EP0126437A2 - Dispositif pour la préparation d'onguents médicinaux - Google Patents

Dispositif pour la préparation d'onguents médicinaux Download PDF

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Publication number
EP0126437A2
EP0126437A2 EP84105604A EP84105604A EP0126437A2 EP 0126437 A2 EP0126437 A2 EP 0126437A2 EP 84105604 A EP84105604 A EP 84105604A EP 84105604 A EP84105604 A EP 84105604A EP 0126437 A2 EP0126437 A2 EP 0126437A2
Authority
EP
European Patent Office
Prior art keywords
bowl
roller
peripheral speed
ointments
driven
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84105604A
Other languages
German (de)
English (en)
Other versions
EP0126437A3 (fr
Inventor
Reinhard Richter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0126437A2 publication Critical patent/EP0126437A2/fr
Publication of EP0126437A3 publication Critical patent/EP0126437A3/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/04—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of ointments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/80—Mixers with rotating receptacles rotating about a substantially vertical axis
    • B01F29/87—Mixers with rotating receptacles rotating about a substantially vertical axis with rotary cylinders

Definitions

  • the invention relates to a device for producing medical ointments and the like viscous or pasty masses with a rotationally symmetrical bowl that can be driven by a motor about its own axis for the ingredients to be processed.
  • Ointments, pastes, creams and the like preparations are manufactured on a recipe-based scale in pharmacies by highly qualified personnel with a great deal of time.
  • the ointments for normal requirements are made using a pestle in a grater.
  • the individual batches of the ointments produced in this way differ from one another in terms of consistency, homogeneity, degree of distribution and the like, because the manufacture of such ointments is by hand and almost never leads to exactly the same results.
  • Particularly fine ointments are obtained by spreading the ointment base on a plate and subsets of the solid components using a porphyrizer, a stamp-shaped device. The This procedure is very cumbersome.
  • DE-OS 29 09 767 discloses a device for preparing pasty masses, in particular medical ointments, which has a horizontal turntable driven by a motor. This disk has fastening means for a stirring bowl rotating with the disk. The ingredients to be processed are put into the mixing bowl and processed by means of a spatula during the rotating movement of the mixing bowl. However, the shear movement is too low, so that a sufficiently homogeneous mixing is not achieved.
  • the spatula is held inside the mixing bowl by the operator.
  • the ointments produced with this device are also largely influenced by individual handwork, so that the individual batches differ from one another with regard to the degree of distribution, consistency, homogeneity and the like.
  • a three-roll machine for treating, in particular smoothing, ointments is known from DE-PS 681 343.
  • two adjacent rolls rotate in the opposite direction at different speeds.
  • a substantial part of the ointment being processed remains on the walls of the rollers and is pushed out to the sides, so that it must be scraped off the rollers again and again.
  • these three-roll machines are complex to set up and cumbersome to handle.
  • devices are known in which a knife insert for comminuting and mixing is rotatably arranged within a bowl.
  • the smallest shots They have a content of 12000 cm 3 and are therefore to be used on a defensive scale, i.e. in the kilogram range.
  • These devices are only suitable for the processing of ointment quantities of more than 12 kg and are therefore not to be used on a recipe-based scale, i.e. for 10 to 200 g.
  • the invention has for its object to provide a device of the type mentioned with which medical ointments and the like viscous or pasty masses can also be produced on a recipe-like scale without manual intervention by an operator.
  • This object is achieved in that a height-adjustable roller with its own rotary drive is provided, which forms a gap with the bowl in the lowered position in the bowl for the ingredients to be processed.
  • a device for producing medical ointments and the like viscous or pasty masses is obtained, with which the stirring process takes place within the bowl without manual intervention by an operator.
  • This device can be equipped in a manner known per se with a timer, so that it is sufficient for the pharmacist if he gives the ointment base and the necessary ingredients in certain proportions to one another in the bowl.
  • the device operates in accordance with the time switched on with the timer and then switches off without the supervision of an operator being necessary for this. This also leads to a reduction in the time required for the manufacturer treatment of such ointments and a reduction in personnel costs.
  • the device designed according to the invention is suitable for processing the liquid-liquid and solid-liquid material systems and for mixing, suspending, emulsifying and grinding. Pasting or predispersion in your own work steps is not necessary. Agglomerates of solid components are reliably ground. Furthermore, it is possible with the device according to the invention to produce ointments and the like on a recipe-based scale, that is to say in small amounts in the gram range.
  • the cleaning effort does not exceed that for the devices used in the recipe, in particular the grater and pestle. So there are no bearings, knives or wipers that are cumbersome to clean in the bowl.
  • the stripping can, as far as necessary, be done by holding a spatula knife into the rotating bowl.
  • the bowl is tapered on the inside and has a dome-shaped bottom. This means that even the smallest quantities in the spherical area of the bowl can be processed.
  • the bowl is expediently rotatably mounted on a lower part by means of a bearing and can easily be lifted off the lower part.
  • the bowl expediently has a volume of 1,500 to 2,000 cm 3 in order to be able to also process larger quantities, in particular quantities of up to 1,000 cm 3 .
  • the roller has a cylindrical ball and at the lower end a spherical head adapted to the spherical bottom, in such a way that the spherical head at the lower end of the roller fits exactly into the spherical cap at the bottom of the bowl.
  • the roller can also have a ball tapering towards the lower end and at the lower end a spherical head adapted to the spherical bottom.
  • the spherical head at the lower end of the roller is also designed so that it "fits exactly into the spherical cap on the ground the bowl fits in order to be able to maintain a precisely defined gap between the roller and the bowl.
  • the device is designed such that a lifting device for lifting and lowering the rollers with a drive is arranged on a vertical rod arranged next to the bowl.
  • this lifting device the roller can be removed from the weft be lifted out and lowered back into the bowl.
  • a drive motor is expediently provided on the axis of the roller and is suspended from the lifting device.
  • the drive motor can be suspended in a pivot bearing on the lifting device.
  • roller be above the bowl when it is lifted out of the bowl. This ensures that, for example, when processing a relatively low-viscosity ointment, it can drip off the roller into the bowl without the area outside the bowl being soiled.
  • the roller can also be raised and lowered during operation. This allows the gap between the roller and the bowl to be regulated.
  • the roller can have a volume of 200 to 400 cm 3 .
  • the bowl and roller can generally be made of melamine or hard porcelain.
  • the bowl and roller can be made of hardened steel.
  • the bowl and the roller can be driven in the same direction of rotation. It is advisable to measure the peripheral speed of the roller higher than the peripheral speed of the bowl. It has proven to be expedient experimentally to measure the peripheral speed of the roller at least twice as high as the peripheral speed of the bowl. This ensures that no lump of ointment can form in front of the roller, but the ointment is forced into the gap between the roller and bowl. In addition, the shear movement is large enough to ensure good mixing.
  • the bowl and the roller can also be driven in opposite directions.
  • the peripheral speed of the roller is higher than that of the bowl.
  • the device shown in the drawing is used to manufacture medical ointments and the like viscous or pasty masses. It is possible to work on a recipe scale, i.e. in the gram range.
  • a bowl 3 On a lower part 1, a bowl 3 is rotatably supported about its vertical axis by means of a bearing 2.
  • the bowl 3 has in the illustrated embodiment at its upper end a ring gear 4, in which a gear 5 of an electric motor 6 engages.
  • the gear 5 of the electric motor 6 is to be brought into and out of engagement with the ring gear 4 of the bowl.
  • Other known drive means such as friction wheels, drive belts and the like, can also be used for this purpose.
  • the bowl is conically tapered towards the bottom and has a dome-shaped bottom 7.
  • the volume of the bowl 3 is approximately 1,500 to 2,000 cm.
  • a roller 8 is provided with a downwardly tapering bale 10, which has a ball head 9 at its lower end. Between the roller 8 and the bowl 3, a roller gap 11 is formed, which runs essentially flat, but in the lower region the bowl 3 is curved in the dome-shaped area 7.
  • an electric motor 13 is mounted in alignment with it as a drive.
  • a rod 14 is provided on the lower part 1, on which a lifting device 15 is guided in a height-adjustable manner.
  • the lifting device 15 can be locked at any point by means of the locking screw 16. It has an arm 17 which has a pivot bearing 18 at its free end, in which the electric motor 13 is pivotally mounted.
  • the roller 8 and the bowl 3 rotate, as can be seen in particular from FIG. 2, counterclockwise in the illustrated embodiment in the same direction of rotation a and b, respectively.
  • the speed of the bowl 3 is n 1 and the speed of the roller 8 n2, the two speeds n 1 and n 2 being chosen so that the peripheral speed of the roller 8 is considerably higher, in particular at least twice the peripheral speed of the bowl 3 . Due to the higher peripheral speed of the roller 8 compared to the bowl 3, the surface of the roller 8 acts on the ointment 19 distributed on the inner surface of the bowl like a porphyrizer opposite a plate.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Jellies, Jams, And Syrups (AREA)
EP84105604A 1983-05-24 1984-05-17 Dispositif pour la préparation d'onguents médicinaux Withdrawn EP0126437A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3318842A DE3318842C2 (de) 1983-05-24 1983-05-24 Vorrichtung zum Herstellen von medizinischen Salben
DE3318842 1983-05-24

Publications (2)

Publication Number Publication Date
EP0126437A2 true EP0126437A2 (fr) 1984-11-28
EP0126437A3 EP0126437A3 (fr) 1986-08-06

Family

ID=6199757

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84105604A Withdrawn EP0126437A3 (fr) 1983-05-24 1984-05-17 Dispositif pour la préparation d'onguents médicinaux

Country Status (2)

Country Link
EP (1) EP0126437A3 (fr)
DE (1) DE3318842C2 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020120A1 (fr) * 1998-10-01 2000-04-13 Orazio Bagnasco Machine pour broyer, melanger, et traiter des matieres par une alimentation centrifuge continue dans un dispositif dente
EP1138391A1 (fr) * 2000-03-28 2001-10-04 DRAISWERKE GmbH Dispositif de broyage, pulvérisation et dispersion de matière à broyer fluide
US6520671B1 (en) * 1998-10-14 2003-02-18 Buhler Ag Rotatable hopper having twin screws
US6588930B2 (en) * 2001-06-12 2003-07-08 Ian Geoffrey Wilson Food mixer with detachable head
JP2005254045A (ja) * 2004-03-09 2005-09-22 Hognon Sa ミキサ
US7217029B2 (en) * 2004-02-26 2007-05-15 Hognon Sa Mixer with lump breaker having multiple axes of rotation
GB2475680A (en) * 2009-11-25 2011-06-01 Christopher John Brown Milling apparatus
WO2021082496A1 (fr) * 2019-10-30 2021-05-06 南京星合精密智能制造研究院有限公司 Dispositif de préparation pour abrasif magnétique composite poreux
WO2023246186A1 (fr) * 2022-06-22 2023-12-28 安徽美邸康药业有限公司 Machine intégrée de préparation entièrement automatique de cataplasme

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2183952C2 (ru) * 2000-05-30 2002-06-27 Руднев Евгений Васильевич Аппарат для приготовления стерильных мазей

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE307917C (fr) *
US1634563A (en) * 1925-11-05 1927-07-05 William N Shaw Drug mixer
US1804707A (en) * 1929-11-18 1931-05-12 Rudin Philip Gordon Mixing machine
GB343759A (en) * 1930-02-28 1931-02-26 Maurice Madore Process of and apparatus for pulverising selid materials
US2192310A (en) * 1938-06-30 1940-03-05 Stanley D Hartshorn Differential roll crusher
GB1253517A (en) * 1968-02-28 1971-11-17 Acheson Ind Inc Roll mill
DE1782168A1 (de) * 1968-07-26 1971-07-22 Alfred Fritsch Ohg Laborgeraet Labor-Kleinmuehle
US4067503A (en) * 1976-04-12 1978-01-10 Broman John S Method of grinding in a mill
DE2853383A1 (de) * 1978-12-11 1980-06-19 Kurt Giradelli Jun Dent Med Ge Vorrichtung zum kneten dentaler abdruckmassen
DE2909767A1 (de) * 1979-03-13 1980-09-18 Heinz Hartmann Vorrichtung zum herstellen von pastoesen massen, insbesondere medizinischen salben
DE3022689A1 (de) * 1980-06-18 1981-12-24 ERKODENT Erich Kopp Dentalfabrikation GmbH & Co, 7293 Pfalzgrafenweiler Mischgeraet fuer zahnaerztliche abdruckmassen

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020120A1 (fr) * 1998-10-01 2000-04-13 Orazio Bagnasco Machine pour broyer, melanger, et traiter des matieres par une alimentation centrifuge continue dans un dispositif dente
US6520671B1 (en) * 1998-10-14 2003-02-18 Buhler Ag Rotatable hopper having twin screws
EP1138391A1 (fr) * 2000-03-28 2001-10-04 DRAISWERKE GmbH Dispositif de broyage, pulvérisation et dispersion de matière à broyer fluide
US6565023B2 (en) 2000-03-28 2003-05-20 Draiswerke Gmbh Apparatus for comminuting, grinding and dispersing flowable grinding stock
US6588930B2 (en) * 2001-06-12 2003-07-08 Ian Geoffrey Wilson Food mixer with detachable head
US7217029B2 (en) * 2004-02-26 2007-05-15 Hognon Sa Mixer with lump breaker having multiple axes of rotation
JP2005254045A (ja) * 2004-03-09 2005-09-22 Hognon Sa ミキサ
GB2475680A (en) * 2009-11-25 2011-06-01 Christopher John Brown Milling apparatus
CN102725065A (zh) * 2009-11-25 2012-10-10 领先漩涡工艺技术有限公司 研磨机和研磨方法
US8752778B2 (en) 2009-11-25 2014-06-17 Maelstrom Advanced Process Technologies Limited Mill and method of milling
CN102725065B (zh) * 2009-11-25 2015-01-07 领先漩涡工艺技术有限公司 研磨机和研磨方法
WO2021082496A1 (fr) * 2019-10-30 2021-05-06 南京星合精密智能制造研究院有限公司 Dispositif de préparation pour abrasif magnétique composite poreux
WO2023246186A1 (fr) * 2022-06-22 2023-12-28 安徽美邸康药业有限公司 Machine intégrée de préparation entièrement automatique de cataplasme

Also Published As

Publication number Publication date
DE3318842A1 (de) 1984-11-29
DE3318842C2 (de) 1985-03-14
EP0126437A3 (fr) 1986-08-06

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