EP0262060A2 - Zentrifugenvorrichtung zum Durchführen von Analysen - Google Patents

Zentrifugenvorrichtung zum Durchführen von Analysen Download PDF

Info

Publication number
EP0262060A2
EP0262060A2 EP87420250A EP87420250A EP0262060A2 EP 0262060 A2 EP0262060 A2 EP 0262060A2 EP 87420250 A EP87420250 A EP 87420250A EP 87420250 A EP87420250 A EP 87420250A EP 0262060 A2 EP0262060 A2 EP 0262060A2
Authority
EP
European Patent Office
Prior art keywords
support plate
plate
rotation
support
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP87420250A
Other languages
English (en)
French (fr)
Other versions
EP0262060B1 (de
EP0262060A3 (en
Inventor
Jean-Pierre Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kis Photo Industrie SARL
Original Assignee
Kis Photo Industrie SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8613550A external-priority patent/FR2604925B1/fr
Priority claimed from FR8613551A external-priority patent/FR2605108B1/fr
Priority claimed from FR8613552A external-priority patent/FR2605104B1/fr
Application filed by Kis Photo Industrie SARL filed Critical Kis Photo Industrie SARL
Publication of EP0262060A2 publication Critical patent/EP0262060A2/de
Publication of EP0262060A3 publication Critical patent/EP0262060A3/fr
Application granted granted Critical
Publication of EP0262060B1 publication Critical patent/EP0262060B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/02—Centrifuges consisting of a plurality of separate bowls rotating round an axis situated between the bowls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B15/00—Other accessories for centrifuges
    • B04B15/02—Other accessories for centrifuges for cooling, heating, or heat insulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/08—Arrangement or disposition of transmission gearing ; Couplings; Brakes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/14—Balancing rotary bowls ; Schrappers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor

Definitions

  • the present invention relates to a centrifuge device for carrying out analyzes, in particular biological and medical, of samples contained in an analysis unit; the latter comprises, in a manner known per se, a reading cell for any spectrophotometric measurement in absorbance.
  • Such a device has for example been described in patent application FR-A-2 524 874, and comprises: - A support plate, driven in rotation by a motor means (13), comprising around its periphery a plurality of individual supports for the various housings, themselves rotary relative to the support plate; - Means for pivoting each individual support relative to the support plate, in order to orient the centrifugal force relative to each analysis unit; - A spectrophotometric measurement assembly, the optical path of which is perpendicular to the plane of the support plate, and capable of passing through the reading cell of each housing, in a predetermined position of the latter in rotation.
  • the present invention relates to means making it possible to rotate the different analysis boxes, and more precisely their different individual supports, responding to the following concerns: - do not significantly increase the inertia of the support plate, so as to limit the power of the drive motor, and lighten the mechanical design of the entire device; - do not use any individual means for controlling the rotation of each individual support of an analysis unit, such as a stepping motor; - controlling the rotation of these same individual supports, by mechanical action, from a fixed part external to the support plate.
  • the means making it possible to pivot each individual support comprise: - A plate fixed relative to the support plate, arranged below the latter, comprising a peripheral guide; - a pivoting portion, coplanar with the fixed plate, articulated at one end on the latter, comprising at least one guide rail, having a radius of curvature coinciding with that of the peripheral guide of the fixed plate, the pivoting portion being movable between two positions, a first position in which the guide rail coincides with the guide of the fixed plate, and a second position in which the guide rail coincides with the free end of a fitting projecting externally relative to the fixed plate, and connected to the peripheral guide; - A plurality of axes orthogonal to the support plate, mounted to rotate freely on the latter, at the upper end of which are fixed the different individual supports, and at the lower end of which are fixed different rods parallel to the fixed plate, each rod comprising at its two ends two coplanar rollers bearing on the peripheral guide of the fixed plate.
  • the characteristic means of the present invention are of great mechanical simplicity. It is ultimately the drive motor in rotation of the support plate, which indirectly rotates the analysis boxes.
  • the means according to the invention allow the different analysis boxes to be pivoted gradually, smoothly, relative to the support plate. By thus avoiding any accelerated rotation of an analysis unit, one thus avoids any secondary centrifugation of the latter, relative to its own axis, which would adversely affect the quality of the analysis.
  • the automatic device for carrying out biological and medical analyzes is integrated within a box of generally parallelepiped shape having the general reference (1), observable within FIG. 6.
  • This box has on its face upper two covers respectively (2) and (3), one (2) acting as a liquid crystal screen (4) and releasing, when in the open position, a touch keyboard (5), the other (3) allowing access to the various individual supports of the centrifuge device which will be described later.
  • This cover (3) releases, when in the open position, a semi-circular orifice serving as access to the loading (7) of the analysis boxes (50) on the rotary upper plate of the centrifuge device.
  • the cover (3) has a sealing member (6), intended to fit perfectly into the access orifice (7).
  • the covers (2) and (3) can be locked by means of a locking button (8).
  • the results of the analysis are printed by means of a printer (9) located in the immediate vicinity of the liquid crystal screen (4) and the keyboard (5).
  • the entire device is in a known manner governed by a microcomputer whose software of the PROM type is observed in reference (10).
  • the housing (1) also has at its upper face a hatch (11) for changing the lamp of the optical system, also described later.
  • the centrifuge device will now be described in more detail.
  • This consists first of all of a lower fixed circular plate (12), to which is attached a stepping motor (13), fixed by means of four screws and nuts of which the fixing holes (14) have been materialized.
  • the motor (13) has in a known manner a centering boss (15), allowing better positioning accuracy.
  • the fixed plate (12) is suspended by three shock absorbers of the silent-block type, one of the application points of which has been indicated by the reference (16).
  • the fixed plate (12) also has a flange or peripheral guide (17), intended to cooperate with pivoting members, which will also be described later.
  • the motor (13) is integral with an axis (18) on which are nested and fixed three successive plates, namely in order: - a support plate (19), fixed on the axis (18) by means of a conical insert (20); - a plate called the locking plate (21); an upper plate (22) joining together by means of nuts the said locking plate (21) and itself, namely the upper plate (22), on the conical insert (20) of the support plate (19) and this, on the axis of rotation (18) of the motor (13).
  • the upper plate (22) has five receptacles (23) each intended to receive an analysis unit (50). Within the base (24) of each of these said receptacles, a slot (25) is provided on the one hand, intended to cooperate with a part of the locking plate (21) and a semi-circular orifice (26), intended to cooperate with the pivot axis described later.
  • a circular plate (27) serving as an individual support for an analysis unit (50) has under its underside a mortise (28), intended to cooperate with a tenon (29), formed at the upper end of an axis pivot (30). Each support (27) also has two positioning pins (31), intended to cooperate with the positioning orifices provided within each of the analysis boxes.
  • the support plate (19) has a plurality of orifices (32), each intended to leave a passage for the pivot axis (30).
  • Each of these orifices (32), located on the periphery of the plate (19), is tangent by two radial ramps (33), rising from the center of the plate towards its periphery, each of these ramps (33) being intended to receive a ball said balancing ball (34).
  • These balls (34) are intended to allow dynamic balancing of the rotary assembly of the centrifuge device.
  • the support plate comprises a plurality of pairs of ascending ramps (33), from the center to the periphery, each of these ramps being radial.
  • the number of receptacles (23) present is equal to five, therefore the number of pairs of ramps (33) also.
  • Each pair of ramps (33) is arranged, in the vicinity of the periphery of the support plate (19), on either side of an orifice (32), allowing the passage of an axis (30) for pivoting the housings (50) to be centrifuged in the receptacles (23) of the upper plate (22).
  • Each of said ramps (33) receives a ball (34), made of steel, the diameter of which is a function of the mass of the desired ball. Because the ramps are ascending from the center to the periphery of the plate (19), the angle of inclination being twelve degrees (12 °) relative to the horizontal, when said plate does not rotate, the balls are located in the vicinity of the center of said plate (19), in contact with a crown (80) of limitation of the lower path of the balls, said crown surrounding the conical insert (20), for fixing on the axis of the motor (13).
  • the locking plate (21) is in the form of a corolla, the number of petals (35) coincides with the number of receptacles (23) of the upper plate (22), five in this case.
  • Each of these petals (35) or radial elements is terminated, at its free end, by a lug or stop (36) extending towards the upper plate (22), and intended to cooperate with a slot (35), formed at within the base (24) of each of the receptacles (22) of said tray (22), and this, only in the case where the receptacle (23) considered does not contain a housing (50) to be centrifuged.
  • each petal (35) has on its underside, that is to say, on the side of the support plate (19), a stop (81) or retaining means, come from the molding, and located in the vicinity of the base of the petal (35).
  • This stop (81) is intended to retain the ball (34) towards the crown (80), when the corresponding receptacle (23) receives a casing to be centrifuged, during the centrifugation phases.
  • Each of the petals (35) is subjected to a stress transmitted via the lug (36) when a receptacle (23) receives a centrifuge box, because the plate (21) is made of a plastic material flexible with elastic memory, and that the molding gives it a shape such that it naturally tends to cause the cooperation of the lug (36), with the slot (25), upwards.
  • any lowering of the lug (36) causes the concomitant lowering of the stopper (81) for retaining balls (34).
  • the two extreme positions of the plate (21) are visible respectively in FIGS. 10 and 11.
  • the casings (50) when it is desired to centrifuge the casings (50), the latter are positioned within the receptacles (23), by means of the positioning pins (31), and the various centrifugation phases can be immediately carried out, without worry about balancing the device.
  • the mass of the housings (50) to be centrifuged being known
  • the mass of the balancing balls (34) is adapted, using balls of known diameter (the density of the balls remaining constant, the only parameter being able to vary the mass is the diameter), so that the sum of the moments, relative to the axis of the motor (13), of the centrifugal forces applying on the balls (34) in the low position and on the housing (50 ) to be centrifuged correspondingly, ie equal to the moments with respect to the same axis of the centrifugal forces applying to the balls in the high position of the same pair of ramps (33).
  • the empty receptacles do not cause the petals (35) of the plate (21) to be lowered, therefore do not prevent the balls from rising to the top of the corresponding ramps.
  • the larger the radius of the circle described by the object on which said forces are based, and the greater its moment relative to the axis passing through the center of said circle it is possible, by calculating beforehand the mass of the balls (34) necessary for balancing, to obtain dynamic and automatic balancing.
  • each petal (35) is articulated individually on an axis (83), orthogonal to the axis of rotation, and journalled on the locking plate (21). Under these conditions, the low rest position of a petal (35) is in contact with a ball (34).
  • a corresponding housing (50) is present on the upper plate (22)
  • the corresponding ball (34) cannot go up towards the high end of the corresponding ramp (33) being blocked by the stop (81);
  • the stop (36) is not blocked from above, and the ball (34) pushes the stop (81), and therefore the corresponding petal (35), and can reach the 'high end of the ramp (33).
  • This particular embodiment avoids exerting a rappelling push on each box (50).
  • the fixed plate (12) has in the vicinity of its periphery and on a given sector a portion called “pivoting portion” (37).
  • This pivoting portion (37) has two guide rails (38) and (39), concentric and orthogonal to the plane of the fixed plate (12).
  • the pivoting portion (37) coplanar with said fixed plate (12) integrates with this plate and defines a flange or peripheral guide (17) complete, that is to say - say defining a perfect circle.
  • the pivoting device also has an electromagnet (40) intended to attract towards the outside of the fixed plate (12) said pivoting portion (37), which is articulated at one of its ends to pivot in the plane.
  • each pivot axis (30) mentioned above has at its lower end a stud (41) intended to cooperate with a mortise (42) formed on a link (43) arranged parallel to the fixed plate (12); each link (43) acts as a link between two coplanar and identical rollers (44) and (45), the pivot axis of which is parallel to the axis (30).
  • the rollers (44) and (45) of each pivoting member are rotated by means of the axis (30), the latter being itself driven by means of the orifices (32) formed on the support plate (19).
  • the rails (38,39) are spaced apart by a distance corresponding to the diameter of the rollers (44,45).
  • the radius of curvature of the outer guide rail (39) has the same value as that of the peripheral edge (17) of the fixed plate (12), and this in order to provide a complete peripheral edge when it is not desired to carry out a pivoting phase.
  • the length of the internal guide rail (38) is shorter than the external guide rail (39), and this by a value corresponding to the diameter of the rollers (44,45), with variations in circumference , because the radii of the circles on which the rails (38,39) are based do not have the same value, as can be seen more clearly in Figure 7.
  • the edge (46) is connected to the peripheral rim (17) of said plate (12), and it constitutes, in fact, a simple extension of said rim (17) outside the fixed plate (12). Therefore, it has the same thickness and the same height as this rim (17).
  • the free end of the edge (46) coincides with one of the ends of the external guide rail (39), that opposite to the pivot axis (47) of the pivot portion (37), when said pivot portion is actuated.
  • the free end of the connecting edge (46) has a circular curvature whose radius is equal to the radius of the rollers (44,45), to the different thicknesses.
  • the device comprises means capable of causing the pivoting portion (37) to pivot.
  • this means is an electromagnet (40), fixed on the fixed plate (12).
  • This electromagnet is advantageously controlled by means of a microcomputer, in order to synchronize in a simple and rapid manner the pivoting or non-pivoting of the different rotary axes (30) that the device comprises.
  • a magnetic core (83) slides conventionally in the body of the electromagnet (40), and is fixed at one of its ends to a fixing lug (84) located on the pivoting portion (8) .
  • the device comprises a spiral spring in tension (85), the points of application of which are respectively located on a lug (88), fixed at the free end of the connection edge (46), and on a lug (87), fixed in the vicinity from the end of the pivoting portion (37) located towards the pivot axis (47).
  • FIGS 8 and 9 illustrate clearly the mode of action of the device according to the invention.
  • the pivoting portion (37) when the electromagnet is not activated, defines a peripheral circular rim (17) complete with the plate (12), and when said electromagnet (40) is activated, then allows, as it will be now described, the pivoting of the axis (30) considered.
  • each of the two rollers (44,45) of the axes (30) are in contact with the peripheral circular rim complete (17) of the plate (12), owing to the fact that the axis (30) follows a constant circular trajectory imposed by the rotating plate (19), this trajectory being located in the vicinity of said edge, in order to involve the contact of the said rollers (44,45) with the flange (17).
  • the link (43), connecting the two rollers (44,45) to the axis (30) being rigid, it imposes, due to the trajectory of the axis (30), the contact of the two rollers with the rim (17).
  • the electromagnet (40) When one wishes to cause the pivoting of one hundred and eighty degrees (180 °) of one or more mobiles (30), the electromagnet (40) is actuated which attracts the pivoting portion (37) towards it, by rotation of the latter around its own pivot axis (47).
  • the front roller (45) due to the rotation of the axis or axes (30), engages in the guide track defined by the two rails (38,39).
  • the pivoting portion (37) Because the pivoting portion (37) is in a position spaced from its original position, the roller (45) itself deviates from its circular path, causing a separation of the rear roller (44) from the flange (17 ), and this towards the inside of the fixed plate (12), due to the constant circular trajectory of the axis (30) and the rigidity of the link (43).
  • the trajectory of the rear roller (44) is imposed by the rotation of the rod (43) around the pivot axis (30), rotation itself imposed by the path followed by the front roller (45).
  • roller (44) continues its own trajectory inside the plate (12) and joins the circular peripheral rim (17) in front of the roller (45), which has completed its stroke in the pivoting portion (37).
  • the turntable (19) must rotate anticlockwise (that is to say counterclockwise), so that the front roller ( 45) of each of the axes (30) penetrates the correct side of the pivoting portion (37).
  • the analysis boxes (50) comprise in a known manner a chamber for the reagent, a chamber for the reagent and a reading cell (82) having at least two parallel faces. They are secured to each individual support (27) by means of positioning lugs (31). They undergo a pivoting of 180 °, by means of the pivoting axis (30), in order to allow the inversion of the centrifugal force which is exerted on them, said centrifugal force being intended to transfer liquids, due to the use of capillaries to connect the different chambers within this housing (50). It should be noted that each of the boxes (50) has on one of the side surfaces a code / bar carrying the analysis parameter used and the expiration date of said box.
  • optical system allowing, in addition to reading the code / bar, spectrophotometric analysis by absorbance of the result of the reaction between the reagent and the reagent present in said housing (50).
  • This optical system (see FIG. 5) comprises a lamp (51) fixed on a swivel plate (52) at 90 °, in order to facilitate the lamp changing phases via the hatch (11).
  • the lamp (51) is surmounted by a spherical mirror (53) intended to focus at the level of a first diaphragm (54) the light beam which it receives.
  • the diaphragm (54) is followed by a lens (55) intended to form a parallel beam of light from the diaphragm (54).
  • This parallel beam is then calibrated by means of a second diaphragm (56), and sent through the reading cell (83) of the boxes (50).
  • the optical system is constructed in such a way that it frees up a space corresponding to the thickness of the housing (50).
  • the light beam transmitted by the reading cells of the housings (50) is focused by means of a converging lens (57) on the end of a single-strand optical fiber (58) made of silica, intended to transmit the light beam up to to the optical analysis system.
  • This code / bar reading cell (59) is connected to an electronic card decrypting the code / bar and the parameter used in the boxes and the expiration date. This first part of the optical system is detailed in FIG. 5.
  • the optical analysis system is detailed in FIG. 2.
  • the other end of the optical fiber (58) is located in the vicinity of a second set of optical elements, constituting the optical analysis system.
  • the light beam transmitted by the optical fiber (58) is focused by means of a converging lens (65) on a calibrated diaphragm (60), which allows the light beam to be routed over a flat field holographic network (61 ), which, in a known manner, reflects: - source light, called by convention, order "0"(zero); - different spectra of source light diffracted at known angles; by convention, these spectra are called orders 1, -1, 2, -2, etc., in the order of their least transmission.
  • a cell (62) makes it possible to carry out a measurement at zero order of the total light, in order to monitor the variations of the lamp (51). Simultaneously, the intensity of certain lines of the order -1 is analyzed by means of a strip of photodiodes (63), practically facing the holographic network (61). The characteristics of the photodiodes are predetermined.
  • the assembly constituted by the holographic network (61), the arrays of photodiodes (63) and the second optical assembly are inserted within the housing (64), protected from light and dust.
  • the connections from the photodiodes (63) are connected to electronic cards in a conventional manner, and then interpreted by means of a microcomputer previously mentioned.
  • the thermostat member illustrated in FIG. 4, firstly comprises a fan (70) pulsating air through heating resistors (71), at the end of which the pulsed air is guided through the by means of a heat flow guide (72), on the centrifuge device.
  • the upper plate of the latter has in its center a dome (73), intended to distribute the heat flow over all of the housings (50). Due to the presence of the cover (3) and the sealing member (6), the hot air is recycled, and re-aspirated via a channel (74) located under the fan (70).
  • the whole device is governed by a microcomputer which orders the different phases of centrifugation, pivoting, thermostatization and optical analysis.
  • This microcomputer is controlled by means of a touch keyboard (5).

Landscapes

  • Centrifugal Separators (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP87420250A 1986-09-25 1987-09-24 Zentrifugenvorrichtung zum Durchführen von Analysen Expired - Lifetime EP0262060B1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR8613551 1986-09-25
FR8613550 1986-09-25
FR8613550A FR2604925B1 (fr) 1986-09-25 1986-09-25 Dispositif pour assurer le pivotement d'un mobile rotatif en deplacement sur le rebord d'un plateau
FR8613552 1986-09-25
FR8613551A FR2605108B1 (fr) 1986-09-25 1986-09-25 Dispositif automatique pour la realisation d'analyses notamment biologiques et medicales
FR8613552A FR2605104B1 (fr) 1986-09-25 1986-09-25 Dispositif d'equilibrage dynamique d'un appareil centrifugeur

Publications (3)

Publication Number Publication Date
EP0262060A2 true EP0262060A2 (de) 1988-03-30
EP0262060A3 EP0262060A3 (en) 1989-03-08
EP0262060B1 EP0262060B1 (de) 1991-09-04

Family

ID=27251396

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87420250A Expired - Lifetime EP0262060B1 (de) 1986-09-25 1987-09-24 Zentrifugenvorrichtung zum Durchführen von Analysen

Country Status (3)

Country Link
US (1) US4865810A (de)
EP (1) EP0262060B1 (de)
DE (1) DE3772690D1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061381A (en) * 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266273A (en) * 1986-06-26 1993-11-30 Coombs David H Process and apparatus for forming a solution gradient and for conducting a blotting process
US5171539A (en) * 1986-06-26 1992-12-15 Coombs David H Apparatus for forming a continuous solution gradient
US5104807A (en) * 1988-02-19 1992-04-14 Hitachi, Ltd. Analyzing apparatus in which liquid can be stirred and analyzing method thereof
US5215714A (en) * 1988-04-08 1993-06-01 Toa Medical Electronics Co., Ltd. Immunoagglutination measurement apparatus
FR2634893B1 (fr) * 1988-07-28 1990-09-14 Guigan Jean Laboratoire miniature pour la realisation d'analyses biologiques par reaction chimique a partir d'un echantillon de sang
US5171531A (en) * 1989-10-25 1992-12-15 Hewlett-Packard Company Apparatus for automatic delivery of a vial to an automated sampling system
US5595707A (en) * 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
US6436349B1 (en) 1991-03-04 2002-08-20 Bayer Corporation Fluid handling apparatus for an automated analyzer
EP0715547A4 (de) * 1994-07-01 1998-08-12 Baxter Int Blutbehandlungssystem mit einem geschlossenen heizungskreislauf
US5783446A (en) * 1996-03-04 1998-07-21 Biocircuits Corporation Particle assay using fluid velocity gradients
US6162400A (en) * 1998-08-12 2000-12-19 Agilent Technologies, Inc. Apparatus for controlling reactions
GB2349108B (en) * 1999-02-09 2001-03-28 Michael Cole Centrifugal evaporator
US6348176B1 (en) 1999-02-11 2002-02-19 Careside, Inc. Cartridge-based analytical instrument using centrifugal force/pressure for metering/transport of fluids
US6391264B2 (en) 1999-02-11 2002-05-21 Careside, Inc. Cartridge-based analytical instrument with rotor balance and cartridge lock/eject system
US6531095B2 (en) 1999-02-11 2003-03-11 Careside, Inc. Cartridge-based analytical instrument with optical detector
WO2000047977A1 (en) * 1999-02-11 2000-08-17 Careside, Inc. Cartridge-based analytical instrument
US6309875B1 (en) * 2000-02-29 2001-10-30 Agilent Technologies, Inc. Apparatus for biomolecular array hybridization facilitated by agitation during centrifuging
DE102006027695B4 (de) * 2006-06-14 2013-06-27 Thermo Electron Led Gmbh Gekühlter Zentrifugendeckel und Laborzentrifuge mit gekühltem Zentrifugendeckel
JP4901333B2 (ja) * 2006-06-30 2012-03-21 ローム株式会社 マイクロチップ検査装置
US9677988B1 (en) 2015-07-10 2017-06-13 David E. Doggett Integrating radiation collection and detection apparatus
US9366617B1 (en) * 2015-07-10 2016-06-14 David E. Doggett Self-stirring container
CN110560385B (zh) * 2019-09-30 2021-10-12 萧县众科电磁检测有限公司 一种用于球体检测的自动化流水线

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2762635A (en) * 1951-02-15 1956-09-11 Babcock & Wilcox Co Tube and header connections
US3692236A (en) * 1970-10-30 1972-09-19 Technicon Instr Self-balancing centrifuge method and apparatus
US3848796A (en) * 1971-02-08 1974-11-19 Coulter Electronics A centrifuge apparatus for sedimentation study
US3834613A (en) * 1971-03-01 1974-09-10 Int Equipment Co Centrifuge rotor with sample holding means and means for balancing the same
US3762635A (en) * 1971-04-14 1973-10-02 Damon Corp Apparatus for balancing a bucket centrifuge rotor
US3882716A (en) * 1972-07-17 1975-05-13 Elliott Beiman Centrifugal apparatus and cell
US3800161A (en) * 1972-12-19 1974-03-26 Atomic Energy Commission Portable dynamic multistation photometer-fluorometer
DE3044372A1 (de) * 1980-11-25 1982-07-08 Boehringer Mannheim Gmbh, 6800 Mannheim Rotoreinheit mit einsatzelementen fuer einen zentrifugalanalysator
FR2524874A1 (fr) * 1982-04-07 1983-10-14 Guigan Jean Procede et dispositif pour le transfert de faibles doses liquides
SE8304901D0 (sv) * 1983-09-13 1983-09-13 Alfa Laval Separation Ab Anordning for balansering av rotorn hos en centrifugalseparator
EP0160901B1 (de) * 1984-05-03 1989-06-07 Abbott Laboratories Zentrifuge
US4632908A (en) * 1984-05-03 1986-12-30 Abbott Laboratories Heating system for rotating members
US4671940A (en) * 1985-03-19 1987-06-09 Abbott Laboratories Automatic centrifugal balancing mechanism
DE3668425D1 (de) * 1985-03-19 1990-03-01 Abbott Lab Selbsttaetige zentrifugale ausgleichsvorrichtung.
FR2589085A1 (fr) * 1985-10-29 1987-04-30 Kis Photo Ind Dispositif de centrifugation pour boitiers d'analyses

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061381A (en) * 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids

Also Published As

Publication number Publication date
EP0262060B1 (de) 1991-09-04
DE3772690D1 (de) 1991-10-10
EP0262060A3 (en) 1989-03-08
US4865810A (en) 1989-09-12

Similar Documents

Publication Publication Date Title
EP0262060B1 (de) Zentrifugenvorrichtung zum Durchführen von Analysen
EP0759124B1 (de) Peristaltische pumpe
CH646809A5 (fr) Dispositif pour l'entrainement d'un disque flexible.
EP0286770B1 (de) Vorrichtung zur automatischen Zentrierung von Platten von verschiedenen Durchmessern auf die Lademittel eines Plattenspielers
FR2597646A1 (fr) Lecteur de disque comprenant un organe spiculaire
FR2538597A1 (fr) Dispositif de chargement de disque
FR2488715A1 (fr) Cassette a disque magnetique souple et appareil d'enregistrement et/ou de reproduction utilisant un tel disque
LU84182A1 (fr) Assemblage de disque magnetique,cartouche pour cet assemblage et appareil d'enregistrement/reproduction utilise avec cet assemblage
EP0331663A2 (de) Automatischer Platenn-Zentriermechanismus
EP1043071A1 (de) Vorrichtung zum Zentrifugieren von Flüssigkeiten und Verwendung dieser Vorrichtung
CH650871A5 (en) Machine for automatically sorting coins
FR2551578A1 (fr) Appareil d'enregistrement et/ou de lecture de disque souple
FR2522760A1 (fr) Mecanisme de transmission de puissance a vis globique
EP0718837B1 (de) Plattenteller mit Plattenklemmvorrichtung
EP0183672A2 (de) Aufnahme- und Wiedergabegerät mit Fronteinschub
FR2672721A1 (fr) Dispositif de stockage et de lecture de supports d'informations plats.
EP0160992B1 (de) Plattenspeicher mit einer auswechselbaren magnetischen Plattenkassette und Kassette für einen derartigen Speicher
WO2018193184A1 (fr) Dispositif de conditionnement de billes pour cuvettes de réaction destinées à un appareil d'analyse
FR2525796A1 (fr) Dispositif automatique pour tourne-disques de mise en position operative d'un disque
EP0177529B1 (de) Wiedergabegerät für mehrseitig-vielfältige videoplatten
FR2545967A1 (fr) Tourne-disque equipe d'un organe de maintien destine a maintenir un disque place sur le plateau tournant
EP0907903B1 (de) Kinematographische kamera und aufnahmevorrichtung für filmspulen
FR2605108A1 (fr) Dispositif automatique pour la realisation d'analyses notamment biologiques et medicales
FR2536569A1 (fr) Tourne-disque
EP0096608A1 (de) Faseroptischer Kollimator, Anwendung zur Realisierung optischer Schaltervorrichtungen

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): BE DE ES FR GB IT

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): BE DE ES FR GB IT

17P Request for examination filed

Effective date: 19890828

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: KIS PHOTO INDUSTRIE S.A.R.L.

17Q First examination report despatched

Effective date: 19901129

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): BE DE ES FR GB IT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 19910904

Ref country code: GB

Effective date: 19910904

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19910926

Year of fee payment: 5

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Effective date: 19910930

REF Corresponds to:

Ref document number: 3772690

Country of ref document: DE

Date of ref document: 19911010

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 19911215

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 19911230

Year of fee payment: 5

GBV Gb: ep patent (uk) treated as always having been void in accordance with gb section 77(7)/1977 [no translation filed]
BERE Be: lapsed

Owner name: KIS PHOTO INDUSTRIE S.A.R.L.

Effective date: 19910930

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Effective date: 19930528

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Effective date: 19930602

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST