EP0174654A3 - Dérivés carbonyles - Google Patents

Dérivés carbonyles Download PDF

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Publication number
EP0174654A3
EP0174654A3 EP85111494A EP85111494A EP0174654A3 EP 0174654 A3 EP0174654 A3 EP 0174654A3 EP 85111494 A EP85111494 A EP 85111494A EP 85111494 A EP85111494 A EP 85111494A EP 0174654 A3 EP0174654 A3 EP 0174654A3
Authority
EP
European Patent Office
Prior art keywords
lower alkyl
group
carbon atoms
groups
alk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP85111494A
Other languages
German (de)
English (en)
Other versions
EP0174654A2 (fr
Inventor
Markus Dr. Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of EP0174654A2 publication Critical patent/EP0174654A2/fr
Publication of EP0174654A3 publication Critical patent/EP0174654A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP85111494A 1984-09-14 1985-09-11 Dérivés carbonyles Withdrawn EP0174654A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH4388/84 1984-09-14
CH438884 1984-09-14

Publications (2)

Publication Number Publication Date
EP0174654A2 EP0174654A2 (fr) 1986-03-19
EP0174654A3 true EP0174654A3 (fr) 1987-07-22

Family

ID=4275188

Family Applications (2)

Application Number Title Priority Date Filing Date
EP85111494A Withdrawn EP0174654A3 (fr) 1984-09-14 1985-09-11 Dérivés carbonyles
EP85111493A Withdrawn EP0174653A3 (fr) 1984-09-14 1985-09-11 Dérivés phénylalkyles

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP85111493A Withdrawn EP0174653A3 (fr) 1984-09-14 1985-09-11 Dérivés phénylalkyles

Country Status (16)

Country Link
US (1) US4853393A (fr)
EP (2) EP0174654A3 (fr)
JP (2) JPS6172751A (fr)
KR (1) KR890000225B1 (fr)
AU (1) AU4744985A (fr)
DD (1) DD237165A5 (fr)
DK (2) DK416985A (fr)
ES (4) ES8802025A1 (fr)
FI (2) FI853477A7 (fr)
GR (2) GR852215B (fr)
HU (1) HU194871B (fr)
IL (1) IL76366A (fr)
NO (1) NO853609L (fr)
NZ (1) NZ213461A (fr)
PT (2) PT81116B (fr)
ZA (1) ZA857034B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK159420C (da) * 1983-03-09 1991-03-11 Ciba Geigy Ag N-(piperidinyl-alkyl)-carboxamider og salte deraf, farmaceutiske praeparater indeholdende disse forbindelser samt anvendelsen af forbindelserne til fremstilling af antipsykotiske farmaceutiske praeparater
FI853477A7 (fi) * 1984-09-14 1986-03-15 Ciba Geigy Ag Menetelmä karbonyyliyhdisteiden valmistamiseksi.
JPS61227567A (ja) * 1985-04-01 1986-10-09 Eisai Co Ltd １，４−ジヒドロピリジン誘導体
EP0216542B1 (fr) * 1985-09-13 1991-12-11 The Green Cross Corporation Dérivés de la dihydropyridine
EP0222702A3 (fr) * 1985-11-06 1988-01-07 Ciba-Geigy Ag Dérivés carbonyliques basiques
DE3601397A1 (de) * 1986-01-18 1987-07-23 Bayer Ag Substituierte 1,4-dihydropyridin-3-carbonsaeurepiperazide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4994461A (en) * 1987-03-27 1991-02-19 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydropyridine enantiomers
WO1988007531A1 (fr) * 1987-03-27 1988-10-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouveaux composes optiquement actifs
DE3724909A1 (de) * 1987-07-28 1989-02-09 Bayer Ag Neue substituierte nitro-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
US5258519A (en) * 1990-11-13 1993-11-02 Glaxo Inc. Dihydropyridine vasodilators agents
US6211198B1 (en) 1993-04-05 2001-04-03 Synaptic Pharmaceutical Corporation Dihydropyridines and new uses thereof
US5767131A (en) * 1993-04-05 1998-06-16 Synaptic Pharmaceutical Corporation Dihydropyridines and new uses thereof
EE200100502A (et) 1999-03-26 2002-12-16 Astrazeneca Ab Ühendid
NZ521853A (en) * 2000-04-11 2003-11-28 Sankyo Co Stabilized pharmaceutical compositions containing a calcium blocker
GB0013060D0 (en) * 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
GB0021670D0 (en) * 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
GB0117899D0 (en) * 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
SE0102809D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab Novel compounds
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003249A1 (fr) * 1982-03-17 1983-09-29 Yoshitomi Pharmaceutical Derives de 1,4-dihydropyridine-3,5-dicarboxylate
EP0094159A1 (fr) * 1982-05-10 1983-11-16 Takeda Chemical Industries, Ltd. Dérivés de la dihydropyridine, leur préparation et leur application
WO1983004023A1 (fr) * 1982-05-10 1983-11-24 Takeda Chemical Industries, Ltd. Derives de dihydropyridine
WO1984002132A1 (fr) * 1982-11-24 1984-06-07 Cermol Sa Nouveaux esters de 1,4-dihydropyridines et leurs procedes de preparation et medicaments contenant lesdits esters
WO1984002702A1 (fr) * 1983-01-11 1984-07-19 Takeda Chemical Industries Ltd Derives de dihydropyridine
EP0138505A2 (fr) * 1983-10-17 1985-04-24 Takeda Chemical Industries, Ltd. Dérivés de dihydropyridine, leur préparation et leur utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284634A (en) * 1975-07-02 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
JPS5283672A (en) * 1976-01-01 1977-07-12 Yamanouchi Pharmaceut Co Ltd Novel 2-amino-1,4-dihydropyridine derivatives
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
JPS58201765A (ja) * 1982-05-10 1983-11-24 Takeda Chem Ind Ltd ジヒドロピリジン誘導体，その製造法および用途
IT1198377B (it) * 1982-06-03 1988-12-21 Pierrel Spa Esteri basici ad attivita' calcioanatagonista,procedimenti per la loro preparazione e relative composizioni farmaceutiche
EP0111455A3 (fr) * 1982-12-10 1984-07-25 Ciba-Geigy Ag Lactones non-saturés
FI853477A7 (fi) * 1984-09-14 1986-03-15 Ciba Geigy Ag Menetelmä karbonyyliyhdisteiden valmistamiseksi.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003249A1 (fr) * 1982-03-17 1983-09-29 Yoshitomi Pharmaceutical Derives de 1,4-dihydropyridine-3,5-dicarboxylate
EP0094159A1 (fr) * 1982-05-10 1983-11-16 Takeda Chemical Industries, Ltd. Dérivés de la dihydropyridine, leur préparation et leur application
WO1983004023A1 (fr) * 1982-05-10 1983-11-24 Takeda Chemical Industries, Ltd. Derives de dihydropyridine
WO1984002132A1 (fr) * 1982-11-24 1984-06-07 Cermol Sa Nouveaux esters de 1,4-dihydropyridines et leurs procedes de preparation et medicaments contenant lesdits esters
WO1984002702A1 (fr) * 1983-01-11 1984-07-19 Takeda Chemical Industries Ltd Derives de dihydropyridine
EP0138505A2 (fr) * 1983-10-17 1985-04-24 Takeda Chemical Industries, Ltd. Dérivés de dihydropyridine, leur préparation et leur utilisation

Also Published As

Publication number Publication date
IL76366A (en) 1989-07-31
GR852215B (fr) 1986-01-14
DK416985A (da) 1986-03-15
ES8800926A1 (es) 1987-12-01
PT81117B (en) 1987-07-15
PT81117A (en) 1985-10-01
NZ213461A (en) 1989-07-27
EP0174653A3 (fr) 1987-06-16
FI853478A0 (fi) 1985-09-11
JPS6172752A (ja) 1986-04-14
FI853477A0 (fi) 1985-09-11
EP0174653A2 (fr) 1986-03-19
ES546945A0 (es) 1986-11-16
ES8802025A1 (es) 1987-02-16
DK416885A (da) 1986-03-15
ZA857034B (en) 1987-05-27
DD237165A5 (de) 1986-07-02
GR852216B (fr) 1986-01-14
ES554488A0 (es) 1987-12-01
HU194871B (en) 1988-03-28
US4853393A (en) 1989-08-01
PT81116B (en) 1987-07-15
NO853609L (no) 1986-03-17
PT81116A (en) 1985-10-01
JPS6172751A (ja) 1986-04-14
EP0174654A2 (fr) 1986-03-19
ES8706669A1 (es) 1987-07-01
ES554487A0 (es) 1987-07-01
DK416985D0 (da) 1985-09-13
FI853477L (fi) 1986-03-15
ES546946A0 (es) 1987-02-16
IL76366A0 (en) 1986-01-31
HUT38339A (en) 1986-05-28
KR860002496A (ko) 1986-04-26
ES8701158A1 (es) 1986-11-16
KR890000225B1 (ko) 1989-03-11
AU4744985A (en) 1986-03-20
FI853478A7 (fi) 1986-03-15
FI853478L (fi) 1986-03-15
FI853477A7 (fi) 1986-03-15
DK416885D0 (da) 1985-09-13

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Inventor name: ZIMMERMANN, MARKUS, DR.