EG20396A - Process for preparing of 5-aryundole derivatives - Google Patents

Process for preparing of 5-aryundole derivatives

Info

Publication number
EG20396A
EG20396A EG69793A EG69793A EG20396A EG 20396 A EG20396 A EG 20396A EG 69793 A EG69793 A EG 69793A EG 69793 A EG69793 A EG 69793A EG 20396 A EG20396 A EG 20396A
Authority
EG
Egypt
Prior art keywords
alkyl
aryl
hydrogen
ring
membered
Prior art date
Application number
EG69793A
Other languages
English (en)
Inventor
John E Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG20396A publication Critical patent/EG20396A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
EG69793A 1992-11-02 1993-11-02 Process for preparing of 5-aryundole derivatives EG20396A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02

Publications (1)

Publication Number Publication Date
EG20396A true EG20396A (en) 1999-02-28

Family

ID=25517470

Family Applications (1)

Application Number Title Priority Date Filing Date
EG69793A EG20396A (en) 1992-11-02 1993-11-02 Process for preparing of 5-aryundole derivatives

Country Status (27)

Country Link
US (1) US5886008A (mo)
EP (2) EP0666858B1 (mo)
JP (1) JP2788551B2 (mo)
KR (1) KR0163371B1 (mo)
CN (1) CN1051313C (mo)
AT (1) ATE202102T1 (mo)
AU (1) AU685066B2 (mo)
BR (1) BR9307348A (mo)
CA (2) CA2148380C (mo)
CZ (1) CZ283001B6 (mo)
DE (1) DE69330351T2 (mo)
DK (1) DK0666858T3 (mo)
EG (1) EG20396A (mo)
ES (1) ES2157224T3 (mo)
FI (2) FI111257B (mo)
GR (1) GR3036579T3 (mo)
HU (1) HU222235B1 (mo)
IL (1) IL107386A (mo)
MY (1) MY109696A (mo)
NO (1) NO309652B1 (mo)
NZ (1) NZ257059A (mo)
PL (1) PL176091B1 (mo)
PT (1) PT666858E (mo)
RU (1) RU2134266C1 (mo)
TW (1) TW251284B (mo)
WO (1) WO1994010171A1 (mo)
ZA (1) ZA938137B (mo)

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PL337888A1 (en) 1997-07-03 2000-09-11 Du Pont Pharm Co Imidazoprimidines and imidazopyridines for use in treating neurological disorders
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6353008B1 (en) * 1998-06-30 2002-03-05 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
US20040102360A1 (en) * 2002-10-30 2004-05-27 Barnett Stanley F. Combination therapy
EP1558586B1 (en) 2002-10-30 2011-03-30 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
AU2004233827B2 (en) 2003-04-24 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
DE10337184A1 (de) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
SG131944A1 (en) * 2003-08-21 2007-05-28 Osi Pharm Inc N3-substituted imidazopyridine-derivatives as c-kit inhibitors
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
EP1673087B1 (en) 2003-10-03 2015-05-13 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
EP1687307B1 (en) 2003-11-25 2016-01-06 3M Innovative Properties Company Substituted imidazo ring systems and methods
DE102004014304A1 (de) * 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CN101405285B (zh) * 2006-03-22 2012-10-10 詹森药业有限公司 作为mdm2和p53间相互作用的抑制剂的环状-烷基胺衍生物
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
MA41988B1 (fr) 2015-04-29 2021-03-31 Janssen Pharmaceutica Nv Azabenzimidazoles et leur utilisation comme modulateurs du recepteur ampa
BR112017023200A2 (pt) 2015-04-29 2018-08-07 Janssen Pharmaceutica Nv compostos de indolona e seu uso como moduladores do receptor de ampa
KR20170141768A (ko) 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 이미다조피라진 및 피라졸로피리미딘 및 ampa 수용체 조절제로서의 이의 용도
EP3288936B1 (en) 2015-04-29 2020-05-06 Janssen Pharmaceutica NV Benzimidazolone and benzothiazolone compounds and their use as ampa receptor modulators
MX384391B (es) 2015-05-22 2025-03-14 Agenebio Inc Composiciones farmacéuticas de levetiracetam de liberación extendida.
RU2727179C2 (ru) 2015-11-06 2020-07-21 Ф. Хоффманн-Ля Рош Аг Производные индолин-2-она
JP6857653B2 (ja) 2015-11-06 2021-04-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ及び関連障害の治療において使用するためのインドリン−２−オン誘導体
EP3371174B1 (en) 2015-11-06 2021-03-17 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives
WO2017076932A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
CN111822047B (zh) * 2020-07-17 2022-05-27 曲阜师范大学 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法
WO2025104491A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto
WO2025104490A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

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CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
DE69132691T2 (de) * 1990-06-07 2002-06-20 Astrazeneca Ab, Soedertaelje Indolderivate als 5-HT1-like Agonisten
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Also Published As

Publication number Publication date
US5886008A (en) 1999-03-23
WO1994010171A1 (en) 1994-05-11
KR0163371B1 (ko) 1998-12-01
DE69330351T2 (de) 2001-09-20
PL176091B1 (pl) 1999-04-30
HU222235B1 (hu) 2003-05-28
DK0666858T3 (da) 2001-08-27
MY109696A (en) 1997-04-30
IL107386A (en) 1999-03-12
FI934825L (fi) 1994-05-03
GR3036579T3 (en) 2001-12-31
AU5329494A (en) 1994-05-24
CZ110895A3 (en) 1995-11-15
EP0666858B1 (en) 2001-06-13
FI111257B (fi) 2003-06-30
ES2157224T3 (es) 2001-08-16
NZ257059A (en) 1997-07-27
DE69330351D1 (de) 2001-07-19
RU2134266C1 (ru) 1999-08-10
NO951633L (no) 1995-04-28
EP0666858A1 (en) 1995-08-16
KR950704313A (ko) 1995-11-17
NO951633D0 (no) 1995-04-28
ATE202102T1 (de) 2001-06-15
TW251284B (mo) 1995-07-11
NO309652B1 (no) 2001-03-05
CA2340999A1 (en) 1994-05-11
ZA938137B (en) 1995-05-02
EP1094064A1 (en) 2001-04-25
HUT66011A (en) 1994-08-29
FI20002505A7 (fi) 2000-11-15
CA2340999C (en) 2005-01-04
AU685066B2 (en) 1998-01-15
CZ283001B6 (cs) 1997-12-17
CN1094727A (zh) 1994-11-09
JPH07508759A (ja) 1995-09-28
RU95109927A (ru) 1997-01-10
CA2148380C (en) 2001-08-14
CA2148380A1 (en) 1994-05-11
PL308669A1 (en) 1995-08-21
PT666858E (pt) 2001-09-28
FI20002505L (fi) 2000-11-15
BR9307348A (pt) 1999-05-11
JP2788551B2 (ja) 1998-08-20
FI934825A0 (fi) 1993-11-01
IL107386A0 (en) 1994-01-25
CN1051313C (zh) 2000-04-12

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