EP0221277A2 - Gélatine contenant du bêta-carotène - Google Patents
Gélatine contenant du bêta-carotène Download PDFInfo
- Publication number
- EP0221277A2 EP0221277A2 EP86112053A EP86112053A EP0221277A2 EP 0221277 A2 EP0221277 A2 EP 0221277A2 EP 86112053 A EP86112053 A EP 86112053A EP 86112053 A EP86112053 A EP 86112053A EP 0221277 A2 EP0221277 A2 EP 0221277A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- gelatin
- weight
- carotene
- parts
- light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0033—Blends of pigments; Mixtured crystals; Solid solutions
Definitions
- the food coloring agent ß-carotene (Color Index No. 40800) is soluble in oils or fats in yellowish to orange-red color. It is the main component of natural carotene (CI no. 75130) and is preferred for coloring foods such as margarine or fruit drinks.
- a major disadvantage of this dye is its lack of lightfastness (see DFG Dye Commission, ring binder dyes for food). In view of the instability of light, it is recommended to store the dye cool and in the dark under inert gas.
- iron oxides and / or certain food dyes such as yellow-orange S (CI No. 15985) as colorants and light stabilizers in soft gelatin (cf. DE-OS 22 09 526).
- larger amounts of about 1 to 2% by weight of iron oxides are often necessary to achieve optimal sun protection.
- the amount of iron in the form of iron oxides that can be administered to a patient per day is limited official requirements limited.
- the permissible upper limit for the application of iron in the form of iron oxides in the USA is 5 mg per day and patient.
- the official approval of food dyes, in particular the approval of representatives of azo dyes is also subject to restrictive conditions in some countries, since individual representatives of these dyes are suspected of triggering side effects such as allergies.
- capsules with 5 mg of nisoldipine per capsule are produced by encapsulating 226 mg of a mixture of 2.5 parts by weight of nisoldipine with 95 parts by weight of polyethylene glycol 400 and 6 parts by weight of water and 10 parts by weight of glycerol.
- the capsule format is 4 minims.
- 0.1 kg of ⁇ -carotene is dissolved in 5 kg of trichlorethylene.
- the solution turns into a mixture heated to 60 ° C 0.2 kg of yellow iron oxide, 28 kg of glycerol, 5 kg of water and 5 kg of gelatin.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3532129 | 1985-09-10 | ||
| DE19853532129 DE3532129A1 (de) | 1985-09-10 | 1985-09-10 | Ss-carotin enthaltende gelatine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0221277A2 true EP0221277A2 (fr) | 1987-05-13 |
| EP0221277A3 EP0221277A3 (en) | 1988-07-20 |
Family
ID=6280478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP86112053A Withdrawn EP0221277A3 (en) | 1985-09-10 | 1986-09-01 | Gelatin containing beta-carotene |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4693892A (fr) |
| EP (1) | EP0221277A3 (fr) |
| JP (1) | JPS6268860A (fr) |
| KR (1) | KR870003165A (fr) |
| AU (1) | AU6215986A (fr) |
| DE (1) | DE3532129A1 (fr) |
| ES (1) | ES2001945A6 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2664814A1 (fr) * | 1990-07-20 | 1992-01-24 | Egyt Gyogyszervegyeszeti Gyar | Compositions pharmaceutiques solides et leur procede de preparation. |
| WO2001015702A1 (fr) * | 1999-08-31 | 2001-03-08 | Chugai Seiyaku Kabushiki Kaisha | Capsules molles |
| US8420057B2 (en) | 2011-09-01 | 2013-04-16 | Qualicaps, Inc. | Capsule having broad color spectrum |
| US8435545B2 (en) | 2011-09-01 | 2013-05-07 | Qualicaps, Inc. | Capsule having broad color spectrum |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0272336B1 (fr) * | 1986-12-18 | 1991-10-23 | Kurt H. Prof. Dr. Bauer | Concentré de nifédipine stabilisé contre l'influence de la lumière et mode de préparation |
| US4978533A (en) * | 1988-11-01 | 1990-12-18 | Pharmaconsult, Inc. | Liquid nifidipine composition |
| JPH04346929A (ja) * | 1991-05-22 | 1992-12-02 | Takada Seiyaku Kk | 光に安定なメシル酸ブロモクリプチン製剤 |
| GB9411115D0 (en) * | 1994-06-03 | 1994-07-27 | Secr Defence | Stabilisation of photosensitive material |
| JP4730985B2 (ja) * | 1997-09-10 | 2011-07-20 | 武田薬品工業株式会社 | 安定化された医薬製剤 |
| EP1335652B1 (fr) * | 2000-11-24 | 2009-12-16 | Unilever N.V. | Produit alimentaire contenant des carotenoides |
| US6844020B2 (en) * | 2002-07-26 | 2005-01-18 | Kemin Foods, L.C. | Solutions of carotenoids for use in foods and personal care products |
| CN102186351A (zh) * | 2008-08-01 | 2011-09-14 | 医药公司 | 药物组合物和用于稳定药物组合物的方法 |
| WO2010014727A1 (fr) | 2008-08-01 | 2010-02-04 | The Medicines Company | Compositions pharmaceutiques, et procédés pour produire de faibles concentrations d'impureté de celles-ci |
| KR20150027154A (ko) * | 2012-07-02 | 2015-03-11 | 디에스엠 아이피 어셋츠 비.브이. | 타이모퀴논을 함유하는 캡슐 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6809267A (fr) * | 1968-07-01 | 1970-01-05 | ||
| SU432703A3 (fr) * | 1971-08-24 | 1974-06-15 | Фридрих Боссерт, Вульф Фатер, Курт Бауер | |
| US3998753A (en) * | 1974-08-13 | 1976-12-21 | Hoffmann-La Roche Inc. | Water dispersible carotenoid preparations and processes thereof |
| CH642990A5 (de) * | 1978-07-24 | 1984-05-15 | Parke Davis & Co | Verfahren zum faerben von gelatine fuer kapseln mit hilfe eines gegen den abbau durch licht oder oxidation stabilisierten natuerlichen farbstoffes. |
-
1985
- 1985-09-10 DE DE19853532129 patent/DE3532129A1/de not_active Withdrawn
-
1986
- 1986-09-01 EP EP86112053A patent/EP0221277A3/de not_active Withdrawn
- 1986-09-02 JP JP61205238A patent/JPS6268860A/ja active Pending
- 1986-09-02 AU AU62159/86A patent/AU6215986A/en not_active Abandoned
- 1986-09-05 US US06/904,733 patent/US4693892A/en not_active Expired - Fee Related
- 1986-09-09 ES ES8601708A patent/ES2001945A6/es not_active Expired
- 1986-09-09 KR KR1019860007524A patent/KR870003165A/ko not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2664814A1 (fr) * | 1990-07-20 | 1992-01-24 | Egyt Gyogyszervegyeszeti Gyar | Compositions pharmaceutiques solides et leur procede de preparation. |
| GR910100319A (el) * | 1990-07-20 | 1992-08-26 | Egyt Gyogyszervegyeszeti Gyar | Μέ?οδος για την παρασκευή στερεών συν?έσεων περιλαμβανουσών ευαισ?ητοποιημένο εις το φως και δυσκόλως υδατοδιαλυτό ενεργό συστατικό. |
| BE1006829A3 (fr) * | 1990-07-20 | 1995-01-03 | Egyt Gyogyszervegyeszeti Gyar | Compositions pharmaceutiques solides. |
| WO2001015702A1 (fr) * | 1999-08-31 | 2001-03-08 | Chugai Seiyaku Kabushiki Kaisha | Capsules molles |
| US8420057B2 (en) | 2011-09-01 | 2013-04-16 | Qualicaps, Inc. | Capsule having broad color spectrum |
| US8435545B2 (en) | 2011-09-01 | 2013-05-07 | Qualicaps, Inc. | Capsule having broad color spectrum |
| WO2013033304A3 (fr) * | 2011-09-01 | 2013-06-13 | Qualicaps, Inc. | Capsule ayant un large spectre de couleurs |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0221277A3 (en) | 1988-07-20 |
| KR870003165A (ko) | 1987-04-15 |
| JPS6268860A (ja) | 1987-03-28 |
| AU6215986A (en) | 1987-03-12 |
| DE3532129A1 (de) | 1987-03-12 |
| ES2001945A6 (es) | 1988-07-01 |
| US4693892A (en) | 1987-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19860901 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE FR GB IT LI NL SE |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
| PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
| 18W | Application withdrawn |
Withdrawal date: 19880419 |
|
| PUAF | Information related to the publication of a search report (a3 document) modified or deleted |
Free format text: ORIGINAL CODE: 0009199SEPU |
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| AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE FR GB IT LI NL SE |
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| D17D | Deferred search report published (deleted) | ||
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HEGASY, AHMED, DR. Inventor name: WINTER, MANFRED, DR. |