EP0006556B1 - Procédé et dispositif pour déposer dans un récipient une dose prédéterminée d'une substance liquide - Google Patents

Procédé et dispositif pour déposer dans un récipient une dose prédéterminée d'une substance liquide Download PDF

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Publication number
EP0006556B1
EP0006556B1 EP19790101983 EP79101983A EP0006556B1 EP 0006556 B1 EP0006556 B1 EP 0006556B1 EP 19790101983 EP19790101983 EP 19790101983 EP 79101983 A EP79101983 A EP 79101983A EP 0006556 B1 EP0006556 B1 EP 0006556B1
Authority
EP
European Patent Office
Prior art keywords
thread
substance
receptacle
tubular part
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP19790101983
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German (de)
English (en)
French (fr)
Other versions
EP0006556A1 (fr
Inventor
Jean Guigan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0006556A1 publication Critical patent/EP0006556A1/fr
Application granted granted Critical
Publication of EP0006556B1 publication Critical patent/EP0006556B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0203—Burettes, i.e. for withdrawing and redistributing liquids through different conduits
    • B01L3/0206—Burettes, i.e. for withdrawing and redistributing liquids through different conduits of the plunger pump type
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/04—Processes
    • Y10T83/0405—With preparatory or simultaneous ancillary treatment of work
    • Y10T83/041—By heating or cooling

Definitions

  • the present invention relates to a method and a device for depositing in a container a predetermined dose of a liquid substance.
  • the dose deposited in the container can only be determined with an accuracy corresponding to the volume of a drop, this volume not being negligible compared to that of the dose.
  • the present invention aims to overcome these drawbacks and to implement a precise method for depositing in a container a very low dose of a liquid substance, this method can be easily applied to an automatic filling device.
  • FIG. 1 schematically represents an embodiment of the device according to the invention
  • FIG. 2 is a partial sectional view, on a larger scale, of a member of the device illustrated in FIG. 1.
  • FIG. 1 a tubular part 1, for example made of glass, essentially composed of a calibrated tube 2, of internal section of one square millimeter for example, surmounted by a filling tube 3 of larger diameter.
  • the two tubes are aligned along the same vertical axis and their interior volumes are in communication by a cylindrical connection wall 4.
  • a piston 5 is placed inside the tube 3.
  • One end of a vertical rod 6 is fixed on the piston 5 while its other end engages in an eyelet 7 located at one end of an arm of a lever 8 rotatably mounted about a horizontal axis 9.
  • the arm of the lever 8 opposite to that which comprises the ring 7 is in contact with a cam 10 rotatably mounted about a horizontal axis 11.
  • Contact between the lever 8 and the cam 10 is provided by a spring 12, one end of which is secured to a point 13 fixed in the plane vertical rotation of the lever 8, the other end of this spring being fixed to the lever 8.
  • the cam 10 is rotated about the axis 11 by an electric motor 14 via a reduction gear 39.
  • a lateral opening 15 located at the lower part of the tube 3 is connected by a pipe 16 to a reservoir 17 containing a liquid substance 18 such as a reagent.
  • a valve 38 is placed inside the pipe 16.
  • an enclosure 19 connected by two pipes 20 and 21 to a refrigeration unit 22.
  • a laser generator 23 for example of the neodymium doped glass type, emitting a horizontal laser beam 24 on the path of which is placed an optical system such as a converged lens gente 25 capable of focusing the energy of the beam 24 at a point 26 located on the extension of the vertical axis 27 of the calibrated tube 2.
  • a light-emitting diode 28 supplied by a circuit 29 emits a horizontal light beam 30 which cuts the axis 27 at a point 31 located below point 26 at a predetermined distance 32 which can be of the order of 5 millimeters.
  • the beam 30 is intercepted beyond point 31 by a photoelectric receiver 33 whose electrical output is connected to a trigger circuit 34, itself connected to the laser generator 23.
  • an electric furnace 35 of tubular shape is arranged vertically so as to surround the axis 27.
  • a container 36 is placed below the oven 35, substantially along the axis 27.
  • Figure 2 is a partial sectional view of the tubular part 1 showing on a larger scale the calibrated tube 2. It is visible in this figure that the inner cylindrical surface of the tube 2 is coated with a layer 37 of a material to low coefficient of friction such as polytetrafluoroethylene, this layer being able to extend as shown towards the connection wall 4.
  • a layer 37 of a material to low coefficient of friction such as polytetrafluoroethylene
  • the rotation of the cam 10 causes an alternating rotation from bottom to top and from top to bottom of the lever 8 about its axis 9.
  • This alternative rotation causes an alternating vertical displacement of the piston 5.
  • the piston 5 In the position represented in FIG. 1, the piston 5 is in its lowest position, slightly above the opening 15; the highest position of the piston 5 is shown in dotted lines in 5 ′, this position corresponding to the position 8 ′ of the lever 8.
  • the circulation of the coolant in the 19 "enclosure causes intense cooling and the freezing of the substance occupying the interior volume of the tube 2.
  • the coolant can be, for example, at a temperature of the order of - 20 ° C.
  • the circuit 34 reacts to this reduction in amplitude by controlling the triggering of a laser pulse.
  • the laser energy concentrated at point 26 causes the cord 40 to break at this point. A fragment of length 32 is detached from this cord and falls into the container 36.
  • the interior volume of the tube 3 is capable of storing a quantity of substance sufficient to obtain the successive detachment of the cord 40 from a plurality of identical fragments during a single descent of the piston 5. These fragments are then received respectively in a plurality of containers such as 36 carried by a conveyor belt moving transversely with respect to the axis 27.
  • the profile of the cam 10 can be determined so that the running of the cord 40 leaving the tube 2 takes place at constant speed and on the other hand the laser generator 23 can be controlled to emit a series of laser pulses at a constant repetition rate. Under these conditions, knowing the speed of travel, the emission rate of the laser generator is chosen to obtain the desired length 32 of the fragment.
  • the very high energy density caused by the concentration of the laser beam makes it possible to achieve a clear cut in the cord 40 and very high precision over the length 32 of the fragment, that is to say over the volume of the dose to be deposited. in the container. It should be noted that it is possible to further increase the dosing precision by using as a focusing optical system a cylindrical lens arranged to concentrate the energy of the beam along a segment cutting the cord 40 perpendicularly to its axis 27.
  • heating can be obtained more generally by any known thermal means, and in particular using an infrared radiation generator.
  • Heating the fragment before it arrives in the container may be absolutely necessary when the container 36 is very small and the fragment is relatively long. In fact, in this case the entire length of the frozen fragment cannot be accommodated in the internal volume of the container and part of the substance risks flowing out of the container when the fragment warms up.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
EP19790101983 1978-06-23 1979-06-18 Procédé et dispositif pour déposer dans un récipient une dose prédéterminée d'une substance liquide Expired EP0006556B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7818831A FR2429418A1 (fr) 1978-06-23 1978-06-23 Procede et dispositif pour deposer dans un recipient une dose predeterminee d'une substance liquide
FR7818831 1978-06-23

Publications (2)

Publication Number Publication Date
EP0006556A1 EP0006556A1 (fr) 1980-01-09
EP0006556B1 true EP0006556B1 (fr) 1982-04-07

Family

ID=9209912

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19790101983 Expired EP0006556B1 (fr) 1978-06-23 1979-06-18 Procédé et dispositif pour déposer dans un récipient une dose prédéterminée d'une substance liquide

Country Status (17)

Country Link
US (1) US4226266A (da)
EP (1) EP0006556B1 (da)
JP (1) JPS554593A (da)
AU (1) AU525733B2 (da)
BR (1) BR7903962A (da)
CA (1) CA1115984A (da)
DE (1) DE2962437D1 (da)
DK (1) DK263079A (da)
EG (1) EG14226A (da)
ES (1) ES481825A1 (da)
FR (1) FR2429418A1 (da)
IE (1) IE48293B1 (da)
IL (1) IL57487A (da)
IN (1) IN152238B (da)
MX (1) MX148134A (da)
RO (1) RO81191A (da)
SU (1) SU925257A3 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127979A3 (en) * 1983-06-07 1985-05-22 Imperial Chemical Industries Plc Feeder for centrifugal apparatus

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2639529B1 (fr) * 1988-11-29 1992-03-06 Basch Armand Dispositif pour la presentation en couches superposees de liquides de differentes densites, en particulier de liquides alimentaires
US5197633A (en) * 1992-01-21 1993-03-30 Hines Industries, Inc. Material metering apparatus
GB2388585A (en) * 2002-05-17 2003-11-19 Unilever Plc Dosing system with multi-spout nozzle
DE10233662B4 (de) * 2002-07-24 2004-07-22 Uhu Gmbh & Co. Kg Abfüllanlage für ein Produkt aus viskosem Material
KR100647282B1 (ko) * 2003-12-24 2006-11-17 삼성전자주식회사 ＤＮＡ 마이크로어레이 스폿팅(Ｓｐｏｔｉｎｇ) 장치 및이를 이용한 스폿팅 방법
US11800890B2 (en) 2020-03-02 2023-10-31 Sorting Robotics, Inc. Automated deposition of highly viscous fluids into thin-walled cylinders
CN113665862B (zh) * 2021-10-25 2021-12-24 南通市技美自动化设备有限公司 一种智能型液体用自动包装设备
CN116280456A (zh) * 2023-04-17 2023-06-23 江西赣电电气有限公司 一种定量稳定胶液分装装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3844896A (en) * 1970-10-29 1974-10-29 Lever Brothers Ltd Apparatus for performing bacteriological tests automatically
US3958045A (en) * 1971-12-09 1976-05-18 Coleman Charles M Method of making an automatic volume control pipet
US4015440A (en) * 1974-11-13 1977-04-05 Airco, Inc. Apparatus for depositing carbon dioxide snow

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127979A3 (en) * 1983-06-07 1985-05-22 Imperial Chemical Industries Plc Feeder for centrifugal apparatus

Also Published As

Publication number Publication date
ES481825A1 (es) 1980-02-16
DK263079A (da) 1979-12-24
BR7903962A (pt) 1980-02-20
IL57487A (en) 1983-05-15
SU925257A3 (ru) 1982-04-30
AU4828379A (en) 1980-01-03
IE48293B1 (en) 1984-11-28
EP0006556A1 (fr) 1980-01-09
AU525733B2 (en) 1982-11-25
CA1115984A (fr) 1982-01-12
EG14226A (en) 1983-12-31
DE2962437D1 (en) 1982-05-19
RO81191A (ro) 1983-02-01
FR2429418B1 (da) 1980-10-31
IL57487A0 (en) 1979-10-31
IE791177L (en) 1979-12-23
RO81191B (ro) 1983-01-30
MX148134A (es) 1983-03-16
US4226266A (en) 1980-10-07
FR2429418A1 (fr) 1980-01-18
JPS554593A (en) 1980-01-14
IN152238B (da) 1983-11-26

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