EP0312760A2 - Dispositif de fermeture pour capsules en deux parties - Google Patents

Dispositif de fermeture pour capsules en deux parties Download PDF

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Publication number
EP0312760A2
EP0312760A2 EP19880114821 EP88114821A EP0312760A2 EP 0312760 A2 EP0312760 A2 EP 0312760A2 EP 19880114821 EP19880114821 EP 19880114821 EP 88114821 A EP88114821 A EP 88114821A EP 0312760 A2 EP0312760 A2 EP 0312760A2
Authority
EP
European Patent Office
Prior art keywords
cap
nozzle
sealing agent
capsule
capsule body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19880114821
Other languages
German (de)
English (en)
Other versions
EP0312760B1 (fr
EP0312760A3 (en
Inventor
Eberhard Dipl.-Ing. Krieger
Theo Moser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Publication of EP0312760A2 publication Critical patent/EP0312760A2/fr
Publication of EP0312760A3 publication Critical patent/EP0312760A3/de
Application granted granted Critical
Publication of EP0312760B1 publication Critical patent/EP0312760B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S53/00—Package making
    • Y10S53/90—Capsules

Definitions

  • the invention relates to a closing device for two-part capsules according to the preamble of claim 1.
  • a closing device of this type in which a sealing agent on the inside of an annular die of a plunger in a cap the cap is injected. It can happen that the excess sealing agent exits in the form of droplets and wets the outer surface not only of the cap but also of the capsule body connected to it.
  • the sealing agent deposited there which consists of water, liquid gelatin or the like adhesive or solvent, dissolves the surface of the capsules consisting of gelatin, starch or the like soluble substances, so that visible damage to the otherwise smooth surface is brought about.
  • the excess sealant can also cause several capsules to stick together. Furthermore, it is possible that excess sealing agent is displaced into the interior of the capsule so that it comes into contact with the filling material, which should also be avoided.
  • the device according to the invention with the characterizing features of claim 1 has the advantage that too much applied sealant is immediately removed by suction, so that a uniform film of sealant adheres to the junction of the one capsule part, which ensures a tight connection between capsule body and cap.
  • the thickness of the film can be controlled in a simple manner so that when the two capsule parts are plugged together, no sealant emerges from the seam.
  • the device according to the invention has the advantage that the sealing agent can be applied up to close to the edge of the cap without parts of it protruding outwards over the edge. This results in a particularly firm connection between the cap and the capsule part, since the edge of the cap cannot be lifted off.
  • FIG. 1 shows a cap receiving station
  • FIG. 2 shows a sealing agent application station
  • FIG. 3 shows a cap placement station, each in section of a closing device for two-part capsules.
  • the closing device is part of a machine known per se for filling and closing two-part capsules made of hard gelatin, starch or similar easily digestible substances, in which in particular powdery or liquid medicaments are packaged.
  • the capsules consist of a capsule body 1 receiving the filling material, which has a cylindrical or conical body 2 and a dome-shaped bottom 3.
  • a cap 4 can be plugged onto the capsule body 1, which cap has an upper dome-shaped closure 5 and a cylindrical extension 6 which engages over the upper part of the capsule body 2.
  • the upper part of the capsule body 2 has an externally offset part 7, over which an internally offset part 8 of the cap extension 6 engages.
  • the cap 4 is firmly and tightly connected to the capsule body 1 by a viscous sealing agent, for example liquid gelatin or water, which dissolves the wetted surface.
  • the closing device has, for example, three cap holders 11 on a switching wheel, not shown, which is rotated in cycles.
  • a cap holder 11 consists of a sleeve 12 and a plunger 13, which is guided coaxially at a distance therein.
  • the lower end of the sleeve 12 has a dome-shaped recess 14, de ren radius is adapted to the outer radius of a cap 4.
  • a cap 4 is partially receivable and is held in it by negative pressure, which acts on the cap 4 through a bore 15 in the sleeve 12 and through the gap between the sleeve interior and the plunger 13.
  • a vacuum source 18 is connected to the bore 15 via a valve 17.
  • the cap 4 thus held for transfer is removed from the cap holder 11 in that, after the negative pressure has been switched off, the sleeve 12 is pulled back relative to the plunger 13, the plunger 13 pushing the held cap 4 out of the recess 14.
  • a cap holder 11 On a cap receiving station 10 (FIG. 1) of the closing device, a cap holder 11 takes over the foremost of several caps 4 lined up in succession in a feeder 16. By rotation with an upward component, a translation component and a downward component, the cap holder 11 brings a cap 4 into each Area of a sealant application station 20 ( Figure 2).
  • a nozzle body 22 In this station 20, a nozzle body 22 is seated in a stationary block 21, the head 23 of which has a slightly smaller diameter than the inside diameter of a cap 4.
  • the nozzle body 22 has a cylindrical cavity 24 tapered at its ends and near its upper end in the head 23 several, for example twelve, cross bores 25. These cross bores 25 do not run radially to the nozzle body 22, but rather are inclined at 45 ° to the radial.
  • a tube 26 is inserted, which delimits the cavity 24 to form an annular gap 27, which is closed above the bores 25 and at the lower end of the nozzle body 22.
  • a plurality of transverse bores 28 lead to the annular gap 27 in the nozzle body 22 and are connected via a bore 29 in the block 21 to a metering pump 30 for feeding a viscous sealing agent in portions.
  • the lower end of the pipe 26 passes through the block 21 and is connected to it via a liquid separator 32 a vacuum source 33 connected.
  • the upper end of the tube 26 is flush with the upper end of the head 23 of the nozzle body 22. It wears a flat hat 36 on two narrow supports 35, the diameter of which almost corresponds to the diameter of the head 23.
  • the underside of the hat 36 forms, together with the top of the tube 26 and that of the head 23, an annular slot 37 through which air is drawn through the tube 26 by the vacuum source 33.
  • the cap 4 When transferring a cap 4 with the cap holder 11, the cap 4 is lowered over the hat 36 and the head 23 of the nozzle body 22, so that the ring slot 37 and the openings of the transverse bores 25 are immersed in the stepped part 7 of the neck 6 of the cap 4 , wherein the openings of the transverse bores 25 are arranged near the lower edge of the cap 4.
  • a short amount of sealing agent is sprayed through the transverse bores 25 almost tangentially against the inside of the cap 4 by briefly actuating the metering pump 30. The amount sprayed out is greater than that necessary for wetting the annular surface of the cap 4.
  • the cap 4 thus prepared for closing a capsule body 1 is in turn replaced by an upward, a translational and a Downward movement of the cap holder 11 is fed to the closing station 40 of the closing machine ( Figure 3).
  • a filled capsule body 1 is simultaneously brought into the closing station 40 in a carrier 41 of a feed wheel 42 rotated step by step.
  • the cap 4 carried along is placed on the upper part 7 of the fuselage 2.
  • the sleeve 12 and later the plunger 13 of the cap holder 11 is raised so that the cap 4 remains on the capsule body 1.
  • the sealing agent film previously applied to the inside of the cap 4 now also wets the adjoining upper part 7 of the capsule body 1.
  • a plurality of holders 11, sealing agent application nozzles 22 and carrier 41 can each be combined to form a unit, so that, as in known capsule filling and closing machines, a number of capsules are treated in one work cycle for higher output.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Basic Packing Technique (AREA)
EP88114821A 1987-10-17 1988-09-09 Dispositif de fermeture pour capsules en deux parties Expired - Lifetime EP0312760B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3735260 1987-10-07
DE19873735260 DE3735260A1 (de) 1987-10-17 1987-10-17 Verschliessvorrichtung fuer zweiteilige kapseln

Publications (3)

Publication Number Publication Date
EP0312760A2 true EP0312760A2 (fr) 1989-04-26
EP0312760A3 EP0312760A3 (en) 1990-06-27
EP0312760B1 EP0312760B1 (fr) 1992-12-02

Family

ID=6338583

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88114821A Expired - Lifetime EP0312760B1 (fr) 1987-10-17 1988-09-09 Dispositif de fermeture pour capsules en deux parties

Country Status (4)

Country Link
US (1) US4899516A (fr)
EP (1) EP0312760B1 (fr)
JP (1) JPH01126972A (fr)
DE (2) DE3735260A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10137054A1 (de) * 2001-07-28 2003-02-13 Boehringer Ingelheim Pharma Verfahren zum Verschweißen von medizinischen Kapseln für die Inhalation, Inhalationskapseln und Apparat zum Verschweißen
US6949154B2 (en) 2001-07-28 2005-09-27 Boehringer Ingelheim Pharma Kg Method and apparatus for sealing medicinal capsules

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07504612A (ja) * 1992-03-12 1995-05-25 ナイロック・ファスナー・コーポレーション ねじ付きファスナー製造方法および製造装置
IT1260882B (it) * 1993-06-29 1996-04-29 Ferrero Spa Dispositivo per l'assemblaggio di contenitori e relativo procedimento
ATE223692T1 (de) * 1994-06-16 2002-09-15 Warner Lambert Co Verfahren und vorrichtung zum herstellen von geschlossenen kapseln
EP1204410B1 (fr) 1999-07-30 2012-09-12 Capsugel Belgium NV Forme de dosage pharmaceutique a plusieurs composants
US6544336B1 (en) * 2000-05-30 2003-04-08 Creo Inc. Apparatus for a high efficiency spray system
US7883721B2 (en) 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
US7842308B2 (en) * 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
US20050175687A1 (en) * 2001-01-30 2005-08-11 Mcallister Stephen M. Pharmaceutical formulations
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
TW200526274A (en) 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
PE20060003A1 (es) * 2004-03-12 2006-03-01 Smithkline Beecham Plc Formulacion farmaceutica polimerica para moldear por inyeccion
EP1886657A1 (fr) * 2006-08-11 2008-02-13 Pfizer Products Inc. Dispositif et méthode pour sceller des capsules
US8454992B2 (en) * 2007-10-15 2013-06-04 Capsugel Belgium Nv Paneled capsule shells for release of pharmaceutical compositions
CN101827573A (zh) * 2007-10-15 2010-09-08 葛兰素集团有限公司 已装填的连接件的制造装置和方法
EP2209456B1 (fr) * 2007-10-15 2013-03-06 Capsugel Belgium NV Dispositifs de liaison pour formes posologiques à éléments multiples et permettant l'administration d'une ou plusieurs compositions pharmaceutiques, et formes posologiques en résultant
AU2009256572A1 (en) * 2008-06-13 2009-12-17 Capsugel Belgium Nv Hydroxypropyl cellulose capsule shell
CN103987357B (zh) 2011-10-06 2017-12-12 康宝卡普股份有限公司 胶囊的制造方法和装置
US9456987B2 (en) 2013-04-03 2016-10-04 Binutra, Inc. Capsule with internal diaphragm
EP3219300B1 (fr) * 2016-03-15 2019-06-19 Capsugel Belgium NV Appareil de scellement de capsule dure aseptique et procédés
CN114681324B (zh) * 2017-07-10 2024-05-03 盖尔凯普科技有限公司 双释放剂型胶囊及其制备方法、装置和系统
EP3607931B1 (fr) * 2018-08-07 2023-03-29 Harro Höfliger Verpackungsmaschinen GmbH Dispositif de fermeture de capsule permettant de fermer des capsules en deux parties
EP3861974B1 (fr) * 2020-02-07 2023-06-07 Harro Höfliger Verpackungsmaschinen GmbH Dispositif de fermeture de capsule permettant de fermer des capsules en deux parties
JP7756156B2 (ja) * 2020-10-02 2025-10-17 キャプシュゲル・ベルジウム・エヌ・ヴィ 単一液滴をカプセルのキャップ又は本体に吐出するための装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1077392A (en) * 1912-04-08 1913-11-04 Arthur Colton Company Capsule-filling machine.
US2811131A (en) * 1956-08-13 1957-10-29 Westinghouse Electric Corp Electrostatic coating machine for incandescent lamp envelopes
US3078629A (en) * 1960-01-08 1963-02-26 Upjohn Co Method for sealing hard filled capsules
GB1111722A (en) * 1965-12-13 1968-05-01 Millard Fillmore Smith Coating process and apparatus
GB1274818A (en) * 1969-04-05 1972-05-17 Pirelli Improvements relating to the application of insulating linings to conductive tubes
JPS509640A (fr) * 1973-05-30 1975-01-31
US3995586A (en) * 1976-01-21 1976-12-07 W. R. Grace & Co. Coating apparatus
IT1069355B (it) * 1976-03-05 1985-03-25 Zanasi Nigris Spa Perfezionamenti particolarmente nelle macchine automatiche per il confezionamento di dosi di prodotto medicinale entro capsule di gelatina
JPS5480348A (en) * 1977-12-12 1979-06-27 Onoda Cement Co Ltd Electrostatic powder coating and its device
DE2830849A1 (de) * 1978-07-13 1980-01-24 Capsugel Ag Verschliessmaschine fuer steckkapseln
JPS5881032A (ja) * 1981-11-07 1983-05-16 田淵　和久 座位分娩台
DE3148037C2 (de) * 1981-12-04 1983-10-27 Maschinenfabrik Alfred Schmermund Gmbh & Co, 5820 Gevelsberg Vorrichtung zum intermittierenden Auftragen von Klebstoff

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10137054A1 (de) * 2001-07-28 2003-02-13 Boehringer Ingelheim Pharma Verfahren zum Verschweißen von medizinischen Kapseln für die Inhalation, Inhalationskapseln und Apparat zum Verschweißen
US6949154B2 (en) 2001-07-28 2005-09-27 Boehringer Ingelheim Pharma Kg Method and apparatus for sealing medicinal capsules

Also Published As

Publication number Publication date
EP0312760B1 (fr) 1992-12-02
US4899516A (en) 1990-02-13
EP0312760A3 (en) 1990-06-27
DE3735260A1 (de) 1989-04-27
DE3876374D1 (de) 1993-01-14
JPH01126972A (ja) 1989-05-19

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