EP0299057A4 - Augmentation de la puissance de conjugues cytotoxiques. - Google Patents

Augmentation de la puissance de conjugues cytotoxiques.

Info

Publication number: EP0299057A4
Authority: EP; European Patent Office
Prior art keywords: reinforcement; cytotoxic conjugates; conjugates; cytotoxic
Prior art date: 1987-01-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19880901988

Other languages

German (de)

English (en)

Other versions

EP0299057A1 (fr

Inventor

Vera S Byers

Robert W Baldwin

Patrick J Scannon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Xoma Royalty Corp

Original Assignee

Xoma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-27

Filing date

1988-01-26

Publication date

1990-02-22

1988-01-26 Application filed by Xoma Corp filed Critical Xoma Corp

1989-01-18 Publication of EP0299057A1 publication Critical patent/EP0299057A1/fr

1990-02-22 Publication of EP0299057A4 publication Critical patent/EP0299057A4/fr

Status Withdrawn legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP19880901988 1987-01-27 1988-01-26 Augmentation de la puissance de conjugues cytotoxiques. Withdrawn EP0299057A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US704587A	1987-01-27	1987-01-27
US7045		1987-01-27

Publications (2)

Publication Number	Publication Date
EP0299057A1 EP0299057A1 (fr)	1989-01-18
EP0299057A4 true EP0299057A4 (fr)	1990-02-22

Family

ID=21723902

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19880901988 Withdrawn EP0299057A4 (fr)	1987-01-27	1988-01-26	Augmentation de la puissance de conjugues cytotoxiques.

Country Status (4)

Country	Link
EP (1)	EP0299057A4 (fr)
JP (1)	JPH01502195A (fr)
KR (1)	KR890700357A (fr)
WO (1)	WO1988005309A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4921690A (en) *	1986-12-29	1990-05-01	City Of Hope	Method of enhancing the biodistribution of antibody for localization in lesions
NZ225372A (en) *	1987-07-17	1991-04-26	Xoma Corp	Immunotoxin composition comprising purified ricin-a-chain species
US5173293A (en) *	1989-02-23	1992-12-22	Becton Dickinson And Company	Anti-T-cell antibodies as adjuvants
KR920702229A (ko) *	1990-06-29	1992-09-03	마에다 카쯔노스케	면역 독소 복합체
AU2593192A (en)	1992-09-14	1994-04-12	Oystein Fodstad	Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
NO180658C (no)	1994-03-10	1997-05-21	Oeystein Fodstad	Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0811075B2 (ja) *	1982-06-30	1996-02-07	雄治松岡	単クローン性抗ｃｅａ抗体
US4590071A (en) *	1984-09-25	1986-05-20	Xoma Corporation	Human melanoma specific immunotoxins

1988
- 1988-01-26 WO PCT/US1988/000243 patent/WO1988005309A1/fr not_active Ceased
- 1988-01-26 EP EP19880901988 patent/EP0299057A4/fr not_active Withdrawn
- 1988-01-26 JP JP63501891A patent/JPH01502195A/ja active Pending
- 1988-09-27 KR KR1019880701179A patent/KR890700357A/ko not_active Withdrawn

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HYBRIDOMA, vol. 5, no. 3, 1986, pages 199-213, Mary Ann Liebert, Inc., Publishers; R. WELLERSON et al.: "Enhanced binding activity observed between anti-carcinoembryonic monoclonal antibodies" *

Also Published As

Publication number	Publication date
JPH01502195A (ja)	1989-08-03
KR890700357A (ko)	1989-04-24
EP0299057A1 (fr)	1989-01-18
WO1988005309A1 (fr)	1988-07-28

Legal Events

Date	Code	Title	Description
1988-12-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1989-01-18	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1989-02-22	17P	Request for examination filed	Effective date: 19881219
1990-04-11	A4	Supplementary search report drawn up and despatched	Effective date: 19900222
1992-05-13	17Q	First examination report despatched	Effective date: 19920331
1994-04-29	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1994-06-22	18W	Application withdrawn	Withdrawal date: 19940425

Publication	Publication Date	Title
DE3883899D1 (de)	1993-10-14	Geänderte antikörper.
DE3586313D1 (de)	1992-08-13	Konjugate von pharmazeutisch nuetzlichen proteinen.
DE3884461D1 (de)	1993-11-04	Antibiotikum-polymer zusammensetzung.
DE68922559D1 (de)	1995-06-14	Taktempfindlicher Zweikammer-Herzschrittmacher.
DE3850411D1 (de)	1994-07-28	Katheter.
FI880196A0 (fi)	1988-01-18	Foerfarande foer kontroll av fuktmaengden i en materialbana av roerligt material.
DE3870011D1 (de)	1992-05-21	Hartbutter-zusammensetzung.
FI883238L (fi)	1989-01-11	Mikrobicid komposition.
DE3873024D1 (de)	1992-08-27	Atherektomie-katheter.
NO881658D0 (no)	1988-04-15	Bifunksjonelle proteiner.
NO881077D0 (no)	1988-03-10	Kjemo-radio-immuno-konjugater.
DE3876997D1 (de)	1993-02-04	Konjugate von superoxiddismutase.
FI873345L (fi)	1989-02-01	Laosanordning.
FI883673A0 (fi)	1988-08-05	Farmaceutiska kompositioner.
FI880158A0 (fi)	1988-01-14	Diuretisk komposition.
FI885008A0 (fi)	1988-11-01	Foerfarande foer omvandling av avfall i pelletformat material.
DE3869471D1 (de)	1992-04-30	Fiebersteigende zusammensetzung.
DE3874071D1 (de)	1992-10-01	Zahnsteinverhindernde zusammensetzung.
FI881972L (fi)	1988-10-28	Anvaendning av en ace-inhibitor foer inhibitering av foerlusten av kognitiva funktioner.
DE3852496D1 (de)	1995-01-26	Katheter.
EP0299057A4 (fr)	1990-02-22	Augmentation de la puissance de conjugues cytotoxiques.
FI900075A0 (fi)	1990-01-05	Medvaexthormon bindande peptid.
FI882741A0 (fi)	1988-06-09	Rekombinant htlv-iii-proteiner och deras anvaendning.
DE3875535D1 (de)	1992-12-03	Buten-1-copolymer-zusammensetzung.
DE3874269D1 (de)	1992-10-08	Chromcarbidsinterkoerper.