EG20476A - Process for preparing of n,n'- substituted imidodicarboninidic diamides derived from hydroxylamines - Google Patents

Process for preparing of n,n'- substituted imidodicarboninidic diamides derived from hydroxylamines

Info

Publication number: EG20476A
Authority: EG; Egypt
Prior art keywords: group; carbon atoms; mono; substituted; salts
Prior art date: 1992-02-14

Application number

EG7993A

Other languages

English (en)

Original Assignee

Jacobus Pharma Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-14

Filing date

1993-02-11

Publication date

1999-05-31

1993-02-11 Application filed by Jacobus Pharma Co Inc filed Critical Jacobus Pharma Co Inc

1999-05-31 Application granted granted Critical

1999-05-31 Publication of EG20476A publication Critical patent/EG20476A/xx

Links

150000001470 diamides Chemical class 0.000 title 1
150000002443 hydroxylamines Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 6
150000003839 salts Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
208000015181 infectious disease Diseases 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
241000187488 Mycobacterium sp. Species 0.000 abstract 1
241001442539 Plasmodium sp. Species 0.000 abstract 1
241000233872 Pneumocystis carinii Species 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/13—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Compositions Of Macromolecular Compounds (AREA)
Paints Or Removers (AREA)
Detergent Compositions (AREA)
Luminescent Compositions (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Seasonings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

EG7993A 1992-02-14 1993-02-11 Process for preparing of n,n'- substituted imidodicarboninidic diamides derived from hydroxylamines EG20476A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/837,258 US5322858A (en)	1992-02-14	1992-02-14	N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines

Publications (1)

Publication Number	Publication Date
EG20476A true EG20476A (en)	1999-05-31

Family

ID=25273975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG7993A EG20476A (en)	1992-02-14	1993-02-11	Process for preparing of n,n'- substituted imidodicarboninidic diamides derived from hydroxylamines

Country Status (25)

Country	Link
US (1)	US5322858A (de)
EP (1)	EP0625967B1 (de)
JP (1)	JP3207200B2 (de)
KR (1)	KR950700243A (de)
CN (1)	CN1057520C (de)
AT (1)	ATE157352T1 (de)
AU (1)	AU668709B2 (de)
CA (1)	CA2129430C (de)
CZ (1)	CZ294257B6 (de)
DE (1)	DE69313438T2 (de)
DK (1)	DK0625967T3 (de)
EG (1)	EG20476A (de)
ES (1)	ES2108862T3 (de)
FI (1)	FI943738A7 (de)
GR (1)	GR3025429T3 (de)
HU (1)	HU220389B (de)
IL (1)	IL104484A (de)
MX (1)	MX9300688A (de)
NO (1)	NO302616B1 (de)
NZ (1)	NZ245865A (de)
OA (1)	OA10094A (de)
PL (2)	PL172001B1 (de)
RU (1)	RU2133737C1 (de)
WO (1)	WO1993016037A1 (de)
ZA (1)	ZA93974B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4321444A1 (de) *	1993-06-28	1995-01-05	Bernd Prof Dr Clement	Pharmazeutische Zubereitung
US6551614B2 (en) *	2001-03-14	2003-04-22	Jacobus Pharmaceutical Co., Inc.	Antimalarial N,N′-substituted biguanides derived from hydroxylamines
EP1483283A4 (de)	2002-03-13	2007-04-11	Signum Biosciences Inc	Modulation der proteinmethylierung und phosphoproteinphosphat
US7256218B2 (en) *	2002-11-22	2007-08-14	Jacobus Pharmaceutical Company, Inc.	Biguanide and dihydrotriazine derivatives
CN1738794B (zh) *	2002-11-22	2010-12-22	雅各布斯制药公司	双胍和二氢三嗪衍生物
CA2601777A1 (en) *	2005-02-03	2006-08-10	Signum Biosciences, Inc.	Compositions and methods for enhancing cognitive function
US7923041B2 (en)	2005-02-03	2011-04-12	Signum Biosciences, Inc.	Compositions and methods for enhancing cognitive function
EP3546452A1 (de)	2007-10-08	2019-10-02	MMV Medicines for Malaria Venture	Antimalaria-verbindungen mit flexiblen seitenketten
KR20100098602A (ko) *	2007-10-13	2010-09-08	코넬 유니버시티	마이코박테리움 아비움 아종 파라투베르쿨로시스에 대한 면역 응답을 유발하기 위한 조성물
AU2009239430B2 (en)	2008-04-21	2015-01-22	Signum Biosciences, Inc.	Compounds, compositions and methods for making the same
US20090280069A1 (en) *	2008-05-09	2009-11-12	Tolmar, Inc.	Proguanil to treat skin/mucosal diseases
US10829440B2 (en)	2015-06-12	2020-11-10	Brown University	Antibacterial compounds and methods of making and using same
US11261157B2 (en)	2016-12-08	2022-03-01	Novatarg, Inc.	Fused bicyclic alkylene linked imidodicarbonimidic diamides, methods for synthesis, and uses in therapy
US11555010B2 (en)	2019-07-25	2023-01-17	Brown University	Diamide antimicrobial agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB603070A (en) *	1946-01-25	1948-06-08	Albert Frederick Crowther	Manufacture of biguanide derivatives
GB665680A (en) *	1948-02-20	1952-01-30	Rhone Poulenc Sa	Improvements in or relating to the production of n-p-chlorophenyl-n-isopropyl biguanide
DE824942C (de) *	1949-01-31	1951-12-17	Ici Ltd	Verfahren zur Herstellung von Biguanidderivaten
GB667116A (en) *	1949-04-25	1952-02-27	Albert Frederick Crowther	Manufacture of biguanide derivatives
GB814563A (en) *	1956-11-15	1959-06-10	Vitamins Ltd	Biguanides
GB1270831A (en) *	1968-11-22	1972-04-19	Beecham Group Ltd	Di-hydro triazine derivatives and processes for their manufacture
GB1250531A (de) *	1969-01-01	1971-10-20
US3723429A (en) *	1969-11-06	1973-03-27	Beecham Group Ltd	Di-hydro triazine derivatives
US3660394A (en) *	1970-01-23	1972-05-02	Vitamins Ltd	4 6-dibenzo-1 2-dihydro-aryloxy-1 3 5-triazines
GB1546937A (en) *	1976-07-29	1979-05-31	Beecham Group Ltd	2,4-diaminopyrimidine derivatives

1992
- 1992-02-14 US US07/837,258 patent/US5322858A/en not_active Expired - Lifetime
1993
- 1993-01-19 KR KR1019940702810A patent/KR950700243A/ko not_active Withdrawn
- 1993-01-19 RU RU94039539A patent/RU2133737C1/ru not_active IP Right Cessation
- 1993-01-19 WO PCT/US1993/000395 patent/WO1993016037A1/en not_active Ceased
- 1993-01-19 AU AU34759/93A patent/AU668709B2/en not_active Ceased
- 1993-01-19 ES ES93903532T patent/ES2108862T3/es not_active Expired - Lifetime
- 1993-01-19 HU HU9401976A patent/HU220389B/hu not_active IP Right Cessation
- 1993-01-19 CA CA002129430A patent/CA2129430C/en not_active Expired - Fee Related
- 1993-01-19 FI FI943738A patent/FI943738A7/fi unknown
- 1993-01-19 CZ CZ19941964A patent/CZ294257B6/cs not_active IP Right Cessation
- 1993-01-19 JP JP51407193A patent/JP3207200B2/ja not_active Expired - Fee Related
- 1993-01-19 DE DE69313438T patent/DE69313438T2/de not_active Expired - Fee Related
- 1993-01-19 AT AT93903532T patent/ATE157352T1/de active
- 1993-01-19 DK DK93903532.5T patent/DK0625967T3/da active
- 1993-01-19 PL PL93304776A patent/PL172001B1/pl not_active IP Right Cessation
- 1993-01-19 EP EP93903532A patent/EP0625967B1/de not_active Expired - Lifetime
- 1993-01-19 PL PL93315533A patent/PL173258B1/pl not_active IP Right Cessation
- 1993-01-22 IL IL10448493A patent/IL104484A/en not_active IP Right Cessation
- 1993-02-08 NZ NZ245865A patent/NZ245865A/en not_active IP Right Cessation
- 1993-02-09 MX MX9300688A patent/MX9300688A/es unknown
- 1993-02-11 EG EG7993A patent/EG20476A/xx active
- 1993-02-12 ZA ZA93974A patent/ZA93974B/xx unknown
- 1993-02-13 CN CN93101894A patent/CN1057520C/zh not_active Expired - Fee Related
1994
- 1994-08-12 NO NO942988A patent/NO302616B1/no not_active IP Right Cessation
- 1994-08-12 OA OA60554A patent/OA10094A/en unknown
1997
- 1997-11-19 GR GR970403074T patent/GR3025429T3/el unknown

Also Published As

Publication number	Publication date
CN1057520C (zh)	2000-10-18
NZ245865A (en)	1996-02-27
HU220389B (hu)	2002-01-28
RU2133737C1 (ru)	1999-07-27
NO942988L (no)	1994-10-05
WO1993016037A1 (en)	1993-08-19
KR950700243A (ko)	1995-01-16
HU9401976D0 (en)	1994-09-28
AU668709B2 (en)	1996-05-16
AU3475993A (en)	1993-09-03
CA2129430A1 (en)	1993-08-15
IL104484A (en)	1998-07-15
JP3207200B2 (ja)	2001-09-10
CZ294257B6 (cs)	2004-11-10
EP0625967B1 (de)	1997-08-27
CA2129430C (en)	2004-04-06
PL172001B1 (pl)	1997-07-31
FI943738A7 (fi)	1994-10-12
OA10094A (en)	1996-12-18
GR3025429T3 (en)	1998-02-27
EP0625967A1 (de)	1994-11-30
ZA93974B (en)	1993-09-14
NO942988D0 (no)	1994-08-12
PL173258B1 (pl)	1998-02-27
IL104484A0 (en)	1993-05-13
JPH07503730A (ja)	1995-04-20
MX9300688A (es)	1993-08-01
ES2108862T3 (es)	1998-01-01
HUT68802A (en)	1995-07-28
FI943738A0 (fi)	1994-08-12
NO302616B1 (no)	1998-03-30
DK0625967T3 (da)	1998-03-23
RU94039539A (ru)	1997-05-27
US5322858A (en)	1994-06-21
DE69313438T2 (de)	1998-03-19
DE69313438D1 (de)	1997-10-02
ATE157352T1 (de)	1997-09-15
CN1076689A (zh)	1993-09-29
CZ196494A3 (en)	1995-10-18

Publication	Publication Date	Title
EG20476A (en)	1999-05-31	Process for preparing of n,n'- substituted imidodicarboninidic diamides derived from hydroxylamines
DK0602454T3 (da)	1996-07-29	N-oxycarbonylsubstituerede 5-deoxy-5-fluorcytidiner
JPS6447749A (en)	1989-02-22	Desferrioxamine compound
MY110821A (en)	1999-05-31	Oxidation inhibited arylcyclobutene polymers
ES8500902A1 (es)	1984-11-01	Un procedimiento para la preparacion de un derivado del indol.
PT1021405E (pt)	2003-02-28	Derivados de azetidinona para o tratamento de infeccoes de hcmv
CA2113630A1 (fr)	1993-02-04	Procede de protection des protheses des materiaux implantables provisoires ou definitifs contre la colonisation et l'infection bacterienne
DK0548338T3 (da)	1996-11-18	Fremgangsmåde til fremstilling af cephalosporinmellemprodukter
ATE165810T1 (de)	1998-05-15	N-substituierte derivate des n-methyl-3-(p- trifluormethylphenoxy)-3-phenylpropylamins und verfahren zu deren herstellung
CS185091A3 (en)	1992-01-15	Novel n-benzyl-n'-phenyl and phenylalkyl-thioureas
ZA946659B (en)	1995-04-20	2(1h)-quinolone compounds process for preparing them and pharmaceutical compositions containing them
DE3870468D1 (de)	1992-06-04	Ergolinylheterocyclen.
CA2036643A1 (en)	1992-03-11	Sulfur-containing esters as synergists of amine and phenolic antioxidants
DK0504807T3 (da)	1996-11-18	Anvendelse af bis(p-hydroxyphenylthio)methanderivater til inhibering af progressiv udvikling af insulinafhængig diabetes mellitus
FR2794122B1 (fr)	2001-09-07	Nouveaux antioxydants, procedes de preparation et utilisations