EG20539A - Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressure - Google Patents

Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressure

Info

Publication number: EG20539A
Authority: EG; Egypt
Prior art keywords: hydrogen; pct; blood pressure; chloro; methyl
Prior art date: 1993-11-05

Application number

EG68994A

Other languages

English (en)

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-05

Filing date

1994-11-02

Publication date

1999-07-31

1994-11-02 Application filed by Astra Ab filed Critical Astra Ab

1999-07-31 Application granted granted Critical

1999-07-31 Publication of EG20539A publication Critical patent/EG20539A/xx

Links

230000036772 blood pressure Effects 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)

EG68994A 1993-11-05 1994-11-02 Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressure EG20539A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9303657A SE9303657D0 (sv)	1993-11-05	1993-11-05	Short-acting dihydropyridines

Publications (1)

Publication Number	Publication Date
EG20539A true EG20539A (en)	1999-07-31

Family

ID=20391655

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG68994A EG20539A (en)	1993-11-05	1994-11-02	Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressure

Country Status (35)

Country	Link
US (1)	US5856346A (de)
EP (1)	EP0726894B1 (de)
JP (1)	JP3712209B2 (de)
KR (1)	KR100331663B1 (de)
CN (1)	CN1049428C (de)
AT (1)	ATE194330T1 (de)
AU (1)	AU685532B2 (de)
BR (1)	BR9407946A (de)
CA (1)	CA2174969C (de)
CZ (1)	CZ285691B6 (de)
DE (1)	DE69425152T2 (de)
DK (1)	DK0726894T3 (de)
EE (1)	EE03230B1 (de)
EG (1)	EG20539A (de)
ES (1)	ES2150544T3 (de)
FI (1)	FI110429B (de)
FR (1)	FR12C0053I2 (de)
GR (1)	GR3034469T3 (de)
HU (1)	HU215591B (de)
IL (1)	IL111127A (de)
IS (1)	IS1674B (de)
LU (1)	LU92209I2 (de)
MY (1)	MY111770A (de)
NO (1)	NO305656B1 (de)
NZ (1)	NZ275915A (de)
PL (1)	PL185099B1 (de)
PT (1)	PT726894E (de)
RU (1)	RU2139278C1 (de)
SA (1)	SA94150250B1 (de)
SE (1)	SE9303657D0 (de)
SK (1)	SK281467B6 (de)
TW (1)	TW279859B (de)
UA (1)	UA45959C2 (de)
WO (1)	WO1995012578A1 (de)
ZA (1)	ZA947570B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9804002D0 (sv) *	1998-11-23	1998-11-23	Astra Ab	New manufacturing process
US8097270B2 (en) *	2001-12-21	2012-01-17	Novartis Ag	Use of nanoparticles as carriers for biocides in ophthalmic compositions
FR2922439B1 (fr) *	2007-10-18	2010-12-10	Hill Rom Ind Sa	Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre
CA3108961C (en) *	2008-08-01	2024-07-02	Hospira, Inc.	Pharmaceutical compositions comprising clevidipine and methods for producing low concentrations of impurities thereof
KR101644286B1 (ko) *	2009-09-30	2016-08-10	마이크로도스 테라퓨특스, 인코포레이티드	레이노 증후군의 치료를 위한 방법들 및 조성물들
CN101780036B (zh) *	2010-03-30	2011-11-16	武汉武药科技有限公司	丁酸氯维地平脂微球注射液及其制备方法
CA2701087A1 (en) *	2010-04-12	2011-10-12	Alphora Research Inc.	Preparation of clevidipine butyrate ring the same
US8455655B2 (en)	2010-05-07	2013-06-04	Laboratorios Lesvi, S.L.	Preparation of dihydropyridines
EP2386544B1 (de)	2010-05-07	2016-02-10	Laboratorios Lesvi, S.L.	Herstellung von Dihydropyridinen
US8658676B2 (en)	2010-10-12	2014-02-25	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
WO2012051116A1 (en)	2010-10-12	2012-04-19	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
RU2623039C2 (ru) *	2011-04-01	2017-06-21	КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.	Дигидропиридины (клевидипин) кратковременного действия для применения в восстановлении после инсульта
KR101708538B1 (ko)	2011-08-26	2017-02-20	욱크하르트 리미티드	심혈관 질환의 치료 방법
CN103420899B (zh) *	2012-05-25	2016-01-27	四川科伦药物研究有限公司	一种丁酸氯维地平的纯化方法
CN110840890A (zh)	2012-10-26	2020-02-28	凯西制药公司	用于在心力衰竭中控制血压和减轻呼吸困难的方法
CN103073485B (zh) *	2013-01-17	2015-09-02	北京嘉林药业股份有限公司	一种丁酸氯维地平的制备方法
CN103086956B (zh) *	2013-01-17	2015-11-04	北京嘉林药业股份有限公司	一种丁酸氯维地平中间体的纯化方法
MX385243B (es)	2014-05-19	2025-03-14	The Medicines Co	Nanoparticulas de clevidipina y composiciones farmaceuticas que las contienen.
CN105367487A (zh) *	2014-08-23	2016-03-02	南京海纳医药科技有限公司	一种丁酸氯维地平重要中间体新的合成方法
CN104370802A (zh) *	2014-09-24	2015-02-25	北京蓝丹医药科技有限公司	氯维地平衍生物及其制备方法
RS62130B1 (sr)	2015-05-20	2021-08-31	Boehringer Ingelheim Animal Health Usa Inc	Antihelmintička depsipeptidna jedinjenja
EP3397638B1 (de)	2015-12-28	2023-08-23	Boehringer Ingelheim Animal Health USA Inc.	Anthelmintische depsipeptidverbindungen
BR112019009977A2 (pt)	2016-11-16	2019-08-27	Boehringer Ingelheim Animal Health Usa Inc	compostos depsipeptídicos anti-helmínticos
RU2755349C1 (ru) *	2021-02-16	2021-09-15	Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ")	Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2117571C3 (de) *	1971-04-10	1979-10-11	Bayer Ag, 5090 Leverkusen	Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) *	1975-11-05	1979-05-15	Bayer Aktiengesellschaft	2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2847236A1 (de) *	1978-10-31	1980-05-14	Bayer Ag	Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
KR940003492B1 (ko) *	1988-10-27	1994-04-23	주식회사 유한양행	1,4-디하이드로피리딘유도체 및 그의 제조방법
US5134139A (en) *	1989-08-31	1992-07-28	Tanabe Seiyaku Co., Ltd.	1,5-benzothiazepine derivatives and preparation thereof
JPH0641075A (ja) *	1990-09-01	1994-02-15	Kazuo Achinami	新規な１，４−ジヒドロピリジン化合物及びその製造方法

1993
- 1993-11-05 SE SE9303657A patent/SE9303657D0/xx unknown
1994
- 1994-09-28 ZA ZA947570A patent/ZA947570B/xx unknown
- 1994-09-29 TW TW083108995A patent/TW279859B/zh not_active IP Right Cessation
- 1994-09-30 IS IS4218A patent/IS1674B/is unknown
- 1994-10-03 IL IL11112794A patent/IL111127A/xx not_active IP Right Cessation
- 1994-10-19 SA SA94150250A patent/SA94150250B1/ar unknown
- 1994-11-02 EG EG68994A patent/EG20539A/xx active
- 1994-11-03 EP EP95900347A patent/EP0726894B1/de not_active Expired - Lifetime
- 1994-11-03 US US08/356,224 patent/US5856346A/en not_active Expired - Lifetime
- 1994-11-03 RU RU96112152A patent/RU2139278C1/ru active
- 1994-11-03 CZ CZ961273A patent/CZ285691B6/cs not_active IP Right Cessation
- 1994-11-03 DK DK95900347T patent/DK0726894T3/da active
- 1994-11-03 JP JP51317095A patent/JP3712209B2/ja not_active Expired - Lifetime
- 1994-11-03 NZ NZ275915A patent/NZ275915A/en not_active IP Right Cessation
- 1994-11-03 AU AU81196/94A patent/AU685532B2/en not_active Expired
- 1994-11-03 UA UA96041753A patent/UA45959C2/uk unknown
- 1994-11-03 ES ES95900347T patent/ES2150544T3/es not_active Expired - Lifetime
- 1994-11-03 EE EE9600051A patent/EE03230B1/xx unknown
- 1994-11-03 WO PCT/SE1994/001031 patent/WO1995012578A1/en not_active Ceased
- 1994-11-03 CN CN94194500A patent/CN1049428C/zh not_active Expired - Lifetime
- 1994-11-03 PT PT95900347T patent/PT726894E/pt unknown
- 1994-11-03 SK SK559-96A patent/SK281467B6/sk not_active IP Right Cessation
- 1994-11-03 KR KR1019960702346A patent/KR100331663B1/ko not_active Expired - Lifetime
- 1994-11-03 DE DE69425152T patent/DE69425152T2/de not_active Expired - Lifetime
- 1994-11-03 CA CA002174969A patent/CA2174969C/en not_active Expired - Lifetime
- 1994-11-03 PL PL94314128A patent/PL185099B1/pl unknown
- 1994-11-03 AT AT95900347T patent/ATE194330T1/de active
- 1994-11-03 BR BR9407946A patent/BR9407946A/pt not_active Application Discontinuation
- 1994-11-03 HU HU9601187A patent/HU215591B/hu unknown
- 1994-11-04 MY MYPI94002934A patent/MY111770A/en unknown
1996
- 1996-05-02 NO NO961776A patent/NO305656B1/no not_active IP Right Cessation
- 1996-05-06 FI FI961914A patent/FI110429B/fi not_active IP Right Cessation
2000
- 2000-09-21 GR GR20000402158T patent/GR3034469T3/el unknown
2012
- 2012-09-18 FR FR12C0053C patent/FR12C0053I2/fr active Active
2013
- 2013-06-10 LU LU92209C patent/LU92209I2/fr unknown

Also Published As

Publication number	Publication date
LU92209I2 (fr)	2013-08-23
DE69425152T2 (de)	2001-03-22
EP0726894B1 (de)	2000-07-05
WO1995012578A1 (en)	1995-05-11
HU215591B (hu)	1999-01-28
CN1137269A (zh)	1996-12-04
PL185099B1 (pl)	2003-02-28
HK1013292A1 (en)	1999-08-20
ZA947570B (en)	1995-05-29
SK55996A3 (en)	1996-12-04
TW279859B (de)	1996-07-01
CZ285691B6 (cs)	1999-10-13
CN1049428C (zh)	2000-02-16
BR9407946A (pt)	1996-11-26
EP0726894A1 (de)	1996-08-21
ATE194330T1 (de)	2000-07-15
EE03230B1 (et)	1999-10-15
DE69425152D1 (de)	2000-08-10
FI961914L (fi)	1996-05-06
SE9303657D0 (sv)	1993-11-05
FI110429B (fi)	2003-01-31
FR12C0053I1 (de)	2012-02-11
CA2174969A1 (en)	1995-05-11
SA94150250B1 (ar)	2006-03-01
CZ127396A3 (en)	1996-09-11
PT726894E (pt)	2000-10-31
NZ275915A (en)	1997-04-24
UA45959C2 (uk)	2002-05-15
MY111770A (en)	2000-12-30
JP3712209B2 (ja)	2005-11-02
IS4218A (is)	1995-05-06
IS1674B (is)	1997-12-31
NO305656B1 (no)	1999-07-05
ES2150544T3 (es)	2000-12-01
PL314128A1 (en)	1996-08-19
NO961776L (no)	1996-05-02
KR100331663B1 (ko)	2002-09-26
DK0726894T3 (da)	2000-10-23
HU9601187D0 (en)	1996-07-29
IL111127A (en)	2000-11-21
FI961914A0 (fi)	1996-05-06
JPH09504542A (ja)	1997-05-06
SK281467B6 (sk)	2001-04-09
IL111127A0 (en)	1994-12-29
US5856346A (en)	1999-01-05
RU2139278C1 (ru)	1999-10-10
AU685532B2 (en)	1998-01-22
CA2174969C (en)	2005-05-17
NO961776D0 (no)	1996-05-02
AU8119694A (en)	1995-05-23
HUT75316A (en)	1997-05-28
FR12C0053I2 (fr)	2013-08-16
GR3034469T3 (en)	2000-12-29

Publication	Publication Date	Title
HUT75316A (en)	1997-05-28	Short-acting dihydropyridines and pharmaceutical compositions containing them
TW274547B (de)	1996-04-21
NZ238206A (en)	1993-05-26	The stereoselective preparation of phenylisoserine derivatives and the use of such derivatives in preparing baccatin-iii and 10-deacetylbaccatin-iii derivatives
IE892795L (en)	1990-03-01	Ó,Ó-Disubstituted N-cycloalkylalkylbenzylamines, process for¹their preparation, their use as a medicament and their¹synthesis intermediates
IL108969A0 (en)	1994-06-24	Substituted (arylalkoxybenzyl) aminopropionamide derivatives, their preparation and pharmaceutical compositions containing them
CA2042113A1 (en)	1991-11-22	Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
MX9604687A (es)	1997-04-30	Procedimiento para la preparacion de derivados de imidazo-benzodiacepina.
IL113002A0 (en)	1995-10-31	4 - methylene - 2H - chromen - 3(4H)- one derivatives their preparation and use
HUT64309A (en)	1993-12-28	Process for production pharmaceutical preparations having benzazepine compounds as effective substance and the new effective substance
GB9306899D0 (en)	1993-05-26	Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
HUT70761A (en)	1995-10-30	Alkyl derivatives of trazodone having action for central nervous system, pharmaceutical compositions for preparing thereof
AU5111393A (en)	1994-05-09	Benzopyranones, method of preparing them and their use
ES8207519A1 (es)	1982-10-01	Procedimiento para la obtencion de derivados del imidazol.
GR3000773T3 (en)	1991-10-10	2,2;6,6-diethylene-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactones, process for their preparation and pharmaceutical compositions containing them
TW355184B (en)	1999-04-01	Substituted thiophenylsulfonylureas and -thioureas, process for their preparation, their use as a medicament or diagnostic, and medicament containing them