EG20747A - Method for preparing galanthamine derivatives as acetylcholinesterase inhibitors - Google Patents

Method for preparing galanthamine derivatives as acetylcholinesterase inhibitors

Info

Publication number: EG20747A
Authority: EG; Egypt
Prior art keywords: acetylcholinesterase inhibitors; galanthamine derivatives; alkylaminocarbonyloxy; preparing; preparing galanthamine
Prior art date: 1993-10-15

Application number

EG63794A

Other languages

English (en)

Inventor

Raymond W Kosley Jr

Larry Davis

Veronica Taberna

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-15

Filing date

1994-10-12

Publication date

2000-01-31

1994-10-12 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

2000-01-31 Application granted granted Critical

2000-01-31 Publication of EG20747A publication Critical patent/EG20747A/xx

Links

239000000544 cholinesterase inhibitor Substances 0.000 title 1
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical class O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title 1
125000005195 alkyl amino carbonyloxy group Chemical group 0.000 abstract 3
125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EG63794A 1993-10-15 1994-10-12 Method for preparing galanthamine derivatives as acetylcholinesterase inhibitors EG20747A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/137,443 US6323196B1 (en)	1993-10-15	1993-10-15	Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (1)

Publication Number	Publication Date
EG20747A true EG20747A (en)	2000-01-31

Family

ID=22477457

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG63794A EG20747A (en)	1993-10-15	1994-10-12	Method for preparing galanthamine derivatives as acetylcholinesterase inhibitors

Country Status (24)

Country	Link
US (1)	US6323196B1 (pl)
EP (2)	EP1020469A3 (pl)
JP (1)	JP2718637B2 (pl)
KR (1)	KR100189043B1 (pl)
CN (1)	CN1039011C (pl)
AT (1)	ATE201687T1 (pl)
AU (1)	AU679560B2 (pl)
CA (1)	CA2118171C (pl)
CZ (1)	CZ283561B6 (pl)
DE (1)	DE69427332T2 (pl)
DK (1)	DK0648771T3 (pl)
EG (1)	EG20747A (pl)
ES (1)	ES2158876T3 (pl)
FI (1)	FI108724B (pl)
GR (1)	GR3036068T3 (pl)
IL (1)	IL111273A (pl)
NO (1)	NO307463B1 (pl)
NZ (1)	NZ264681A (pl)
PL (1)	PL177754B1 (pl)
PT (1)	PT648771E (pl)
RO (1)	RO114132B1 (pl)
RU (1)	RU2113438C1 (pl)
TW (1)	TW375615B (pl)
ZA (1)	ZA948060B (pl)

Families Citing this family (23)

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AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
AU1738800A (en)	1998-11-23	2000-06-13	Bonnie Davis	Dosage formulations for acetylcholinesterase inhibitors
KR100437105B1 (ko)	1998-12-24	2004-06-23	얀센 파마슈티카 엔.브이.	방출 조절형 갈란타민 조성물
EP2311463A1 (en) *	1999-12-10	2011-04-20	Bonnie M. Davis	Analogs of galanthamine and lycoramine as modulators of nicotinic receptors
PL202463B1 (pl)	2000-03-31	2009-06-30	Sanochemia Pharmazeutika Ag	Pochodne galantaminy, sposób ich wytwarzania, środek leczniczy zawierajacy te pochodne, zastosowanie pochodnej galantaminy do wytwarzania środków leczniczych, sposób wytwarzania środków leczniczych oraz sposób oddzielania (+)- i (-)-izomerów
US20030162770A1 (en) *	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
WO2004041281A1 (en) *	2002-11-01	2004-05-21	Oregon Health And Science University	Treatment of hyperkinetic movement disorder with donepezil
US20050048543A1 (en) *	2003-07-11	2005-03-03	Jeroen Aerssens	CHRNA2 genetic markers associated with galantamine response
WO2005042762A2 (en) *	2003-10-28	2005-05-12	Genaissance Pharmaceuticals, Inc.	Lrpap1 genetic markers associated with galantamine response
US20050143350A1 (en) *	2003-11-19	2005-06-30	Seed John C.	Combination drug therapy to treat obesity
US7250258B2 (en) *	2003-12-15	2007-07-31	Pgxhealth Llc	CDK5 genetic markers associated with galantamine response
WO2005065662A1 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Solid dosage formulations of galantamine
WO2005065661A2 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Immediate, controlled and sustained release formulations of galanthamine
JPWO2006004201A1 (ja) *	2004-07-01	2008-04-24	エーザイ・アール・アンド・ディー・マネジメント株式会社	神経再生促進剤
WO2006124584A2 (en) *	2005-05-13	2006-11-23	Alza Corporation	Multilayer drug delivery system with barrier against reservoir material flow
US20080188510A1 (en) *	2005-05-23	2008-08-07	Eisai R & D Management Co., Ltd.	Novel methods using zonisamide
EP1777222A1 (en) *	2005-09-22	2007-04-25	Galantos Pharma GmbH	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2007035941A2 (en) *	2005-09-23	2007-03-29	Alza Corporation	Transdermal galantamine delivery system
KR100786371B1 (ko) *	2006-12-07	2007-12-17	한국화학연구원	갈란타민의 제조방법
CN102007129B (zh)	2008-04-14	2014-05-07	神经动力生命科学公司	用作治疗人类脑疾病的前药的雪花胺衍生物
EP2456434A1 (en) *	2009-07-23	2012-05-30	Shire LLC	Galantamine amino acid and peptide prodrugs and uses thereof
US12551491B1 (en) *	2025-07-23	2026-02-17	Alpha Cognition Inc.	Dosage regimens for benzgalantamine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL122665B1 (en)	1978-11-21	1982-08-31	Edinen Zentar Chim	Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en)	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
US6150354A (en) *	1987-01-15	2000-11-21	Bonnie Davis	Compounds for the treatment of Alzheimer's disease
JP2755403B2 (ja) *	1987-05-04	1998-05-20	デイービス、ボニー	アルツハイマー病の治療のための化合物
NL8800350A (nl)	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
EP0584185B1 (en) *	1991-05-14	1999-08-11	Ernir Snorrason	Treatment of fatigue syndrome with cholinesterase inhibitors
US5336675A (en) *	1991-05-14	1994-08-09	Ernir Snorrason	Method of treating mania in humans
US5231093A (en) *	1991-10-01	1993-07-27	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

1993
- 1993-10-15 US US08/137,443 patent/US6323196B1/en not_active Expired - Lifetime
1994
- 1994-10-10 DE DE69427332T patent/DE69427332T2/de not_active Expired - Lifetime
- 1994-10-10 DK DK94115960T patent/DK0648771T3/da active
- 1994-10-10 AT AT94115960T patent/ATE201687T1/de active
- 1994-10-10 PT PT94115960T patent/PT648771E/pt unknown
- 1994-10-10 EP EP00107569A patent/EP1020469A3/en not_active Withdrawn
- 1994-10-10 ES ES94115960T patent/ES2158876T3/es not_active Expired - Lifetime
- 1994-10-10 EP EP94115960A patent/EP0648771B1/en not_active Expired - Lifetime
- 1994-10-12 EG EG63794A patent/EG20747A/xx active
- 1994-10-13 IL IL111273A patent/IL111273A/en not_active IP Right Cessation
- 1994-10-13 RU RU94036761A patent/RU2113438C1/ru active
- 1994-10-13 FI FI944822A patent/FI108724B/fi not_active IP Right Cessation
- 1994-10-13 NZ NZ264681A patent/NZ264681A/en not_active IP Right Cessation
- 1994-10-14 AU AU75812/94A patent/AU679560B2/en not_active Expired
- 1994-10-14 TW TW083109528A patent/TW375615B/zh not_active IP Right Cessation
- 1994-10-14 NO NO943894A patent/NO307463B1/no not_active IP Right Cessation
- 1994-10-14 CN CN94117061A patent/CN1039011C/zh not_active Expired - Lifetime
- 1994-10-14 ZA ZA948060A patent/ZA948060B/xx unknown
- 1994-10-14 CA CA002118171A patent/CA2118171C/en not_active Expired - Lifetime
- 1994-10-14 CZ CZ942547A patent/CZ283561B6/cs not_active IP Right Cessation
- 1994-10-14 KR KR1019940026304A patent/KR100189043B1/ko not_active Expired - Lifetime
- 1994-10-14 RO RO94-01668A patent/RO114132B1/ro unknown
- 1994-10-14 PL PL94305455A patent/PL177754B1/pl unknown
- 1994-10-17 JP JP6250776A patent/JP2718637B2/ja not_active Expired - Fee Related
2001
- 2001-06-19 GR GR20010400911T patent/GR3036068T3/el unknown

Also Published As

Publication number	Publication date
AU679560B2 (en)	1997-07-03
PL305455A1 (en)	1995-04-18
NZ264681A (en)	1997-12-19
GR3036068T3 (en)	2001-09-28
ES2158876T3 (es)	2001-09-16
TW375615B (en)	1999-12-01
EP0648771B1 (en)	2001-05-30
AU7581294A (en)	1995-05-04
EP0648771A1 (en)	1995-04-19
RU2113438C1 (ru)	1998-06-20
ZA948060B (en)	1995-06-09
CN1108658A (zh)	1995-09-20
JPH07188238A (ja)	1995-07-25
PT648771E (pt)	2001-09-28
CZ283561B6 (cs)	1998-05-13
IL111273A0 (en)	1994-12-29
RO114132B1 (ro)	1999-01-29
EP1020469A2 (en)	2000-07-19
FI944822L (fi)	1995-04-16
PL177754B1 (pl)	2000-01-31
ATE201687T1 (de)	2001-06-15
DE69427332D1 (de)	2001-07-05
DE69427332T2 (de)	2001-10-11
KR100189043B1 (ko)	1999-06-01
JP2718637B2 (ja)	1998-02-25
RU94036761A (ru)	1996-09-10
CA2118171C (en)	1999-12-28
NO943894L (no)	1995-04-18
KR950011444A (ko)	1995-05-15
DK0648771T3 (da)	2001-08-27
CA2118171A1 (en)	1995-04-16
NO307463B1 (no)	2000-04-10
EP1020469A3 (en)	2000-07-26
IL111273A (en)	1998-04-05
US6323196B1 (en)	2001-11-27
FI944822A0 (fi)	1994-10-13
NO943894D0 (no)	1994-10-14
CZ254794A3 (en)	1995-05-17
CN1039011C (zh)	1998-07-08
FI108724B (fi)	2002-03-15

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GR3036068T3 (en)	2001-09-28	Galanthamine derivatives, a process for their preparation and their use as medicaments.
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EP0573659A4 (en)	1994-09-07	Pyrazolothiazolopyrimidine derivative
TW239123B (pl)	1995-01-21