содержащая препарат коагуляционного фактора viii, способ ее получения и применение поверхностно-активного вещества в качестве стабилизатора
TR199801018A2 (xx)	1999-11-22	Burun içine uygulama için bir spreyli besleyici içindeki, calcitonin içeren farmasötik terkipler.