EP0287005A2 - Procédé pour l'analyse chimique d'un échantillon, par utilisation d'un dispositif des test - Google Patents

Procédé pour l'analyse chimique d'un échantillon, par utilisation d'un dispositif des test Download PDF

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Publication number
EP0287005A2
EP0287005A2 EP88105695A EP88105695A EP0287005A2 EP 0287005 A2 EP0287005 A2 EP 0287005A2 EP 88105695 A EP88105695 A EP 88105695A EP 88105695 A EP88105695 A EP 88105695A EP 0287005 A2 EP0287005 A2 EP 0287005A2
Authority
EP
European Patent Office
Prior art keywords
applying
test piece
cover
sample
piece
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP88105695A
Other languages
German (de)
English (en)
Other versions
EP0287005A3 (en
EP0287005B1 (fr
Inventor
Ichiro Takahata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arkray Inc
Original Assignee
Kyoto Daiichi Kagaku KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Daiichi Kagaku KK filed Critical Kyoto Daiichi Kagaku KK
Publication of EP0287005A2 publication Critical patent/EP0287005A2/fr
Publication of EP0287005A3 publication Critical patent/EP0287005A3/en
Application granted granted Critical
Publication of EP0287005B1 publication Critical patent/EP0287005B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00079—Evaporation covers for slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00108—Test strips, e.g. paper
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00108—Test strips, e.g. paper
    • G01N2035/00118—Test strips, e.g. paper for multiple tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00455—Controlling humidity in analyser
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403—Sample carriers with closing or sealing means
    • G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/110833—Utilizing a moving indicator strip or tape
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack

Definitions

  • This invention relates to a biochemical analysis apparatus for analyzing and measuring chemically body fluid, particularly blood, by using a test piece with a reagent layer containing reagent, and particularly to the improvement of apparatus for applying a sample to each reagent layer of a multi-item test piece or plural single item test pieces set on a test piece table.
  • Measurement technology has made a large progress along with the progress of reagent and analysis instrument, and by combination of the information of the single item measuement such as a glucose concentration and multi-components the diagnosis of various diseases or organs disorders and synthetic health examination have been generally made to help the treatment.
  • liver disorders For example, by a set test of GOT, GPT, ALP, LAP, ⁇ -GTP, and BUN in blood the diagnosis of liver disorders is conducted.
  • blood sugar, creatinine, uric acid, BUN, cholesterol, TP, amylase, LDH, and GOT are analyzed as a profile test.
  • the applying quantiy is several-ten-odd ⁇ l, extremely small, and by standing after applying the higher concentration tends to appear as a measuring value because of evaporation of water in the sample.
  • the reaction proceeds with keeping relatively higher temperature(ca 37°C)
  • evaporation is accelerated.
  • by standing fluctuation in reaction temperature tends to occur.
  • test piece table is made slidable without a gap in a photometric part and a small closed space is prepared, and immediately after applying sample a test piece is sent to the closed space.
  • moving mechanism of individual test piece(a single item test piece with a reagent layers) becomes extremely complex.
  • a multi-item test piece with plural reagent layers(same or different type) is measured concurrently by plural measurement means, movement of individual reagent layer into a closed space is impossible.
  • the object of the invention is to solve the above problems, and is to assure accurate measurement with reproducible reaction by preventing evaporation of water from sample applied to reagent layer and by keeping constantly the reaction temperature at either a single item or multi-item test piece in measurement of multi-items or single item or multi-samples such as a set or profile test. Further, the object of the invention is to speed up test ⁇ diagnosis ⁇ treatment by conducting concurrently the combination test.
  • a sample liquid applying part wherein plural applying holes were arranged sideways with specified space, is arranged on a test piece table closely parallel to a measuring part to form a temperature keeping part, and each applying hole is fitted with a cover to close the applying hole after applying sample to prevent water evaporation and temperature lowering. Further, opening or shutting of the cover is operated by a cover opening and shutting rod moved unifiedly with a sample applying nozzle.
  • Fig.1 is a rough oblique drawing showing an example of the main part of the biochemical analysis apparatus of the invention.
  • Fig.2 shows the front of the nozzle part
  • Fig.3 a graph showing movement of the nozzle part
  • Fig.4(a) opening action of the cover due to the nozzle action Fig.4(b) a graph showing shutting action
  • Fig. 5 is a oblique drawing showing the other example of the cover.
  • test piece table of this specification refers to the table for setting test pieces. It has an arbitrary form, and that having both of a multi-item test piece setting part and a single item test piece setting part is convenient, though that having only the other one may be usable.
  • the multi-item test piece setting part positioned parallel to the sample applying part is suitable, which is normally single though may be plural.
  • the single item test piece setting part is plural, suitably positioned at a nearly right angle to the sample applying part.
  • the single item test piece setting part may be only one.
  • a sample refers to sample liquid, normally body fluid, particularly blood.
  • Applying refers to sticking a sample to a reagent layer, including dropping, contact sticking, and the like. In case a developing layer or the other layer exists over the reagent layer, applying to the reagent layer means from over the other layer.
  • the order of applying is arbitrary, it is preferable to apply from the reagent layer of the longer reaction time(one of the longer time till a measurement start) to shorten the measuring time. Though applying is conducted, of course, only to an applying hole wherein a reagent layer exists, opening or shutting of covers may be conducted to all applying holes.
  • a constant temperature room refers to a certain space having the inner part kept at a constant temperature, and a space nearly closed and kept at nearly constant temperature may be usable, since it is not a constant temperature room in a strict sense here.
  • the volume of the constant temperature room is preferably small because of evaporation of sample water in the inner part.
  • An applying part refers to a plaece for applying a sample to a reagent layer in the analyzing apparatus.
  • An applying hole refers to an eyehole, through which a sample is applied to a reagent layer from over, set at the applying part. Its form, arrangement, and disposition are arbitrary, but normally a row sideways is convenient because of relation to the position of a reagent layer of a test piece. However, it is preferable to change the position of the applying hole correspondingly to the change of the setting arrangement of test pieces or the arranged position of the reagent layers on the test piece, for example circular or zigzag.
  • a cover refers to a thing for covering the applying hole to suppress evaporation of water in sample.
  • the form of the cover is not specially restricted, but L-shaped or slide-shutter type is convenient.
  • the test piece In finishing covering by covers after applying, the test piece may be moved to the measuring part in any time till a measurement start after applying.
  • a measurement start time refers to a time till measurement is practicable after applying sample, depending upon the calibration line used for conversion to concentration.
  • a measuring part refers to a place for measuring reflectivity after finishing reaction( or after the lapse of measurement start time), normally comprising a luminous part and a light receiving part. Besides measurement of reflectivity, measurement of fluorescence obtained by radiation of exciting light and of voltage by contacting a terminal are considered.
  • Fig.1 shows roughly an example of biochemical analyzing apparatus comprising a sample liquid applying apparatus(1) of the invention, which comprises a lengthways long movable test piece table(2), a sample liquid applying part(3) fixed covering the test piece table(2) on the upper part of the table, a photometric part(4), a test piece judging part(5), a nozzle part(6), a sample holding part(7), an apparatus for driving them(omission in Fig.), and a microcomputer(omission in Fig.) for driving instructions and memories.
  • the sample liquid applying apparatus(1) comprises a sample liquid applying part(3) and a nozzle part(6).
  • applying holes(8 ⁇ ) are perforated every specified space, that is at the position of a reagent layer of a test piece described later, on a plate of small width, and a cover(9) is fitted on each applying hole.
  • a cover(9) wherein a cover piece(9a) and a moving piece(9b) are joined into L-shape and a supporting axis(9c) is fitted to the joint part(the crossing part), turns on the supporting axis(9c) to close the applying hole(8) by the cover piece(9a).
  • Both of the cover piece(9a) and moving piece(9b) are fitted with a notch(9d, 9e).
  • a magnet(10) may be buried in at least one part around the applying hole(8) to prevent shaking of the cover(9).
  • the nozzle part(8) comprises a nozzle for applying sample(hereafter nozzle)(11) and a cover opening and shutting rod(12), which are moved in the direction of left-right(X axis) and up-down(7 axis).
  • the nozzle(11) is fitted with a pipette tip(32), which sucks sample(15) from a sample vessel(14) supported by a sample rack(13) with the tip.
  • the sample holding part(7) comprises a sample rack(13) and the driving part(omission in Fig.).
  • the test piece table(2) is moved in the direction of for-back(Y axis) by the driving apparatus(omission in Fig.), on which one lateral groove(17) to set a multi-item test piece(16) and plural(6 in Fig.) longitudinal grooves(19 ⁇ ) to set single item test pieces(18) exist.
  • the lateral groove(17) is prepared parallel to the photometric part(4) on the nearly center of the test piece table(2).
  • the longitudinal groove(19) is prepared at a right angle to the lateral groove(17) on each position corresponding to the position of the reagent layer when setting a test piece(16) on the lateral groove(17).
  • a heater is fitted at the part of the lateral groove(17) and the front of the longitudinal groove(19), that is the position of each reagent layer(20 ⁇ , 21), to prepare a constant temperature zone(22).
  • a standard reflex piece(23) of white ceramic plate and plural (6 in the example) black damping cones(24) are fitted. These are for correction of reflectivity, as reflectivity 100% in the former and 0% the latter.
  • test piece table(2) in the example is a special type able to measure both of a multi-item test piece(16) and a single item test piece(18).
  • reagent layers(20 ⁇ ) retained reagents which react with different substances necessary for the above-mentioned set test or profile test respectively, are fixed in order with a specified space from the end part of a strip(25) with the list of plural measuring substances names or notation(26) of a disease name measurable by the combination near the base of the strip and a bar-code(27 ⁇ ) (notation of only one data bit on one position in relation to the reading direction) as a means for judging the test piece. Accordingly, accurate and rapid measurement is possible with no mistake, of test pieces and saving labor for arranging many test pieces.
  • a single item test piece(18) In a set test, if the other item is necessary, it is supplemented by a single item test piece(18).
  • the use of a multi-item test piece(16) with plural same pads(20) is convenient for measurement of a special item of multi-samples.
  • a single item test piece is fitted with a bar-code(27) and a name notation(26).
  • test piece table(2) On the form and movement of the test piece table(2), besides the example various changes are considered.
  • plural longitudinal grooves(19 ⁇ ) only 2 or more of lateral grooves(17), and a disk type test piece table(2) constructed so that setting test pieces, judgment, measurement, and removal are operated in order by providing several groups of a group of a lateral groove(17) and plural longitudinal grooves(19 ⁇ ) selected depending on a required treatment capacity.
  • plural(6 in Fig.) measurement devices(30), a combination of the luminous part(28) and the light receiving part(29), are sideways arranged with a specified space.
  • the luminous part(28) radiates a light(multi-wavelength) from a light source(omission in Fig.) on each pad, in the example, the end of light fiber(light-guide) existing over the position of the reagent layer.
  • the light recerving part(29) composed of a light detector receives a light reflected from the surface of the reagent layer.
  • measurement devices(30) an integrating sphere and the other devices may be also usable.
  • the test piece judging part(5) reads a bar-code(27) of each test piece, wherein plural(11 in Fig.) measurement devices(31 ⁇ ) composed of a photo-interruptor, a combination of a luminous diode and a photo-transistor, are sideways arranged.
  • the measurement devices(31) are more than those(30) of the photometric part(4) because of the difference of the position of the bar-codes(20 ⁇ , 21) between the multi-item test piece(16) and the single item test piece(18).
  • a measurement device(31) may be composed of a light-guide and a light-detector.
  • each longitudinal groove(19) by shifting sideways each longitudinal groove(19) the number of the applying holes(8) at the sample liquid applying part(3) and of the measurement devices(30) at the photometric part(4) may be also 11.
  • a color notation, an eyehole, or a notch may be fitted using the corresponding detecting device.
  • each reagent layer may be observed by transmitted light or fluorescence in place of reflected light.
  • the symbol 35, 35 are a guide rod 35, 35 for the test piece table(2).
  • the table(2) is driven by a pulse motor(omission in Fig.) by controlled by the microcomputer.
  • the nozzle part(6) is driven by two pulse motors(omission in Fig.) separately.
  • the nozzle(11) and the cover open-shut rod(12) may be separately driven.
  • Fig.5 is the oblique drawing showing only near the cover(9) and the applying hole(8).
  • a moving part(41) is prepared at a right angle to the hole, and moved by pushing with a cover open-shut rod.
  • the cover(9) is moved along the edge part(42).
  • a groove may be prepared.
  • the operating and shutting of the cover may be automatically operated by the use of spring.
  • plural applying holes are sideways made with a specified space in a sample liquid applying part arranged at the upper part of a movable test piece table, and a cover, wherein a cover piece and movable piece are crossing in L-shape and a supporting axis is fitted in the crossing part, is fitted on each applying hole, and a cover open-shut rod, which opens or shuts the cover by pushing the cover piece and moving piece, is moved unifiedly with the nozzle for applying sample.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP88105695A 1987-04-11 1988-04-11 Procédé pour l'analyse chimique d'un échantillon, par utilisation d'un dispositif des test Expired - Lifetime EP0287005B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55044/87 1987-04-11
JP5504487 1987-04-11

Publications (3)

Publication Number Publication Date
EP0287005A2 true EP0287005A2 (fr) 1988-10-19
EP0287005A3 EP0287005A3 (en) 1990-01-10
EP0287005B1 EP0287005B1 (fr) 1993-03-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP88105695A Expired - Lifetime EP0287005B1 (fr) 1987-04-11 1988-04-11 Procédé pour l'analyse chimique d'un échantillon, par utilisation d'un dispositif des test

Country Status (3)

Country Link
US (1) US5039615A (fr)
EP (1) EP0287005B1 (fr)
JP (1) JP2561509B2 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377505A3 (fr) * 1989-01-05 1990-10-10 Eastman Kodak Company Incubateur ou analyseur avec moyen amélioré pour enlever un bouchon
EP0394048A3 (fr) * 1989-04-21 1991-06-12 Ciba Corning Diagnostics Corp. Cassette de réaction avec ecran protecteur contre le liquides
US5026526A (en) * 1990-02-09 1991-06-25 Eastman Kodak Company Automated capping means for analyzer pipette
WO1995001919A1 (fr) * 1993-07-09 1995-01-19 Baxter Diagnostics Inc. Recipient pour reactifs liquides a mecanisme de fermeture primaire et secondaire
WO2000063679A3 (fr) * 1999-04-14 2001-01-11 Zeiss Carl Jena Gmbh Dispositif d'analyse de reactions d'identification a base fluorescente
WO2014066946A1 (fr) 2012-11-01 2014-05-08 Leica Biosystems Melbourne Pty Ltd Système de transport de lames porte-objets
US8883455B2 (en) 1998-05-01 2014-11-11 Gen-Probe Incorporated Method for detecting the presence of a nucleic acid in a sample
US8956570B2 (en) 2010-07-23 2015-02-17 Beckman Coulter, Inc. System and method including analytical units

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0299519B1 (fr) * 1987-07-15 1995-05-03 Fuji Photo Film Co., Ltd. Appareil d'analyses biochimiques
US5169600A (en) * 1987-07-15 1992-12-08 Fuji Photo Film Co., Ltd. Biochemical analysis apparatus for incubating and analyzing test sites on a long tape test film
DE3940152A1 (de) * 1989-12-05 1991-06-06 Boehringer Mannheim Gmbh Teststreifenauswertegeraet fuer mehrfachteststreifen
US5232668A (en) * 1991-02-27 1993-08-03 Boehringer Mannheim Corporation Test strip holding and reading mechanism for a meter
US5246858A (en) * 1991-02-27 1993-09-21 Boehringer Mannheim Corporation Apparatus and method for analyzing a body fluid
ES2210231T3 (es) * 1991-02-27 2004-07-01 Roche Diagnostics Corporation Aparato y metodo para analisis de fluidos corporales.
US5578494A (en) 1992-03-27 1996-11-26 Abbott Laboratories Cap actuator for opening and closing a container
CA2639400A1 (fr) * 1992-03-27 1993-10-14 Abbott Laboratories Systeme analytique automatise d'acces continu et aleatoire et ses composantes
US5371687A (en) * 1992-11-20 1994-12-06 Boehringer Mannheim Corporation Glucose test data acquisition and management system
DE4425432A1 (de) * 1994-07-19 1996-01-25 Boehringer Mannheim Gmbh Auswertevorrichtung zur reflektometrischen Auswertung von Testelementen
DE4425439A1 (de) * 1994-07-19 1996-01-25 Boehringer Mannheim Gmbh Teststreifenauswertegerät mit einer Transporteinheit für Teststreifen
US5582222A (en) * 1995-03-29 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Bottle closure mechanism using a sliding shutter
JP3624203B2 (ja) * 1995-10-26 2005-03-02 アークレイ株式会社 分析装置
ES2231589T3 (es) 1997-05-02 2005-05-16 Gen-Probe Incorporated Dispositivo con receptaculos de reaccion.
JPH11295323A (ja) * 1998-04-13 1999-10-29 Matsushita Electric Ind Co Ltd 自動分注装置および分注方法
US6572824B1 (en) 1998-09-18 2003-06-03 Cytyc Corporation Method and apparatus for preparing cytological specimens
US6562299B1 (en) 1998-09-18 2003-05-13 Cytyc Corporation Method and apparatus for preparing cytological specimens
US20030059347A1 (en) 1998-09-18 2003-03-27 Roy A. Ostgaard Sample vial for use in preparing cytological specimen
US6180409B1 (en) * 1998-10-13 2001-01-30 Bayer Corporation Spectrophotometric apparatus with multiple readheads
US8460616B2 (en) * 2005-04-20 2013-06-11 Arkray, Inc. Analyzer, method for cleaning photometry mechanism in such analyzer, and cleaning tool
US9116129B2 (en) 2007-05-08 2015-08-25 Idexx Laboratories, Inc. Chemical analyzer
US8372343B2 (en) * 2007-12-07 2013-02-12 Sheldon Goldstein Multiple coagulation test cartridge and method of using same
JP5570240B2 (ja) 2010-02-22 2014-08-13 アークレイ株式会社 試料の分析処理におけるデータ出力方法、分析装置、分析システム、前記方法を実施するためのプログラム、およびこのプログラムの記憶媒体
JP5216820B2 (ja) 2010-07-29 2013-06-19 株式会社日立ハイテクノロジーズ 分注装置および核酸分析装置
WO2015106008A1 (fr) 2014-01-10 2015-07-16 Idexx Laboratories, Inc. Analyseur chimique
US10429377B1 (en) 2019-03-15 2019-10-01 Coagulation Sciences Llc Coagulation test device, system, and method of use
EP4179290A2 (fr) 2020-07-10 2023-05-17 Idexx Laboratories, Inc. Analyseur de diagnostic médical au point de soins et dispositifs, systèmes et procédés d'analyse diagnostique médicale d'échantillons

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3942952A (en) * 1974-08-22 1976-03-09 The Perkin-Elmer Corporation Sample platter moisturizing system
US4298571A (en) * 1976-12-17 1981-11-03 Eastman Kodak Company Incubator including cover means for an analysis slide
JPH0217341Y2 (fr) * 1981-02-10 1990-05-15
JPS5821566A (ja) * 1981-07-31 1983-02-08 Fuji Photo Film Co Ltd インキユベ−タ
US4689202A (en) * 1984-09-11 1987-08-25 Miles Laboratories, Inc. Reagent test strip reading instrument
JPS6191571A (ja) * 1984-10-11 1986-05-09 Kyoto Daiichi Kagaku:Kk 試験片を用いる連続自動分析方法及び装置
JPS61130859A (ja) * 1984-11-27 1986-06-18 シンテツクス・ダイアグノステイツク・リミテツド・パ−トナ−シツプ ポ−タブルアナライザ−
JPS61259143A (ja) * 1985-05-14 1986-11-17 Konishiroku Photo Ind Co Ltd 生化学分析装置

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377505A3 (fr) * 1989-01-05 1990-10-10 Eastman Kodak Company Incubateur ou analyseur avec moyen amélioré pour enlever un bouchon
US5034191A (en) * 1989-01-05 1991-07-23 Eastman Kodak Company Incubator and analyzer with improved cap raising means
EP0394048A3 (fr) * 1989-04-21 1991-06-12 Ciba Corning Diagnostics Corp. Cassette de réaction avec ecran protecteur contre le liquides
AU618461B2 (en) * 1989-04-21 1991-12-19 Biotrack, Inc. Liquid shield for cartridge
US5026526A (en) * 1990-02-09 1991-06-25 Eastman Kodak Company Automated capping means for analyzer pipette
EP0441431A3 (en) * 1990-02-09 1992-02-05 Eastman Kodak Company Automated capping means for analyzer pipette
WO1995001919A1 (fr) * 1993-07-09 1995-01-19 Baxter Diagnostics Inc. Recipient pour reactifs liquides a mecanisme de fermeture primaire et secondaire
US5542575A (en) * 1993-07-09 1996-08-06 Dade Interantional Inc. Liquid reagent container having a primary and secondary closure mechanism
US9598723B2 (en) 1998-05-01 2017-03-21 Gen-Probe Incorporated Automated analyzer for performing a nucleic acid-based assay
US8883455B2 (en) 1998-05-01 2014-11-11 Gen-Probe Incorporated Method for detecting the presence of a nucleic acid in a sample
US9150908B2 (en) 1998-05-01 2015-10-06 Gen-Probe Incorporated Method for detecting the presence of a nucleic acid in a sample
WO2000063679A3 (fr) * 1999-04-14 2001-01-11 Zeiss Carl Jena Gmbh Dispositif d'analyse de reactions d'identification a base fluorescente
US8962308B2 (en) 2010-07-23 2015-02-24 Beckman Coulter, Inc. System and method including thermal cycler modules
US8996320B2 (en) 2010-07-23 2015-03-31 Beckman Coulter, Inc. System and method including analytical units
US9046455B2 (en) 2010-07-23 2015-06-02 Beckman Coulter, Inc. System and method including multiple processing lanes executing processing protocols
US9140715B2 (en) 2010-07-23 2015-09-22 Beckman Coulter, Inc. System and method for controlling thermal cycler modules
US8956570B2 (en) 2010-07-23 2015-02-17 Beckman Coulter, Inc. System and method including analytical units
US9274132B2 (en) 2010-07-23 2016-03-01 Beckman Coulter, Inc. Assay cartridge with reaction well
US9285382B2 (en) 2010-07-23 2016-03-15 Beckman Coulter, Inc. Reaction vessel
US9519000B2 (en) 2010-07-23 2016-12-13 Beckman Coulter, Inc. Reagent cartridge
CN104884930A (zh) * 2012-11-01 2015-09-02 莱卡生物系统墨尔本私人有限公司 载玻片输送系统
EP2914948A4 (fr) * 2012-11-01 2016-07-06 Leica Biosystems Melbourne Pty Système de transport de lames porte-objets
WO2014066946A1 (fr) 2012-11-01 2014-05-08 Leica Biosystems Melbourne Pty Ltd Système de transport de lames porte-objets
CN104884930B (zh) * 2012-11-01 2017-11-14 莱卡生物系统墨尔本私人有限公司 载玻片输送系统
US9927332B2 (en) 2012-11-01 2018-03-27 Leica Biosystems Melbourne Pty Ltd Slide transport system

Also Published As

Publication number Publication date
JPS6453167A (en) 1989-03-01
JP2561509B2 (ja) 1996-12-11
US5039615A (en) 1991-08-13
EP0287005A3 (en) 1990-01-10
EP0287005B1 (fr) 1993-03-10

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