EP0105834A2 - Procédé et dispositif de transfert d'échantillons liquides en doses allant du microlitre au millilitre - Google Patents

Procédé et dispositif de transfert d'échantillons liquides en doses allant du microlitre au millilitre Download PDF

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Publication number
EP0105834A2
EP0105834A2 EP83810382A EP83810382A EP0105834A2 EP 0105834 A2 EP0105834 A2 EP 0105834A2 EP 83810382 A EP83810382 A EP 83810382A EP 83810382 A EP83810382 A EP 83810382A EP 0105834 A2 EP0105834 A2 EP 0105834A2
Authority
EP
European Patent Office
Prior art keywords
cannula
profile body
sample
point
storage tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP83810382A
Other languages
German (de)
English (en)
Other versions
EP0105834A3 (fr
Inventor
Rudolf Oberli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GREINER INSTRUMENTS AG
Original Assignee
Greiner Electronic AG
GREINER INSTRUMENTS AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greiner Electronic AG, GREINER INSTRUMENTS AG filed Critical Greiner Electronic AG
Publication of EP0105834A2 publication Critical patent/EP0105834A2/fr
Publication of EP0105834A3 publication Critical patent/EP0105834A3/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements

Definitions

  • the method can advantageously be developed further according to claims 2 and 3. After these further process steps there is only a homogeneous, bubble-free dilution of the sample in the cannula, storage tube and transition point, which is then downward, e.g. can be delivered to several process vessels. These levies have a uniform concentration, regardless of the time and amount of the respective levy.
  • the syringe 1 as an example of a displacement pump device has a cylinder 2 serving as a storage tube, in which the piston 3 is fitted from above, the cannula 4 is cemented in from below and the hose nozzle with opening 5 is glued to the side at top dead center 6 of the piston 3.
  • Below the bottom dead center 7 sits in the 45 ° conical transition 8 a cylindrical profile body 9, which ends at the bottom in a three-sided regular inverted pyramid 10 with a 45 ° surface inclination. This results in three passages 12 between the three contact points 11 of the profile body 9 in the transition 8.
  • the shape of the profile body (9) described approximately represents an easily producible streamlined shape, and if the material selected is corrosion-resistant steel, the result is a weight that is sufficient with bubble-free suction to prevent such a profile body 9 from moving in the opposite direction to the flow in the To keep crossing point 8 sizzling.
  • the profile body 9 also sits against the flow due to its weight Mung in the transition point 8, so that the inflowing liquid column between the profile body 9 and cannula 4 in the transition point 8 distributed to the outside, passed in the space 15 along the profile body 9 and finally reunited on the upper side of the profile body 9 facing away from the cannula 4, now filling the entire cross section of the cylinder 2.
  • the liquid is introduced from the cannula 4 into the cylinder 2, turbulence and other negative pressure zones are avoided, in which the liquid outgasses and could give rise to spontaneous formation of gas bubbles.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
EP83810382A 1982-09-07 1983-08-25 Procédé et dispositif de transfert d'échantillons liquides en doses allant du microlitre au millilitre Withdrawn EP0105834A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH5307/82 1982-09-07
CH530782 1982-09-07

Publications (2)

Publication Number Publication Date
EP0105834A2 true EP0105834A2 (fr) 1984-04-18
EP0105834A3 EP0105834A3 (fr) 1984-10-10

Family

ID=4291396

Family Applications (1)

Application Number Title Priority Date Filing Date
EP83810382A Withdrawn EP0105834A3 (fr) 1982-09-07 1983-08-25 Procédé et dispositif de transfert d'échantillons liquides en doses allant du microlitre au millilitre

Country Status (3)

Country Link
US (1) US4526046A (fr)
EP (1) EP0105834A3 (fr)
JP (1) JPS5965722A (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5174162A (en) * 1989-07-10 1992-12-29 Hitachi, Ltd. Pipetter, pipette tube, sample analyzing apparatus including them and method of mixing and pipetting liquids
EP0624395A1 (fr) * 1993-05-08 1994-11-17 Kernforschungszentrum Karlsruhe GmbH Chambre de mélange
FR2972646A1 (fr) * 2011-03-14 2012-09-21 Total Sa Melange d'un fluide multiphase
WO2013153187A3 (fr) * 2012-04-11 2013-12-05 Stat-Diagnostica & Innovation, S.L. Broyeur à billes magnétique intégré de manière fluidique

Families Citing this family (35)

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US4711766A (en) * 1984-07-09 1987-12-08 Standard Oil Company (Indiana) Apparatus for mixing cracking catalyst with a fluid hydrocarbon
US4836037A (en) * 1986-12-16 1989-06-06 Ciba-Geigy Corporation Sample metering valve for a sample preparation system
ATE80325T1 (de) * 1987-03-02 1992-09-15 Ionode Pty Ltd Mischungsgeraet und -verfahren.
JP2648944B2 (ja) * 1988-10-20 1997-09-03 東亜医用電子株式会社 流体回路ユニット
GB2249171A (en) * 1990-10-25 1992-04-29 N Proizv Ob Biolog Priborostro Liquid sampling
US5507410A (en) * 1992-03-27 1996-04-16 Abbott Laboratories Meia cartridge feeder
US5635364A (en) * 1992-03-27 1997-06-03 Abbott Laboratories Assay verification control for an automated analytical system
JP3439210B2 (ja) * 1992-03-27 2003-08-25 アボツト・ラボラトリーズ 自動連続ランダム・アクセス分析システム及びその構成要素
US5610069A (en) * 1992-03-27 1997-03-11 Abbott Laboratories Apparatus and method for washing clinical apparatus
US5376313A (en) * 1992-03-27 1994-12-27 Abbott Laboratories Injection molding a plastic assay cuvette having low birefringence
US5605665A (en) * 1992-03-27 1997-02-25 Abbott Laboratories Reaction vessel
US5536471A (en) * 1992-03-27 1996-07-16 Abbott Laboratories Syringe with bubble flushing
US5646049A (en) * 1992-03-27 1997-07-08 Abbott Laboratories Scheduling operation of an automated analytical system
US5578494A (en) * 1992-03-27 1996-11-26 Abbott Laboratories Cap actuator for opening and closing a container
US5627522A (en) * 1992-03-27 1997-05-06 Abbott Laboratories Automated liquid level sensing system
US6190617B1 (en) 1992-03-27 2001-02-20 Abbott Laboratories Sample container segment assembly
US5540890A (en) * 1992-03-27 1996-07-30 Abbott Laboratories Capped-closure for a container
US5575978A (en) * 1992-03-27 1996-11-19 Abbott Laboratories Sample container segment assembly
US5960160A (en) * 1992-03-27 1999-09-28 Abbott Laboratories Liquid heater assembly with a pair temperature controlled electric heating elements and a coiled tube therebetween
USD349861S (en) 1992-07-20 1994-08-23 Abbott Laboratories Automated analytical instrument
JP3115501B2 (ja) * 1994-06-15 2000-12-11 プレシジョン・システム・サイエンス株式会社 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置
DE4423878A1 (de) * 1994-07-07 1996-01-11 Boehringer Mannheim Gmbh Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln
US5895631A (en) * 1995-03-20 1999-04-20 Precision System Science Co., Ltd. Liquid processing method making use of pipette device and apparatus for same
US6759014B2 (en) * 2001-01-26 2004-07-06 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
US6913934B2 (en) * 1998-08-13 2005-07-05 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
US6296452B1 (en) 2000-04-28 2001-10-02 Agilent Technologies, Inc. Microfluidic pumping
DE60130057T2 (de) * 2000-05-01 2008-05-15 Fujifilm Corp. Vorrichtung zur Abgabe eines Fluids
WO2002066151A2 (fr) * 2001-01-26 2002-08-29 Symyx Technologies, Inc. Appareil et procede permettant de traiter en paralleles de multiples melanges de reaction
WO2003086637A1 (fr) 2002-04-12 2003-10-23 Instrumentation Laboratory Company Sonde d'immunodosage
US7396512B2 (en) 2003-11-04 2008-07-08 Drummond Scientific Company Automatic precision non-contact open-loop fluid dispensing
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
DE102016225209A1 (de) * 2016-12-15 2018-06-21 Hamilton Bonaduz Ag Pipettiervorrichtung zur verbesserten impulsartigen Flüssigkeitspipettierung
CN115155687B (zh) * 2022-09-06 2022-11-08 广州达安基因股份有限公司 一种定量加样装置及微流控检测设备
CN117443476A (zh) * 2023-11-03 2024-01-26 杭州创新生物检控技术有限公司 微量的液体定量等量分流系统
EP4647152A1 (fr) * 2024-05-10 2025-11-12 Abb Schweiz Ag Système de mesure

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US620066A (en) * 1899-02-21 Paul weissgerber
US2129502A (en) * 1935-09-20 1938-09-06 Chicago Television & Res Lab I Liquid distribution apparatus
US3622279A (en) * 1968-06-14 1971-11-23 Hycel Inc Automatic chemical testing apparatus
US3716338A (en) * 1968-06-14 1973-02-13 Hycel Inc Sample fluid dispensing apparatus for chemical testing apparatus
DE2156083A1 (de) * 1971-11-11 1973-05-17 Matti Reunanen Verfahren und vorrichtung zur dosierung bzw. abteilung und umsetzung bzw. inkubation von reagenzien und entnahme von proben der reaktionsmischung
US3831618A (en) * 1972-12-22 1974-08-27 Abbott Lab Apparatus for the precision metering of fluids
US3864979A (en) * 1973-03-30 1975-02-11 Becton Dickinson Co Blood sedimentation tube barrier
US3972683A (en) * 1974-06-07 1976-08-03 Hycel, Inc. Fluid transfer apparatus
US3985165A (en) * 1975-07-11 1976-10-12 G. D. Searle & Co. Dosing apparatus
DE2848535C2 (de) * 1978-11-09 1982-12-02 Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht Blutaufnahmevorrichtung
DK143719C (da) * 1979-01-03 1982-03-08 Radiometer As Fremgangsmaade til udluftning af en vaeskedoserende stempelpumpe og stempelpumpe med et arrangement til brug ved udoevelse affremgangsmaaden
JPS58129366A (ja) * 1982-01-29 1983-08-02 Olympus Optical Co Ltd 分配分注方法

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5174162A (en) * 1989-07-10 1992-12-29 Hitachi, Ltd. Pipetter, pipette tube, sample analyzing apparatus including them and method of mixing and pipetting liquids
EP0624395A1 (fr) * 1993-05-08 1994-11-17 Kernforschungszentrum Karlsruhe GmbH Chambre de mélange
FR2972646A1 (fr) * 2011-03-14 2012-09-21 Total Sa Melange d'un fluide multiphase
WO2012123454A3 (fr) * 2011-03-14 2012-12-20 Total S.A. Mélange d'un fluide multiphase
RU2585783C2 (ru) * 2011-03-14 2016-06-10 Тоталь С.А. Способ и устройство для смешивания многофазного флюида
WO2013153187A3 (fr) * 2012-04-11 2013-12-05 Stat-Diagnostica & Innovation, S.L. Broyeur à billes magnétique intégré de manière fluidique
US9333471B2 (en) 2012-04-11 2016-05-10 STAT—Diagnostica & Innovation, S.L. Fluidically integrated magnetic bead beater

Also Published As

Publication number Publication date
JPS5965722A (ja) 1984-04-14
EP0105834A3 (fr) 1984-10-10
US4526046A (en) 1985-07-02

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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18D Application deemed to be withdrawn

Effective date: 19861114

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Inventor name: OBERLI, RUDOLF