EG27000A - Process for the preparation of ibodutant (MEN15596) and related intermediates - Google Patents

Process for the preparation of ibodutant (MEN15596) and related intermediates

Info

Publication number: EG27000A
Authority: EG; Egypt
Prior art keywords: men15596; ibodutant; preparation; related intermediates; intermediates
Prior art date: 2009-05-21

Application number

EG2011111951A

Other languages

English (en)

Inventor

Fabrizio Bonaccorsi

Valentina Fedi

Danilo Gianotti

Original Assignee

Malesci Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-21

Filing date

2011-11-17

Publication date

2015-03-23

2011-11-17 Application filed by Malesci Sas filed Critical Malesci Sas

2015-03-23 Application granted granted Critical

2015-03-23 Publication of EG27000A publication Critical patent/EG27000A/xx

Links

YQYSVMKCMIUCHY-WJOKGBTCSA-N 6-methyl-n-[1-[[(2r)-1-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide Chemical compound S1C2=CC(C)=CC=C2C=C1C(=O)NC1(C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 YQYSVMKCMIUCHY-WJOKGBTCSA-N 0.000 title 2
108010048200 6-methylbenzo(b)thiophene-2-carboxylic acid (1-(2-phenyl-((1-(tetrahydropyran-4-ylmethyl)piperidin-4-ylmethyl)carbamoyl)ethylcarbamoyl)cyclophenyl)amide Proteins 0.000 title 1
108010091949 ibodutant Proteins 0.000 title 1
229950007749 ibodutant Drugs 0.000 title 1
239000000543 intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

EG2011111951A 2009-05-21 2011-11-17 Process for the preparation of ibodutant (MEN15596) and related intermediates EG27000A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI2009A000897A IT1394304B1 (it)	2009-05-21	2009-05-21	Processo per la preparazione di ibodutant (men15596) e relativi intermedi
PCT/EP2010/002884 WO2010133306A1 (en)	2009-05-21	2010-05-11	Process for the preparation of ibodutant (men15596) and related intermediates

Publications (1)

Publication Number	Publication Date
EG27000A true EG27000A (en)	2015-03-23

Family

ID=41264221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG2011111951A EG27000A (en)	2009-05-21	2011-11-17	Process for the preparation of ibodutant (MEN15596) and related intermediates

Country Status (28)

Country	Link
US (1)	US8431684B2 (ru)
EP (1)	EP2432778B1 (ru)
JP (1)	JP5645926B2 (ru)
KR (1)	KR101695346B1 (ru)
CN (1)	CN102428081B (ru)
AR (1)	AR076785A1 (ru)
AU (1)	AU2010251514B2 (ru)
BR (1)	BRPI1013073A2 (ru)
CA (1)	CA2762625A1 (ru)
CY (1)	CY1114079T1 (ru)
DK (1)	DK2432778T3 (ru)
EA (1)	EA019777B1 (ru)
EG (1)	EG27000A (ru)
ES (1)	ES2409705T3 (ru)
HR (1)	HRP20130380T1 (ru)
IL (1)	IL216400A (ru)
IT (1)	IT1394304B1 (ru)
MA (1)	MA33375B1 (ru)
MX (1)	MX2011012317A (ru)
NZ (1)	NZ596523A (ru)
PL (1)	PL2432778T3 (ru)
PT (1)	PT2432778E (ru)
SG (1)	SG176171A1 (ru)
SI (1)	SI2432778T1 (ru)
TW (1)	TWI424996B (ru)
UA (1)	UA105523C2 (ru)
WO (1)	WO2010133306A1 (ru)
ZA (1)	ZA201108483B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20240010642A1 (en) *	2021-01-05	2024-01-11	Southern Research Institute	Modulators of programmed death-ligand-1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY130373A (en) *	2001-10-29	2007-06-29	Malesci Sas	Linear basic compounds having nk-2 antagonist activity and formulations thereof
ITFI20040221A1 (it) *	2004-10-27	2005-01-27	Guidotti & C Spa	Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico
EP2036920B1 (en) *	2006-01-11	2011-05-18	Seikagaku Corporation	Cycloalkylcarbonylamino acid ester derivative and process for producing the same

2009
- 2009-05-21 IT ITMI2009A000897A patent/IT1394304B1/it active
2010
- 2010-05-11 AU AU2010251514A patent/AU2010251514B2/en not_active Ceased
- 2010-05-11 MX MX2011012317A patent/MX2011012317A/es active IP Right Grant
- 2010-05-11 HR HRP20130380AT patent/HRP20130380T1/hr unknown
- 2010-05-11 PT PT107216871T patent/PT2432778E/pt unknown
- 2010-05-11 CN CN201080021722.5A patent/CN102428081B/zh not_active Expired - Fee Related
- 2010-05-11 UA UAA201113614A patent/UA105523C2/ru unknown
- 2010-05-11 PL PL10721687T patent/PL2432778T3/pl unknown
- 2010-05-11 NZ NZ596523A patent/NZ596523A/xx not_active IP Right Cessation
- 2010-05-11 CA CA2762625A patent/CA2762625A1/en not_active Abandoned
- 2010-05-11 JP JP2012511171A patent/JP5645926B2/ja not_active Expired - Fee Related
- 2010-05-11 EA EA201190267A patent/EA019777B1/ru not_active IP Right Cessation
- 2010-05-11 US US13/321,501 patent/US8431684B2/en not_active Expired - Fee Related
- 2010-05-11 DK DK10721687.1T patent/DK2432778T3/da active
- 2010-05-11 MA MA34472A patent/MA33375B1/fr unknown
- 2010-05-11 WO PCT/EP2010/002884 patent/WO2010133306A1/en not_active Ceased
- 2010-05-11 EP EP10721687A patent/EP2432778B1/en active Active
- 2010-05-11 BR BRPI1013073A patent/BRPI1013073A2/pt not_active IP Right Cessation
- 2010-05-11 SG SG2011085545A patent/SG176171A1/en unknown
- 2010-05-11 KR KR1020117027585A patent/KR101695346B1/ko not_active Expired - Fee Related
- 2010-05-11 SI SI201030192T patent/SI2432778T1/sl unknown
- 2010-05-11 ES ES10721687T patent/ES2409705T3/es active Active
- 2010-05-20 TW TW099116060A patent/TWI424996B/zh not_active IP Right Cessation
- 2010-05-20 AR ARP100101759A patent/AR076785A1/es unknown
2011
- 2011-11-17 IL IL216400A patent/IL216400A/en not_active IP Right Cessation
- 2011-11-17 EG EG2011111951A patent/EG27000A/xx active
- 2011-11-18 ZA ZA2011/08483A patent/ZA201108483B/en unknown
2013
- 2013-05-16 CY CY20131100392T patent/CY1114079T1/el unknown

Also Published As

Publication number	Publication date
MX2011012317A (es)	2012-03-07
EA019777B1 (ru)	2014-06-30
EP2432778B1 (en)	2013-03-20
CN102428081B (zh)	2014-09-17
TW201100406A (en)	2011-01-01
JP5645926B2 (ja)	2014-12-24
ITMI20090897A1 (it)	2010-11-22
WO2010133306A1 (en)	2010-11-25
DK2432778T3 (da)	2013-05-27
IT1394304B1 (it)	2012-06-06
EA201190267A1 (ru)	2012-05-30
EP2432778A1 (en)	2012-03-28
SG176171A1 (en)	2011-12-29
HRP20130380T1 (hr)	2013-05-31
KR101695346B1 (ko)	2017-01-12
SI2432778T1 (sl)	2013-05-31
WO2010133306A8 (en)	2011-02-03
AR076785A1 (es)	2011-07-06
NZ596523A (en)	2013-07-26
BRPI1013073A2 (pt)	2016-04-05
HK1169828A1 (en)	2013-02-08
JP2012527410A (ja)	2012-11-08
US20120065370A1 (en)	2012-03-15
PT2432778E (pt)	2013-06-03
CN102428081A (zh)	2012-04-25
KR20120023675A (ko)	2012-03-13
IL216400A (en)	2014-07-31
CA2762625A1 (en)	2010-11-25
IL216400A0 (en)	2012-01-31
AU2010251514B2 (en)	2014-06-12
ZA201108483B (en)	2013-01-30
PL2432778T3 (pl)	2013-08-30
CY1114079T1 (el)	2016-07-27
UA105523C2 (ru)	2014-05-26
MA33375B1 (fr)	2012-06-01
ES2409705T3 (es)	2013-06-27
TWI424996B (zh)	2014-02-01
AU2010251514A1 (en)	2011-12-08
US8431684B2 (en)	2013-04-30

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