EP0221277A2 - Gélatine contenant du bêta-carotène - Google Patents

Gélatine contenant du bêta-carotène Download PDF

Info

Publication number
EP0221277A2
EP0221277A2 EP86112053A EP86112053A EP0221277A2 EP 0221277 A2 EP0221277 A2 EP 0221277A2 EP 86112053 A EP86112053 A EP 86112053A EP 86112053 A EP86112053 A EP 86112053A EP 0221277 A2 EP0221277 A2 EP 0221277A2
Authority
EP
European Patent Office
Prior art keywords
gelatin
weight
carotene
parts
light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86112053A
Other languages
German (de)
English (en)
Other versions
EP0221277A3 (en
Inventor
Ahmed Dr. Hegasy
Manfred Dr. Winter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of EP0221277A2 publication Critical patent/EP0221277A2/fr
Publication of EP0221277A3 publication Critical patent/EP0221277A3/de
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B61/00Dyes of natural origin prepared from natural sources, e.g. vegetable sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0033Blends of pigments; Mixtured crystals; Solid solutions

Definitions

  • the food coloring agent ß-carotene (Color Index No. 40800) is soluble in oils or fats in yellowish to orange-red color. It is the main component of natural carotene (CI no. 75130) and is preferred for coloring foods such as margarine or fruit drinks.
  • a major disadvantage of this dye is its lack of lightfastness (see DFG Dye Commission, ring binder dyes for food). In view of the instability of light, it is recommended to store the dye cool and in the dark under inert gas.
  • iron oxides and / or certain food dyes such as yellow-orange S (CI No. 15985) as colorants and light stabilizers in soft gelatin (cf. DE-OS 22 09 526).
  • larger amounts of about 1 to 2% by weight of iron oxides are often necessary to achieve optimal sun protection.
  • the amount of iron in the form of iron oxides that can be administered to a patient per day is limited official requirements limited.
  • the permissible upper limit for the application of iron in the form of iron oxides in the USA is 5 mg per day and patient.
  • the official approval of food dyes, in particular the approval of representatives of azo dyes is also subject to restrictive conditions in some countries, since individual representatives of these dyes are suspected of triggering side effects such as allergies.
  • capsules with 5 mg of nisoldipine per capsule are produced by encapsulating 226 mg of a mixture of 2.5 parts by weight of nisoldipine with 95 parts by weight of polyethylene glycol 400 and 6 parts by weight of water and 10 parts by weight of glycerol.
  • the capsule format is 4 minims.
  • 0.1 kg of ⁇ -carotene is dissolved in 5 kg of trichlorethylene.
  • the solution turns into a mixture heated to 60 ° C 0.2 kg of yellow iron oxide, 28 kg of glycerol, 5 kg of water and 5 kg of gelatin.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
EP86112053A 1985-09-10 1986-09-01 Gelatin containing beta-carotene Withdrawn EP0221277A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3532129 1985-09-10
DE19853532129 DE3532129A1 (de) 1985-09-10 1985-09-10 Ss-carotin enthaltende gelatine

Publications (2)

Publication Number Publication Date
EP0221277A2 true EP0221277A2 (fr) 1987-05-13
EP0221277A3 EP0221277A3 (en) 1988-07-20

Family

ID=6280478

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86112053A Withdrawn EP0221277A3 (en) 1985-09-10 1986-09-01 Gelatin containing beta-carotene

Country Status (7)

Country Link
US (1) US4693892A (fr)
EP (1) EP0221277A3 (fr)
JP (1) JPS6268860A (fr)
KR (1) KR870003165A (fr)
AU (1) AU6215986A (fr)
DE (1) DE3532129A1 (fr)
ES (1) ES2001945A6 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664814A1 (fr) * 1990-07-20 1992-01-24 Egyt Gyogyszervegyeszeti Gyar Compositions pharmaceutiques solides et leur procede de preparation.
WO2001015702A1 (fr) * 1999-08-31 2001-03-08 Chugai Seiyaku Kabushiki Kaisha Capsules molles
US8420057B2 (en) 2011-09-01 2013-04-16 Qualicaps, Inc. Capsule having broad color spectrum
US8435545B2 (en) 2011-09-01 2013-05-07 Qualicaps, Inc. Capsule having broad color spectrum

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272336B1 (fr) * 1986-12-18 1991-10-23 Kurt H. Prof. Dr. Bauer Concentré de nifédipine stabilisé contre l'influence de la lumière et mode de préparation
US4978533A (en) * 1988-11-01 1990-12-18 Pharmaconsult, Inc. Liquid nifidipine composition
JPH04346929A (ja) * 1991-05-22 1992-12-02 Takada Seiyaku Kk 光に安定なメシル酸ブロモクリプチン製剤
GB9411115D0 (en) * 1994-06-03 1994-07-27 Secr Defence Stabilisation of photosensitive material
JP4730985B2 (ja) * 1997-09-10 2011-07-20 武田薬品工業株式会社 安定化された医薬製剤
EP1335652B1 (fr) * 2000-11-24 2009-12-16 Unilever N.V. Produit alimentaire contenant des carotenoides
US6844020B2 (en) * 2002-07-26 2005-01-18 Kemin Foods, L.C. Solutions of carotenoids for use in foods and personal care products
CN102186351A (zh) * 2008-08-01 2011-09-14 医药公司 药物组合物和用于稳定药物组合物的方法
WO2010014727A1 (fr) 2008-08-01 2010-02-04 The Medicines Company Compositions pharmaceutiques, et procédés pour produire de faibles concentrations d'impureté de celles-ci
KR20150027154A (ko) * 2012-07-02 2015-03-11 디에스엠 아이피 어셋츠 비.브이. 타이모퀴논을 함유하는 캡슐

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6809267A (fr) * 1968-07-01 1970-01-05
SU432703A3 (fr) * 1971-08-24 1974-06-15 Фридрих Боссерт, Вульф Фатер, Курт Бауер
US3998753A (en) * 1974-08-13 1976-12-21 Hoffmann-La Roche Inc. Water dispersible carotenoid preparations and processes thereof
CH642990A5 (de) * 1978-07-24 1984-05-15 Parke Davis & Co Verfahren zum faerben von gelatine fuer kapseln mit hilfe eines gegen den abbau durch licht oder oxidation stabilisierten natuerlichen farbstoffes.

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664814A1 (fr) * 1990-07-20 1992-01-24 Egyt Gyogyszervegyeszeti Gyar Compositions pharmaceutiques solides et leur procede de preparation.
GR910100319A (el) * 1990-07-20 1992-08-26 Egyt Gyogyszervegyeszeti Gyar Μέ?οδος για την παρασκευή στερεών συν?έσεων περιλαμβανουσών ευαισ?ητοποιημένο εις το φως και δυσκόλως υδατοδιαλυτό ενεργό συστατικό.
BE1006829A3 (fr) * 1990-07-20 1995-01-03 Egyt Gyogyszervegyeszeti Gyar Compositions pharmaceutiques solides.
WO2001015702A1 (fr) * 1999-08-31 2001-03-08 Chugai Seiyaku Kabushiki Kaisha Capsules molles
US8420057B2 (en) 2011-09-01 2013-04-16 Qualicaps, Inc. Capsule having broad color spectrum
US8435545B2 (en) 2011-09-01 2013-05-07 Qualicaps, Inc. Capsule having broad color spectrum
WO2013033304A3 (fr) * 2011-09-01 2013-06-13 Qualicaps, Inc. Capsule ayant un large spectre de couleurs

Also Published As

Publication number Publication date
EP0221277A3 (en) 1988-07-20
KR870003165A (ko) 1987-04-15
JPS6268860A (ja) 1987-03-28
AU6215986A (en) 1987-03-12
DE3532129A1 (de) 1987-03-12
ES2001945A6 (es) 1988-07-01
US4693892A (en) 1987-09-15

Similar Documents

Publication Publication Date Title
EP0221277A2 (fr) Gélatine contenant du bêta-carotène
DE2925364C2 (de) Verwendung eines stabilisierten Farbstoffs zum Anfärben von Arzneimittelkapseln
DE2126954A1 (de) Mittel gegen das Ausbleichen von Farbfotografien
DE60124826T2 (de) Umkehrbare thermochromische Zusammensetzung mit verbesserter Lichtechtheit und diese enthaltendes Erzeugnis
DE2836300C2 (fr)
DE3609962C2 (fr)
DE1293780B (de) 3-Phenyl-spiro-benzopyrane und Verfahren zu deren Herstellung
DE2505309C3 (de) Mischung aus Triazol und phenolischen Antioxydationsmitteln zum Stabilisieren von Polyurethan gegen UV-Uchteinwirkung
DE2532036A1 (de) Autooxidierbare haarfaerbezusammensetzung und haarfaerbeverfahren
DE1299297B (de) 3'-Methyl-spiro-benzonaphthopyrane und Verfahren zu deren Herstellung
EP0376047A1 (fr) Dérivés du 2-amino-6-chloro-4-nitrophénol, procédé pour leur préparation et composition pour la teinture des cheveux contenant ces composés
EP0727203A1 (fr) Colorant d'oxydation pour cheveux
DE3237219A1 (de) Faerbemittel fuer keratinische fasern auf der basis von nitrobenzol-farbstoffen sowie faerbeverfahren
EP0303878B1 (fr) Teintures pour cheveux a base des dérivés de diamino-2,5-nitro-6-pyridine
DE1003402B (de) Verfahren zum Faerben von Haaren
DE60303156T2 (de) Gefärbte Hartkapseln
EP0132568A1 (fr) Dérivés de 1,4-diamino-5-chloro-2-nitrobenzène, procédé de leur production et agents pour la teinture des cheveux
EP0150765B1 (fr) Utilisation de composés p-uréidoalkylamino nitrobenzéniques dans des compositions de teinture des cheveux et composés p-uréidoalkylamine nitrobenzèniques
DE3806072A1 (de) Verfahren zum faerben von synthetischen fasermaterialien
DE1031758B (de) Faerbeverfahren fuer aromatische Polyester
DE3442861C2 (fr)
DE2913821A1 (de) Neue para-phenylendiamine, verfahren zu deren herstellung und diese enthaltende mittel
DE3942315A1 (de) Schaumfoermiges haartoenungsmittel
DD147009A1 (de) Verfahren zur dispergierung von hydrophoben fotografischen zusaetzen
DE1769381B2 (de) Rote Monoazofarbstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19860901

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LI NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

18W Application withdrawn

Withdrawal date: 19880419

PUAF Information related to the publication of a search report (a3 document) modified or deleted

Free format text: ORIGINAL CODE: 0009199SEPU

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LI NL SE

D17D Deferred search report published (deleted)
RIN1 Information on inventor provided before grant (corrected)

Inventor name: HEGASY, AHMED, DR.

Inventor name: WINTER, MANFRED, DR.